Open access peer-reviewed Edited volume

Topics on Drug Metabolism

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

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Topics on Drug MetabolismEdited by James Paxton

Published: February 22nd 2012

DOI: 10.5772/1180

ISBN: 978-953-51-0099-7

Copyright year: 2012

Books open for chapter submissions

66070 Total Chapter Downloads

15 Crossref Citations

43 Web of Science Citations

58 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability

By Ayman El-Kattan and Manthena Varma

22340

Open access peer-reviewed

2. Phase II Drug Metabolism

By Petra Jančová and Michal Šiller

10304

Open access peer-reviewed

3. Pharmacogenetics and Metabolism: Past, Present and Future

By Fabricio Rios-Santos and Luiz Alexandre V. Magno

2717

Open access peer-reviewed

4. Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance

By Viola Tamási and András Falus

1870

Open access peer-reviewed

5. Altered Drug Metabolism and Transport in Pathophysiological Conditions

By Adarsh Gandhi and Romi Ghose

2406

Open access peer-reviewed

6. Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

By Hanane Akhdar, Claire Legendre, Caroline Aninat and Fabrice More

7619

Open access peer-reviewed

7. Transcription Factors Potentially Involved in Regulation of Cytochrome P450 Gene Expression

By Piotr Czekaj and Rafał Skowronek

2525

Open access peer-reviewed

8. Determination of Cytochrome P450 Metabolic Activity Using Selective Markers

By Jan Jurica and Alexandra Sulcova

7128

Open access peer-reviewed

9. Electrochemical Methods for the In Vitro Assessment of Drug Metabolism

By Alejandro Álvarez-Lueje, Magdalena Pérez and Claudio Zapata

3281

Open access peer-reviewed

10. Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism Using Liquid Chromatography-Tandem Mass Spectrometry Technology

By Jinsong Ni and Josh Rowe

2420

Open access peer-reviewed

11. Label-Free Quantitative Analysis Using LC/MS

By Atsumu Hirabayashi

1703

Open access peer-reviewed

12. Recent Advances in Pharmacogenomic Technology for Personalized Medicine

By Toshihisa Ishikawa and Yoshihide Hayashizaki

1757

Edited volume and chapters are indexed in

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  • CNKI
  • BKCI
  • BIOSIS Previews

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