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1. Introduction
Stem borers constitute the most widely distributed and injurious group of insect pests of cereal crops. They are commonly known to be one of the limiting factors of cereal production worldwide. They are present in field throughout the crop growing stage from seedling to maturity. The stem borers found on cereal crops in Africa are mainly lepidopterans and dipterans. Cereal crops such as rice, sorghum, maize, sugarcane and pearl millet suffer from the attack of stem borers. The larval stage constitutes the most damaging developmental stage of the pest. They are concealed inside the stem where they feed on the internal cavity of the plant making them very difficult to control. Stem borers cause severe damage on plant stems particularly the destruction of the central leaves (dead-heart) and the drying of the panicle (white head). Their attack leads to significant yield losses. According to [1], the most serious pests of cereal crops in Africa include stem borers. The severity of damage depends not only on the species and density of the pest but also on the phenology stage of the crops. Yield losses of about 10 and 100% due to stem borer have been recorded in rice fields [2].
To control these pests, various strategies have been practiced. These include cultural practices, host plant resistance, habitat management, biocontrol and the use of synthetic pesticides. Each management method has some advantages and limitation regarding its impact on environment, human health and its economic costs and sustainability. Nowadays, the integrated management, combining two or several of these management methods appears to be the most effective and sustainable option. This chapter comprises two main sections. The first section gives an overview of the main stem borers and their host range in Africa and the second section describes the various management options used to control stem borers and discusses the advantage and limitation of each method while exploring option of combining multiple methods to sustainably mitigate the effect of the stem borer on stakeholder farmers in Africa. This chapter will support the current research on the sustainable management of stem borers attacking cereal crops and will contribute to increase their productivity in Africa.
2. Overview of the main stem borers of cereal crops in Africa
Several stem borers species have been reported to cause severe damage on various cereals crop in Africa.
The maize stalkborer, Busseola fusca (Lepidoptera: Noctuidae) is reported to be of economic importance for maize and sorghum [3] while maintaining its population on some alternative hosts. The spotted stem borer, Chilo partellus (Lepidoptera: Pyralidae) is considered to be one of the devastating stem borer of sorghum and maize [4, 5] and also makes severe damage on rice in some African countries (Togola, unpublished data). The African striped rice borer, Chilo zacconius Bleszynski (Lepidoptera: Pyralidae) is among the major rice stem borer species occurring in the humid forest and savanna zones according to Akinsola [6]. The host range comprises cultivated rice, wild rice, Oryza longistaminata, Panicum sp., and Paspalum scrobiculatum but it has been found also on maize [7]. Other host plants include Pennisetum spp., Rottboellia cochinchinensis (Loureiro) W.D. Clayton, Saccharum officinarum L and Sorghum arundinaceum (Desv.) Stapf. [6, 8, 9]. The pink Stem Borer Sesamia calamistis (Noctuidae) is generally less important than Busseola fusca and Chilo partellus as a pest of cereal crops in Africa but may be locally abundant. It attacks sorghum, maize, rice and sugarcane as main host. It can be found also on wheat and pearl millet.as secondary crop host and at less extend on wild grass such as Pennisetum purpureum, Setaria sp., Rottboellia exaltata and Cyperus distans as alternative host [10, 11]. The millet stem borer Coniesta ignefusalis Hampson (Lepidoptera: Pyralidae) is an important pest of pearl millet (Pennisetum glaucum (L.) especially in West Africa [12]. The damage caused by C. ignefusalis is estimated to 15 and 100% of crop losses annually, depending on location and season [13]. The last generation enters diapause at the beginning of the dry season and stay for 6 months the time the next growing season comes. The sugarcane stem borer Eldana saccharina (Pyralidae) is a stem borer of cereal crops in Africa with particular economically importance on sugarcane. In the past E. saccharina appeared to be of very little important pest in Africa, except on sugarcane. But it has recently increased in importance on other crops such as maize, and sorghum in several African countries [14]. Also it can attack rice. Its hosts among wild grasses are Panicum maximum, Cyperus papyrus [15], Sorghum halepense, S. verticilliflorum and Pennisetum purpureum. The white rice borer Maliarpha separatella Ragonot (Lepidoptera: Pyralidae) is an important stem-borer of rice in West Africa [16]. The larva bores into the stem from the lowest internode where it feeds on the internal tissue preventing the nutrient to rise up until the panicle. The damage caused by this stem borer is said to be unique among rice stem borers because it rarely causes deadhearts or whiteheads [7]. The symptoms of M. separatella damage are similar to that of the sheath rot caused by a fungus pathogen Sarocladium oryzae. The stem of the infested plant becomes weakened, the panicles incompletely exerted from the flag leaf and the grains incompletely filled with brown coloration. M. separatella is more severe in low land, irrigated and floated rice. It also attacks the wild rices Oryza longistaminata and Oryza punctata [17]. It was also reported on some wild grasses such as Andropogon tectorum and Echinochloa holubii [18]. The rice yellow stem borer Scirpophaga spp (Lepidoptera: Pyralidae) are among the minor rice stem borers in Africa. Several species of Scirpophaga exist but the most dominant in Africa is S. melanoclista Meyrick [7]. The stalk-eyed fly Diopsis spp. (Diptera: Diopsidae) is a serious pest of rice in Africa. The two main species commonly found in rice in Africa are Diopsis thoracica Westwood and Diopsis apicalis Westwood [7]. Diopsid can be found in all rice ecological zones but preferentially in humid and shady lowland [19, 20, 21] and also in irrigated rice fields [7]. Damage from Diopsid larvae is similar to the primary damage made by Lepidopteran larvae resulting to the death of the central leaf of rice plant (deadheart). Feeding by the larvae significantly reduces the tiller density, the effective panicles, the grains weight and the total yield [7] and increases the number of immature panicles. The damage level increases according to Diopsis density. In endemic area 60% of the tillers can be infested [22]. Finally the African rice gall midge (AfRGM), Orseolia oryzivora Harris and Gagné (Diptera: Cecidomyiidae) is an indigenous dipteran borer of rice that was first reported from southern Sudan in 1947 [23, 24]. The pest is now spread in more than 20 African countries where severe yield losses have been reported. The damage converted the shoot meristem into a gall. The infested plant is no longer able to develop into a floral meristem and then the reproductive potential of the plant is severely compromised [23]. Larval feeding causes severe damage to rice during the vegetative stages (seedling to panicle initiation). Heavy yield losses of 45–80% in farmers’ rice crops have been recorded in some fields [25, 26].
A clear knowledge of these stem borer species and their host crop are of key importance for a sustainable management action.
3. Management of the main stem borers of cereal crops in Africa
Because of the nature of the habitat of stem borers (internal shelter), their management requires some specific control measures and actions. Various strategies exist for managing stem borers’ population and damage in cereals crops. These include cultural practices, host plant resistance, biocontrol and use of synthetic pesticides.
3.1 Preventive cultural practices
Cultural practices are considered as classic pest control methods. This method consist of manipulating the cropping systems in order (1) to avoid the meeting of crop susceptible stage with pest highest density or (2) to improve the crop growing condition or (3) to make the environment unfavorable for pest proliferation. The cultural practices have the advantage to be easy to implement with less cost. They are more convenient for smallholder farmers in developing countries [27]. Preventives cultural practices comprise a wide range of agronomic practices. These tactics need to be undertaken as first line defense measures to prevent high infestation of stem borers in cereals fields. Among the most effectives cultural practices in controlling stem borers there is cereals intercropping or strip cropping with non-host crops such as cowpea, soybeans and groundnut. Also the choice of appropriate date for planting cereals crops allows the crops to escape to critical period where the pest pressure is high [28]. The sol fertilization and field hygiene are cultural practices that reinforce the plant vigor and increase its defense system. [29, 30] demonstrated that zinc fertilization and potassium fertilization significantly decrease stem borers population in rice and increase paddy yield. Other practice such as destruction of crop residues (burning, plowing or disking) appears to be an effective cultural tactic for limiting the number of diapausing larva of stem borer. [31] demonstrated that plowing and disking crop residues destroyed 24% of the stem borers’ population on sorghum and 19% of maize stem borers. Similarly, [32] reported that the destruction of sugarcane residue after harvest significantly reduced the infestation of subsequent crops by Eldana saccharina. Burning of crop residues was also reported to be effective against Chilo spp. and Busseola fusca as well [15]. Burning or composting old stalks before the onset of the rains is effective against B. fusca [13]. The management of the maize stalkborer B. fusca includes intercropping maize with non-hosts crops like cassava and cowpea or with a repellent plant such as silver leaf desmodium (Desmodium uncinatum) [33]. Others cultural practices such as destruction of alternatives host plants or ratoons, synchronized plantings, crop rotations, high cropping density, use of trap crops, good irrigation and good fertilization are good cultural tactics against the insect pests in general and stem borers in particular [27]. The use of trap crops or intercropping upland NERICA rice and maize have also been suggested as an effective method for controlling M. separatella in rice ecosystems in Nigeria [26]. Practices such as irrigation, planting density and dates of planting were all found to be effective as well important factors for consideration [17, 34]. According to [24], the management of the African rice gall midge take into account early and synchronized planting as rice fields planted early are less likely suffer serious damage than those planted late. Also destruction of alternative host plants such as rice ratoons, volunteers and Oryza longistaminata as well as the use of moderate levels of fertilizer (e.g. 60 kg/ha) prevent the build-up of AfRGM population. The same author highlighted the importance of plant spacing as close spacing provides a suitable micro-environment for the survival of the exposed life stages of AfRGM. Cleaning of the rice field especially the destruction of the wild rice are good cultural practice for managing the African striped rice borer, C. zacconius. The ‘push-pull’ method based on the intercropping of Desmodium with millet was report to effectively act as a repellent that ‘pushes’ the millet stem borer C. ignefusalis away from the millet [35]. The most useful advantage of the cultural practices is that they are compatible to all pest control measures. They represent an important component of the integrated pest management of the stems borers. The main disadvantage of the cultural practices is that they need to be continuous and collective process from field preparation to harvest. A good cultural practices field can get infested if the surrounding farmers do not apply same or no management option.
3.2 Varietal resistance
Plant resistance is the genetically inherited qualities that confer the plant ability to ward off or withstand pest attacks or recover from injury due to a pest [36, 37]. This method is the most farmer-friendly pest control option that can significantly reduce stem borer damage when supplemented with other options such as cultural or biological measures. It is most attractive as the use of insecticides is largely beyond the means of the small farmer. Considerable progress has been made in screening and breeding for host plant resistance to cereals’ stem borers but only limited number of varieties have shown good level of resistance. Wiseman [38] showed that the resistant cultivar should be the base from which integrated pest management strategies arise. Rana et al. [39] reported that antibiotic property in sorghum plays more role in plant resistance to stem borer than ovipositional non-preference. Some plant biophysical characters such as stem hardness, leaf hairiness are important in plant resistance to stem borers. Sorghum varieties having these traits are rejected by the moths for oviposition. Pearl millet varieties such as Zongo was reported to be moderately resistant to Coniesta ignefusalis [40]. According to [41], hairiness of leaves and leaf sheaths were partly responsible for the differences in genotypic vulnerability to C. ignefusalis. Also they reported that plants with trichomes were not preferred by this pest for oviposition. [42] reported good level of resistance in the sweet sorghums BR 501, BR 504, and BR 505 to the sugarcane borer Eldana saccharina. [20], found good source of resistance to diopsids among upland NERCA varieties. Also, they reported that rice varieties having ability to produce new tillers to compensate the infested stems can tolerate the damage by diopsid. So far no improved rice variety was identified to be resistant to O. oryzivora attack but some tolerance was noted in Oryza glaberrima and also in some improved released rice varieties in Nigeria such as Cisadane and FARO 51 [24]. Despite limited achievement on varietal resistance to stem borer, this option remain a promising IPM component. Recent advances in biotechnology can increase the prospects of generating resistance materials and accelerate the transfer of gene for improving new genotypes.
3.3 Biological control measures
Biological control is the manipulation of natural enemies with the aim to maintain pest population below the economic injury level (EIL). Several organisms such as insects, fungus, virus and bacteria can be used as biocontrol agents [13, 43]. Insects based organisms acting as natural enemies are either predators (using the host as food) or parasitoids (laying their eggs in the host). Most of these insects belong to hymenoptera or diptera orders [27]. Biocontrol appears to be one of the most effective and environment friendly management option of stem borers. Indeed, stem borer’s population and damage can be regulated by sustaining the action of natural enemies. This can be done through a good habitat management to favor the buildup of the population of natural enemies (spiders, wasps, ladybirds, etc.) or through mass rearing and field release of specific parasitoids to control target pest species. The success of the release of several parasitoids was reported in managing cereals stem borers in Africa. Two natural enemies of the maize stalkborer (B. fusca) are the larval parasitoids Cotesia sesamiae and Bracon sesamiae [31, 44]. Parasitoids such as Tetrastichus atriclavus, Apanteles sesamiae, and Pediobius furvus have been reported by [13] to be most important parasites of B. fusca. Similarly Cotesia flavipes and Xanthopimpla stemmator was reported to effectively control the spotted stem borer C. partellus [4]. The parasitoids Cotesia sesamiae, Xanthopimpla stemmator, Trichogramma spp, etc. are cited as good biocontrol agent against the pink Stem Borer Sesamia calamistis (Togola, unpublished data). The biological control of the cereal stem borers is mainly based on habitat management to sustain natural enemies including various parasitoids wasp. [45] found that that the contribution of egg parasitism is more important in controlling lepidopteran stem borers than parasitism of larvae and pupae. The African rice gall midge (AfRGM) is attacked by two parasitoids such as Platygaster diplosisae (Hymenoptera: Platygastridae) and Aprostocetus procerae (Hymenoptera: Eulophidae) that can decrease the population of the pest below the economic injury threshold in rice-production systems [25]. Several insects species such as Cyrtorhinus viridis (Heteroptera: Miridae), Conocephalus longipennis (Orthoptera: Tettigoniidae) and Anaxipha longipennis (Orthoptera: Gryllidae) are predators of AfRGM [24]. The effectiveness and sustainability of the biological control methods depends on the availability of the biocontrol agent at suitable density. Practices such as habitat management or avoiding the use of wide spectrum chemicals can contribute to increase the carry-over of population of natural enemies and maintain the pest population below a critical level. The main constraints of the biocontrol measures are the difficulty to find the specific biocontrol agents for targeted pest species, the complexity of the mass rearing and the complication to be explained by extension workers and to be implemented by farmers.
3.4 Chemical control
Chemical control, despite all the danger and environmental hazard, remains an important option to consider in situation where the pest population is already established. Also it can be used as IPM component to supplement varietal resistance or cultural practices. Chemical control can be achieved by applications of granules or dusts to the leaf whorl early in crop growth to kill early larval instars of E. saccharina [10]. Controlling M separatella using chemical insecticides is effective but not widely practiced because of the high costs involved [46]. As for O. oryzivora, chemical control can be envisaged in conditions of high infestation of rice field. In all cases, choice of selective systemic insecticides is needed to avoid adverse effects on non-target organisms and biodiversity.
3.5 Integrated pest management option
The individual control methods discussed above have their limitations and none often is sufficient to adequately control stem borer outbreaks. Hence, the integrated pest management (IPM), also known as integrated pest control (IPC) appears to be the most appropriate option for managing these pests. IPM requires the combination of several compatible and complementary practices with the aim to maintain pest populations below the economic injury level (EIL) while reducing the use of high hazardous pesticides and sustaining the action of natural enemies. Several studies have reported the success of IPM in the management of cereals’ stem borers. [25] reported that varietal resistance/tolerance, cultural practices and biological control are important components of integrated management of rice stem borers. Similarly [24] found that the effective control of the African Rice Gall Midge relies on the combination of cultural practices, habitat management and moderate use of insecticide chemical. Kega [47] demonstrated that the use of resistant rice cultivars and entomopathogenic nematodes is a viable method to control M. separatella. Nwanze and Mueller [48] indicated that host plant resistance and cultural practices should be major components in the integrated management of sorghum stem borers. According to [49] an increase of yield can be obtained when sorghum varieties with tolerance or moderate resistance to stem borer are coupled with need-based application of pesticides. Youm et al. [41] suggested options such as early planting, destruction of crop residues and use pheromone bait traps for successful management of the millet stem borer C. ignefusalis. According to the conclusion from an international workshop organized by the International Institute for Semi-Arid Tropics, cultural methods and host plant resistance should be considered as the major components of the integrated management of cereals’ stem borers [50]. However these practices need to be reinforced with other measures such as biological control and if necessary the use of selective systemic chemical . It is important to quote that integrated stem borer management is likely to be severely constrained by the limited capability of farmers to implement several options . For this reason it is highly important that the IPM takes into account the community farming systems and know-how.
4. Conclusion
The stem borers represent a group of insects of economic importance to cereal crops in Africa. Because of the nature of their attacks and the complexity of their biology, the success of the management options will depends on the integration of various strategies ranging from cultural practices to host plant resistance, biological control and moderate use of systemic chemical when necessary. The cultural practices and host plant resistance remains the major component of the IPM of cereal’s stem borers. They can be reinforced by the biological and chemical control. The cultural practices involve farmers’ engagement and cooperation. As for varietal resistance, more research action is needed to identify or develop varieties that tolerate the stem borers attack. Regarding the deployment of chemical and biocontrol options, more intensive action from extension service is need to increase the capacity of farmers so that they can engage appropriate action to limit yield losses in cereal and increase their incomes.
\n',keywords:"IPM, environment friendly, yield loss, biocontrol, cultural practices",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65296.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65296.xml",downloadPdfUrl:"/chapter/pdf-download/65296",previewPdfUrl:"/chapter/pdf-preview/65296",totalDownloads:978,totalViews:0,totalCrossrefCites:2,totalDimensionsCites:2,totalAltmetricsMentions:1,impactScore:1,impactScorePercentile:60,impactScoreQuartile:3,hasAltmetrics:1,dateSubmitted:"June 5th 2018",dateReviewed:"December 21st 2018",datePrePublished:"January 15th 2020",datePublished:"February 19th 2020",dateFinished:"January 22nd 2019",readingETA:"0",abstract:"The economic importance of the stem borer in Africa results in their severe damage that affect directly cereal yield factors such as the density of fertile tillers and the number of effective panicles. The objective of this paper is to describe and discuss the management options of the main prevalent stem borer of cereal crops in Africa. Host plant resistance, cultural practices, biological control and reasoning chemical control are among the most encouraging options. Integrated pest management combining several compatible methods was highlighted as the most sustainable control option. This paper will served as support for the current research on cereal crops but also as relevant prospect document for entomologists and breeders from across the world.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65296",risUrl:"/chapter/ris/65296",book:{id:"7545",slug:"pests-control-and-acarology"},signatures:"Abou Togola, Ousmane Boukar, Manuele Tamo and Siva Chamarthi",authors:[{id:"261663",title:"Dr.",name:"Abou",middleName:null,surname:"Togola",fullName:"Abou Togola",slug:"abou-togola",email:"a.togola@cgiar.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"274308",title:"Dr.",name:"Ousmane",middleName:null,surname:"Boukar",fullName:"Ousmane Boukar",slug:"ousmane-boukar",email:"o.boukar@cgiar.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"274309",title:"Dr.",name:"Manuele",middleName:null,surname:"Tamo",fullName:"Manuele Tamo",slug:"manuele-tamo",email:"m.tamo@cgiar.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"274310",title:"Dr.",name:"Siva",middleName:null,surname:"Chamarthi",fullName:"Siva Chamarthi",slug:"siva-chamarthi",email:"s.chamarthi@cgiar.org",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Overview of the main stem borers of cereal crops in Africa",level:"1"},{id:"sec_3",title:"3. Management of the main stem borers of cereal crops in Africa",level:"1"},{id:"sec_3_2",title:"3.1 Preventive cultural practices",level:"2"},{id:"sec_4_2",title:"3.2 Varietal resistance",level:"2"},{id:"sec_5_2",title:"3.3 Biological control measures",level:"2"},{id:"sec_6_2",title:"3.4 Chemical control",level:"2"},{id:"sec_7_2",title:"3.5 Integrated pest management option",level:"2"},{id:"sec_9",title:"4. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Bosque-Pérez NA, Mareck JH. Distribution and species composition of Lepidopterous maize borers in southern Nigeria. Bulletin of Entomological Research. 1990;80(4):363-368'},{id:"B2",body:'Schulthess F, Bosque-Pérez NA, Gounou S. Sampling lepidopterous pests on maize in West Africa. Bulletin of Entomological Research. 1991;81(3):297-301'},{id:"B3",body:'Annecke DP, Moran VC. 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In: Proceedings of the International Workshop on Sorghum Stem Borers. 1987, November. pp. 17-20'},{id:"B50",body:'ICRISAT (International Crops Research Institute for Semi-Arid Tropics). International workshop on sorghum stem borers, 17-20 Nov, 1987, ICRISAT Center, India Patancheru. 1989. AP. 502324 India: ICRISAT'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Abou Togola",address:"a.togola@cgiar.org",affiliation:'
International Institute of Tropical Agriculture, Nigeria
International Institute of Tropical Agriculture, Nigeria
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\n
1. Introduction
\n
Alpine skiing is a very popular sports with an increasing number of participants worldwide although being considered a high-risk sports with a high incidence of injuries in its participants. It is a sports with a great diversity in the profile and level of people practicing it, from amateur skiers to professional athletes with a high number of hours of exposure to injury risk.
\n
Among the most frequent injuries, there are those affecting the knee joint, with a wide specter of severity: from mild sprains or contusions to serious multiligamentary injuries or complex fractures.
\n
The aim of this study is to perform a literature review to assess the more common injuries in alpine skiing, see if there is a change in recent years due to new equipment and attitudes, look for its risk factors, and analyze possible preventive measures to reduce the risk of serious injuries.
\n
\n
\n
2. Epidemiology
\n
Alpine skiing is the most popular winter sports [1] worldwide. Only in the United States, more than 18 million people 5 years old or older participated in alpine skiing or snowboarding at least in one occasion in the 2011–2012 season [2], and there are about 200 million skiers worldwide [3]. Even more this popularity seems to be increasing all around the world.
\n
Professional skiing is also a popular sports, with 3625 ski races arranged by the International Ski Federation (FIS) in the 2007–2008 season, of those 74 were Alpine Ski World Cup races in which up to 443 athletes participated [4]. Ski racing comprises diverse disciplines from aggressive-turning and highly technical demands like slalom to high speed with big jumps with almost no protective wear like downhill. Besides, alpine ski racing is a popular TV sports, with up to 250 million of TV spectators in 2009 according to FIS data.
\n
It is a well-known fact that skiing is a sports with a high incidence of injuries, some estimate about 2.5–3 injuries per 1000 skier days in amateur practice [3], with head trauma and injuries around the knee being the most frequently reported. Knowing this data one can simply imagine the huge sanitary, social, and economic burden that skier injuries suppose in our societies.
\n
\n
\n
3. Material and methods
\n
A literature search was made using the PubMed database. We used keywords as ski and knee in order to maximize the number of results. In this first search, we obtained 285 results. We decided to include articles from 1995 to 2018 to be able to compare data published before many technological innovations were introduced with more recent data; this limited the number of articles to 211. All titles and abstracts were analyzed to identify the articles of interest: those investigating about the incidence, types, and risk factors for knee injuries during the practice of alpine skiing in adult population, either amateur or professional.
\n
Descriptive and analytical studies were included, and some reviews were taken into account for its particular interest and value. Experimental and laboratory studies were excluded, as well as case reports. We had to discard all articles not written in English and those whose complete text was not possible to obtain for any reason. All the process with its phases is detailed in \nFigure 1\n.
\n
Figure 1.
Chart showing the selection process of our study.
\n
Given the reduced number of studies with high-quality evidence in knee injuries in alpine skiing, it was deemed that the best methodology was to do a narrative review.
\n
\n
\n
4. Results
\n
After applying the process explained in the previous point, we had 21 results, 18 original articles, and 3 reviews.
\n
When analyzing all the studies, the first thing that stands out is the big variability between them. We could find studies referring to professional athletes and others to general amateur skiers. We could also find studies done in high-level trauma centers and others done in small ski resort clinics without a physician, with great differences in the diagnostics and clinical information reported. Moreover, the studies’ designs also presented a great variability.
\n
\n
4.1 Athlete skiers
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Referring to the alpine ski racers’ population, Stenroos and Handolin [1] reported no differences in the absolute injury rate in men compared to women, although the mean age of their study is 14 years old, which in our opinion can produce some bias. The most common injury mechanism was the fall down on the same level, with 56% of injuries taking place on giant slalom runs (characterized by higher speed runs) and 31% on slalom runs. About 74% of injuries in this study group required hospitalization. Knee injuries represented the 34.4% of all injuries: 81% were ligamentous injuries being 47% of them anterior cruciate ligament (ACL) injuries (which means the ACL injuries were the 13% of the total). Ligamentous knee injuries were more common in women than in men; in the ACL group, 75% of injured skiers were women. Recovery after an ACL injury took a mean time of 175 days (range 150–180 days) without skiing, and all those patients reported mild or great discomfort in skiing 6 months after the injury. No knee fractures were reported; but 26% of injuries were leg (tibia and fibula) fractures, a surprising high rate when comparing to literature, probably due to the relative young age of this study population.
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Similar results were reported by Schmitt et al. [5] in a study in athletes in the Swiss national ski teams. A knee injury rate of 35% was reported, with no differences between men and women; 71% were ACL injuries, of which 26% were isolated ACL injuries and 44% presented an associated injury of a collateral ligament and/or menisci. Their conclusion is that ACL is the most frequent knee injury in competitive alpine skiing. In their objective to describe risk factors for ACL injury, they report a higher risk in slalom runs (with more aggressive and technical turns but at lower speeds) and in athletes with better FIS score and rank, highlighting a higher prevalence of ACL ruptures in the top 30 World Cup skiers. Finally, body mass index, weight, and fitness status (assessed with a specific fitness test: Swiss Ski Power Test) did not correlate with ACL injury risk.
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In two successive studies, Flørenes et al. [4] and Bere et al. [6] investigated the sex differences in risk injury in World Cup skiers, first for two seasons [4] and then for six seasons [6]. They report a mean absolute injury rate of 36.2 injuries/100 athletes/season with a higher relative injury rate in men (11.3 injuries/1000 runs) than in women (7.1 injuries/1000 runs). Of this 82.3% were time-loss injuries, with 43% being reported as severe (absence from skiing >28 days) and 31% moderate (absence 8–28 days). 45.5% of the injuries took place during the World Cup races. Knee injuries represented the 38% and lower leg and Achilles tendon injuries the 9%. In ACL injuries, there were no sex differences (5.4 ACL injuries/100 athletes/season in men vs. 5.5 in women).
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When analyzing knee injuries, they reported that 83% were ligamentous injuries, of which 45% were ACL injuries (that makes the ACL the most common ligament injury), and only 4.4% were fractures. They report that 50% of knee injuries are classified as severe. The relative ACL injury rate was higher in downhill and supergiant races (high speed with softer turns) than in giant and slalom races; this result matches with Stenroos’ study results [1].
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In [7, 8], Jordan et al. made a review in which they report literature finding that only 55% of alpine skiing athletes are able to return to their preinjury level after an ACL rupture. They also support the result we have found that in this group of skiers there is no sex difference in ACL injury rates.
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4.2 Amateur skiers
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Referring to amateur skiers, Patrick et al. [2] made a study comparing injury epidemiology in skiers between the 1996 and 2013 seasons. In both years, the knee was the most commonly injured body part (28%). An interesting fact they report is that helmet use augmented from only 6 to 84%, which means that although there is an increasing effort to make skiing a safer sports this has had no impact on the amount of knee injuries. They also report and increase in injuries among people older than 45 years. This results match with the published by Stenroos et al. [1] when they report an injury risk of 1 injury/10,000 ski lifts or in their calculation 1.97 injuries/1000 skier days in amateur people. Knee lesions were the 28.5% of the total, almost half of them being suspected as moderate or severe injuries. A major limitation in this study, which is also present in similar ones, is the lack of precise diagnostics, as data is collected by rescuers and/or in small ski resort clinics.
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Continuing with the epidemiology review, Girardi et al. [9] studied factors affecting injury severity using the Injury Severity Score (ISS). They found that being a man and being older than 60 years were risk factors for an increased ISS, while the ISS was lower in beginner skiers and during a snowfall. There is no information in this article about these risk factors relating to knee injury risk. In [10], Khalilifar et al. report a lower knee injury rate, of only 14%, but this rate being higher in women, a result also found in other studies [11, 12, 13, 14].
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In [15], Davidson and Laliotis, a 9-year survey (from 1983 to 1992) of injury patterns in alpine skiers, reported an increase in injury rate from 1.9 to 3 injuries/1000 skier days. Knee injuries were 35%, and what is more relevant is a 92% increase in the number of knee injuries during their study period.
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A very similar study period is researched by Warme et al. in [16] reporting a stable injury rate of 3.7 injuries/1000 skier days and knee injuries being 34% of the total. The most relevant part is that they report an exact diagnostic information (30% of the total on injuries affected the knee ligaments): 18% the medial collateral ligament (MCL), 16.5% the ACL, and in 20% of knee sprains, both ligaments were affected. They report a significant increase in ACL injuries.
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Coury et al. [17] compared the epidemiology of skiing injuries in a ski resort clinic between 1995 and 2000 and the 2009/2010 seasons. Their results show also the knee injury as the most frequent (43%). Knee ligament sprain or strain was diagnosed in 25% on injured people, 10% with torn cruciate ligament, and 6% with what they call “internal derangement of the knee” (probably, a torn meniscus was to be diagnosed in this group of patients). Skiing injuries were more common in intermediate- or advanced-level skiers, but beginner skiers were the ones most at risk for knee injuries. They report only 3.2% on tibia and fibula fractures, and only 3.6% of ankle injuries in skiers, while snowboarders present up to 13% of ankle injuries. This difference may be explained by the use of hard-shell boots in ski.
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A recent interesting study [18] discusses about injuries from 2001 to 2006 in a level 1 trauma center, which probably means a loss of minor injuries but on the other hand can inform about the most severe ones. They report a 52.3% of lower extremity injuries, the majority classified as soft tissue knee injuries but with a 2% of knee dislocation, 26% of tibia fractures (ankle not included), and 15.7% of femur fractures. The mean hospitalization rate was of 3.36 days, and 13.9% of patients required a surgical intervention. In our opinion, the high rates of severe injuries, especially major bone fractures, are because of a selection bias due to the nature of the hospital where the study took place. Results published by Ekeland et al. [19] support our conclusion: injury rate of 1.27 injuries/1000 skier days with leg fractures being only 3.6% in adult population. In children these fractures made up to 12.6% of injuries. They conclude that while there was a huge reduction in leg fractures during the 1970s–1980s probably due to higher quality of boots, making them higher and hard-shelled, and bindings, this reduction was not observed in children to the same degree.
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In the same direction point, the article by Castellani et al. [14] reported that fractures in skiers are more common in men and especially in younger patients (<15 years old). Knee injuries are the most common (28.3–31.3% of injuries), with knee fractures being between 2 and 5%. A result that is important to be highlighted is their finding of an increased risk in women for knee ligamentous injury: men presented 14–15% of ligamentous knee injuries and 36–41% in women. In their data, the hospitalization rate was of 26%, from which 62% underwent surgery; mean hospital stay was 10.5–12.8 days. Knee arthroscopy was realized in 1.9–6.3% of operations. These results can be biased by the fact that almost half of injured patients were referred to their home hospital for treatment of lesions; and as ligamentous injuries are not a surgical emergency, the probability of being referred to in the presence of such an injury grows when compared to a patient with a fracture.
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4.2.1 Risk factors in amateur skiers
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Some studies did an effort to clarify which risk factors play a role in knee injuries in alpine skiers. As commented before this is a more heterogeneous group with big differences with respect to ski racers, so risk factors may be completely different.
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Sulheim et al. [20] reported that beginners (OR 2.7) and children younger than 13 years old (OR 1.32) were more at risk for injury. In their data, 27.3% of injuries affected the knee joint, and more than half of injuries required reference to a hospital as a potentially severe injury was suspected. When considering knee injuries alone, they also found that beginners (OR 3.13) were at increased risk, which matches results found by Coury et al. [17]. Alpine skiing was a risk factor for knee injury (OR 1.82) when comparing with other snow sports like snowboarding and telemark.
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Ruedl et al. [13] confirm that women are at higher risk for knee and ACL injuries presenting almost double prevalence for this kind of lesions in their data (30.1% in men and 57.4% in women). They report that 93% of knee injuries happened on slopes, and while off-piste skiing had a higher risk injury, it was not at an expense of knee ones. When analyzing by sex, no environmental risk factors for knee injury were found in men, while in women skiing during a snowfall doubled the prevalence on knee injuries compared with injuries of other body parts. Additionally, they found an increased risk when temperature was low (OR 1.6 when skiing at −10°C vs. +2.7°C). Finally, in this study more knee injuries were found in situations of grippy snow in which, as reported by them, this finding is contrary to other literature reporting a higher index on icy snow.
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A very interesting study [11] researched the relationship between ACL injury and ski binding failure. In this study 77.9% of ACL-injured patients reported a failure of ski bindings to release. The percentage of failure to release bindings was even higher in female skiers, in skiers injured after a fall backward (vs. a forward fall), and in those who were skiing slow or very slow. There is always a significantly higher percentage of failure to release in patients diagnosed with a complete tear of the anterior cruciate ligament (vs. those with a partial tear), probably because when the ski is not released it acts as a lever at the knee joint for a longer time. Similar results are reported in [12]: bindings only released in 23.8% of knee-injured skiers, with an even worse percentage if only adults (>18 years old) are considered, and 19.3% of binding release among amateur skiers with a knee injury.
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5. Discussion
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In the elite alpine skiers, there is a high injury rate, especially in knee injuries and ACL. This high prevalence of knee ligament injuries can also be found in amateur skiers, but probably a more aggressive skiing and risk-taking behavior trying to achieve the best results is what explains the higher injury rate in this expert skiers’ group. Comparing to studies done in general population, studies in ski racers present better data with more exact diagnostic information and prognosis. ACL and other knee structure injuries present the same incidence in both men and women; this was a surprising finding when taking into account what literature reports about amateur skiers and other high-risk sports for ACL injury: a higher incidence in women. Differences in skiing technique, fitness, behavior, and equipment between elite alpine skiers and amateurs may explain why ACL injury rate is equal in men and women, among ski racers. Whatever the reason is, in our opinion an effort should be made to minimize ACL injury risk in all athlete skiers, as it is a devastating injury that can be the end of the skier’s professional career. We found no agreement in the literature about the most dangerous alpine ski discipline for the knee: slalom is characterized for aggressive technique with short turning-radius skis, which may be a risk factor of a knee ligament lesion with a rotational injury mechanism; on the other side, downhill and giant slalom are characterized for higher speeds, which means higher kinetic energy, plus the fact that a longer ski means a greater lever-arm rotational force being transmitted to the knee joint.
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Even with the limitations present in studies involving amateur skiers due to their heterogeneity in methodology and limits on precise diagnostic, treatment, and follow-up, we found that the knee joint is the most frequently injured body part, and some studies show there is an increasing trend in ligamentous knee injuries among alpine skiers. Literature found reports that up to half of the injuries are moderate or severe, especially among older skiers, who present a higher injury risk and also a higher risk for serious injury. In our opinion this may be explained by the decrease in physical capabilities associated with aging. Another group at risk for knee injury is the beginner skiers; no explanations for this were found in the literature. In our opinion a poorer technique, bad decision taken related to poorer risk awareness, and probably less knowledge about the correct settings of equipment gear as ski bindings may explain it.
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As also found in other sports studies, amateur women have a higher ACL injury risk when skiing. This was found to be supported widely in literature [10, 11, 12, 13, 14]. To explain this difference in incidence, we found literature suggesting on a combination of intrinsic factors: anthropometric differences, decreased notch width, augmented articular laxity and muscle (hamstring) flexibility, age, fitness status, and menstruation phases, plus the extrinsic ones such as the type of ski, ski binding setting, slope, and weather. We agree that most probably a combination of anatomic, functional, and extrinsic factors justifies this higher risk. The exact reasons have still to be discovered, but at least we should be able to focus the preventing efforts in the higher injury-risk groups.
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We found literature reporting that in 44% of lower extremity injuries (in 44% of MCL injuries and 43% of ACL injuries) skiers were going slow or were stationary, meaning that skiing slowly increments the risk for ACL injury and the risk of bindings fails to release. This last result probably explains the increased ACL injury risk in a fall when skiing slowly, as a lower kinetic energy, should mean a lower injury risk for knee structures.
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Skiing in bad weather situations, lower temperature, and/or during a snowfall also were risk factors for knee injury, especially in women. The explanation for this last finding may be the increased risk of cooling which causes a decrease of muscle performance. In [13], there is reference to literature where a 10 times increase in ACL injury risk is reported in bad light conditions and also in case of strong snowfalls (double of risk) probably due to bad visibility plus lower temperatures. In our opinion bad visibility conditions like snowfalls are high-risk situations as it can make the skier to run into bumps able to turn the ski without being able to see and avoid it. This knowledge should be used to warn or even prevent people from skiing in bad weather days.
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5.1 ACL biomechanics and injury mechanisms
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As multiple articles in the literature report, the ACL is probably the most common injured ligament of the knee in alpine skiers. The second most common injured structure would be the MCL, although not all series agree on this order.
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The anterior cruciate ligament is a primary stabilizer of the knee joint, being the main structure to resist tibia anterior translation with respect to the femur. It also restricts tibia internal rotation with knee between 0 and 30° of flexion, prevents hyperextension, and is a secondary stabilizer against the valgus, especially with the knee in extension, when the MCL has a decreasing role.
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The medial collateral ligament is the most important knee-stabilizing structure in the medial part of the joint; its main function is to resist the valgus forces and tibia internal rotation and has a secondary role in preventing the anterior translation of the tibia with respect to the femur.
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As just seen both ligaments have similar or supplementary functions and are believed to act synergistically. This can explain the prevalence of combined total and partial injuries in skiing and other sports accidents. In other ACL injury high-risk sports, such as soccer, this lesion usually happens when with a foot planted on the ground the player does a sudden deceleration plus external rotation and/or valgus, presenting a twist at the level of the knee joint. Skiing mechanics involve a dual-surface movement [17], and skiers tend to sustain injuries when the ski catches an edge and there is a body torqueing with relation to the knee joint.
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A consequence of special mechanics involved in skiing is that several injury mechanisms have been proposed. Shea et al. [12] affirm that injury mechanism in elite and amateur skiers might be different, a point partially supported by other literature when they report different percentages of each injury mechanism in each one of these groups.
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In [12], and also in two interesting reviews [7, 21], proposed injury mechanisms are explained; a summary of this is of high interest for a better understanding of knee injuries in skiers:
Valgus external rotation: after losing balance and shifting the center of gravity forward, the inside edge of the ski touches the ground producing abduction and external rotation of the tibia, while the skier’s body advances respect to the knee, creating a valgus force. This mechanism is thought to damage the MCL and the ACL due to the valgus plus the rotation force applied to the knee. The presence of a valgus deformity may also cause a lateral meniscus traumatic tear. This was found to be the most common mechanism of injury in recreational skiers (up to 32.9% of cases) since the generalized use of carving skies [11, 12], and in one publication [12], it was related to high-level amateur skiers. This injury mechanism was found to be related with the failure of ski bindings to release [11].
Hyperextension internal rotation: occurring in heavy snow, it happens when the ski is slowed while the body keeps advancing forward. Usually, it associates a crossing of ski tips, producing internal rotation and varus force. The forced internal rotation in a probably extended knee is responsible for the ACL injury; as in an extended position, the ACL is the main knee joint restrictor against the internal rotation. This forced movement can also damage lateral structures like the lateral collateral ligament by distraction or the lateral meniscus if it is trapped under the femoral condyle when turning. This is the reported mechanism in 19% of injured skiers.
Boot-induced anterior drawer: when the skier lands from a jump, the ski tail is the first part to contact the snow causing the body weight to go backward while the leg is driven forward by the boot attached to the ski, applying an anterior force on the tibia. This effect can be increased by a strong quadriceps contraction to avoid a fall. With this mechanism the ACL is putted under great tension to avoid the anterior translation of the tibia with respect to the femur causing the injury. As the ACL is isolated and there is no rotation or varus-valgus deforming forces, the MCL and other knee structures remain unharmed. This mechanism was reported as the one responsible for only 7.8% of ACL injuries in amateur skiers [12], but it seems to be the most frequent mechanism in elite skiers [4]. Ski bindings are not designed to release when a backward-directed force is applied in the absence of rotational forces, so in this mechanism bindings will not release.
Phantom foot: it happens when the skier losses balance and falls backward on the rear part of skis, placing the hips below the knees with all body weight on the downhill ski, which internally rotates the knee in hyperflexion. Knee hyperflexion puts the ACL under strain, which facilitates its injury due to the forced rotation. The MCL is also injured, as it is the main restrictor structure against internal rotation in the flexed knee. The fact that all body weight is on this ski makes the lateral meniscus vulnerable to injury as it can get trapped under the turning femoral condyle with axial load. This was reported as the most frequent mechanism before the introduction of carving skis [11], and a recent study reports a 22.5% of cases caused by this mechanism, being the second most frequent in skiers between 30 and 40 years old [12]. There is no agreement in literature about the influence of ski binding’s failure to release in these cases.
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In elite skiers another two mechanisms have been described:
Dynamic snowplow: with the weight backward and skis in split position, the unweighted ski forces the knee in valgus and internal rotation. It is believed to be the cause of 15% of ACL injury. It has big similarities with the hyperextension mechanism. The ACL, and also the MCL, limits knee valgus and internal rotation, so in this mechanism both structures are under strain and vulnerable to injury.
Slip and catch: it is very similar to the previous one but is considered more frequent. This happens during a turn, after losing contact with the snow by the outer ski; when it recovers the ski catches the edge causing rapid flexion, internal rotation, and valgus. A very important reported fact is that in 100% of slip-catch ACL injuries in athletes ski bindings do not release or are release after the injury took place [7].
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These two mechanisms are believed to be related with the use of more aggressive and smaller turn radius skis like the ones used in slalom races; even some authors suggest that carving skies (shorter, wider in tip and tail, easier to turn) may augment the injury risk as their design may increase kinetic energy in slopes [7], although this last point is controversial [12].
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5.2 Associated injuries
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When an ACL injury occurs, other knee joint structures may be at risk, as up to 68% of skiers with an ACL injury present a lesion of another knee joint structure.
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If, as seen before, a valgus force is present in the injury mechanism, the medial collateral ligament will probably suffer a tear; the rate of associated ACL + MCL injury has been reported between 16 and 57% [21]. The isolated MCL injury is caused by a direct valgus load of the knee. A problem exist in preventing these injuries, as ski bindings are designed to release when falling forward or when rotating force is applied, so no releasing mechanism exists in cases of isolated valgus torque.
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In alpine skiing, the most commonly affected menisci is the lateral. This is reported to be found in 23–55% of ACL-injured knees. Some authors [2, 21] tried to explain the lower incidence of menisci lesions in ACL-injured knees when comparing to other ACL injury high-risk sports. The fact that some injury mechanisms are caused by forces that do not contain rotation or valgus may explain that. Another point is that, contrary to soccer or basketball, at the moment of injury in skiing there can be a distraction of the knee joint and by that not loading the meniscus and saving it from tears and less secondary trauma to the joint. Independent of the cause of a lower incidence of menisci, cartilage, and other joint structure injuries, this is a positive point, as all these lesions can be responsible for the onset of early osteoarthritis in young and active patients.
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In two literature reviews, we found contradictory affirmations about the trends in tibia plateau fractures, associated or not with ACL injury. In [3], authors report the finding of a rise in tibia plateau fractures, almost in all cases affecting the anterior part of the lateral plateau (Schatzker I, II, and III fractures) caused by valgus axial forces. In an opposite direction point, the results found in [21] report a 92% decrease in tibia plateau fractures from 1970 to 2003. In our literature review, reports about fractures affecting the knee joint are very scarce, and even some articles are done in ski resort clinics without RX; others are done in hospitals with all diagnostic methods available. In our opinion, it is very improbable that a tibia plateau fracture can go undiagnosed as the injured skier would not be able to go to his home hospital, a situation much more probable to happen in cases of minor injuries or even moderate to severe knee sprains.
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A conclusion present in the vast majority of literature reviewed is the low prevalence in ankle and lower leg injuries in adult skiers, either amateur or elite athletes. Ankle and tibia diaphysis fractures were once the most feared and frequent injuries; but there are [3] reports of a 92% decrease in ankle fractures and sprains and up to 80% decrease in tibia fractures since the 1970s.
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A general agreement is found in the literature and is also of our opinion that the reason for such a decrease in lower leg injuries while knee injury rates have grown or at least maintained is the change in the skier’s equipment. Back in the 1960–1970s, ski boots were made of leather, shorter, and soft-shelled. It is evident that a major change has occurred; nowadays, boots are made of plastic, hard-shelled, and much higher than before. Ski is still a high-risk sports, with falls with or without collision being very frequent; and the kinetic energy of the fall is the same than it was 30–40 years ago. With actual equipment these forces bypass the ankle joint and the leg with all the energy absorbed and dissipated at the knee joint’s level. In the authors’ opinion, the sole fact of the existence of an injury mechanism called “boot-induced anterior drawer” should be enough to prove this point.
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Another gear part that has had major improvements in quality is ski bindings. It is very probable that these changes also played a role in the decrease of lower leg fractures and are considered as key safety equipment. Ski bindings are designed to release when there is a fall forward with or without body rotation (reproducing the most frequent injury mechanisms) but are not done to free the skier’s foot in case of a backward fall. In our opinion this is a big design deficiency that has to be fixed soon if there is a will to make skiing a safer sports. The problem now is that, as explained previously, several articles report high percentages of ski binding failure to release, especially linked to some injury mechanisms. In our opinion these equipment failures’ high rates are to be considered unacceptable, and efforts have to be made to keep improving with the goal of reducing skiing injuries, particularly those affecting the knee joint.
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5.3 Treatment
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When considering the management and treatment of knee skiing injuries, the first thing that surprised us is that the majority of authors made no reference to it. Publications using small ski resort clinics, some of them without physician and/or diagnostic tools, admit its limitations and explain their procedure for referring patients with a suspected severe injury to hospitals. In other cases, with data obtained from these near hospitals, great treatment and follow-up evolution are lost when referring the patient for definitive treatment to his/her home hospital [14]. A limitation present in both study types is that of skiers with minor or moderate injuries that do not seek medical attention or that do it later in their home hospital.
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Only in [1] et al. report the time loss after an ACL injury in elite skiers, but many times this is a population group with big differences in treatment strategies and goals.
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Nowadays, the gold standard treatment for an ACL complete tear in a relatively young and active patient is its reconstruction. Debate about the better technique (mono- vs. bifascicular reconstruction, type of graft, graft fixation, etc.) is a topic outside this review’s objectives.
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It is also generally accepted that the treatment for an isolated MCL injury is a conservative treatment, which is thought to heal without sequels. There is less evidence about the best treatment of ACL and MCL combined injury.
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Some surgeons affirm that the best method is to treat each injury in its gold standard way: surgical reconstruction of the ACL and conservative treatment for the MCL. Others argue that in a combined injury an anterior and valgus instability is present and that for this reason the MCL will not heal properly in the presence of an injured ACL. To solve this problem, there are two options, an operative reconstruction of all injured structures and an early surgery for ACL treatment, which would allow for a successful MCL non-operative treatment.
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In our opinion, the majority of combined injuries should be treated with surgery but only for ACL reconstruction. We do not agree with the idea that an early ACL reconstruction surgery is needed; in fact, for us a delayed ACL surgery is a better option, waiting until medial stability is recovered. Only in cases with a grade III MCL tear with great knee instability after at least 2 months of MCL tear conservative treatment, we recommend its surgical treatment, with plasty reconstruction of both structures.
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6. Conclusion
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Alpine skiing is a high-risk sports with an elevated number of people injured every year. Ligamentous knee injuries are among the most common, and it does not seems to be any tendency to decrease its high rate despite changes in attitudes and equipment that have lowered the number of other serious injuries. As seen, the percentage of knee injuries that can be considered severe is high, with ACL tears as the most common knee injury. Having such high rates of serious injuries in alpine skier’s knee implies big challenges in prevention, to identify skiers at risk and to improve equipment parts that are proven to be failing. More research needs to be done to define all risk factors so that prevention efforts can be well directed. Also, more research is needed to identify the best treatment option for ACL and other knee ligamentous injuries, and consensus in treatment and rehabilitation protocols are needed for both elite athletes and amateur-injured alpine skiers.
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Conflict of interest
Authors declare no conflict of interest.
\n',keywords:"knee, ski, ACL, ligament, MCL",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/65256.pdf",chapterXML:"https://mts.intechopen.com/source/xml/65256.xml",downloadPdfUrl:"/chapter/pdf-download/65256",previewPdfUrl:"/chapter/pdf-preview/65256",totalDownloads:816,totalViews:0,totalCrossrefCites:0,dateSubmitted:"October 9th 2018",dateReviewed:"December 19th 2018",datePrePublished:"January 21st 2019",datePublished:"April 22nd 2020",dateFinished:"January 21st 2019",readingETA:"0",abstract:"Ski is a popular sports practiced worldwide although it is considered a high-risk sports with high incidence of injuries. A common place for injuries is the knee, with a wide range from knee sprains to complex ligamentous injuries to fractures. In this chapter, we made a search in PubMed using the words “knee” and “ski.” Later, we selected those articles according to the inclusion criteria. When reviewing the literature, we found that the most common place for a ski-related injury is the knee, with knee sprains and ACL lesions being the most common diagnosis in the latter years with a decreasing incidence of tibia fractures. We could also analyze the risk factors different authors have found, for professional athletes and for recreational skiers. In conclusion, the ACL lesion in the skier presents a high incidence, which suggests an effort should be made to prevent it.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/65256",risUrl:"/chapter/ris/65256",signatures:"Guillem Navarro Escarp, Oscar Ares Rodriguez, Ignacio Moya Molinas, Pilar Camacho Carrasco, Alonso Zumbado Dijeres, Roberto Seijas Vazquez, Andrea Sallent, Manuel Llusa Pérez and Andreu Combalia Aleu",book:{id:"9350",type:"book",title:"Knee Surgery",subtitle:"Reconstruction and Replacement",fullTitle:"Knee Surgery - Reconstruction and Replacement",slug:"knee-surgery-reconstruction-and-replacement",publishedDate:"April 22nd 2020",bookSignature:"João Bosco Sales Nogueira, José Alberto Dias Leite, Leonardo Heráclio Do Carmo Araújo and Marcelo Cortez Bezerra",coverURL:"https://cdn.intechopen.com/books/images_new/9350.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-531-9",printIsbn:"978-1-83880-530-2",pdfIsbn:"978-1-78985-062-8",isAvailableForWebshopOrdering:!0,editors:[{id:"215718",title:"M.Sc.",name:"João Bosco Sales",middleName:null,surname:"Nogueira",slug:"joao-bosco-sales-nogueira",fullName:"João Bosco Sales Nogueira"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"157815",title:"Dr.",name:"Oscar",middleName:null,surname:"Ares",fullName:"Oscar Ares",slug:"oscar-ares",email:"arestraumatologia@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"International University Of Catalonia",institutionURL:null,country:{name:"Spain"}}},{id:"229826",title:"Dr.",name:"Ignacio",middleName:null,surname:"Moya",fullName:"Ignacio Moya",slug:"ignacio-moya",email:"molinas@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"229827",title:"Dr.",name:"Andrea",middleName:null,surname:"Sallent",fullName:"Andrea Sallent",slug:"andrea-sallent",email:"andreasallent@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"229828",title:"Dr.",name:"Pilar",middleName:null,surname:"Camacho",fullName:"Pilar Camacho",slug:"pilar-camacho",email:"pcamacho@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"229829",title:"Dr.",name:"Guillem",middleName:null,surname:"Navarro",fullName:"Guillem Navarro",slug:"guillem-navarro",email:"gunavarro@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"229831",title:"Dr.",name:"Alonso",middleName:null,surname:"Zumbado",fullName:"Alonso Zumbado",slug:"alonso-zumbado",email:"jzumbado@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"229833",title:"Prof.",name:"Andreu",middleName:null,surname:"Combalia",fullName:"Andreu Combalia",slug:"andreu-combalia",email:"combalia@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"235770",title:"Prof.",name:"Roberto",middleName:null,surname:"Seijas",fullName:"Roberto Seijas",slug:"roberto-seijas",email:"seijastraumatologia@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"288955",title:"Prof.",name:"Manuel",middleName:null,surname:"Llusa",fullName:"Manuel Llusa",slug:"manuel-llusa",email:"llusa@clinic.cat",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Epidemiology",level:"1"},{id:"sec_3",title:"3. Material and methods",level:"1"},{id:"sec_4",title:"4. Results",level:"1"},{id:"sec_4_2",title:"4.1 Athlete skiers",level:"2"},{id:"sec_5_2",title:"4.2 Amateur skiers",level:"2"},{id:"sec_5_3",title:"4.2.1 Risk factors in amateur skiers",level:"3"},{id:"sec_8",title:"5. Discussion",level:"1"},{id:"sec_8_2",title:"5.1 ACL biomechanics and injury mechanisms",level:"2"},{id:"sec_9_2",title:"5.2 Associated injuries",level:"2"},{id:"sec_10_2",title:"5.3 Treatment",level:"2"},{id:"sec_12",title:"6. Conclusion",level:"1"},{id:"sec_16",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'\nStenroos AJ, Handolin LE. Alpine skiing injuries in Finland—A two-year retrospective study based on a questionnaire among ski racers. BMC Sports Science, Medicine and Rehabilitation. 2014;6(1):2-6\n'},{id:"B2",body:'\nPatrick E, Cooper JG, Daniels J. Changes in skiing and snowboarding injury epidemiology and attitudes to safety in big sky, Montana, USA: A comparison of 2 cross-sectional studies in 1996 and 2013. Orthopaedic Journal of Sports Medicine. 2015;3(6):1-6\n'},{id:"B3",body:'\nHunter RE. Current concepts skiing injuries. Sports Medicine. 2000;27(3):381-389\n'},{id:"B4",body:'\nFlørenes TW, Bere T, Nordsletten L, Heir S, Bahr R. Injuries among male and female world cup alpine skiers. British Journal of Sports Medicine. 2009;43(13):973-978\n'},{id:"B5",body:'\nSchmitt K-U, Hörterer N, Vogt M, Frey WO, Lorenzetti S. Investigating physical fitness and race performance as determinants for the ACL injury risk in alpine ski racing. BMC Sports Science, Medicine and Rehabilitation. 2016;8(1):23\n'},{id:"B6",body:'\nBere T, Flørenes TW, Nordsletten L, Bahr R. Sex differences in the risk of injury in world cup alpine skiers: A 6-year cohort study. British Journal of Sports Medicine. 2014;48(1):36-40\n'},{id:"B7",body:'\nJordan M, Aagaard P, Herzog W. Anterior cruciate ligament injury/reinjury in alpine ski racing: A narrative review. Open Access Journal of Sports Medicine. 2017;8:71-83\n'},{id:"B8",body:'\nRuedl G, Philippe M, Sommersacher R, Duennwald T, Kopp M, Burtscher M. Current incidence of accidents on Austrian Ski slopes. Sportverletzung-Sportschaden. 2014;28(4):183-187\n'},{id:"B9",body:'\nGirardi P, Braggion M, Sacco G, de Giorgi F, Corra S. Factors affecting injury severity among recreational skiers and snowboarders: An epidemiology study. Knee Surgery, Sport Traumatol Arthrosc. 2010;18(12):1804-1809\n'},{id:"B10",body:'\nKhalilifar AH, Kazemi MH, Hamedanchi A, Hosseini MJ. Skiing injuries at the Dizin ski resort. Trauma Monthly. 2012;17(1):259-261\n'},{id:"B11",body:'\nRuedl G, Helle K, Tecklenburg K, Schranz A, Fink C, Burtscher M. Factors associated with self-reported failure of binding release among ACL injured male and female recreational skiers: A catalyst to change ISO binding standards? British Journal of Sports Medicine. 2016;50(1):37-40\n'},{id:"B12",body:'\nShea KG, Archibald-Seiffer N, Murdock E, Grimm NL, Jacobs JC, Willick S, et al. Knee injuries in downhill skiers: A 6-year survey study. Orthopaedic Journal of Sports Medicine. 2014;2(1):1-6\n'},{id:"B13",body:'\nRuedl G, Fink C, Schranz A, Sommersacher R, Nachbauer W, Burtscher M. Impact of environmental factors on knee injuries in male and female recreational skiers. Scandinavian Journal of Medicine & Science in Sports. 2012;22(2):185-189\n'},{id:"B14",body:'\nCastellani C, Singer G, Kaiser M, Petnehazy T, et al. An epidemiologic analysis of winter sport accidents on ski slopes comparing two seasons. The Journal of Sports Medicine and Physical Fitness. 2018\n'},{id:"B15",body:'\nDavidson TM, Laliotis AT. Alpine skiing injuries. A nine-year study. The Western Journal of Medicine. 1996;164(4):310-314\n'},{id:"B16",body:'\nWarme WJ, John A, King P, Lambert KL, Cunningham RR, Hole J. Injury statistics, 1982-1993 Jackson Hole Ski Resort. American Journal of Sports Medicine. 1993;23(5):597-600\n'},{id:"B17",body:'\nCoury T, Napoli AM, Wilson M, Daniels J, Murray T, Milzman D. Injury patterns in recreational alpine skiing and snowboarding at a mountainside clinic. Wilderness & Environmental Medicine. 2013;24(4):417-421\n'},{id:"B18",body:'\nWasden CC, McIntosh SE, Keith DS, McCowan C. An analysis of skiing and snowboarding injuries on Utah slopes. Journal of Trauma, Injury, Infection, and Critical Care. 2009;67(5):1022-1026\n'},{id:"B19",body:'\nEkeland A, Rødven A, Heir S. Injuries among children and adults in alpine skiing and snowboarding. Journal of Science and Medicine in Sport. 2018:11-14\n'},{id:"B20",body:'\nSulheim S, Holme I, Rødven A, Ekeland A, Bahr R. Risk factors for injuries in alpine skiing, telemark skiing and snowboarding—Case-control study. British Journal of Sports Medicine. 2011;45(16):1303-1309\n'},{id:"B21",body:'\nPressman A, Johnson DH. A review of ski injuries resulting in combined injury to the anterior cruciate ligament and medial collateral ligaments. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2003;19(2):194-202\n'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Guillem Navarro Escarp",address:null,affiliation:'
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The genus Staphylococcus is major bacteria that cause mastitis in dairy cattle. Staphylococci that cause bovine mastitis are commonly divided into two major groups such as 1) Staphylococcus aureus and 2) non-aureus staphylococci (NAS). Staphylococcus aureus causes clinical and subclinical mastitis in dairy cows. Accurate diagnosis of Staphylococcus species can be made by Matrix-Assisted Laser Desorption/Ionization-Time Of Flight (MALDI-TOF), 16S RNA gene sequencing, and polymerase chain reaction (PCR). In well-managed dairy farms that fully applied mastitis control measures, the incidence of S. aureus mastitis significantly reduced. However, staphylococcal mastitis is still major problem in most farms due to variation in management and presence of some species of non-aureus staphylococci in the environment. There is no effective vaccine that prevent staphylococcal mastitis. Treatment with antibiotics is increasingly less effective and increases development of antimicrobial resistant bacteria. Sustainable non-antibiotic staphylococcal mastitis prevention measures such as vaccines, probiotics, good herd health management and other improved methods are required. To develop an innovative control tool detailed understanding of staphylococcal virulence factors, pathogenesis, and host immunological responses is critically important. 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Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. 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Mwenge Kahinda",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/335924/images/15081_n.jpg",biography:"A highly motivated diligent Researcher with 16 years’ combined experience in biological\nscience research and development in both academia and industry. I demonstrate skills in conducting, compiling, and presenting Microbiology, Immunology, Vaccinology, Animal experimental studies and Veterinary Clinical trials research. My current research projects focus on development of improved combination vaccines, containing clostridial and non-clostridial antigens for protection against several diseases in bovine; ovine and caprine, by introducing various downstream applications during the vaccine\nmanufacturing process and testing various vaccine formulations based on the use of\nnovel adjuvants to improve immunogenicity. Having work as a vaccine researcher for 7\nyears, it is time to seek exciting and new opportunity for growth, as an influential\nleader in the field of vaccinology and a contributor to new knowledge / understanding of infectious diseases pathogenesis in order to develop novel therapeutics or vaccines. Further to this, I recently completed a BA honours degree in development studies and hoping to apply the knowledge gained from this to better understand the impact of economic development on health systems and eradication of infectious diseases. As such, working in academia will afford me the opportunity to conduct multidisciplinary\nresearch.",institutionString:null,institution:null},{id:"338825",title:"Dr.",name:"Muhammad Salman",surname:"Younas",slug:"muhammad-salman-younas",fullName:"Muhammad Salman Younas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/338825/images/15048_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"350376",title:"Prof.",name:"Wanxia",surname:"Pu",slug:"wanxia-pu",fullName:"Wanxia Pu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"open-access-funding-funders-list",title:"List of Funders by Country",intro:"
If your research is financed through any of the below-mentioned funders, please consult their Open Access policies or grant ‘terms and conditions’ to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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IMPORTANT: You must be a member or grantee of the listed funders in order to apply for their Open Access publication funds. Do not attempt to contact the funders if this is not the case.
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UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
UK Research and Innovation (former Research Councils UK (RCUK) - including AHRC, BBSRC, ESRC, EPSRC, MRC, NERC, STFC.) Processing charges for books/book chapters can be covered through RCUK block grants which are allocated to most universities in the UK, which then handle the OA publication funding requests. It is at the discretion of the university whether it will approve the request.)
Wellcome Trust (Funding available only to Wellcome-funded researchers/grantees)
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:49,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{paginationCount:148,paginationItems:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",biography:"Vahid Asadpour, MS, Ph.D., is currently with the Department of Research and Evaluation, Kaiser Permanente Southern California. He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. Mohan",middleName:null,surname:"Anand",slug:"p.-mohan-anand",fullName:"P. Mohan Anand",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356696",title:"Ph.D. Student",name:"P.V.",middleName:null,surname:"Sai Charan",slug:"p.v.-sai-charan",fullName:"P.V. Sai Charan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"357086",title:"Prof.",name:"Sandeep K.",middleName:null,surname:"Shukla",slug:"sandeep-k.-shukla",fullName:"Sandeep K. Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}},{id:"351158",title:"Prof.",name:"David W.",middleName:null,surname:"Anderson",slug:"david-w.-anderson",fullName:"David W. Anderson",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Calgary",country:{name:"Canada"}}}]}},subseries:{item:{id:"5",type:"subseries",title:"Parasitic Infectious Diseases",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11401,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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