Open access peer-reviewed Edited Volume

RNA Interference

Edited by Ibrokhim Y. Abdurakhmonov

Academy of Sciences of Uzbekistan

RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment.

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RNA InterferenceEdited by Ibrokhim Y. Abdurakhmonov

Published: April 6th 2016

DOI: 10.5772/60631

ISBN: 978-953-51-2272-2

eBook (PDF) ISBN: 978-953-51-5429-7

Copyright year: 2016

Books open for chapter submissions

38558 Total Chapter Downloads

49 Crossref Citations

44 Web of Science Citations

94 Dimensions Citations


Open access peer-reviewed

1. RNA Interference – A Hallmark of Cellular Function and Gene Manipulation

By Ibrokhim Y. Abdurakhmonov


Open access peer-reviewed

2. RNA Interference Technology — Applications and Limitations

By Devi Singh, Sarika Chaudhary, Rajendra Kumar, Preeti Sirohi, Kamiya Mehla, Anil Sirohi, Shashi Kumar, Pooran Chand and Pankaj Kumar Singh


Open access peer-reviewed

3. The Role of Immune Modulatory MicroRNAs in Tumors

By Barbara Seliger, Anne Meinhardt and Doerte Falke


Open access peer-reviewed

4. Long Noncoding RNAs are Frontier Breakthrough of RNA World and RNAi-based Gene Regulation

By Utpal Bhadra, Debabani Roy Chowdhury, Tanmoy Mondal and Manika Pal Bhadra


Open access peer-reviewed

5. Noncanonical Synthetic RNAi Inducers

By O.V. Gvozdeva and E.L. Chernolovskaya


Open access peer-reviewed

6. Microinjection-Based RNA Interference Method in the Water Flea, Daphnia pulex and Daphnia magna

By Kenji Toyota, Shinichi Miyagawa, Yukiko Ogino and Taisen Iguchi


Open access peer-reviewed

7. ER-targeted Intrabodies Mediating Specific In Vivo Knockdown of Transitory Proteins in Comparison to RNAi

By Oliver Backhaus and Thomas Böldicke


Open access peer-reviewed

8. RNAi Therapeutic Potentials and Prospects in CNS Disease

By Kyoung Joo Cho and Gyung Whan Kim


Open access peer-reviewed

9. RNAi-based Gene Therapy for Blood Genetic Diseases

By Mengyu Hu, Qiankun Ni, Yuxia Yang and Jianyuan Luo


Open access peer-reviewed

10. Non-viral siRNA and shRNA Delivery Systems in Cancer Therapy

By Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan and Jülide Akbuğa


Open access peer-reviewed

11. siRNA-Induced RNAi Therapy in Acute Kidney Injury

By Cheng Yang and Bin Yang


Open access peer-reviewed

12. Preclinical Development of RNAi-Inducing Oligonucleotide Therapeutics for Eye Diseases

By Tamara Martínez, Maria Victoria González, Beatriz Vargas, Ana Isabel Jiménez and Covadonga Pañeda


Open access peer-reviewed

13. RNAi-Induced Immunity

By Wenyi Gu


Open access peer-reviewed

14. Perspectives on RNA Interference in Immunopharmacology and Immunotherapy

By Zhaohua Hou, Qiuju Han, Cai Zhang and Jian Zhang


Open access peer-reviewed

15. RNA Interference as a Tool to Reduce the Risk of Rejection in Cell-Based Therapies

By Constanca Figueiredo and Rainer Blasczyk


Open access peer-reviewed

16. Utility of Potent Anti-viral MicroRNAs in Emerging Infectious Diseases

By Zhabiz Golkar, Donald G. Pace and Omar Bagasra


Open access peer-reviewed

17. RNAi — Implications in Entomological Research and Pest Control

By Nidhi Thakur, Jaspreet Kaur Mundey and Santosh Kumar Upadhyay


Open access peer-reviewed

18. Management of Insect Pest by RNAi — A New Tool for Crop Protection

By Thais Barros Rodrigues and Antonio Figueira


Open access peer-reviewed

19. RNA Interference – Natural Gene-Based Technology for Highly Specific Pest Control (HiSPeC)

By Eduardo C. de Andrade and Wayne B. Hunter


Open access peer-reviewed

20. RNA Interference – A Powerful Functional Analysis Tool for Studying Tick Biology and its Control

By Remil Linggatong Galay, Rika Umemiya-Shirafuji, Masami Mochizuki, Kozo Fujisaki and Tetsuya Tanaka


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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