Open access peer-reviewed Edited Volume

Medical Complications of Type 2 Diabetes

Edited by Colleen Croniger

Case Western Reserve University, United States of America

Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed insulin secretion in both healthy individuals and in patients with type 2 diabetes. Because of the risk associated with progression from insulin resistance to diabetes and cardiovascular complications increases along a continuum, we included several chapters on the damage of endothelial cells in type 2 diabetes and genetic influences on endothelial cell dysfunction. Cardiovascular complications occur at a much lower glucose levels, thus a review on the oral glucose tolerance test compared to other methods was included. The medical conditions associated with type 2 diabetes such as pancreatic cancer, sarcopenia and sleep disordered breathing with diabetes were also discussed. The book concludes with several chapters on the treatments for this disease offering us hope in prevention and successful alleviation of the co-morbidities associated with obesity and type 2 diabetes.

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Medical Complications of Type 2 DiabetesEdited by Colleen Croniger

Published: September 12th 2011

DOI: 10.5772/867

ISBN: 978-953-307-363-7

eBook (PDF) ISBN: 978-953-51-6479-1

Copyright year: 2011

Books open for chapter submissions

58177 Total Chapter Downloads

11 Crossref Citations

22 Web of Science Citations

27 Dimensions Citations


Open access peer-reviewed

1. Insulin Secretion and Actions

By Sarawut Jitrapakdee and Briony E. Forbes


Open access peer-reviewed

2. The Oral Glucose Tolerance Test: An Old but Irreplaceable Test to Evaluate Glucose Metabolism and Cardiovascular Risk

By Gian Paolo Fra, Ettore Bartoli and Gian Piero Carnevale Schianca


Open access peer-reviewed

3. The Role of Parathyroid Hormone-Related Protein (PTHRP) in the Pathophysiology of Diabetes Mellitus

By Ioannis Legakis


Open access peer-reviewed

4. Impaired Vascular BK Channel Function in Type 2 Diabetes Mellitus

By Tong Lu and Hon-Chi Lee


Open access peer-reviewed

5. Endothelial Progenitor Cell Dysfunction in Diabetes Mellitus Type-2: Focus on Nitric Oxide System

By Saher Hamed


Open access peer-reviewed

6. Glycaemic Control and Protection of the Vasculature from Glucose Toxicity

By Hong Ding and Chris R. Triggle


Open access peer-reviewed

7. Endothelial Dysfunction and Therapeutic Intervention in Type 2 Diabetes

By Fernando Grover Páez


Open access peer-reviewed

8. Using Gene Expression Signatures to Dissect Insulin Resistance Subtypes

By Brad Hayward, Nicky Konstantopoulos and Ken R. Walder


Open access peer-reviewed

9. The Role of Single Nucleotide Polymorphisms of Untranslated Regions (Utrs) in Insulin Resistance Pathogenesis in Patients with Type 2 Diabetes

By Małgorzata Małodobra


Open access peer-reviewed

10. Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

By Lorena García, Carlos Wolff, Verónica Araya, Gloria López, Sergio Lobos, Pilar Durruty and Daniela Seelenfreund


Open access peer-reviewed

11. Functional Context Network of T2DM

By Anja Thormann and Axel Rasche


Open access peer-reviewed

12. Sarcopenia, Sarcopenic Obesity and Insulin Resistance

By John A. Batsis and Silvio Buscemi


Open access peer-reviewed

13. Type 2 Diabetes and Pancreatic Cancer – A Possible Reason

By Parviz M Pour


Open access peer-reviewed

14. Pathophysiology in Type 2 Diabetes – Type 2 Diabetes and Sleep-Disordered Breathing/Sleep Apnea – Role of Adipocytokines

By Ken Kishida


Open access peer-reviewed

15. Can Bariatric or Metabolic Surgery Cure Type 2 Diabetes?

By Gustavo P. S. Miguel, Perseu Carvalho, João Luiz Azevedo, Murilo Hosken Júnior, Évelyn Zambrana, Otávio Azevedo and Isaac Abreu


Open access peer-reviewed

16. Nuclear Imaging of Glucose Transport/Metabolism – An Interesting Tool to Screen Insulin Resistance, Refine Diagnosis of Type 2 Diabetes, Understand Disease Mechanisms, and/or Evaluate New Therapies

By P. Perret, M. Henri, L. Slimani, D.Fagret and C. Ghezzi


Open access peer-reviewed

17. Targeting PKA Signaling to Prevent Metabolic Syndrome and Delay Aging

By Linda C Enns and Warren C Ladiges


Open access peer-reviewed

18. Targeting AMPK for Therapeutic Intervention in Type 2 Diabetes

By Mohamed Kodiha and Ursula Stochaj


Open access peer-reviewed

19. Design and Evaluation of a Complex Phytoceutical Formulation for Circulatory Diseases

By J. Olalde, A. Antoshechkin, O. del Castillo, R. Guzmán and F. Améndola


Open access peer-reviewed

20. Effectiveness of Fenugreek for Lowering Hemoglobin (HbA1c) in Patients with Self-Management of Type 2 Diabetes: A Randomized Controlled Trial

By Rashid Ansari and Saiqaa Ansari


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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