Open access peer-reviewed Edited Volume

Drug Discovery

Edited by Hany El-Shemy

Cairo University

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

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Drug DiscoveryEdited by Hany El-Shemy

Published: January 23rd 2013

DOI: 10.5772/3388

ISBN: 978-953-51-0906-8

eBook (PDF) ISBN: 978-953-51-7066-2

Copyright year: 2013

Books open for chapter submissions

70943 Total Chapter Downloads

34 Crossref Citations

70 Web of Science Citations

116 Dimensions Citations


Open access peer-reviewed

1. Fruit/Vegetable-Drug Interactions: Effects on Drug Metabolizing Enzymes and Drug Transporters

By Lourdes Rodríguez-Fragoso and Jorge Reyes-Esparza


Open access peer-reviewed

2. Anticancer Drug Discovery — From Serendipity to Rational Design

By Jolanta Natalia Latosińska and Magdalena Latosińska


Open access peer-reviewed

3. Drug Interactions, Pharmacogenomics and Cardiovascular Complication

By Irina Piatkov, Trudi Jones and Mark McLean


Open access peer-reviewed

4. Interactions with Drugs and Dietary Supplements Used For Weight Loss

By Melanie A. Jordan


Open access peer-reviewed

5. Small Molecule Screens to Identify Inhibitors of Infectious Disease

By Elizabeth Hong-Geller and Sofiya Micheva-Viteva


Open access peer-reviewed

6. Practical Considerations of Liquid Handling Devices in Drug Discovery

By Sergio C. Chai, Asli N. Goktug, Jimmy Cui, Jonathan Low and Taosheng Chen


Open access peer-reviewed

7. Data Analysis Approaches in High Throughput Screening

By Asli N. Goktug, Sergio C. Chai and Taosheng Chen


Open access peer-reviewed

8. Oxidative Stress in Human Infectious Diseases – Present and Current Knowledge About Its Druggability

By Carsten Wrenger, Isolmar Schettert and Eva Liebau


Open access peer-reviewed

9. Discovery of Selective and Potent Inhibitors of Palmitoylation

By Sonia Lobo Planey


Open access peer-reviewed

10. The Antibacterial Drug Discovery

By Jie Yanling, Liang Xin and Li Zhiyuan


Open access peer-reviewed

11. Air, Water and Soil: Resources for Drug Discovery

By Luis Jesús Villarreal-Gómez, Irma Esthela Soria-Mercado, Ana Leticia Iglesias and Graciela Lizeth Perez-Gonzalez


Open access peer-reviewed

12. Transition State Analogues of Enzymatic Reaction as Potential Drugs

By Karolina Gluza and Pawel Kafarski


Open access peer-reviewed

13. Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes

By Charles J. Malemud


Open access peer-reviewed

14. Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

By Louise L. Major, Helen Denton and Terry K. Smith


Open access peer-reviewed

15. Colon Cancer: Current Treatments and Preclinical Models for the Discovery and Development of New Therapies

By Samuel Constant, Song Huang, Ludovic Wiszniewski and Christophe Mas


Open access peer-reviewed

16. Applications of Snake Venom Proline-Rich Oligopeptides (Bj- PROs) in Disease Conditions Resulting from Deficient Nitric Oxide Production

By Claudiana Lameu and Henning Ulrich


Open access peer-reviewed

17. Introduction to Biochemical Pharmacology and Drug Discovery

By Gabriel Magoma


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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