Open access peer-reviewed Edited Volume

Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

Edited by Reinhart Grundmann

Kreiskliniken Reutlingen, Germany

This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention.

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Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm RuptureEdited by Reinhart Grundmann

Published: July 27th 2011

DOI: 10.5772/995

ISBN: 978-953-307-523-5

eBook (PDF) ISBN: 978-953-51-6440-1

Copyright year: 2011

Books open for chapter submissions

45878 Total Chapter Downloads

7 Crossref Citations

30 Web of Science Citations

33 Dimensions Citations


Open access peer-reviewed

1. Etiology and Pathogenisis of Aortic Aneurysm

By Carl W. Kotze and Islam G. Ahmed


Open access peer-reviewed

2. Matrix metalloproteinases in aortic aneurysm - executors or executioners?

By Tomasz Grzela, Barbara Bikowska and Malgorzata Litwiniuk


Open access peer-reviewed

3. Mast cell density and distribution in human abdominal aortic aneurysm

By Sumiharu Sakamoto, Toshihiro Tsuruda, Kinta Hatakeyama, Yoko Sekita, Takuroh Imamura, Yujiro Asada and Kazuo Kitamura


Open access peer-reviewed

4. The Role of Complement in the Pathogenesis of Artery Aneurysms

By Fengming Liu, Annie Qin, Lining Zhang and Xuebin Qin


Open access peer-reviewed

5. Immunoglobulin G4-related inflammatory aortic aneurysm

By Hidetoshi Okabe and Mitsuaki Ishida


Open access peer-reviewed

6. Transcriptomic and proteomic profiles of vascular cells involved in human abdominal aortic aneurysm

By Florence Pinet, Nicolas Lamblin, Philippe Ratajczak, David Hot, Emilie Dubois, Maggy Chwastyniak, Olivia Beseme, Hervé Drobecq, Yves Lemoine, Mohammad Koussa and Philippe Amouyel


Open access peer-reviewed

7. Multifaceted Role of Angiotensin II in Vascular Inflammation and Aortic Aneurysmal Disease

By Allan Brasier, Brooke Ju and Ronald Tilton


Open access peer-reviewed

8. Aortitis and aortic aneurysm in systemic vasculitis

By Ana García-Martínez, Sergio Prieto-González, Pedro Arguis Giménez, Georgina Espígol-Frigolé, José Hernández-Rodríguez and Maria C Cid


Open access peer-reviewed

9. Drug-induced aortic aneurysms, ruptures and dissections

By Olav Spigset


Open access peer-reviewed

10. Pathopysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem

By Efstratios Georgakarakos and Christos Ioannou


Open access peer-reviewed

11. An analysis of blood flow dynamics in AAA

By Sandor Bernad, Elena-Silvia Bernad, Tiberiu Barbat, Cosmin Brisan and Vlad Albulescu


Open access peer-reviewed

12. Numerical Simulation in Aortic Arch Aneurysm

By Teruo Matsuzawa, Feng Gao, Aike Qiao, Osamu Ohta and Hiroshi Okada


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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