Open access peer-reviewed Edited volume

Topics on Drug Metabolism

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Read more >Order hardcopy
IntechOpen
Topics on Drug MetabolismEdited by James Paxton

Published: February 22nd 2012

DOI: 10.5772/1180

ISBN: 978-953-51-0099-7

Copyright year: 2012

Books open for chapter submissions

66465 Total Chapter Downloads

15 Crossref Citations

43 Web of Science Citations

60 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability

By Ayman El-Kattan and Manthena Varma

22463

Open access peer-reviewed

2. Phase II Drug Metabolism

By Petra Jančová and Michal Šiller

10387

Open access peer-reviewed

3. Pharmacogenetics and Metabolism: Past, Present and Future

By Fabricio Rios-Santos and Luiz Alexandre V. Magno

2735

Open access peer-reviewed

4. Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance

By Viola Tamási and András Falus

1884

Open access peer-reviewed

5. Altered Drug Metabolism and Transport in Pathophysiological Conditions

By Adarsh Gandhi and Romi Ghose

2424

Open access peer-reviewed

6. Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

By Hanane Akhdar, Claire Legendre, Caroline Aninat and Fabrice More

7649

Open access peer-reviewed

7. Transcription Factors Potentially Involved in Regulation of Cytochrome P450 Gene Expression

By Piotr Czekaj and Rafał Skowronek

2549

Open access peer-reviewed

8. Determination of Cytochrome P450 Metabolic Activity Using Selective Markers

By Jan Jurica and Alexandra Sulcova

7149

Open access peer-reviewed

9. Electrochemical Methods for the In Vitro Assessment of Drug Metabolism

By Alejandro Álvarez-Lueje, Magdalena Pérez and Claudio Zapata

3296

Open access peer-reviewed

10. Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism Using Liquid Chromatography-Tandem Mass Spectrometry Technology

By Jinsong Ni and Josh Rowe

2441

Open access peer-reviewed

11. Label-Free Quantitative Analysis Using LC/MS

By Atsumu Hirabayashi

1718

Open access peer-reviewed

12. Recent Advances in Pharmacogenomic Technology for Personalized Medicine

By Toshihisa Ishikawa and Yoshihide Hayashizaki

1770

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

Order a hardcopy of the Edited volume

Free shipping with DHL Express

Hardcover (ex. VAT)£140

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase