Open access peer-reviewed Edited Volume

Topics on Drug Metabolism

Edited by James Paxton

University of Auckland, New Zealand

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

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Topics on Drug MetabolismEdited by James Paxton

Published: February 22nd 2012

DOI: 10.5772/1180

ISBN: 978-953-51-0099-7

eBook (PDF) ISBN: 978-953-51-4354-3

Copyright year: 2012

Books open for chapter submissions

81667 Total Chapter Downloads

53 Crossref Citations

96 Web of Science Citations

122 Dimensions Citations


Open access peer-reviewed

1. Oral Absorption, Intestinal Metabolism and Human Oral Bioavailability

By Ayman El-Kattan and Manthena Varma


Open access peer-reviewed

2. Phase II Drug Metabolism

By Petra Jančová and Michal Šiller


Open access peer-reviewed

3. Pharmacogenetics and Metabolism: Past, Present and Future

By Fabricio Rios-Santos and Luiz Alexandre V. Magno


Open access peer-reviewed

4. Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance

By Viola Tamási and András Falus


Open access peer-reviewed

5. Altered Drug Metabolism and Transport in Pathophysiological Conditions

By Adarsh Gandhi and Romi Ghose


Open access peer-reviewed

6. Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

By Hanane Akhdar, Claire Legendre, Caroline Aninat and Fabrice More


Open access peer-reviewed

7. Transcription Factors Potentially Involved in Regulation of Cytochrome P450 Gene Expression

By Piotr Czekaj and Rafał Skowronek


Open access peer-reviewed

8. Determination of Cytochrome P450 Metabolic Activity Using Selective Markers

By Jan Jurica and Alexandra Sulcova


Open access peer-reviewed

9. Electrochemical Methods for the In Vitro Assessment of Drug Metabolism

By Alejandro Álvarez-Lueje, Magdalena Pérez and Claudio Zapata


Open access peer-reviewed

10. Microdosing Assessment to Evaluate Pharmacokinetics and Drug Metabolism Using Liquid Chromatography-Tandem Mass Spectrometry Technology

By Jinsong Ni and Josh Rowe


Open access peer-reviewed

11. Label-Free Quantitative Analysis Using LC/MS

By Atsumu Hirabayashi


Open access peer-reviewed

12. Recent Advances in Pharmacogenomic Technology for Personalized Medicine

By Toshihisa Ishikawa and Yoshihide Hayashizaki


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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