Open access peer-reviewed Edited Volume


Edited by Shuji Miyagawa

Osaka University

Accompanied by the advent of animal cloning, the technique of nuclear transfer produced alpha1,3-galactosyltransferase-knockout (Gal-KO) pigs in many institutes, including the ones in Japan, at the beginning of 21st Century. In addition, the controversy of the risks of PERV has gradually minimized, because of the fact that there are no cases of PERV infections reported in humans. Furthermore, a large clinical wave for islet allotransplantation resumed the interest of xenotransplantation, especially porcine islet transplantation and some exceptions. Clinical trials were done in many countries so far, such as Sweden, China, Mexico, USA (Inventory of Human Xenotransplantation Practices - IXA and HUG in collaboration with WHO). In addition, a new clinical trial was approved by the government, and resumed the porcine islet transplantation research in New Zealand two years ago.

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XenotransplantationEdited by Shuji Miyagawa

Published: February 3rd 2012

DOI: 10.5772/1514

ISBN: 978-953-307-997-4

eBook (PDF) ISBN: 978-953-51-6787-7

Copyright year: 2012

Books open for chapter submissions

13465 Total Chapter Downloads

3 Crossref Citations

17 Web of Science Citations

9 Dimensions Citations


Open access peer-reviewed

1. Anti-Gal and Anti-Non Gal Antibody Barriers in Xenotransplantation

By Uri Galili


Open access peer-reviewed

2. Piscine Islet Xenotransplantation

By James R. Wright, Jr.


Open access peer-reviewed

3. Cloning of Homozygous a1,3-Galactosyltransferase Gene Knock-Out Pigs by Somatic Cell Nuclear Transfer

By Hitomi Matsunari, Masahito Watanabe, Kazuhiro Umeyama, Kazuaki Nakano, Yuka Ikezawa, Mayuko Kurome Barbara Kessler, Eckhard Wolf, Shuji Miyagawa, Hiromitsu Nakauchi and Hiroshi Nagashima


Open access peer-reviewed

4. Function Measurements of HLA-II Transgenic Pigs for Xenotransplantation

By Hao-Chih Tai, Ching-Fu Tu, Tien-Shuh Yang, Jang-Ming Lee, San-Yuan Huang, and Bao-Tyan Wang


Open access peer-reviewed

5. Targeted Toxin as a Useful Reagent for Enrichment of a-Gal Epitope-Negative Cells Used for Somatic Cell Nuclear Transfer in Pigs

By Masahiro Sato, Haiying Chi and Kazuchika Miyoshi


Open access peer-reviewed

6. Developing Xenostandards for Microbiological Safety: New Zealand Experience

By O. Garkavenko, S. Wynyard, D. Nathu and R. Elliott


Open access peer-reviewed

7. The Use of Xenotransplantation in Neurodegenerative Diseases: A Way to Go?

By Xavier Lévêque, Kyle Fink, Julien Rossignol, Gary L Dunbar and Laurent Lescaudron


Open access peer-reviewed

8. Methods and Tools for Detection and Evaluation of the Risks of Porcine Endogenous Retrovirus in Porcine to Human Xenotransplantation

By Takele Argaw and Carolyn A. Wilson


Edited Volume and chapters are indexed in

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  • Base
  • CNKI

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