Rupesh K. Srivastava

All India Institute of Medical Sciences, New Delhi, India

Dr. Rupesh Kumar Srivastava Associate Professor Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL) Department of Biotechnology 41, Male, Married All India Institute of Medical Sciences (AIIMS) 20th August 1981 New Delhi -110029, India Cell # (+91)-9179567399 Lab. website: ORCiD : EDUCATIONAL TRAINING 2012-2013 Roswell Park Cancer Institute, Buffalo, New York, USA Research Affiliate, CD8+ T Cell Memory 2011-2012 Trudeau Institute, New York, USA Resident Affiliate, Calcium Channels in T cell development 2011-2011 Columbia University Medical Centre, New York, USA Postdoctoral Research Scientist, Bone Developmental Biology 2006-2011 National Centre for Cell Science (NCCS), Pune, India Doctorate of Philosophy, Biotechnology (Immunology) 2010 Symbiosis Centre for Distance Learning (SCDL), Pune, India MBA, Human Resource Management, A+ Grade 2009 World Intellectual Property organization (WIPO), Geneva, Switzerland Certificate, Intellectual Property (Online), First Division 2008 Sikkim Manipal University of Health Medical & Tech. Sciences, Sikkim, India Master of Science, Ecology & Environment (Distance), First Division 2006 Bioinformatics Institute of India (BII), Noida, India Post Graduate Diploma, Bioinformatics (Distance), First Division 2002-2004 Deen Dayal Upadhyay Gorakhpur University, Gorakhpur (U.P.), India Master of Science, Zoology (Cell Biology), First Division (GOLD MEDAL) 1998-2001 Deen Dayal Upadhyay Gorakhpur University, Gorakhpur (U.P.), India Bachelor of Science (Zoology, Botany & Chemistry), First Division AWARDS AND HONORS 2022 AIIMS Research Excellence Award at '2nd Annual Research Day Celebration' of AIIMS on 17th October, 2022. 2022 First Prize for Oral presentation at 'ISBMR' National conference held at PGIMER, Chandigarh on September 24-25, 2022. 2022 Executive Council Member of Indian Immunology Society-IIS (2022-2024) 2021 Invited Fellow of BD’s PARADIGM (Master’s group of Hi Parameter Hi Dimensional User Club) 2020 Associate Editor Frontiers in Immunology (Inflammation) 2022 Associate Editor Frontiers in Endocrinology (Bone Research) 2021 Review Editor Frontiers in Cell & Developmental Biology 2021 Review Editor Frontiers in Molecular Biosciences 2020 Certificate of Appreciation by AIIMS for contribution towards establishing CCRF-Flow Facility at AIIMS-CCRF (Inauguration on January 24th, 2020). 2020 Featured among Elsevier’s 'Bone Reports” 'Top-Downloaded and Top-Cited authors” list. 2020 Part of 'Young Science Leadership” (YSL) program of Tri-Science Academies of India. 2019 Featured on Cover page of 'Immunity” journal’s 25th Anniversary issue, April 16, 2019 for pioneer work in 'Immunoporosis” (Immunology of Osteoporosis). 2019 'G. P. Talwar Young Scientist Award”, Indian Society for the study of Reprocuction & Fertility, India. 2018 Letter of Appreciation, from CMET-AIIMS for contribution towards 63rd Institute day exhibition (27th Sept. 2018). 2017 International Travel Grant, DST, 2017. 2017 Science Communicator Award, Indian Science Congress, 2017. 2016 International Travel Grant, DBT, 2016. 2012-2013 Post-Doctoral Fellowship, National Institute of Health (NIH), USA. 2011-12 Post-Doctoral Fellowship, Columbia University Medical Centre, NY, USA. 2010 'G. P. Talwar Young Scientist Award”, Indian Immunology Society, India. 2010 Overseas Fellowship, DBT, 2010. 2008-2011 Senior Research Fellowship (SRF), CSIR, New Delhi, India. 2006-2008 Junior Research Fellowship (JRF), CSIR, New Delhi, India. 2006 Qualified Graduate Aptitude Test in Engineering (GATE-2006) MHRD, India. 2005 Qualified National Eligibility Test (NET-JRF), UGC-CSIR, New Delhi, India. 2005 Qualified Graduate Aptitude Test in Engineering (GATE-2005) MHRD, India. 2004 University Gold Medal Winner (Six Medals) for standing first in M.Sc. Zoology. EDITORIAL BOARDS/REVIEWER  Advanced Science (Wiley; IF: 18)  American Journal of Physiology-Endocrinology and Metabolism (IF : 4.125)  Anti-Cancer Agents in Medicinal Chemistry (IF: 2.85, Bentham Science)  Biomedicine & Pharmacotherapy (IF : 7.4; Elsevier)  BMC Immunology (IF : 3.8, BMC)  BMJ Open (IF : 2.7, BMJ)  Cells (MDPI; IF: 8.2)  Current Drug Targets (IF: 3.5, Bentham Science)  Cytokine (IF : 3.8, Elsevier)  Environmental Pollution (IF : 8.1, Elsevier)  Frontiers in Bioscience (IF : 4.0)  Frontiers in Cell & Developmental Biology (IF : 6.7, Frontiers Gp.)  Frontiers in Cellular and Infection Microbiology (IF : 5.5, Frontiers Gp.)  Frontiers in Chemistry (IF : 4.5, Frontiers Gp.)  Frontiers in Endocrinology (IF : 5.5, Frontiers Gp.)  Frontiers in Immunology (IF : 7.5, Frontiers Gp.)  Frontiers in Microbiology (IF : 6.5, Frontiers Gp.)  Frontiers in Molecular Biosciences (IF : 5.2, Frontiers Gp.)  Frontiers in Pharmacology (IF : 5.8, Frontiers Gp.)  Genes (MDPI; IF: 4.5)  Gut Microbes (Taylor&Francis; IF: 9.5)  Heliyon (IF : 4.2, FM)  Immunity & Ageing (IF : 6.4, BMC)  Immunotherapy (IF : 4.2, FM)  Indian J. of Microbiology (IF : 2.6)  Inflammation Research (IF : 7.0, Springer Nature Publishing Gp.)  International Immunopharmacology (IF : 5.7)  iScience (IF : 6.1, Cell Press)  IUBMB Life (IF : 3.8, Wiley)  Journal of Biosciences - Springer (IF: 1.9, Indian Academy of Sciences, Bangalore)  Journal of Bone & Mineral Research (IF : 6.8)  Journal of Cell Communication and Signaling (IF : 5.8, Springer Nature Publishing Gp.)  Journal of Inflammation Research (IF : 6.0)  Life Sciences (IF : 5.0, Elsevier)  Medical Principles and Practice (IF : 2.0, Karger Interantional)  MethodsX (Elsevier)  Microbial Pathogenesis (IF : 4.0, Elsevier)  Molecular Immunology (IF : 4.2, FM)  Osteology (MDPI; IF: 4.0)  PeerJ  Phytomedicine (IF : 6.8, Wiley)  Phytotherapy Research (IF : 5.8, Wiley)  PLOS Neg. Trop. Diseases (IF : 4.8, Wiley)  Scientific Reports (IF : 5.8, Springer Nature Publishing Gp.)  Therapeutic Advances in Chronic Diseases (IF : 5.6, SAGE)  Toxicon (IF : 3.0, Elsevier) MEMBERSHIPS  Life Member-International Osteoporosis Foundation (IOF), USA  Member-American Society for Bone and Mineral research (ASBMR), USA  Member-The American Association of Immunologists (AAI), USA  Life Member-International Society for Infectious Diseases (ISID), USA  Life Member-Autoimmunity Network, Europe  Member-British Society for Immunology, London  Member-National Geographic Society Insider Panel, Washington D.C., USA  Member-The Science Advisory Board, USA  Life Member-Indian Immunology Society (IIS), New Delhi, India  Life Member-Indian Society for Bone and Mineral research (ISBMR), New Delhi, India  Life Member-Indian Society for the Study of Reproduction and Fertility (ISSRF), India  Life Member-Biotech Research Society of Inida (BRSI), Trivandrum, India  Life Member-Indian Science Congress Association (ISCA), Kolkata, India  Life Member-Society for Conservation of Domestic Animal Biodiversity(SOCDAB), India GRANTS AWARDED 1. Principal Investigator (PI) – Department of Biotechnology (DBT) Grant of 82 Lacs INR on 'To elucidate the immunomodulatory role of probiotics in modulating bone health in post-menopausal osteoporosis via its effect on ILC3-ILCreg cell axis ', 2021-2024. 2. Principal Investigator (PI) - Indian Council of Medical Research (ICMR) Grant of 73 Lacs INR on 'To investigate the therapeutic potential of probiotics in treatment and management of osteoporosis: 'Role of regulatory B cells (Bregs)”, 2022-2025. 3. Principal Investigator (PI) - Science and Engineering Research Board (SERB)-Extra Mural Research Grant of 65 Lacs INR (Department of Science and technology, Govt. of India) on 'Elucidation of Cellular mechanisms involving GUT resident regulatory T cells in Probiotics mediated inhibition of Osteoporosis', 2018-2022. 4. Principal Investigator (PI) – AIIMS-University College London Collaborative Research Grant of 10 Lacs INR on 'To investigate the therapeutic potential of extracellular vesicles (EV) released by human induced pluripotent stem cell (hiPSC)-derived mesenchymal stem cells (iMSCs) to counteract oestrogen deficiency induced bone deterioration”, 2022-2023. 5. Principal Investigator (PI) – AIIMS-Interdisciplinary Research Grant of 20 Lacs INR on 'To investigate the regulatory potential of Estrogen in modulating differentiation and function of regulatory B cells: Implications in bone remodeling”, 2021-2023. 6. Principal Investigator (PI) – AIIMS-Interdisciplinary COVID-19 Research Grant of 10 Lacs INR on 'To investigate the long-term impact of COVID-19 on bone health”, 2021-2023. 7. Principal Investigator (PI) – AIIMS-Intra Mural Research Grant of 10 Lacs INR on 'To establish the role of regulatory B cells (Bregs) in post-menopausal Osteoporosis”, 2020-2022. 8. Principal Investigator (PI) – AIIMS-IIT-Delhi Inter Institutional Collaborative Research Grant of 20 Lacs INR on 'Development of novel mushroom based synbiotic food supplement for management of Osteoporosis”, 2019-2021. 9. Principal Investigator (PI) – AIIMS-Intra Mural Research Grant of 10 Lacs INR on 'To Dissect the role of Treg-Th17 cells in Lactobacillus rhamnosus mediated inhibition of Bone loss in ovx mice”, 2018-2020. 10. Co-Investigator (Co-PI) - DST-SERB Extra Mural Research Grant of 40 Lacs INR on 'Identification and functional characterization of tRNA-derived RNA fragments in DENV pathogenesis”, 2018-2021 (PI-Dr. Bhupendra K. Verma) 11. Co-Investigator (Co-PI) - AIIMS-Intra Mural Research Grant of 10 Lacs INR on 'Quantification of systemic inflammatory biomarkers and immunophenotyping of immune cells in post tuberculosis sequalae patients”, 2020-2022 (PI-Dr. Dr. Geetanjali Bade) 12. Co-Investigator (Co-PI) - AIIMS-Intra Mural Research Grant of 10 Lacs INR on 'To elucidate the role of HSD on male fertility- Role of Osteoimmune system”, 2018-2020 (PI-Dr. Shrabani Saugandhika) 13. Co-Investigator (Co-PI) - AIIMS-Intra Mural Research Grant of 10 Lacs INR on Novel gene regulatory circuits associated with Dengue Virus: exploring therapeutic potential”, 2018-2020 (PI-Dr. Bhupendra K. Verma). 14. Co-Investigator (Co-PI) - AIIMS-Intra Mural Research Grant of 10 Lacs INR on 'A study of adaptive immune cells in the pathogenesis of chronic pancreatitis” (PI-Dr. Pramod Garg & Dr. Kalpana Luthra). 15. Principal Investigator (PI) - University Grant Commission (UGC)-Start Up Grant (06 Lacs INR) on Effect of regulating 'mammalian Target of Rapamycin” (mTOR) activity on RANKL induced Osteoclastogenesis, 2014-2016. CURRENT RESEARCH FOCUS During my doctoral research work form NCCS, Pune I got a glimpse of the very exciting and thrilling field of Immunology. This led me to further continue my research work in the field of Bone and Immunology at Columbia University Medical Centre, NY, USA and Roswell Park Cancer Institute (RPCI), New York, USA. After coming back to India in 2013 as an Assistant professor at Central University, Sagar (MP), and now at All India Institute of Medical Sciences (AIIMS), New Delhi, I am actively involved in deciphering this new field which is still in its very naive state. My research specifically focuses on the cellular and molecular interactions between the Immune and Bone systems i.e 'Osteoimmunology” (Frontiers in Biosciences, 2018), a very recent branch of modern biology which specifically deals with the interplay between the immune cells (CD4, CD8 T cells, B cells, DCs, Macrophages, ILCs etc.) and bone cells (Osteoclast, Osteoblast & Osteocytes). During normal physiology both systems are at homeostasis but during an imbalance due to various stimuli (infection, autoimmunity, environment, ageing, hormones etc.), it leads to various inflammatory conditions such as Osteoarthritis, Rheumatoid Arthritis & Osteoporosis (viz. post-menopausal osteoporosis-PMO). Thus, a molecular understanding of these interactions is at the heart of my research which would ultimately lead to discovery of novel therapeutics for various inflammatory bone conditions. My Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL) for the first time had clearly highlighted and established the specific role of immune system in the development and pathophysiology of post-menopausal osteoporosis leading to establishment of a new field of biology proposed/coined by me as 'Immunoporosis: The Immunology of Osteoporosis”. The breakthrough moment was when we discovered the pivotal role of 'Treg-Th17 cell axis” in inflammatory bone loss in PMO. Moving ahead we recently discovered the role of Bregs in Osteoclastogenesis and Osteoporosis (2021). SELECTED PUBLICATIONS 1. Jay R Dave, Sayali S Chandekar, Shubhanath Behera, Kaushik U Desai, Pradnya M Salve, Neha B Sapkal, Suhas T Mhaske, Ankush M Dewle, Parag S Pokare, Megha Page, Ajay Jog, Pankaj A Chivte, Rupesh K. Srivastava, Geetanjali B Tomar. Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age. Science Advances (2022), Jun 24;8(25). doi: 10.1126/sciadv.abm6504 (IF : 14.14). 2. Srivastava, Rupesh K., Leena Sapra, and Pradyumna K. Mishra. 'Osteometabolism: Metabolic Alterations in Bone Pathologies.' Cells 11, no. 23 (2022): 3943. (IF : 7.7). 3. Zafar Azam, Leena Sapra, Asha Bhardwaj, Sumedha Yadav, Pradyumna Kumar Mishra, Prashant Shukla, Versha Sharma and Rupesh K. Srivastava*. Crocin attenuates osteoclastogenesis and enhances bone health by skewing the immunoporotic 'Treg-Th17” cell axis in post-menopausal osteoporotic mice model. Phytomedicine Plus (2022) 2 (3): 100302, 10.1016/j.phyplu.2022.100302 (IF: 6.6). 4. Leena Sapra, Niti Shokeen, Konica Porwal, Chaman Saini, Asha Bhardwaj, Mary Mathew, Pradyumna Kumar Mishra, Naibedya Chattopadhyay, Hamid Yousf Dar, Bhupendra Verma and Rupesh K. Srivastava*. Bifidobacterium longum ameliorates ovariectomy-induced bone loss via enhancing anti-osteoclastogenic and immunomodulatory potential of regulatory B cells (Bregs). Frontiers in Immunology (2022) 10.3389/fimmu.2022.875788 (IF: 8.8). 5. Leena Sapra, Chaman Saini, Bhavuk Garg, Ranjan Gupta, Bhupendra Verma, Pradyumna K. Mishra & Rupesh K. Srivastava*. Long‑term implications of COVID‑19 on bone health: pathophysiology and therapeutics. Inflammation Research (2022). (IF: 7.0). 6. Srivastava RK*, Sapra L. The Rising Era of 'Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis. Journal of Inflammation Research (2022) 15:1667-1698. (IF: 6.92). 7. Bhardwaj A, Sapra L, Tiwari A, Mishra PK, Sharma S and Srivastava RK*. 'Osteomicrobiology”: The Nexus between Bone and Bugs. Frontiers in Microbiology (2022). doi: 10.3389/fmicb.2021.812466 (IF: 6.0). 8. Leena Sapra, Asha Bhardwaj, Pradyumna K. Mishra, Bhavuk K. Garg, Bhupendra Verma, Gyan C. Mishra and Rupesh K. Srivastava*. Regulatory B cells (Bregs) inhibit osteoclastogenesis and play a potential role in ameliorating ovariectomy induced bone loss. Frontiers in Immunology (2021) 10.3389/fimmu.2021.691081 (IF: 8.8). 9. Sapra, Leena, Hamid Y. Dar, Asha Bhardwaj, Amit Pandey, Surbhi Kumari, Zaffar Azam, Vishu Upmanyu, Aleena Anwar, Prashant Shukla, Pradyumna K. Mishra, Chaman Saini1, Bhupendra Verma and Rupesh K. Srivastava*. 'Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice. Scientific Reports (2021) 11:1807. (IF: 5.8). 10. Asha Bhardwaj, Leena Sapra, Chaman Saini, Zaffar Azam, Pradyumna K. Mishra, Bhupendra Verma, Gyan C. Mishra and Rupesh K. Srivastava*. COVID-19: Immunology, Immunopathogenesis and Potential Therapies. International Reviews of Immunology (2021) (IF : 5.5). 11. Rashmi Saini, Zaffar Azam, Leena Sapra, Rupesh K. Srivastava*. Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight. Reviews of Physiology, Biochemistry and Pharmacology (2021). (IF : 6.0). 12. Leena Sapra, Asha Bhardwaj, Zaffar Azam, Deekhsha Madhry, Bhupendra Verma, Sumit Rathore, Rupesh K. Srivastava*. Phytotherapy for treatment of cytokine storm in COVID-19. Frontiers In Bioscience, Landmark Ed. (2021) 5, 51-75, 10.52586/4924 (IF : 4.0). 13. Leena Sapra, Zaffar Azam, Lekha Rani, Chaman Saini, Asha Bhardwaj, Niti Shokeen, Ayaan Ahmad, Gyan C. Mishra and Rupesh K. Srivastava*. 'Immunoporosis”: Immunology of Osteoporosis. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. (2021) 10.1007/s40011-021-01238-x (Invited Review). 14. Rupesh K. Srivastava*, Katharina Schmidt-Bleek, Naibedya Chattopadhyay, Massimo De Martinis and Pradyumna Kumar Mishra. Editorial: Recent Advances in Basic and Translational Osteoimmunology. Frontiers in Immunology (2021) doi: 10.3389/fimmu.2021.800508 (IF: 8.8). 15. Zaffar Azam, Vikas Pandey, Navita Gupta, Leena Sapra, Hamid Y. Dar, Niti Shokeen, Asha Bhardwaj, Ayaan Ahmad, Vandana Soni, Rupesh K. Srivastava*. Phytoconstituents as novel osteo-protective agents: Implications in bone health. Frontiers In Bioscience, Landmark Ed., (2020) March 1;25:1259-1296. (IF : 4.0). 16. H. Y. Dar, Anjali Singh, Prashant K. Shukla, Rajaneesh Anupam, Rajesh Mondal, Pradyumna K. Mishra and Rupesh K. Srivastava*. High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice. Scientific Reports (2018) 8:2503, doi: 10.1038/s41598-018-20896-y (IF: 5.8). 17. Hamid Y. Dar, Subhashis Pal, Prashant Shukla, Pradyumna K. Mishra, Geetanjali B. Tomar, Naibedya Chattopadhyay, Rupesh K. Srivastava*. Bacillus clausii inhibits bone loss by skewing Treg-Th17 cell equilibrium in postmenopausal osteoporotic mice. Nutrition (2018), 20;54:118-128. doi: 10.1016/j.nut.2018.02.013. (IF:4.1). 18. Hamid Y. Dar, Yaqoob Lone, Raj Kumar Koiri, Pradyumna K. Mishra, and Rupesh K. Srivastava*. Microcystin-LR induces bone loss and impairs bone micro-architecture by modulating host immunity in mice: Implications for Bone health. Environmental Pollution (2018). 3;238:792-802. doi: 10.1016/j.envpol.2018.03.059. (IF:10.0). 19. H. Y. Dar, Prashant K. Shukla, Pradyumna K. Mishra, Rajaneesh Anupam, Rajesh Mondal, Geetanjali B. Tomar, Versha Sharma and Rupesh K. Srivastava*. Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance. Bone Reports (2018). Feb 8:46–56 doi: 10.1016/j.bonr.2018.02.001. (IF:4.62). 20. H. Y. Dar , Z. A. Choudhary , Rajesh Mondal, Rajaneesh Anupam, Rupesh K. Srivastava*. Osteoimmunology : The Nexus between Bone and Immune system. Frontiers In Bioscience, Landmark Ed., (2018) Jan 1;23:464-492, DOI 10.2741/4600 (IF : 4.0). 21. Rupesh K. Srivastava*, H. Y. Dar and Pradyumna K. Mishra. Immunoporosis: Immunology of Osteoporosis - Role of T cells Frontiers in Immunology (2018), 5;9:657. doi: 10.3389/fimmu.2018.00657. eCollection. (IF: 8.8). 22. Rupesh K. Srivastava, Adam Utley and Protul A. Shrikant. Rapamycin: A rheostat for CD8+ T cell-mediated tumor therapy (Review). Oncoimmunology (2012, 1:7, 1189-1190), ISSN: 2162-402X, (IF : 8.71). 23. Amruta P. Barhanpurkar, Navita Gupta, Rupesh K. Srivastava, Geetanjali B. Tomar, Sameer P. Naik, Snehal R. Joshi, Satish T. Pote, Gyan C. Mishra, Mohan R. Wani. IL-3 promotes osteoblast differentiation and bone formation in human mesenchymal stem cells. Biochemical and Biophysical Research Communications (2012, 418(4):669-75), ISSN: 0006-291X, (IF : 2.9). 24. Rupesh K. Srivastava, Geetanjali Tomar, Amruta P. Barhanpurkar, Navita Gupta, Satish T. Pote, Gyan C. Mishra, Mohan R. Wani. IL-3 attenuates collagen induced arthritis by modulating the development of regulatory T cells. Journal of Immunology (2011, 186: 2262-2272), ISSN: 0022-1767, (IF : 5.5). 25. Rupesh K. Srivastava, Gyan C. Mishra and Mohan R. Wani. Response to Comment on 'IL-3 attenuates collagen-induced arthritis by modulating the development of Foxp3+ regulatory T cells”. Journal of Immunology (2011, 187:1071-1072), ISSN: 0022-1767, (IF : 5.5). 26. Navita Gupta, Amruta P. Barhanpurkar, Geetanjali Tomar, Rupesh K. Srivastava, Supinder Kour, Satish T. Pote, Gyan C. Mishra, Mohan R. Wani. IL-3 Inhibits Human Osteoclastogenesis and Bone Resorption through Down-Regulation of c-Fms and Diverts the Cells to Dendritic Cell Lineage. Journal of Immunology (2010, 185: 2261–2272), (IF : 5.5). 27. Geetanjali B. Tomar, Rupesh K. Srivastava, Navita Gupta, Amruta P. Barhanpurkar, Satish T. Pote, Hiral M. Jhaveri, Gyan C. Mishra, Mohan R. Wani. Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine. Biochemical and Biophysical Research Communications (2010, 393: 377–383), (IF : 2.9). 28. S. D. Yogesha, Shruti M. Khapli, Rupesh K. Srivastava, Latha S. Mangashetti, Satish T. Pote, Gyan C. Mishra and Mohan R. Wani. IL-3 inhibits TNF-α induce bone resorption and prevents inflammatory arthritis. Journal of Immunology (2009, 182: 361–370), (IF : 5.5).

Rupesh K. Srivastava

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Latest work with IntechOpen by Rupesh K. Srivastava

Osteoporosis is defined as a systemic bone loss disease exemplified by the deterioration of bone tissues and low bone mineral density (BMD), subsequently leading to an enhanced risk of developing fragility-related fractures. It’s a chronic inflammatory condition and is the 4th most burdensome chronic disease after ischemic heart disease, dementia, and lung cancer, with a huge economic burden on the world economy. This skeletal disorder affects predominantly women compared to men, and the risk increases with age. Although currently available therapies to treat osteoporosis are effective, side effects (real and perceived) are impediments to treatment adherence by the patients. Thus, there is an exigent need for renewed interest in managing osteoporosis with a better understanding of the pathophysiology, diagnosis, and treatment regime so that safer and more effective management and treatment modalities can be developed. Research in the last decade has led to enormous interest in the pathophysiology of osteoporosis. Importantly, the immune system is now an established player in the development of osteoporosis (Immunoporosis). Also, various off-the-track management and treatment approaches (probiotics, Synbiotics, FMT, etc.) are now being considered for managing osteoporosis. The present edited book will compile the latest trends and knowledge in the field, thereby creating a novel knowledge database for effective and efficient management and therapy of osteoporosis.

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