Open access peer-reviewed Edited Volume

Drug Metabolism

Edited by Katherine Dunnington

Celerion (United States)

Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism.

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Drug MetabolismEdited by Katherine Dunnington

Published: December 22nd 2021

DOI: 10.5772/intechopen.91543

ISBN: 978-1-83968-880-5

Print ISBN: 978-1-83968-879-9

eBook (PDF) ISBN: 978-1-83968-881-2

Copyright year: 2021

Books open for chapter submissions

517 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Hepatocytes and Their Role in Metabolism

By Shweta Dutta, Saraswati Prasad Mishra, Anil Kumar Sahu, Koushlesh Mishra, Pankaj Kashyap and Bhavna Sahu

97
Erratum to: Hepatocytes and Their Role in Metabolism

By Shweta Dutta, Saraswati Prasad Mishra, Anil Kumar Sahu, Koushlesh Mishra, Pankaj Kashyap and Bhavna Sahu

Open access peer-reviewed

2. Drug Metabolism in Drug Discovery and Preclinical Development

By Benjamin Mann, Roger Melton and David Thompson

172

Open access peer-reviewed

3. From Pharmacogenetics to Gene Expression: Implications for Precision Medicine in Diabetes

By Katy Sánchez-Pozos, María de los Ángeles Granados-Silvestre and María Guadalupe Ortíz-López

162

Open access peer-reviewed

4. Metabolism of Phytochemicals

By Tanu Dixit, Akash Tiwari, Sneha Bose, Himani Kulkarni, Jitendra Suthar and Selvan Ravindran

32

Open access peer-reviewed

5. In vitro Metabolic Stability of Drugs and Applications of LC-MS in Metabolite Profiling

By Marothu Vamsi Krishna, Kantamaneni Padmalatha and Gorrepati Madhavi

56

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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