About the book
Ingredients of foods stimulate taste receptors and stimulated taste receptors send neural messages to the brain. Disorders of foods intake result in obesity, atherosclerosis, hormonal disturbances leading to type 2 diabetes mellitus and cardiovascular diseases. Brain cells need glucose for the activities. Increase in glucose intake results in obesity and metabolic syndromes. However, glucose intake is prerequisite for brain functions. Salt is also important for the electrolytes balances, but too much salt intakes result in hypertension and renal diseases. Hypertension causes atherosclerosis and thrombosis. In the brain, stroke takes place in narrowed arteries caused by constriction of vessels. Serotonin and kynurenine (tryptophan metabolites) are important factors in brain functions and periphery. IDO regulates functions of T-cells in tumors, especially in lung cancer.
In this book, roles of tryptophan metabolites in activities of checkpoint inhibitors will be discussed. We welcome contribution of chapters from experts of nutrition and food related diseases to elucidate roles of eating in pathophysiology of body and brain functions.