\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10477",leadTitle:null,fullTitle:"Pheochromocytoma, Paraganglioma and Neuroblastoma",title:"Pheochromocytoma, Paraganglioma and Neuroblastoma",subtitle:null,reviewType:"peer-reviewed",abstract:"Pheochromocytoma, paraganglioma and neuroblastoma are the most common neural crest-derived tumors in adults and children, respectively. These neoplasms are associated with significant morbidity and mortality. Some international studies currently underway are researching and evaluating the presence of any similarities and differences between these tumors. Hopefully, future results will reveal several potential novel genes and pathways that might have major roles in the pathogenesis and progression of these neoplasms. This book discusses epidemiology, genetics, and treatment of these malignancies.",isbn:"978-1-83968-948-2",printIsbn:"978-1-83968-947-5",pdfIsbn:"978-1-83968-949-9",doi:"10.5772/intechopen.92492",price:119,priceEur:129,priceUsd:155,slug:"pheochromocytoma-paraganglioma-and-neuroblastoma",numberOfPages:130,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"ea4b534c4c57be0eaa9c5624c7e2b139",bookSignature:"Pasquale Cianci, Enrico Restini and Amit Agrawal",publishedDate:"August 18th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10477.jpg",numberOfDownloads:1500,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 30th 2020",dateEndSecondStepPublish:"December 9th 2020",dateEndThirdStepPublish:"February 7th 2021",dateEndFourthStepPublish:"April 28th 2021",dateEndFifthStepPublish:"June 27th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"196218",title:"Dr.",name:"Pasquale",middleName:null,surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci",profilePictureURL:"https://mts.intechopen.com/storage/users/196218/images/system/196218.png",biography:"General Surgeon at 'Lorenzo Bonomo” Hospital-Department of Surgery and Traumatology-ASL BAT-Andria-Puglia (Italy), and Ph.D. at the Department of Medical and Surgical Sciences, University of Foggia (Italy), Fellow of American College of Surgeons (FACS). Contract Professor in General and Emergency Surgery, Gastroenterology and Human Physiology, Faculty of Medicine - Nursing Science and Physiotherapy Courses. Professor in surgical anatomy at the specialty school in general surgery. Contract Professor of I Level Masters: Intestinal stoma care nurse, Operating room nurse and Emergency medicine and critical area. Member of some of the most important Italian Scientific Surgical Societies: EAES, SICE, ACOI, SPIGC, SIUCP, ACS. Author of 70 national and international scientific papers, books and book chapters which are well appreciated in the health community. Editorial Board member of Frontiers in Surgical Oncology, BMC Surgery, Annals of Medicine, WJSP, Asian Journal of Research and Reports in Endocrinology, IntechOpen Edition. Reviewer of major international scientific journals such as Medicina, the Turkish Journal of Gastroenterology, Medical Principles and Practice, IntechOpen Edition, World Journal of Surgical Procedures, Oxford Medical Case Reports, BMJ Case Reports, Austin Pancreat Disord, World Journal of Gastroenterology, Case Studies in Surgery, World Journal of Surgical Oncology, Journal of Cancer and Tumor International, Journal of Basic and Applied Research International, International Journal of Medical and Pharmaceutical Case Reports, British Journal of Medicine and Medical Research, Faculty and Speaker at numerous national and international Surgical Congresses. Special interest in laparoscopic surgery, robotic surgery, endocrine surgery and coloproctology.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"302435",title:"Dr.",name:"Enrico",middleName:null,surname:"Restini",slug:"enrico-restini",fullName:"Enrico Restini",profilePictureURL:"https://mts.intechopen.com/storage/users/302435/images/system/302435.jpg",biography:"Enrico Restini, MD, is head of the Department of Surgery and Traumatology-Andria, Italy. He is a contract professor in Surgery and Health Management and an expert in advanced technologies and their impact on health organizations (HTA) (LUM University-BA). Since 2007, Dr. Restini has been honorary president of the Apulian section of Aistom. He is a member of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), the Italian Society of Endoscopic and Minimally Invasive Surgery (SICE), SICOB, SIC, Italian Society of Private Hospital Surgery, and Association of Italian Hospital Surgeons (ACOI). He is a founding member of ARTOI, and has been a SICE National Councilor since 2012. He has spoken at numerous national and international surgical congresses and authored fifty national and international scientific papers. His special interests include laparoscopic surgery, robotic surgery, endocrine surgery, and digestive surgery.",institutionString:"ASL BAT - Department of Surgery and Traumatology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"100142",title:"Prof.",name:"Amit",middleName:null,surname:"Agrawal",slug:"amit-agrawal",fullName:"Amit Agrawal",profilePictureURL:"https://mts.intechopen.com/storage/users/100142/images/system/100142.jfif",biography:"Dr. Agrawal completed his neurosurgery training at the National Institute of Mental Health and Neurosciences, Bangalore, India, in 2003. He is a self-motivated, enthusiastic, and results-oriented professional with more than eighteen years of experience in research and development, as well as teaching and mentoring in the field of neurosurgery. He is proficient in managing and leading teams for running successful process operations and has experience in developing procedures and service standards of excellence. He has attended and participated in many international and national symposiums and conferences and delivered lectures on vivid topics. Dr. Agrawal has published more than 750 scientific articles in various national and international journals. His expertise is in identifying training needs, designing training modules, and executing the same while working with limited resources. He has excellent communication, presentation, and interpersonal skills with proven abilities in teaching and training various academic and professional courses. Presently, he is working at the All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.",institutionString:"All India Institute of Medical Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"8",institution:{name:"All India Institute of Medical Sciences",institutionURL:null,country:{name:"India"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"428",title:"Cancer Biology",slug:"biochemistry-genetics-and-molecular-biology-oncology-cancer-biology"}],chapters:[{id:"76248",title:"Introductory Chapter: Neural Crest Cell-Derived Tumors. An Introduction on Pheocromocytoma, Paraganglyoma and Neuroblastoma",doi:"10.5772/intechopen.97386",slug:"introductory-chapter-neural-crest-cell-derived-tumors-an-introduction-on-pheocromocytoma-paraganglyo",totalDownloads:146,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Pasquale Cianci, Giandomenico Sinisi and Sabino Capuzzolo",downloadPdfUrl:"/chapter/pdf-download/76248",previewPdfUrl:"/chapter/pdf-preview/76248",authors:[{id:"196218",title:"Dr.",name:"Pasquale",surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale Cianci"},{id:"196220",title:"Dr.",name:"Sabino",surname:"Capuzzolo",slug:"sabino-capuzzolo",fullName:"Sabino Capuzzolo"},{id:"357493",title:"Dr.",name:"Giandomenico",surname:"Sinisi",slug:"giandomenico-sinisi",fullName:"Giandomenico Sinisi"}],corrections:null},{id:"74954",title:"Pheochromocytomas and Paragangliomas: Genotype-Phenotype Correlations",doi:"10.5772/intechopen.95888",slug:"pheochromocytomas-and-paragangliomas-genotype-phenotype-correlations",totalDownloads:220,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Pheochromocytomas and paragangliomas are rare neuroendocrine tumors, with genetic background in about 40% of cases, involving more than 30 susceptibility genes. The susceptibility genes can be divided into three main molecular clusters: pseudohypoxic, kinase signaling, and Wnt signaling. Biochemical characterization of these particular tumors should be integrated into the diagnostic algorithm because it can help apply personalized medicine principles and targeted therapy. These tumors can present with very different genotype-phenotype correlations, and their characterization can help the clinical practitioner make optimal clinical management decisions and prioritize genetic testing. This chapter summarizes the most important aspects of genetics and clinical characteristics, together with new genotype-phenotype correlation data.",signatures:"Diana Loreta Paun and Alexandra Mirica",downloadPdfUrl:"/chapter/pdf-download/74954",previewPdfUrl:"/chapter/pdf-preview/74954",authors:[{id:"190860",title:"Dr.",name:"Diana Loreta",surname:"Paun",slug:"diana-loreta-paun",fullName:"Diana Loreta Paun"},{id:"335620",title:"Dr.",name:"Alexandra",surname:"Mirica",slug:"alexandra-mirica",fullName:"Alexandra Mirica"}],corrections:null},{id:"75125",title:"Metastatic Paragangliomas and Pheochromocytomas: An Epigenetic View",doi:"10.5772/intechopen.96126",slug:"metastatic-paragangliomas-and-pheochromocytomas-an-epigenetic-view",totalDownloads:263,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Paragangliomas and pheochromocytoma (PPGLs) are hereditary tumors in about 40% of cases. Mutations in the genes encoding for components of the mitochondrial succinate dehydrogenase protein complex (SDHB, SDHD, SDHC) are among the most prevalent. Most PPGLs have a benign behavior, but patients with germline SDHB mutations may develop metastatic PPGLs in up to 30% of cases. This suggest that the SDH substrate, succinate, is key for the activation of the metastatic cascade. The last decade has witnessed significant advances in our understanding of how succinate may have oncogenic properties. It is now widely accepted that succinate is an oncometabolite that modifies the epigenetic landscape of SDH-deficient tumors via modulating the activities of DNA and histone modification enzymes. In this chapter, we summarize recent discoveries linking SDH-deficiency and metastasis in SDH-deficient PPGLs via inhibition of DNA methylcytosine dioxygenases, histone demethylases and modified expression of non-coding RNAs. We also highlight promising therapeutic avenues that may be used to counteract epigenetic deregulations.",signatures:"María-Dolores Chiara, Lucía Celada, Andrés San José Martinez, Tamara Cubiella, Enol Álvarez-González and Nuria Valdés",downloadPdfUrl:"/chapter/pdf-download/75125",previewPdfUrl:"/chapter/pdf-preview/75125",authors:[{id:"334857",title:"Prof.",name:"María-Dolores",surname:"Chiara",slug:"maria-dolores-chiara",fullName:"María-Dolores Chiara"},{id:"345989",title:"MSc.",name:"Andrés",surname:"San José Martinez",slug:"andres-san-jose-martinez",fullName:"Andrés San José Martinez"},{id:"345990",title:"MSc.",name:"Enol",surname:"Álvarez-González",slug:"enol-alvarez-gonzalez",fullName:"Enol Álvarez-González"},{id:"345991",title:"MSc.",name:"Tamara",surname:"Cubiella",slug:"tamara-cubiella",fullName:"Tamara Cubiella"},{id:"345992",title:"Ph.D. Student",name:"Lucía",surname:"Celada",slug:"lucia-celada",fullName:"Lucía Celada"},{id:"345994",title:"Dr.",name:"Nuria",surname:"Valdés",slug:"nuria-valdes",fullName:"Nuria Valdés"}],corrections:null},{id:"75164",title:"Surgical Approach in Pheochromocytoma",doi:"10.5772/intechopen.96066",slug:"surgical-approach-in-pheochromocytoma",totalDownloads:189,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Pheochromocytomas are tumors composed of chromaffin cells that can produce, secrete and metabolise catecholamines. The surgical excision procedure of these tumors may present the risk of significant variations in blood pressure, as well as the chance of cardiovascular complications in the perioperative period. During surgery, patients may be at risk for cardiovascular events such as major variations in blood pressure, pulmonary edema, stroke, myocardial infraction and a long period of intubation. The surgical approach to pheochromocytomas must always be preceded by accurate imaging evaluation, endocrine screening and identification of associated genetic mutations. In addition, the surgical technique of choice consists in using minimally invasive surgical methods, with a transabdominal or retroperitoneal approach.",signatures:"Radu Mihail Mirica and Sorin Paun",downloadPdfUrl:"/chapter/pdf-download/75164",previewPdfUrl:"/chapter/pdf-preview/75164",authors:[{id:"337478",title:"Dr.",name:"Sorin",surname:"Paun",slug:"sorin-paun",fullName:"Sorin Paun"},{id:"337479",title:"Dr.",name:"Radu Mihail",surname:"Mirica",slug:"radu-mihail-mirica",fullName:"Radu Mihail Mirica"}],corrections:null},{id:"77159",title:"Primary Central Nervous System Neuroblastoma: An Enigmatic Entity",doi:"10.5772/intechopen.98244",slug:"primary-central-nervous-system-neuroblastoma-an-enigmatic-entity",totalDownloads:230,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Neuroblastoma is one of the most common solid tumour in the paediatric age group. Central nervous system (CNS) involvement in neuroblastoma is commonly due to metastasis from the extracranial primary. Primary CNS Neuroblastoma (PCNS-NB) is a rare entity and highlights errors in development of neural crest cells and CNS. A lot has been published since the first description of PCNS-NB four decades ago. Over the years, neuroscientists, geneticists, and clinicians have improved the understanding of PCNS-NB. PCNS-NB is an enigmatic entity with variable presentation, epidemiology, clinical features and outcomes. Recent update in knowledge is seen in 2016 WHO classification of CNS tumours with reclassification of CNS neuroblastoma. It further subclassified different histological variants of PCNS-NB and its molecular correlates. Most common histological subtype of PCNS-NB is neuroblastoma followed by ganglioneuroblastoma. Studies support the view that younger age group, less number of lesions, ganglioneuroblastoma histology subtype and surgical management are good prognostic indicators. This chapter provides an updated overview of epidemiology, clinical features, histological and molecular diagnosis, and outcomes of PCNS-NB in addition to the role of adjuvant therapy.",signatures:"Rakesh Mishra and Amit Agrawal",downloadPdfUrl:"/chapter/pdf-download/77159",previewPdfUrl:"/chapter/pdf-preview/77159",authors:[{id:"100142",title:"Prof.",name:"Amit",surname:"Agrawal",slug:"amit-agrawal",fullName:"Amit Agrawal"},{id:"419056",title:"Dr.",name:"Rakesh",surname:"Mishra",slug:"rakesh-mishra",fullName:"Rakesh Mishra"}],corrections:null},{id:"75419",title:"The Scaffold Protein p140Cap as a Molecular Hub for Limiting Cancer Progression: A New Paradigm in Neuroblastoma",doi:"10.5772/intechopen.96383",slug:"the-scaffold-protein-p140cap-as-a-molecular-hub-for-limiting-cancer-progression-a-new-paradigm-in-ne",totalDownloads:208,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Neuroblastoma, the most common extra-cranial pediatric solid tumor, is responsible for 9–15% of all pediatric cancer deaths. Its intrinsic heterogeneity makes it difficult to successfully treat, resulting in overall survival of 50% for half of the patients. Here we analyze the role in neuroblastoma of the adaptor protein p140Cap, encoded by the SRCIN1 gene. RNA-Seq profiles of a large cohort of neuroblastoma patients show that SRCIN1 mRNA levels are an independent risk factor inversely correlated to disease aggressiveness. In high-risk patients, SRCIN1 was frequently altered by hemizygous deletion, copy-neutral loss of heterozygosity, or disruption. Functional assays demonstrated that p140Cap is causal in dampening both Src and Jak2 kinase activation and STAT3 phosphorylation. Moreover, p140Cap expression decreases in vitro migration and anchorage-independent cell growth, and impairs in vivo tumor progression, in terms of tumor volume and number of spontaneous lung metastasis. p140Cap also contributes to an increased sensitivity of neuroblastoma cells to chemotherapy drugs and to the combined usage of doxorubicin and etoposide with Src inhibitors. Overall, we provide the first evidence that SRCIN1/p140Cap is a new independent prognostic marker for patient outcome and treatment, with a causal role in curbing the aggressiveness of neuroblastoma. We highlight the potential clinical impact of SRCIN1/p140Cap expression in neuroblastoma tumors, in terms of reducing cytotoxic effects of chemotherapy, one of the main issues for pediatric tumor treatment.",signatures:"Giorgia Centonze, Jennifer Chapelle, Costanza Angelini, Dora Natalini, Davide Cangelosi, Vincenzo Salemme, Alessandro Morellato, Emilia Turco and Paola Defilippi",downloadPdfUrl:"/chapter/pdf-download/75419",previewPdfUrl:"/chapter/pdf-preview/75419",authors:[{id:"47942",title:"Prof.",name:"Paola",surname:"Defilippi",slug:"paola-defilippi",fullName:"Paola Defilippi"},{id:"60247",title:"Prof.",name:"Emilia",surname:"Turco",slug:"emilia-turco",fullName:"Emilia Turco"},{id:"346179",title:"Dr.",name:"Giorgia",surname:"Centonze",slug:"giorgia-centonze",fullName:"Giorgia Centonze"},{id:"346180",title:"Dr.",name:"Jennife",surname:"Chapelle",slug:"jennife-chapelle",fullName:"Jennife Chapelle"},{id:"346181",title:"Dr.",name:"Costanza",surname:"Angelini",slug:"costanza-angelini",fullName:"Costanza Angelini"},{id:"346182",title:"Dr.",name:"Dora",surname:"Natalini",slug:"dora-natalini",fullName:"Dora Natalini"},{id:"346183",title:"Dr.",name:"Davide",surname:"Cangelosi",slug:"davide-cangelosi",fullName:"Davide Cangelosi"},{id:"346184",title:"Dr.",name:"Vincenzo",surname:"Salemme",slug:"vincenzo-salemme",fullName:"Vincenzo Salemme"},{id:"346185",title:"Dr.",name:"Alessandro",surname:"Morellato",slug:"alessandro-morellato",fullName:"Alessandro Morellato"}],corrections:null},{id:"75151",title:"Targeting MYC and HDAC8 with a Combination of siRNAs Inhibits Neuroblastoma Cells Proliferation In Vitro and In Vivo Xenograft Tumor Growth",doi:"10.5772/intechopen.96021",slug:"targeting-myc-and-hdac8-with-a-combination-of-sirnas-inhibits-neuroblastoma-cells-proliferation-in-v",totalDownloads:245,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"HDAC8, c MYC and MYCN are involved in the tumorigenesis of neuroblastoma. A mouse Neuroblastoma (NB) tumor model was used to understand the role of miRNA, miR-665 in NB tumorigenesis and cellular differentiation. During cellular differentiation of NB cells there is an up regulated miRNA-665. We found that HDAC 8, c MYC and MYCN are the direct targets of mimic miR-665 which was validated by luciferase reporter plasmid with 3’ UTR and ELISA. Mimic miR-665 inhibited cell proliferation, arrested cells in G1 stage and decreased S Phase in cell cycle. miR-665 increased the acetylation of histones and activated Caspase 3. This is the first report to recognize miRNA 665 as a suppressor miRNA of NB. The effects of miR-665 were confirmed with the transfection of siRNA for HDAC8 and siRNA for MYC. Individual siRNA- HDAC8 or siRNA-MYC inhibited 40–50% of cell proliferation in vitro, however, the treatment with the combination of both siRNA-MYC + siRNA- HDAC8 inhibited 86% of cell proliferation. Indicating that both the targets c MYC and HDAC 8 should be reduced to obtain a significant inhibition of cell proliferation. Intratumoral treatment of xenograft tumors in mice with the combination of siRNA-MYC + siRNA- HDAC8 reduced the levels of target c-MYC protein by 64% and target HDAC 8 protein by 85% and the average tumor growth reduced by 80% compared to control tumors treated with NC-siRNA. Our results suggest the potential therapeutic effect of suppressor miR-665 and the combination of siRNA-MYC + siRNA-HDAC8 for neuroblastoma treatment.",signatures:"Nagindra Prashad",downloadPdfUrl:"/chapter/pdf-download/75151",previewPdfUrl:"/chapter/pdf-preview/75151",authors:[{id:"338413",title:"Ph.D.",name:"Nagindra",surname:"Prashad",slug:"nagindra-prashad",fullName:"Nagindra Prashad"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6591",title:"Proctological Diseases in Surgical Practice",subtitle:null,isOpenForSubmission:!1,hash:"df22314ee5125fe03618cc962080552f",slug:"proctological-diseases-in-surgical-practice",bookSignature:"Pasquale Cianci",coverURL:"https://cdn.intechopen.com/books/images_new/6591.jpg",editedByType:"Edited by",editors:[{id:"196218",title:"Dr.",name:"Pasquale",surname:"Cianci",slug:"pasquale-cianci",fullName:"Pasquale 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Thisbook covers the above topics in a nutshell. The authors from various countries have contributed valuable topics, enriching the contents scientifically and socially. This introductory chapter gives the important and updated details of the topics covered in the book.
\nThe uterus, anatomically, is a pear-shaped organ, placed between urinary bladder and rectum. The etymology of ‘cervix’ is that it is from Latin, meaning ‘neck’ and it opens into the vagina. The invasive cancer occurs in the cervix and is called cervical cancer (Figure 1).
\nThe anatomy of uterus.
Squamous epithelium and columnar epithelium are both types of epithelium lining in the surface of the cervix.
\nThe squamocolumnar junction is the junction between squamous epithelium and columnar epithelium and it migrates from the periphery of the ectocervix inward towards the external os and finally to the distal cervical canal when age increases.
\nThe process by which the columnar epithelium is replaced by stratified squamous epithelium is termed as squamous metaplasia and the area where this transformation takes place is referred to as the transformation zone (IARC, 2005; WHO, 2006).
\nThe cervix is protected by stratified squamous cell epithelium from injuries by toxins and from infections. The human papilloma virus (HPV) primarily targets the squamous cells, and persistent infection by the high-risk strains leads to change of cells to metaplasia and dysplasia, which is the precancer stage and this occurs in the transformation zone—TZ.
\nHPV16 and 18 are responsible for the development of all the precancers and invasive cancers of the uterine cervix.
\nHPV types:
High-risk 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59;
Low-risk 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81.
HPV transmission occurs through skin and mucous contact during sexual contact, and the cofactors are early sexual exposures and multiple partners.
\nPersistent HPV infections cause cervical cancers but most of the HPV infections are transient due to the protection from cell-mediated immunity.
\n\n
Low-grade squamous intraepithelial lesion (LSIL):
occurs due to persistent HPV infection;
cervical intraepithelial neoplasia grade 1 (CIN1);
mild squamous dysplasia;
flat condyloma; koilocytotic atypia; koilocytosis.
High-grade squamous intraepithelial lesion (HSIL):
a squamous lesion with high risk of developing into cancer;
cervical intraepithelial neoplasia grade 2 (CIN2);
cervical intraepithelial neoplasia grade 3 (CIN3);
carcinoma in situ (CIS).
Squamous cell carcinoma (SCC):
an invasive epithelial tumour composed of squamous cells of varying degrees of differentiation.
Cervical cancer begins with abnormal changes in the cervical tissue. The risk of developing these abnormal changes has been associated with the following factors:
relationship to sexual intercourse;
many partners during lifetime;
frequent intercourse;
early onset of sexual activity;
first pregnancy in teenage years;
multiparity (several children) by mid 20s;
venereal diseases;
genital herpes (herpes simplex virus type 2—HSV-2);
human papilloma virus (HPV);
race: incidence higher in blacks and Hispanics;
low socioeconomic status;
poor genital hygiene;
cigarette smoking;
peak incidence over 40 years.
\n
post-coital or unexplained vaginal spotting or bleeding;
persistent vaginal discharge;
pelvic pain.
Adenocarcinomas of the cervix have a worse prognosis than squamous cell cancers.
\nSquamous cell carcinoma, adenocarcinoma:
Stage 0 = 100%;
Stage I = 60–85%;
Stage II = 40–60%;
Stage III = up to 40%;
Stage IV = <15%.
\n
Ablation: cryotherapy, laser ablation.
Excision: loop electro excision procedure—LEEP, laser conisation, or cold knife conisation—CKC.
Success rate of all the above modalities is 80–100%.
\nGARDASIL is a quadrivalent vaccine against HPV types 6, 11, 16 and 18 and is given in a three-dose schedule.
\nCERVARIX is a bivalent vaccine against HPV types 16 and 18 for the prevention of CIN and cervical cancer in females aged 10–25 years.
\nThe efficacy of these vaccines ranges from 0 to 80%.
\nHPV infection is the causal factor and it can be prevented by Health Education and Vaccination.
\nHealth education:
genital and menstrual hygiene;
stop tobacco use;
encourage male circumcision;
condom promotion;
safe sex;
Prophylactic HPV vaccines for girls before sexual life exposure;
\nTwo-dose vaccine.
\nThe WHO recommends two-dose vaccine (given at 0 and 6 month or 0 and 12 month) for those starting vaccine before 15 years of age.
\nScreening is a process in which the apparently normal population is subjected to a rapidly applied test to detect an abnormality or a disease condition.
\nPap smear screening of women from the age of 25 years can be implemented in the population and the resources need to be planned well to ensure success.
\nHPV testing is a highly sensitive test, but is costly and resource intensive.
\nThe most successful and cost-effective methods are as follows:
visual inspection with acetic acid (VIA);
magnified visual inspection with acetic acid (VIAM);
visual inspection with Lugol’s iodine (VILI).
Colposcopy is very useful in visual inspection positive lesions to make colposcopic diagnosis, apply a directed biopsy and in guidance of LEEP.
\nScreen and treat policy for low-resource settings:
\nMost suited strategy for limited resource settings. A single visit approach has resulted in reduction of incidence rate and mortality rate due to cervical cancer in many countries.
\nModalities:
VIA positive—cryotherapy;
VIA positive—colposcopy positive—cryotherapy;
VIA positive—colposcopy positive—biopsy taken—cryotherapy;
VIA positive—colposcopy positive—biopsy taken—biopsy positive—recall for treatment.
In most research settings and in some programmatic settings (e.g., mostly in Asia in countries such as India, Bangladesh and Nepal), colposcopy is used for triaging VIA positives in screen and treat policy.
\nCriteria to provide cryotherapy:
less than 75% of TZ is involved;
lesion does not extend to endocervical canal or vagina;
no extension of the lesion onto the vaginal walls;
lesion adequately covered by cryoprobe;
entire squamocolumnar junction is visible;
no doubt of invasive cancer.
LEEP:
Ideal to treat CIN 3 lesions and large lesions.
The diagnosis and management of invasive cervical cancer is called tertiary prevention.
\nStage 0: Carcinoma in situ, preinvasive carcinoma.
\nLEEP, conisation.
\nStage I: Invasive carcinoma strictly confined to the cervix.
\nStage IA: Invasive carcinoma identified microscopically (all macroscopically visible lesions, even with superficial invasion, should be assigned to stage IB):
Stage IA1: Measured invasion of stroma 3.0 mm or less in depth and 7.0 mm or less in horizontal spread;
Simple hysterectomy or trachelectomy, conisation in selected cases.
Stage IA2: Measured invasion of stroma more than 3.0 mm but not greater than 5.0 mm in depth and 7.0 mm or less in horizontal spread;
Simple or radical hysterectomy and bilateral pelvic lymphadenectomy (or trachelectomy and pelvic lymphadenectomy) depending on local or regional guidelines.
Stage IB: Clinically visible lesion confined to cervix or microscopic lesion greater than stage IA2:
Stage IB1 Clinical lesions of 4.0 cm or less in size;
Radical hysterectomy and bilateral pelvic lymphadenectomy or radiotherapy (or trachelectomy and pelvic lymphadenectomy).
Stage IB2 Clinical lesions more than 4.0 cm in size;
Chemoradiation or radical hysterectomy and bilateral pelvic lymphadenectomy +/− adjuvant radiotherapy or chemoradiation.
Stage II: Carcinoma extending beyond cervix but not to pelvic sidewall; carcinoma involves vagina but not its lower third.
\nStage IIA: No parametrial involvement
Chemoradiation or radical hysterectomy and bilateral pelvic lymphadenectomy in selected patients +/− adjuvant radiotherapy or chemoradiation
Stage IIB: Parametrial involvement
Chemoradiation or radical hysterectomy and bilateral pelvic lymphadenectomy in selected patients +/− adjuvant radiotherapy or chemoradiation
Stage III: Carcinoma extending onto pelvic wall; the tumour involves lower third of the vagina. All patients with hydronephrosis or nonfunctioning kidney are included unless known to be result of other causes.
\nStage IIIA: Involvement of lower third of the vagina; no extension of pelvic sidewall.
\nStage IIIB: Extension to pelvic sidewall and/or hydronephrosis or nonfunctioning kidney.
Chemoradiation or radiotherapy
Stage IV: Carcinoma extends beyond true pelvic or clinically involves mucosa of bladder or rectum. Bullous oedema does not allow a case to be designated as stage IV.
\nStage IVA: Spread of growth to adjacent organs:
Chemoradiation or radiotherapy.
Stage IVB: Spread to distant organs:
Palliative chemotherapy or radiotherapy.
Sources: (Benedet, 2000; FIGO, 2009).
\nCervical cancer, though a highly prevalent cancer, is largely and effectively preventable and treatable. The great advances in science and sociology well contribute towards the global crusade to eliminate cervical cancer, especially among the underserved and unreached poor women in the world. The InTech publishers, editor and authors, dedicate this book towards this noble mission (Appendix A and B).
\nCervical cancer—health education pamphlet.
Cervical cancer—clinical information banner.
The author-editor places on record high appreciation and gratefulness to Ms. Marina Dusevic, the Author Service Manager, IntechOpen, for her meticulous care and highly efficient technical guidance, in bringing out this book in a very successful manner. Gratefully, I acknowledge the warmth, love, care and efficient assistance of my daughter Dr. R. Rijula Raj MPT and my son Er. R. Rixon Raj during the edition of this book, I thankfully acknowledge Er. S. Pavithraj for his expert computer assistance. My highest regards to R. Celin Rani for her limitless love, care and support. My deep sense of gratitude and thanks to the IntechOpen publishers, for collaborating with me for fourth book, in succession. May all our efforts bring goodness to the poorest of the poor in the world, by prevention of diseases and promotion of health, true to the wish of God and man.
\nSamples of Health education materials as seen in www.
\nThe global dichotomy between the global North and global South is not a mere fiction but a fact that actually plays out in many spheres of life [1]. The current position of many nations in the global South is involuntary, however, the derogatory characteristics of a global South nation can change when there is a sincere, determined resolution by all stakeholders to make the nation functional and efficient. The much needed functional cities in the global South cannot be achieved without deliberate, effective and apt urban planning. A clog in the wheel of progressive change in urbanization trend of these cities is hinged on the unrelenting position of many global South planners who cling to their colonial-master-bequeathed planning approaches without consideration of current realities, with the results that these cities evolve and grow without circumspective direction and proper management of urbanization trends.
In the light of the above scenario, the characterization of global South cities as informal-economy-cities has not only just persisted but is expanding and taking new dimensions. Consequently, this chapter briefly discusses the trend of planning at different epochs in history; examined urbanization, and its major consequence in global South cities, which is informal economy. It further explores the Neo-liberal thinking and trends, which underpins and sustains the perpetration of informal economy, and details and interrogates the predominance of informal economy in global South cities. The Chapter specifically devotes sections to discuss the relationship between urban planning and informal economy; the need for adjustment in global south urban planning standards to meet current realities, with lessons drawn from successful story of Singapore, a global South city that has become a model for other global South cities, showing that being an
The discussion on the trend of urban planning will be incomprehensive without retrospection on the trends of human settlements/development. In fact, each stage of urban planning can only be effectively discussed within the context of the prevailing development era and so a better chronological order is to discuss the type and level of planning that prevailed in each human development era. The focus of this section though on planning in global South cities, needs to first discuss planning globally since most global south planning systems are bequeathed by their colonial masters especially in African cities and their contemporary planning practices still have its foundation on the inherited system. The following section therefore focuses on planning during the six major historical human development eras before the contemporary period.
The human settlement is an organized grouping of human habitation. The first stage of prehistoric human era known as the
In the global South, most of the locations known today as cities started as rural areas and had some form of informal planning. Typical examples are some communities in Nigeria (which are part of the global South cities) as Ile-Ife, Kano, Oyo and Bini. The planning practice then was characterized by the ordering of the community features in a radial form with the prime feature such as the King’s palace or place of worship at the centre [3].
The contemporary urban planning is traced to the planning standards introduced by the colonial masters in many global South cities. In Nigeria, the 1932 Town and Country Planning Act of the United Kingdom formed the basis for the 1946 Nigerian Town and Country Planning Ordinance (No. 4) [3]. The current Urban and Regional Planning Law (1992) is also rooted in the former existing laws. Many other countries formally colonized in the global South share the same experience of Nigeria. Singapore is another typical example; its planning legislation was based on the British Town and Country Planning Act of 1947 [4]. The impact of colonial planning laws on the colonized global South cities is quite obvious in the physical organization of the cities right from the colonial era till date. The underlying factors that influenced the colonial planning legislations especially that of the 1930s and 1940s in Britain/Europe are no longer tenable even in the originating nations but unfortunately the colonized nations that were bequeathed with these planning legislations still hold tenaciously to them even in contemporary divergent situations [5]. Also the planning standards practiced in the colonial era had some design issues that were elitist, yet contemporary planning systems in the global South have rigidly upheld these standards till date. The Contemporary planning system is vividly captured by Watson ([6], p. 2261).
The traditional forms of planning that have persisted in global South cities are opined to somewhat be driven by some forces [6] even the current trend of global South cities’ urbanization reveals their inadequacy and ineffectiveness.
The global population reached the 7 billion mark in 2011 and is expected to get to the 9 billion mark by 2050. Urbanization, which is the influx of people from rural to urban areas, is a global concern. Globally, urban population reached the 50% mark in 2007 and has continued to increase ever since then with a projected 70% by 2050. Urbanization is a process predominant in the global North in the nineteenth century and has currently shifted to the global South [7]. It is predicted that 80% of the expected 70% urban population by 2050 would be resident in Asian and African cities [8]. The urbanization of the global North was accompanied by many positive effects such as new employment opportunities and poverty reduction. However, global South urbanization is fraught with many challenges in virtually every facet of the society due to its rapid rate and the governments’ unpreparedness for the challenges. The urbanization challenge focus of this work is on the urban economy and its effect on the urban environment. Urbanization in the global South has had a great toll on the economy. The influx of people to urban areas in the South has led to constant increase in the level of unemployment. As the population increase has not been matched with commensurate growth in gross national product (GDP) and employment provisions both by the government and the private sector resulting in high level of unemployment with many urban residents resorting to the informal economy. The urban informal economy characterized by unregistered and unregulated businesses, has become the sole resort for many urban residents. This informal economy has been traced to some government policies and international economic policies which have affected the global South nations more than the developed global North nations. One of the major policies that have influenced and sustained the informal economy is neo-liberalism. Going through history, one can glean insights on how humankind and their groups have identified and reacted to threats and openings which were embedded in their natural settings. Urbanization, in this case, is seen as one of three fundamental approaches in history employed by humans towards problem solving. This particular approach involves movement of people from areas of scarcity and lack to areas of available resources. As for the actual timing of when urbanization started, it is believed to date back as far as the pre-historic period of 2350–1800 B.C.
Urbanization is not restricted to any particular region of the world; however, the rate at which urbanization is taking place is seen to be fastest in global south cities of Africa, Latin-America, Asia, the Pacific and the Caribbean. The United Nations (UN) projection is that higher than 4 billion or 77% of urban residents of the world will be in less developed regions in 2025. This figure will translate to a total increase of 186% or an equivalent of 2.61 billion new urbanities in Latin America, Asia and Africa starting from 1990. The State of World Population indicates that in year 2009, urbanization level in less developed countries stood at 45 and 29% in least developed countries. The growth rate of urban population in the same report indicates 2.6% for less developed countries and 4.1% for least developed countries annually.
A greater percentage of people who move from rural to urban areas find themselves living in harsh or extreme conditions, more often than not, in the worst areas of cities. Such areas are often characterized by slums and squatter settlements. Houses in these areas are mostly shacks and cheap self-made apartments of mud, wood and zinc, corrugated iron sheets, etc. The most unfortunate ones are completely homeless or just manage to put up anywhere possible in global South cities like in Nigeria.
Urbanization has both negative and positive effects on global South cities, though, discussions in this respect often tilt towards the negative effects. The negative effects will be addressed along two broad areas of environment and economy.
Urbanization effects on the environment of global South cities come in two major ways: air and water pollution. The hallmark of cities and towns is the existence of automobiles and factories. As more people move into cities, larger quantities of dangerous gases such as carbon-dioxide, carbon-monoxide and nitrogen oxides, and smoke are emitted into the atmosphere. These gases present severe threats to our health and are known to cause serious respiratory challenges. What is more it is generally responsible for depleting the ozone layer with the many adverse consequences. The next immediate environmental challenge is water pollution. Increase in the population of the cities makes it difficult to manage water generated for use. Most times, waste generated find its way into streams and rivers or onto the streets. Sometimes, solid and other waste from factories is dumped into water bodies. As this happens, the water sources become polluted and dangerous for use. In consequence, city dwellers are presented with more difficulty in assessing clean water.
It has already been pointed out that slums and squatter settlements are unavoidable fallouts of urbanization, management of waste and sewage is a major problem in these areas. One of the reasons is that official health and sanitation arrangements do not adequately cater for these areas. In as much as the city dwellers are not directly involved, any outbreak of diseases or epidemics will definitely not spare city dwellers. Most of the residents of these settlements indulge in open defecation with the attendant health hazards associated with it.
There are a number of other types of pollution which urbanization brings in its wake. They include traffic congestion which comes with the inevitable increase in various kinds of automobiles such as pedicabs; noise pollution which result from extra noise from small production units established by the migrants; inconvenience to pedestrians as they struggle with hawkers and street vendors; and a host of other types of environmental pollution. Another ancillary urbanization issues is the emergence of urban sprawls. This requires special mention as a form of environmental adverse effect of urbanization. The reason is that urban sprawls are not part of the original urban planning policy of any city. A sprawl indicates an increase in space or adjoining area of a city. Sprawls provide a haven for a plethora of informal economic activities which put pressure on the facilities meant for formally planned segments of the cityscape.
The economy of global South cities are affected by urbanization in several ways:
Generally urbanization comes with it a spillover effect of hands that are not engaged in productive activities. The unemployment among developing countries of the global south cities have been a thing of worry. For instance, the official figure of Nigerian unemployment is put at 23%, while youth unemployment figure is put to about 52% as at 2018 [9]. The immediate side effect of this high level of unemployment is unrestrained increase level of poverty. As at 2017, Nigeria with a population estimated at about 200 million people had about 86 million in extreme poverty. This made her exceed India as the highest destination of poor people globally. On the wheels of this growing incidence of poverty is increased spate of criminal activities such as banditry, kidnapping, bribery and corruption among many other crimes. The basic explanation is that man is self-preservative, and in the absence of a genuine means of livelihood, resorts are made to criminal activities for survival. This fits into the age-long proverbial saying; that an idle hand/mind is a devil’s workshop.
The springing up of urban sprawls is attended with the destruction of forests and natural reserves for squatter settlements. This leads to the loss of farm land which ordinarily would have been available to city dwellers for farming.
In as much as urbanization has negative effects on global South cities, however, there are immense benefits that accrue when cities get urbanized. Urban cities enjoy delivery of services in terms of supply of basic amenities such as water, electricity, and health attention. This flows from the fact that administrations of cities are usually planned. Different activities of city life are allotted to specific areas and are carefully monitored to ensure compliance. In comparative terms, life in the city is much more sophisticated and advanced than the rural areas. It boasts of better transport, communications, educational and health facilities. There is much more convenience and comfort in the city. Finally, products of different types both local and foreign normally find their way into the city. Larger markets are cited in the city and these attract buyers and sellers from diverse places. This result to growth in commercial activities much more than what obtains in the rural areas. Other benefits include: growth in economy, social and cultural integration, efficient use of resources.
The word Neo-liberalism etymologically is an amalgam of two words, namely ‘Neo’ which means ‘new’ and ‘liberalism.’ which connotes ‘freedom and without let’. The simple literal translation is that it is a new and revived form of liberal political economic thinking. Impliedly, this definition suggest that there was a time liberal ideology ruled the political-economic thinking of the world; and with time got replaced by other ideological thinking, and has come back into the political-economic thinking with the new christened name- Neo-liberalism [10, 11, 12, 13]. Proponents of this perspective see Neo-liberalism as a revived form of liberalism.
Another perspective of looking at Neo-liberalism is akin to the concept of ‘Neo-conservatism’ which descended from and shares a lot of similarities with conservatism but represent a different thoughts altogether [14, 15, 16]. The implication of this school of thought is that neo-liberalism, albeit, share the same roots and similarities with liberalism it comes with a lot of embellishments to give it an independent school of thought. The key question is what is the essential thrust of Neo-liberalism thinking? What are its trends and how does it affect global south cities?
The concept of neo-liberalism is fraught with polemics and varying interpretations in the literature that it defies uniform and integrated definition. These divergent opinions inhere from the fact that most literature discourse of neo-liberalism is largely approached from the point of critiques rather than an attempt at definition, description and postulations. The heterogeneity of opinions notwithstanding, neo-liberalism shares certain coherent characteristics, strands of thought and ideology that give it a unique characterization in the literature.
The roots of Neo-liberalism can be traced to the realm of political-economy. As a successor to classical liberalism, it shares the belief that the best way to efficiently allocate resources is to leave it in the hands of free market forces. As Munck [17] rightly observes, neo-liberalism is an economic philosophy which believes that the best way to allocates resources is to give free reign to market forces and individual liberty to economic pursuit. Consequently, neo-liberals advocate for less government interference in economic activities as it undermines the fine logic of distributional efficiency of the market. A more concise definitions of Neo-liberalism were given by Harvey [18] and Blomgren [19] thus:
Implicit in these definitions is that Neo-liberalism advocates for and promotes the freedom and liberty of individuals to pursue entrepreneurial activities, free exchange of goods and services and own private property. Inherent in these definitions is that the state should act as umpire and provide the necessary enabling environment for the individuals to actualize their potentials. Given this ensuing analysis, it is axiomatic therefore to conclude that modern day capitalism and the accompanying democratic philosophy is underpinned by Neo-liberal ideology.
It is pertinent to note that neo-liberal thinking has evolved overtime with various prototypes at display in its shelf. These varying typologies descend from the literature polarization of the understanding of the role of the state in economic activities and the degree to which it should intervene. From the time of Adam Smith, who was the proponent of
In a nutshell, Neo-liberalism is a political ideology that believes in the free reign of market forces as a best means of allocating resources with the role of state being to provide the enabling environment to protect individual freedom to economic pursuit and property rights.
There is no doubt that we live in a globalized world, with various nation states linked together in such a way that the world is seen as a global village [23, 24]. The implication is that what happens in one region generate in some ways a ripple effects in other regions of the world. The neo-liberal thinking which was developed in the global west has since permeated and shaped the political and economic thinking in other regions especially in the global south. For instance, the major institutional frameworks that drive neo-liberal thinking are capitalism (economic mode of production) and democracy (political ideology). Prior to the era of neo-liberalism of the nineteenth and twentieth century, various countries of the global South cities adopted various types of political-economic ideological formation. In sub-Saharan African countries for instance, depending on their historical experiences, there were divergent political experimentations. While some practiced various forms of western democratic type of government, others practiced eastern type of communism and yet others experimented on domesticated forms of African socialism. At some point, military type of centralized totalitarian government became the vogue among many countries in the global south nations. However, with the increased specter of neo-liberal thinking there is an overwhelming convergence in the adoption of western democracy as the best form of political ideology. The tenets and values of western democracy has become so internationalized that there is instant global rejection of any overthrow of any democratically elected government by way of coup d’état. Fascism and totalitarian government in any form, including apartheid regime were denounced and repudiated. As a result, what you see, albeit there are various shades, is the enthronement and respect of democracy as the dominant global political thinking; many thanks to neo-liberalism.
The question is how did this neo-liberal thinking permeate the political thinking of these global south cities? The answer to the question takes us back to the nature of the relationship between the global south nations and their previous colonial or trading masters. During and after colonialism the relationship between these developing countries and their colonial masters continued in the form of dependence of the former on the latter. This subservient relationship shifted from direct political and administrative dependence during colonialism to economic dependence during post-colonial dispensation. For instance, most advanced western countries used loans and grants conditionalities to compel these nations to politically align to liberal democracy and to deregulate their economy. The Breton woods institutions (IMF and World Bank) that are used to supervise many of these credit handouts would usually require the beneficiary nations to structurally adjust their economy to align to neoliberal thinking before the deal is struck.
Another manifest influence of Neo-liberal thinking in the global South economies is the unprecedented bilateral, multilateral and international growth in trade relations between and among countries of the various geographical divides. Neo liberalism has supported the removal of barriers and inhibitions to global trade to the extent that most global south cities are net importers of basic necessities of life. Several institutions such as World Trade Organization (WTO), United Nations Conference on Trade and Development (UNCTAD) and a plethora of regional and sub-regional trade agencies were conceived to facilitate international trade. The implications are that the specter of neo-liberalism has left in its wake a clear dismantling of the structural inhibitions to international trade. This move is further supported by credit, aid and donor granting agencies that insists that these barriers would be removed as a condition for continuous financial aid to these countries. The anticipated and sometimes unintended consequences of these unequal economic relations are the growing huge indebtedness of these developing countries to international financial institutions.
The concluding remark of this section is that neoliberalism provides the theoretical context that explains the spiraling growth of informality in the global South cities. Neo-liberalism supports a milieu that promotes free economic enterprise with minimal, if any interference from the state. The implication of the tenets of neo-liberal theory is the roll back of the state and by extension, the reduction of formal sector which unfortunately, contemporary formal urban planning in developing countries superintends [25, 26]. The growth of urbanization and complimentary deregulation of the economy as supported by neoliberal thinking and forces provides theoretical explanation of the growth of informal sector in developing economies of the global South.
Defining informal economy or informal sector has attracted much research within academic circles. In literature, hence, there is a plethora of definitions and perspectives of informal economy. Many more definitions and re-definitions are still on-going. For this study, however, two definitions are trite: (i) The last general discussions of informal economy by the ILO tripartite constituents in 2002 International Labour Conference… define informal economy to include “all economic activities that are—in law or practice—not covered or insufficiently covered by formal arrangements”; and (ii) Employment in the informal sector was defined by the 15th International Conference of Labour Statisticians as “including all jobs in informal sector enterprises, or all persons who, during a given reference period, were employed in at least one informal sector enterprise, irrespective of their status in employment and whether it was their main or a supplementary job”.
Researchers have attempted to delineate the main threads that run in the several definitions. For instance, Kasarda and Grenshaw [27] after synthesizing several works submitted that the conceptualization of informal economy were hinged on four main characteristics namely: (i) size of firm; (ii) source of financial and material resources; (iii) the degree of linkages between regulated and unregulated sectors and (iv) the extent to which firms comply with government regulations. With regards to the main characteristics of enterprises that operate in the informal sector, Becker [28] presented the following characteristics; (a) start-up and conditions are minimal; (b) activity level is normally small with a number of workers; (c) normally, formal education does provide the expertise required for business operations, and (d) goods and services produced require a lot of labour.
The informal economy or sector had existed in various forms in the pre-historic times. In literature, however, two research works are credited with popularizing the concept. The honor of “discovering” the concept has frequently been given to Keith Hart, a British Anthropologist, as a result of the work he did in Ghana from the mid-to-late 1960s [29]. The second work was the research by the International Labour Organization (ILO) alongside the United Nations Development Programme (UNDP) Employment Mission to Kenya in 1972 [30]. These research efforts are believed to have greatly popularized the use of the term and as a result triggered off much research in that field. Going through literature, however, reveals that each bloc/country within the economies in the global south regions have their peculiar version as regards the origin of informal economy.
Evidence is rife in research literature concerning the prevalence of informal economy in the Global South. On a global scale, World Bank [31] observed that an equivalence of two-thirds of the entire workforce is employed in the informal sector. On the African continent [32] observe that a good junk of economic activities are taken-up by the informal sector notably in mining, finance, commerce and manufacturing. Xaba et al. [33], in his sub-Saharan African countries’ study has shown that the informal economy has shown to be the single practical option in the face a drop in rise of formal employment and has effectively functioned as a shock absorber, remained consistent across period and got enlarged in operations. Gali and Kucera [34] in agreement assert that the informal economy has repeatedly acted as a shock absorber for official employment, whereas, the informal sector accounts for 93% of jobs created in the African continent in the 1990s [35]. Comparably, whereas, the portion of formal economy recorded a reduction in the total workforce, the informal economy recorded an increase [33].
More statistics on the prevalence of informal economy in the global South was presented by ILO [36] and; Williams and Nadin [37]. When the incidence of informal sector vis-a-vis the formal sector is disaggregated across the various regions of the world in terms the percentage of the self-employed, we have the following data: 70% in sub-Saharan Africa (SSA); 62% in North America; 60% in Latin America and 59% in Asia. Horn (cited in [38]) notes that: 72% of non-agricultural employment in sub-Saharan Africa is informal; 84% of women non-agricultural workers are informally employed in sub-Saharan Africa and the greater part of recent employment in Africa are in the informal economy. Across the continent of Africa, reports that the informal sector provides between 50 and 75% of jobs, and 72% of non-agricultural employment. The portion of non-agricultural employment rises to 78% with the exclusion of South Africa. The informal economy has the following portions out of some countries’ labour force in Africa: more than 50% in Kenya and Uganda; about 43% in South Africa and Zambia; and 89% in Ghana [35]. Nigeria’s informal economy is believed to have contributed greater than 50% to both the entire country’s labour force as well as its GDP, estimated to have gone up from about 50% in the 1970s to about 65% in the 1980s [39, 40, 41]. Estimate of Nigeria’s average portion of informal economy relative to the nation’s GDP was put at 56% within 1999 to 2005 [42]. A third of Nigeria’s urban labour is believed to come from the informal economy [33].
Informal economy plays a vital role in transition and developing countries in facilitating successful adjustment to globalization and structural reforms. It provides a means of survival to a large number of poor and extremely poor workers in a society and also plays a vital role in unlocking entrepreneurial potentials which could become lost in the bureaucracy of formality.
Urban planning in the global South is established as founded and inherited from the global North [6, 43, 44]. The global South surely appreciates this offer, however, instead of moving ahead to re-examine what has been received and practiced for decades based on current urban realities, many global South cities’ planners have stuck to the traditional planning system, which Watson ([6], p. 2262) has aptly captured as
One of the descriptions of informality in Duminy ([45], p. 1) as
Despite these obvious relevance and permanence of informal economy, many urban planners are yet to view it from a positive perspective resulting in constant conflict between urban planners and informal economy operators. The non-acknowledgement of the role of informal economy operators has also caused planners not to key-into contemporary trends of maximizing the potentials of this group in some global South cities. Urban planners have been alleged to use the very planning instruments in their custody like the master plan and zoning as instruments to dispossess the urban poor among the informal economy operators of their property and source of livelihood many times without compensation or alternative livelihoods. This is particularly peculiar to Nigerian cities. Some governments in the global South are argued to be promoting informal activities by their policies and yet penalize the urban residents caught-up by these policies [50]. However, it’s not all negative attitudes, Onodugo et al. ([26], p. 97) has some of the success stories on positive attitudes of planners/government towards informal economy while Yuen [44] tells the success story of Singapore.
The dogmatic stance of many urban planners in global South cities has aggravated the challenges of many urban areas. Instead of working towards solving the problems, they are concerned with ensuring ‘ordered’ cities at the expense of livelihood, economic growth and accomplishment of many other sustainable development goals. However, Watson [6] has described the reason for the ineffectiveness of global South planners as a complex issue which in some cases lies beyond the powers and will of the planners and linked to some local political ideologies and beyond, to the international policies. One of the tools of traditional urban planning is the master plan, a very powerful tool that has been used by planners to affect the urban rich and the poor in different ways. For the rich, it’s a tool that helps them to maintain their properties at strategic locations of the city while the urban poor have been marginalized using the master plan. The master plan of earlier years concentrated on physical development without much consideration of other aspects of life like economic and social. The continuous use of the traditional planning systems by global South planners especially in African cities to manage contemporary cities has been described as an
Innovative refers to featuring new methods; advanced and original, introducing new ideas; original and creative in thinking. Inclusive means including all the services or items normally expected. Innovative and inclusive urban planning designs therefore refer to planning designs that reflect steps ahead of the foundational planning systems to contextually-effective planning approaches that reflect current Global South urban realities. The innovative design should not be a
An innovative and inclusive planning design should not also be a
Singapore, the smallest nation (area-wise—700 sq km) in Southeast Asia, one of the least urbanized regions of the world like Africa; gained her independence from Britain on the 9th of August, 1965 after it was colonized in 1819. The economic success of Singapore from the 1980s saw it having its unemployment rate reduced to as low as 3% while its GDP growth averaged 8% up till 1999. The March 2019 unemployment figure is 3.2% [54]. The success story of Singapore’s urban planning is detailed in Yuen [44] and would be briefly discussed here. Singapore like other colonized global South cities had its Singapore Master Plan set out in the 1959 Planning Ordinance, which was a 20-year statutory planning for land use with the major objective of
The 1971 concept plan was reviewed in 1991 and 2001 and is planned for a regular 10-year review. Some key lessons to be gleaned from Singapore’s planning approach-Concept plan are as follows:
The concept plan is not all about physical planning but went a step further to give real consideration to the economy and even quality of life. Also the Concept plan entailed an integrated planning process that includes all agencies involved in all facets of development coming together to take a consensus decision on the development of the nation. The Concept plan was prepared to align with the twenty-first century globalization while the strategies are contemporary approaches such as urban greenery and new regional centres with the maximization of the scarce land in perspective. Two key words noted in the Singapore minister for finance’s speech ([55] c.f. [44]) are constant
The key problem that provided impetus for this study is the unprecedented population growth of most developing cities of the global South. This is so much that it is estimated that by 2050 it will provide haven for most of the world’s additional population. The immediate sequel to this is that urbanization trend in these countries has and will continue to overwhelm the formal sector of these cities. Consequently, the unplanned informal sector will fester across the formally planned and inherited urban cities, distorting the original master plan in its wake. Underpinned by neo-liberal thinking that promotes protection of individual’s right to free enterprise and private property ownership, coupled with limited labour absorptive capacity of the formal sector, informal sector will continue to thrive and grow.
This chapter views as anachronistic, moribund and counter-productive, the current rigid top-down exclusive planning approach by conventional urban planners that refuses to appreciate context specific changes in the socio-economic landscape of these global south cities. Insisting on an urban planning that refuses to integrate the views of more than half of the labour market (that operates in the informal market) in the cities is at best shadow boxing and at least an exercise in motions without movement as evidence point to colossal failure.
The import of, and perhaps the contribution of this chapter is the proposal that there should be a reversal of the present planning model that only sees to the formal sector. We propose that modern urban planning should be both innovative (finding new, context specific and creative ways of doing old assignments) and integrative. The latter implies admitting the changes that has occurred in the socio-economic and demographic landscape of urban development and incorporating all the stakeholders in the planning process. Inter alia, people tend to comply with policies that they made inputs in designing.
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\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
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Abdurakhmonov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5940",title:"Vitamin C",subtitle:null,isOpenForSubmission:!1,hash:"e23e79359167bb9d4a53edd78c7b5038",slug:"vitamin-c",bookSignature:"Amal H. Hamza",coverURL:"https://cdn.intechopen.com/books/images_new/5940.jpg",editedByType:"Edited by",editors:[{id:"188326",title:"Associate Prof.",name:"Amal",middleName:null,surname:"Hamza",slug:"amal-hamza",fullName:"Amal Hamza"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:13,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"56013",doi:"10.5772/intechopen.69660",title:"Vitamin C: An Antioxidant Agent",slug:"vitamin-c-an-antioxidant-agent",totalDownloads:7748,totalCrossrefCites:24,totalDimensionsCites:52,abstract:"Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby neutralize, reactive oxygen species. It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"56440",doi:"10.5772/intechopen.70162",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6338,totalCrossrefCites:13,totalDimensionsCites:25,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"50921",doi:"10.5772/63712",title:"Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet",slug:"menaquinones-bacteria-and-foods-vitamin-k2-in-the-diet",totalDownloads:3272,totalCrossrefCites:10,totalDimensionsCites:21,abstract:"Vitamin K2 is a collection of isoprenologues that mostly originate from bacterial synthesis, also called menaquinones (MKs). Multiple bacterial species used as starter cultures for food fermentation are known to synthesize MK. Therefore, fermented food is the best source of vitamin K2. In the Western diet, dairy products are one of the best known and most commonly consumed group of fermented products.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Barbara Walther and Magali Chollet",authors:[{id:"184784",title:"Dr.",name:"Barbara",middleName:null,surname:"Walther",slug:"barbara-walther",fullName:"Barbara Walther"},{id:"188194",title:"Mrs.",name:"Magali",middleName:null,surname:"Chollet",slug:"magali-chollet",fullName:"Magali Chollet"}]},{id:"66098",doi:"10.5772/intechopen.84445",title:"Golden Rice: To Combat Vitamin A Deficiency for Public Health",slug:"golden-rice-to-combat-vitamin-a-deficiency-for-public-health",totalDownloads:3307,totalCrossrefCites:12,totalDimensionsCites:17,abstract:"Vitamin A deficiency (VAD) has been recognised as a significant public health problem continuously for more than 30 years, despite current interventions. The problem is particularly severe in populations where rice is the staple food and diversity of diet is limited, as white rice contains no micronutrients. Golden Rice is a public-sector product designed as an additional intervention for VAD. There will be no charge for the nutritional trait, which has been donated by its inventors for use in public-sector rice varieties to assist the resource poor, and no limitations on what small farmers can do with the crop—saving and replanting seed, selling seed and selling grain are all possible. Because Golden Rice had to be created by introducing two new genes—one from maize and the other from a very commonly ingested soil bacterium—it has taken a long time to get from the laboratory to the field. Now it has been formally registered as safe as food, feed, or in processed form by four industrialised counties, and applications are pending in developing countries. The data are summarised here, and criticisms addressed, for a public health professional audience: is it needed, will it work, is it safe and is it economic? Adoption of Golden Rice, the next step after in-country registration, requires strategic and tactical cooperation across professions, non-governmental organisations (NGOs) and government departments often not used to working together. Public health professionals need to play a prominent role.",book:{id:"7978",slug:"vitamin-a",title:"Vitamin A",fullTitle:"Vitamin A"},signatures:"Adrian Dubock",authors:[{id:"273220",title:"Ph.D.",name:"Adrian",middleName:null,surname:"Dubock",slug:"adrian-dubock",fullName:"Adrian Dubock"}]},{id:"62836",doi:"10.5772/intechopen.79350",title:"The Role of Thiamine in Plants and Current Perspectives in Crop Improvement",slug:"the-role-of-thiamine-in-plants-and-current-perspectives-in-crop-improvement",totalDownloads:1534,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Current research is focusing on selecting potential genes that can alleviate stress and produce disease-tolerant crop variety. The novel paradigm is to investigate the potential of thiamine as a crop protection molecule in plants. Thiamine or vitamin B1 is important for primary metabolism for all living organisms. The active form, thiamine pyrophosphate (TPP), is a cofactor for the enzymes involved in the synthesis of amino acids, tricarboxylic acid cycle and pentose phosphate pathway. Recently, thiamine is shown to have a role in the processes underlying protection of plants against biotic and abiotic stresses. The aim of this chapter is to review the role of thiamine in plant growth and disease protection and also to highlight that TPP and its intermediates are involved in management of stress. The perspectives on its potential for manipulating the biosynthesis pathway in crop improvement will also be discussed.",book:{id:"6709",slug:"b-group-vitamins-current-uses-and-perspectives",title:"B Group Vitamins",fullTitle:"B Group Vitamins - Current Uses and Perspectives"},signatures:"Atiqah Subki, Aisamuddin Ardi Zainal Abidin and Zetty Norhana\nBalia Yusof",authors:[{id:"240031",title:"Dr.",name:"Zetty-Norhana Balia",middleName:null,surname:"Yusof",slug:"zetty-norhana-balia-yusof",fullName:"Zetty-Norhana Balia Yusof"},{id:"261167",title:"Mr.",name:"Aisamuddin Ardi",middleName:null,surname:"Zainal Abidin",slug:"aisamuddin-ardi-zainal-abidin",fullName:"Aisamuddin Ardi Zainal Abidin"},{id:"261169",title:"Ms.",name:"Atiqah",middleName:null,surname:"Subki",slug:"atiqah-subki",fullName:"Atiqah Subki"}]}],mostDownloadedChaptersLast30Days:[{id:"56440",title:"Vitamin C: Sources, Functions, Sensing and Analysis",slug:"vitamin-c-sources-functions-sensing-and-analysis",totalDownloads:6340,totalCrossrefCites:13,totalDimensionsCites:25,abstract:"Vitamin C is a water-soluble compound found in living organisms. It is an essential nutrient for various metabolism in our body and also serves as a reagent for the preparation of many materials in the pharmaceutical and food industry. In this perspective, this chapter can develop interest and curiosity among all practicing scientists and technologists by expounding the details of its sources, chemistry, multifunctional properties and applications.",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Sudha J. Devaki and Reshma Lali Raveendran",authors:[{id:"187911",title:"Associate Prof.",name:"Sudha",middleName:null,surname:"J Devaki",slug:"sudha-j-devaki",fullName:"Sudha J Devaki"},{id:"204937",title:"Mrs.",name:"Reshma",middleName:null,surname:"Laly Ravindran",slug:"reshma-laly-ravindran",fullName:"Reshma Laly Ravindran"}]},{id:"56013",title:"Vitamin C: An Antioxidant Agent",slug:"vitamin-c-an-antioxidant-agent",totalDownloads:7749,totalCrossrefCites:24,totalDimensionsCites:52,abstract:"Vitamin C or ascorbic acid (AsA) is a naturally occurring organic compound with antioxidant properties, found in both animals and plants. It functions as a redox buffer which can reduce, and thereby neutralize, reactive oxygen species. It is a cofactor for enzymes involved in regulating photosynthesis, hormone biosynthesis, and regenerating other antioxidants; which also regulates cell division and growth, is involved in signal transduction, and has roles in several physiological processes, such as immune stimulation, synthesis of collagen, hormones, neurotransmitters, and iron absorption, has also roles in detoxifying the body of heavy metals. Severe deficiency of vitamin C causes scurvy, whereas limited vitamin C intake causes symptoms, such as increased susceptibility to infections, loosening of teeth, dryness of the mouth and eyes, loss of hair, dry itchy skin, fatigue, and insomnia. In contrast, vitamin C can also act as a prooxidant, especially in the presence of transition metals, such as iron and copper, starting different hazardous radical reactions. Vitamin C can both act as a strong, efficient, and cheap antioxidant agent and, at the same time, behave as a radical promoter. Further investigations are needed to illuminate the dual roles of vitamin C",book:{id:"5940",slug:"vitamin-c",title:"Vitamin C",fullTitle:"Vitamin C"},signatures:"Fadime Eryılmaz Pehlivan",authors:[{id:"200567",title:"Dr.",name:"Fadime",middleName:null,surname:"Eryılmaz Pehlivan",slug:"fadime-eryilmaz-pehlivan",fullName:"Fadime Eryılmaz Pehlivan"}]},{id:"69402",title:"Vitamin D Deficiency and Diabetes Mellitus",slug:"vitamin-d-deficiency-and-diabetes-mellitus",totalDownloads:1545,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Vitamin D (VD) is a molecule that can be synthesized directly in the humans’ body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D–1,25(OH)2D. 1,25(OH)2D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells’ functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.",book:{id:"7038",slug:"vitamin-d-deficiency",title:"Vitamin D Deficiency",fullTitle:"Vitamin D Deficiency"},signatures:"Ihor Shymanskyi, Olha Lisakovska, Anna Mazanova and Mykola Veliky",authors:null},{id:"76108",title:"Vitamin D Metabolism",slug:"vitamin-d-metabolism",totalDownloads:424,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Vitamin D plays an important role in bone metabolism. Vitamin D is a group of biologically inactive, fat-soluble prohormones that exist in two major forms: ergocalciferol (vitamin D2) produced by plants in response to ultraviolet irradiation and cholecalciferol (vitamin D3) derived from animal tissues or 7-dehydrocholesterol in human skin by the action of ultraviolet rays present in sunlight. Vitamin D, which is biologically inactive, needs two-step hydroxylation for activation. All of these steps are of crucial for Vitamin D to show its effect properly. In this section, we will present vitamin D synthesis and its action steps in detail.",book:{id:"10631",slug:"vitamin-d",title:"Vitamin D",fullTitle:"Vitamin D"},signatures:"Sezer Acar and Behzat Özkan",authors:[{id:"29878",title:"Dr.",name:"Behzat",middleName:null,surname:"Özkan",slug:"behzat-ozkan",fullName:"Behzat Özkan"},{id:"348287",title:"Dr.",name:"Sezer",middleName:null,surname:"Acar",slug:"sezer-acar",fullName:"Sezer Acar"}]},{id:"50754",title:"Medicinal Chemistry of Vitamin K Derivatives and Metabolites",slug:"medicinal-chemistry-of-vitamin-k-derivatives-and-metabolites",totalDownloads:1875,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Vitamin K acts as a cofactor for γ‐glutamyl carboxylase. Recently, various biological activities of vitamin K have been reported. Anti‐proliferative activities of vitamin K, especially in vitamin K3, are well known. In addition, various physiological and pharmacological functions of vitamin K2, such as transcription modulators as nuclear steroid and xenobiotic receptor (SXR) ligands and anti‐inflammatory effects, have been revealed in the past decade. Characterization of vitamin K metabolites is also important for clinical application of vitamin K and its derivatives. In this chapter, recent progress on the medicinal chemistry of vitamin K derivatives and metabolites is discussed.",book:{id:"5169",slug:"vitamin-k2-vital-for-health-and-wellbeing",title:"Vitamin K2",fullTitle:"Vitamin K2 - Vital for Health and Wellbeing"},signatures:"Shinya Fujii and Hiroyuki Kagechika",authors:[{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika"},{id:"180529",title:"Dr.",name:"Shinya",middleName:null,surname:"Fujii",slug:"shinya-fujii",fullName:"Shinya Fujii"}]}],onlineFirstChaptersFilter:{topicId:"42",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:25,totalDimensionsCites:0,doi:"10.5772/intechopen.103016",abstract:"Potassium is an essential cation critical in fluid and electrolyte balance, acid–base regulation, and neuromuscular functions. The normal serum potassium is kept within a narrow range of 3.5–5.2 meq/L while the intracellular concentration is approximately 140–150 meq/L. The total body potassium is about 45–55 mmol/kg; thus, a 70 kg male has an estimated ~136 g and 60 kg female has ~117 g of potassium. In total, 98% of the total body potassium is intracellular. Skeletal muscle contains ~80% of body potassium stores. The ratio of intracellular to extracellular potassium concentration (Ki/Ke) maintained by Na+/K+ ATPase determines the resting membrane potential. Disturbances of potassium homeostasis lead to hypo- and hyperkalemia, which if severe, can be life-threatening. Prompt diagnosis and management of these problems are important.",book:{id:"10794",title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg"},signatures:"Sairah Sharif and Jie Tang"},{id:"79194",title:"Potassium in Solid Cancers",slug:"potassium-in-solid-cancers",totalDownloads:120,totalDimensionsCites:0,doi:"10.5772/intechopen.101108",abstract:"Electrolyte disorders are a frequent finding in cancer patients. In the majority of cases the etiologies of such disorders are common to all cancer types (i.e. diuretic-induced hyponatremia or hypokalemia). Sometimes, electrolyte disorders are caused by paraneoplastic syndromes or are due to cancer therapy. Potassium is one of the most important electrolytes of the human body since it is involved in the regulation of muscle contraction, maintenance of the integrity of the skeleton, blood pressure and nerve transmission as well as in the normal function of cells. Potassium homeostasis is strictly regulated since the gap between the recommended daily dietary intake (120 mEq/day) and the levels stored in the extracellular fluid (around 70 mEq) is huge. Alterations of potassium homeostasis are frequent in cancer patients as well alterations in potassium channels, the transmembrane proteins that mediate potassium fluxes within the cells. The present chapter is focused on the clinical significance of potassium homeostasis and potassium channels in patients with solid tumors.",book:{id:"10794",title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg"},signatures:"Jessica Iorio, Lisa Lastraioli and Elena Lastraioli"},{id:"78820",title:"Potassium Homeostasis",slug:"potassium-homeostasis",totalDownloads:109,totalDimensionsCites:0,doi:"10.5772/intechopen.100368",abstract:"The average potassium intake in the United States population ranges from 90 to 120 mEq/day. About 98% of the total body’s potassium is intracellular, and only 2% is present in the extracellular compartment. This distributional proportion is essential for cellular metabolic reactions and maintaining a gradient for resting membrane potential. A loss of this gradient results in hyper- or hypopolarization of the cell membrane, especially in cardiac muscles leading to life-threatening arrhythmias. Multiple mechanisms in human maintain homeostasis. Transient initial changes are due to transcellular shifts activating sodium-potassium ATPase pumps on the cell membrane. The kidneys essentially take part in excess potassium excretion, maintaining total body stores constant within normal range. Gastrointestinal secretion of potassium is insignificant in individuals with normal renal function, however plays an essential role in individuals with compromised renal function. So far, a classic feedback mechanism was thought to maintain potassium homeostasis; however, a recently recognized feedforward mechanism acting independently also helps preserve potassium homeostasis. Hence, potassium homeostasis is vital for humans to function at a normal level.",book:{id:"10794",title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg"},signatures:"Shakuntala S. Patil and Sachin M. Patil"},{id:"78193",title:"Potassium and Cardiac Surgery",slug:"potassium-and-cardiac-surgery",totalDownloads:178,totalDimensionsCites:0,doi:"10.5772/intechopen.99735",abstract:"Potassium homeostasis affects cardiac rhythm and contractility, along with vascular reactivity and vascular smooth muscle proliferation. This chapter will focus on potassium dynamics during and after cardiac surgery involving cardioplegic arrest and cardiopulmonary bypass (CPB). Hyperkalemic, hypothermic solutions are frequently used to induce cardioplegic arrest and protect the heart during cardiac surgery involving CPB. Common consequences of hyperkalemic cardioplegic arrest and reperfusion include microvascular dysfunction involving several organ systems and myocardial dysfunction. Immediately after CPB, blood potassium levels often drop precipitously due to a variety of factors, including CPB -induced electrolyte depletion and frequent, long-term administration of insulin during and after surgery. Meanwhile, some patients with pre-existing kidney dysfunction may experience postoperative hyperkalemia following cardioplegia. Any degree of postoperative hyper/hypokalemia significantly elevates the risk of cardiac arrythmias and subsequent myocardial failure. Therefore, proper management of blood potassium levels during and after cardioplegia/CPB is crucial for optimizing patient outcomes following cardiac surgery.",book:{id:"10794",title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg"},signatures:"Shawn Kant, Frank W. 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Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). 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Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. 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He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. 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She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. 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Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. 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