Open access peer-reviewed Edited Volume


Comprehensive Study

Edited by Shuji Miyagawa

Osaka University

Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.

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XenotransplantationComprehensive StudyEdited by Shuji Miyagawa

Published: March 11th 2020

DOI: 10.5772/intechopen.77924

ISBN: 978-1-78985-664-4

Print ISBN: 978-1-78985-663-7

eBook (PDF) ISBN: 978-1-78984-521-1

Copyright year: 2020

Books open for chapter submissions

5304 Total Chapter Downloads

5 Crossref Citations

2 Web of Science Citations

11 Dimensions Citations


Open access peer-reviewed

1. Biosafety Barrier to Xenotransplantation

By Wei Wang, Qi Liang, Wei Nie, Juan Zhang and Cheng Chen


Open access peer-reviewed

2. Pig Islet Transplant

By Masayuki Shimoda


Open access peer-reviewed

3. Porcine Islet Cell Xenotransplantation

By Rajeswar Chinnuswami, Abid Hussain, Gopalakrishnan Loganathan, Siddharth Narayanan, Gene D. Porter and Appakalai N. Balamurugan


Open access peer-reviewed

4. Challenge of Xenotransplantation in Pediatric Heart Transplantation

By Norihide Fukushima, Motohiro Kawauchi, Francois Bouchart, Sandra Nehlsen-Cannarella and Leonard L. Bailey


Open access peer-reviewed

5. Tissue-Specific Bioink from Xenogeneic Sources for 3D Bioprinting of Tissue Constructs

By Sriya Yeleswarapu, Shibu Chameettachal, Ashis Kumar Bera and Falguni Pati


Open access peer-reviewed

6. Optimization of a Decellularization/Recellularization Strategy for Transplantable Bioengineered Liver

By Quanyu Chen, Xiaolin You, Jiejuan Lai, Shifang Jiang, Hongyu Zhang and Lianhua Bai


Open access peer-reviewed

7. Controllable Immunosuppression in Pigs as a Basis for Preclinical Studies on Human Cell Therapy

By Shin Enosawa and Eiji Kobayashi


Open access peer-reviewed

8. A Novel Strategy for Xeno-Regenerative Therapy

By Toshinari Fujimoto, Takashi Yokoo and Eiji Kobayashi


Open access peer-reviewed

9. Pigs as Models of Preclinical Studies and In Vivo Bioreactors for Generation of Human Organs

By Yujiro Kawai, Shugo Tohyama, Hideyuki Shimizu, Keiichi Fukuda and Eiji Kobayashi


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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