Open access peer-reviewed Edited Volume

Role of the Adipocyte in Development of Type 2 Diabetes

Edited by Colleen Croniger

Case Western Reserve University, United States of America

Adipocytes are important in the body for maintaining proper energy balance by storing excess energy as triglycerides. However, efforts of the last decade have identified several molecules that are secreted from adipocytes, such as leptin, which are involved in signaling between tissues and organs. These adipokines are important in overall regulation of energy metabolism and can regulate body composition as well as glucose homeostasis. Excess lipid storage in tissues other than adipose can result in development of diabetes and nonalcoholic fatty liver disease (NAFLD). In this book we review the role of adipocytes in development of insulin resistance, type 2 diabetes and NAFLD. Because type 2 diabetes has been suggested to be a disease of inflammation we included several chapters on the mechanism of inflammation modulating organ injury. Finally, we conclude with a review on exercise and nutrient regulation for the treatment of type 2 diabetes and its co-morbidities.

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Role of the Adipocyte in Development of Type 2 DiabetesEdited by Colleen Croniger

Published: September 22nd 2011

DOI: 10.5772/1543

ISBN: 978-953-307-598-3

eBook (PDF) ISBN: 978-953-51-6495-1

Copyright year: 2011

Books open for chapter submissions

42630 Total Chapter Downloads

15 Crossref Citations

18 Web of Science Citations

31 Dimensions Citations


Open access peer-reviewed

1. The Sick Adipocyte Theory: The Forces of Clustering at Glance

By Valmore Bermúdez, Joselyn Rojas, Miguel Aguirre, Clímaco Cano, Nailet Arraiz, Carlos Silva Paredes,Marcos Lima, Raquel Cano, Eneida Fonseca and Manuel Velasco


Open access peer-reviewed

2. Lipid Droplets and Very Low Density Lipoproteins; Their Relation to Insulin Resistance

By Sven-Olof Olofsson, Linda Andersson, Jeanna Perman, Mikael Rutberg, Lilliana Håversen, Li Lu, Emma Lu, Reza Mobini, Marcus Ståhlman, Susanna Myhre, Christina Olsson, Rosie Perkins,Thomas Larsson, Jan Borén and Martin Adiels


Open access peer-reviewed

3. Role of Triglyceride/Fatty Acid Cycle in Development of Type 2 Diabetes

By Chang-Wen Hsieh, David DeSantis and Colleen M Croniger


Open access peer-reviewed

4. Obesity and Systemic Inflammation: Insights into Epigenetic Mechanisms

By Perla Kaliman and Marcelina Párrizas


Open access peer-reviewed

5. Inflammatory Markers Associated with Chronic Hyperglycemia and Insulin Resistance

By Denisa Margina


Open access peer-reviewed

6. The Regulation of Energy Metabolism Pathways Through L-Carnitine Homeostasis

By Edgars Liepinsh, Ivars Kalvinsh and Maija Dambrova


Open access peer-reviewed

7. Oxidative Stress in Type II Diabetes Mellitus and the Role of the Endogenous Antioxidant Glutathione

By Stephney Whillier, Philip William Kuchel and Julia Elizabeth Raftos


Open access peer-reviewed

8. The Role of Oxidative Stress in Pathogenesis of Diabetic Neuropathy: Erythrocyte Superoxide Dismutase, Catalase and Glutathione Peroxidase Level in Relation to Peripheral Nerve Conduction in Diabetic Neuropathy Patients

By Gordana M. Djordjević, Stojanka S.Djurić, Vidosava B. Djordjević, Slobodan Apostolski and Miroslava Živković


Open access peer-reviewed

9. Interactions Between Total Plasma Homocysteine, Oxidized LDL Levels, Thiolactonase Activities and Dietary Habits in Tunisian Diabetic Patients

By Nadia Koubaa, Maha Smaoui, Sounira Mehri, Amel Nakbi, Sonia Hammami, Raja Chaaba, Khaldoun Ben Hamda, Fethi Betbout, Mohamed Ameur Frih and Mohamed Hammami


Open access peer-reviewed

10. Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance

By Po-Shiuan Hsieh


Open access peer-reviewed

11. Assessment of Abdominal Adiposity and Organ Fat with Magnetic Resonance Imaging

By Houchun H. Hu, Michael I. Goran and Krishna S. Nayak


Open access peer-reviewed

12. Non-Alcoholic Fatty Liver Disease (NAFLD), Adipocytokines and Diabetes Mellitus

By Dhastagir Sultan Sheriff


Open access peer-reviewed

13. Disturbed Chylomicron Metabolism in Type 2 Diabetes - A Preventable Cause of Atherosclerosis?

By Gerald H. Tomkin and Daphne Owens


Open access peer-reviewed

14. The Role of Adipose Tissue in Diabetic Kidney Disease

By Young Sun Kang, Jin Joo Cha, Young Youl Hyun, Ji Eun Lee, Hyun Wook Kim and Dae Ryong Cha


Open access peer-reviewed

15. The Role of the Endocannabinoid System in the Pathogeny of Type 2 Diabetes

By Robert Dinu, Simona Popa and Maria Mota


Open access peer-reviewed

16. Beyond Dietary Fatty Acids as Energy Source: A Point of View for the Prevention and Management of Type 2 Diabetes

By Lourdes M. Varela, Almudena Ortega, Sergio Lopez, Beatriz Bermudez, Rocio Abia and Francisco J.G. Muriana


Open access peer-reviewed

17. Minimizing Postprandial Oxidative Stress in Type 2 Diabetes: The Role of Exercise and Selected Nutrients

By Richard J. Bloomer, Cameron G. McCarthy and Tyler M. Farney


Edited Volume and chapters are indexed in

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  • CNKI

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