Open access peer-reviewed Edited Volume

Gene Therapy - Tools and Potential Applications

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Academic Editor

Francisco Martín-Molina
Francisco Martín-Molina

Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research,
Spain

Published27 February 2013

Doi10.5772/50194

ISBN978-953-51-1014-9

eBook (PDF) ISBN978-953-51-5362-7

Copyright year2013

Number of pages756

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Table of Contents

Open access  chapters

1. Non-Viral Delivery Systems in Gene Therapy

By Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez and María Ángeles Solinís

4,954
14
2. Plasmid Transgene Expression in vivo: Promoter and Tissue Variables

By David Morrissey, Sara A. Collins, Simon Rajenderan, Garrett Casey, Gerald C. O’Sullivan and Mark Tangney

2,574
3. Silencing of Transgene Expression: A Gene Therapy Perspective

By Oleg E. Tolmachov, Tatiana Subkhankulova and Tanya Tolmachova

3,258
4
6. DNA Electrotransfer: An Effective Tool for Gene Therapy

By Aurore Burgain-Chain and Daniel Scherman

2,553
1
7. siRNA and Gene Formulation for Efficient Gene Therapy

By Ian S. Blagbrough and Abdelkader A. Metwally

2,435
2
8. Mesenchymal Stem Cells as Gene Delivery Vehicles

By Christopher Porada and Graça Almeida-Porada

2,737
11. Transposons for Non-Viral Gene Transfer

By Sunandan Saha and Matthew H. Wilson

3,420
1
12. Lentiviral Gene Therapy Vectors: Challenges and Future Directions

By Hélio A. Tomás, Ana F. Rodrigues, Paula M. Alves and Ana S. Coroadinha

5,205
8
13. Lentiviral Vectors in Immunotherapy

By Ines Dufait, Therese Liechtenstein, Alessio Lanna, Roberta Laranga, Antonella Padella, Christopher Bricogne, Frederick Arce, Grazyna Kochan, Karine Breckpot and David Escors

2,502
14. Targeted Lentiviral Vectors: Current Applications and Future Potential

By Cleo Goyvaerts, Therese Liechtenstein, Christopher Bricogne, David Escors and Karine Breckpot

3,093
2
15. Vectors for Highly Efficient and Neuron-Specific Retrograde Gene Transfer for Gene Therapy of Neurological Diseases

By Shigeki Kato, Kenta Kobayashi, Ken-ichi Inoue, Masahiko Takada and Kazuto Kobayashi

2,540
5
16. Retroviral Genotoxicity

By Dustin T. Rae and Grant D. Trobridge

2,377
1
18. Gene Therapy for Primary Immunodeficiencies

By Francisco Martin, Alejandra Gutierrez-Guerrero and Karim Benabdellah

2,132
19. Gene Therapy for Diabetic Retinopathy – Targeting the Renin-Angiotensin System

By Qiuhong Li, Amrisha Verma, Ping Zhu, Bo Lei, Yiguo Qiu, Takahiko Nakagawa, Mohan K Raizada and William W Hauswirth

2,752
2
20. Gene Therapy for Retinitis Pigmentosa

By Hiroshi Tomita, Eriko Sugano, Hitomi Isago, Namie Murayama and Makoto Tamai

2,388
3
21. Gene Therapy for Erythroid Metabolic Inherited Diseases

By Maria Garcia-Gomez, Oscar Quintana-Bustamante, Maria Garcia- Bravo, S. Navarro, Zita Garate and Jose C. Segovia

2,525
1
22. Targeting the Lung: Challenges in Gene Therapy for Cystic Fibrosis

By George Kotzamanis, Athanassios Kotsinas, Apostolos Papalois and Vassilis G. Gorgoulis

2,096
23. Gene Therapy for the COL7A1 Gene

By E. Mayr, U. Koller and J.W. Bauer

2,733
1
2,376
25. Gene Therapy Perspectives Against Diseases of the Respiratory System

By Dimosthenis Lykouras, Kiriakos Karkoulias, Christos Tourmousoglou, Efstratios Koletsis, Kostas Spiropoulos and Dimitrios Dougenis

2,318
1
26. Gene Therapy in Critical Care Medicine

By Gabriel J. Moreno-González and Angel Zarain-Herzberg

1,867
1
28. Gene Therapy for Chronic Pain Management

By Isaura Tavares and Isabel Martins

2,920
29. Insulin Trafficking in a Glucose Responsive Engineered Human Liver Cell Line is Regulated by the Interaction of ATP-Sensitive Potassium Channels and Voltage-Gated Calcium Channels

By Ann M. Simpson, M. Anne Swan, Guo Jun Liu, Chang Tao, Bronwyn A O’Brien, Edwin Ch’ng, Leticia M. Castro, Julia Ting, Zehra Elgundi, Tony An, Mark Lutherborrow, Fraser Torpy, Donald K. Martin, Bernard E. Tuch and Graham M. Nicholson

2,581
30. Feasibility of Gene Therapy for Tooth Regeneration by Stimulation of a Third Dentition

By Katsu Takahashi, Honoka Kiso, Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang and Kazuhisa Bessho

2,471
8

IMPACT OF THIS BOOK AND ITS CHAPTERS

85,099 Total Chapter Downloads

12,260 Total Chapter Views

68 Crossref Citations

105 Web of Science Citations

184 Dimensions Citations

40 Altmetric Score

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