Open access peer-reviewed Edited Volume

Nephrolithiasis - From Bench to Bedside

M Hammad Ather

Aga Khan University

Dr. M Hammad Ather is an international advisory board member of the EAU Section of Urolithiasis (EULIS) and a national representative of the Asia-Pacific Society of Uro-oncology (UAA). He is also the Vice-Chairman of the U-Merge (Urology in Emerging Countries), and a member of several other societies including Societe Internationale de Urologie and Endourological Society, USA.


Nephrolithiasis Urolithiasis Etiology Imaging Stone Management Endourology Metaphylaxis Stone Analysis Metabolic Workup Dietary Influence Metabolic Syndrome Urinary Diversion Staghorn Stone

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About the book

Nephrolithiasis (also known as Urolithiasis) is a complex disorder with a significant interplay between genetic and environmental influences in aetiology. Over the past century, significant work has been performed to understand the aetiology and pathogenesis of nephrolithiasis.

However, it has not been translated into clinically relevant preventive strategies. The rising incidence of nephrolithiasis and its link with metabolic syndrome is an interesting phenomenon. Recently, significant work has been done in this regard as well. Over the past few decades, we have also witnessed a significant change in the diagnostic and follow-up of nephrolithiasis using imaging. Whereas ultrasound and IVU were the mainstays in the past decade, CT has now taken over. CT has very high sensitivity and specificity in the diagnosis of nephrolithiasis but is associated with significant radiation exposure. Modifications and improvements in ultrasound technology with the introduction of contrast-enhanced and duplex ultrasound are significant advancements. The past three decades have also witnessed the rise and fall of shock wave lithotripsy. In recent years, advancements in endourology with miniaturization of instruments and better stone fragmentation modalities have made endourology the predominant mode of treatment for most upper and lower urinary tract stones. Stones can be present in certain challenging situations due to anatomical variations, pregnancy, urinary diversions, etc. In addition, various medical conditions like cystinuria, use of anticoagulants, etc. can make endourology difficult.

This book aims to collect the recent research in the area and provide a comprehensive overview of some of the contemporary developments.

Publishing process

Book initiated and editor appointed

Date completed: March 30th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: June 26th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 14th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 13th 2022

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About the editor

M Hammad Ather

Aga Khan University

Prof. M Hammad Ather is a consulting urological surgeon, and professor and head of Urology at the Aga Khan University, Karachi. He is an editorial board member of many international urological journals, and author of over 110 articles in international peer reviewed journals and 10 book chapters. He is also an adviser and reviewer for over two dozen international urological journals, and for dissertations at various universities nationally and the National University of Singapore. Dr. Ather was trained in Karachi and London, and has many fellowship attachments in Europe at Erasmus University, Rotterdam, Katholique Universiteit Leuven, and University College London. He has also served as the General secretary of Pakistan Association of Urological surgeons (PAUS). He is an international advisory board member of the EULIS (EAU) and national representative of Asia-Pacific society of uro-oncology (UAA). Currently, he is the Vice chairman of the U Merge (Urology in emerging countries). His research interests include topics related to urolithiasis, bladder, and advanced prostate cancer.

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Book chapters authored 3

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