Open access peer-reviewed Edited Volume

Understanding Tuberculosis

New Approaches to Fighting Against Drug Resistance

In 1957, a Streptomyces strain, the ME/83 (S.mediterranei), was isolated in the Lepetit Research Laboratories from a soil sample collected at a pine arboretum near Saint Raphael, France. This drug was the base for the chemotherapy with Streptomicine. The euphoria generated by the success of this regimen lead to the idea that TB eradication would be possible by the year 2000. Thus, any further drug development against TB was stopped. Unfortunately, the lack of an accurate administration of these drugs originated the irruption of the drug resistance in Mycobacterium tuberculosis. Once the global emergency was declared in 1993, seeking out new drugs became urgent. In this book, diverse authors focus on the development and the activity of the new drug families.

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Understanding TuberculosisNew Approaches to Fighting Against Drug ResistanceEdited by Pere-Joan Cardona

Published: February 15th 2012

DOI: 10.5772/2477

ISBN: 978-953-307-948-6

eBook (PDF) ISBN: 978-953-51-4361-1

Copyright year: 2012

Books open for chapter submissions

63726 Total Chapter Downloads

20 Crossref Citations

81 Web of Science Citations

83 Dimensions Citations


Open access peer-reviewed

1. Multi-Drug/Extensively Drug Resistant Tuberculosis (Mdr/Xdr-Tb): Renewed Global Battle Against Tuberculosis?

By Claude Kirimuhuzya


Open access peer-reviewed

2. Chemotherapeutic Strategies and Targets Against Resistant TB

By Neeraj Shakya, Babita Agrawal and Rakesh Kumar


Open access peer-reviewed

3. A New Hope in TB Treatment: The Development of the Newest Drugs

By Ruiru Shi and Isamu Sugawara


Open access peer-reviewed

4. In Search of El Dorado: Current Trends and Strategies in the Development of Novel Anti-Tubercular Drugs

By Héctor R. Morbidoni


Open access peer-reviewed

5. An Approach to the Search for New Drugs Against Tuberculosis

By Fernando R. Pavan, Daisy N. Sato and Clarice Q.F. Leite


Open access peer-reviewed

6. Antitubercular In Vitro Drug Discovery: Tools for Begin the Search

By Juan Bueno


Open access peer-reviewed

7. New Antitubercular Drugs Designed by Molecular Modification

By Jean Leandro dos Santos, Luiz Antonio Dutra, Thais Regina Ferreira de Melo and Chung Man Chin


Open access peer-reviewed

8. The Cord Factor: Structure, Biosynthesis and Application in Drug Research – Achilles Heel of Mycobacterium tuberculosis?

By Ayssar A. Elamin, Matthias Stehr and Mahavir Singh


Open access peer-reviewed

9. Old and New TB Drugs: Mechanisms of Action and Resistance

By Anastasia S. Kolyva and Petros C. Karakousis


Open access peer-reviewed

10. Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity

By Martin Doležal, Jan Zitko and Josef Jampílek


Open access peer-reviewed

11. The Potential Therapeutic Usage of Dithiocarbamate Sugar Derivatives for Multi-Drug Resistant Tuberculosis

By Takemasa Takii, Yasuhiro Horita, Ryuji Kuroishi, Taku Chiba, Mashami Mori, Tomohiro Hasegawa, Tastuya Ito, Tatsuaki Tagami, Tetsuya Ozeki, Saotomo Ito and Kikuo Onozaki


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12. Fighting Against Resistant Strains: The Case of Benzothiazinones and Dinitrobenzamides

By Silvia Buroni, Giovanna Riccardi and Maria Rosalia Pasca


Open access peer-reviewed

13. Quinolone Resistance in Tuberculosis Treatment: A Structural Overview

By Claudine Mayer and Alexandra Aubry


Open access peer-reviewed

14. Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

By Tulin Askun, Gulendam Tumen, Fatih Satil, Seyma Modanlioglu and Onur Yalcin


Open access peer-reviewed

15. Cinnamic Derivatives in Tuberculosis

By Prithwiraj De, Damien Veau, Florence Bedos-Belval, Stefan Chassaing and Michel Baltas


Open access peer-reviewed

16. Potential Use of I. suffruticosa in Treatment of Tuberculosis with Immune System Activation

By Camila Bernardes de Andrade Carli, Marcela Bassi Quilles, Danielle Cardoso Geraldo Maia, Clarice Q. Fujimura Leite, Wagner Vilegas and Iracilda Z. Carlos


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI
  • BKCI
  • BIOSIS Previews

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