Open access peer-reviewed Edited Volume

Physiologic and Pathologic Angiogenesis

Signaling Mechanisms and Targeted Therapy

Edited by Dan Simionescu

Clemson University


The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

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Physiologic and Pathologic AngiogenesisSignaling Mechanisms and Targeted TherapyEdited by Dan Simionescu

Published: April 5th 2017

DOI: 10.5772/64121

ISBN: 978-953-51-3024-6

Print ISBN: 978-953-51-3023-9

eBook (PDF) ISBN: 978-953-51-4101-3

Copyright year: 2017

Books open for chapter submissions

25790 Total Chapter Downloads

24 Crossref Citations

41 Web of Science Citations

60 Dimensions Citations


Open access peer-reviewed

1. TGF-β Activation and Signaling in Angiogenesis

By Paola A. Guerrero and Joseph H. McCarty


Open access peer-reviewed

2. Role of Notch, SDF-1 and Mononuclear Cells Recruitment in Angiogenesis

By Ivanka Dimova and Valentin Djonov


Open access peer-reviewed

3. Angiogenesis Meets Skeletogenesis: The Cross-Talk between Two Dynamic Systems

By Tamara A. Franz-Odendaal, Daniel Andrews and Shruti Kumar


Open access peer-reviewed

4. Corneal Angiogenesis: Etiologies, Complications, and Management

By Sepehr Feizi


Open access peer-reviewed

5. Angiogenesis-Related Factors in Early Pregnancy Loss

By Marina M. Ziganshina, Lyubov V. Krechetova, Lyudmila V. Vanko, Zulfiya S. Khodzhaeva, Ekaterina L. Yarotskaya and Gennady T. Sukhikh


Open access peer-reviewed

6. Pathogenic Angiogenic Mechanisms in Alzheimer's Disease

By Chaahat Singh, Cheryl G. Pfeifer and Wilfred A. Jefferies


Open access peer-reviewed

7. Hypoxia, Angiogenesis and Atherogenesis

By Lamia Heikal and Gordon Ferns


Open access peer-reviewed

8. Coronary Collateral Growth: Clinical Perspectives and Recent Insights

By Bhamini Patel, Peter Hopmann, Mansee Desai, Kanithra Sekaran, Kathleen Graham, Liya Yin and William Chilian


Open access peer-reviewed

9. Angiogenesis and Cardiovascular Diseases: The Emerging Role of HDACs

By Ana Moraga, Ka Hou Lao and Lingfang Zeng


Open access peer-reviewed

10. Unique Phenotypes of Endothelial Cells in Developing Arteries: A Lesson from the Ductus Arteriosus

By Norika Mengchia Liu and Susumu Minamisawa


Open access peer-reviewed

11. Vascular Repair and Remodeling: A Review

By Nicolás F. Renna, Rodrigo Garcia, Jesica Ramirez and Roberto M. Miatello


Open access peer-reviewed

12. Tumor Angiogenesis: A Focus on the Role of Cancer Stem Cells

By Keiko Fujita and Masumi Akita


Open access peer-reviewed

13. VEGF-Mediated Signal Transduction in Tumor Angiogenesis

By Lucia Napione, Maria Alvaro and Federico Bussolino


Open access peer-reviewed

14. Noncoding RNAs in Lung Cancer Angiogenesis

By Ioana Berindan-Neagoe, Cornelia Braicu, Diana Gulei, Ciprian Tomuleasa and George Adrian Calin


Open access peer-reviewed

15. Recent Advances in Angiogenesis Assessment Methods and their Clinical Applications

By Imran Shahid, Waleed H. AlMalki, Mohammed W. AlRabia, Muhammad Ahmed, Mohammad T. Imam, Muhammed K. Saifullah and Muhammad H. Hafeez


Open access peer-reviewed

16. Novel Methods to Study Angiogenesis Using Tissue Explants

By Tomoko Takahashi, Keiko Fujita and Masumi Akita


Open access peer-reviewed

17. Therapeutic Angiogenesis: Foundations and Practical Application

By Pavel Igorevich Makarevich and Yelena Viktorovna Parfyonova


Open access peer-reviewed

18. Platelet Lysate to Promote Angiogenic Cell Therapies

By Scott T. Robinson and Luke P. Brewster


Open access peer-reviewed

19. Anti-VEGF Therapy in Cancer: A Double-Edged Sword

By Victor Gardner, Chikezie O. Madu and Yi Lu


Open access peer-reviewed

20. Antiangiogenic Therapy for Hepatocellular Carcinoma

By Kosuke Kaji and Hitoshi Yoshiji


Open access peer-reviewed

21. MCAM and its Isoforms as Novel Targets in Angiogenesis Research and Therapy

By Jimmy Stalin, Lucie Vivancos, Nathalie Bardin, Françoise Dignat- George and Marcel Blot-Chabaud


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI

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