Open access peer-reviewed Edited Volume

Melanoma

Edited by Ahmed Lasfar

Rutgers University

Co-editor:

Karine Cohen-Solal

Rutgers University

Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease.

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IntechOpen
MelanomaEdited by Ahmed Lasfar

Published: May 27th 2021

DOI: 10.5772/intechopen.91524

ISBN: 978-1-83880-879-2

Print ISBN: 978-1-83880-878-5

eBook (PDF) ISBN: 978-1-83880-880-8

Copyright year: 2021

Books open for chapter submissions

1956 Total Chapter Downloads

4 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Melanoma and Therapeutic Perspectives

By Karine Cohen Solal and Ahmed Lasfar

170

Open access peer-reviewed

2. Uveal Melanoma

By Kristina Horkovicova and Alena Furdova

289

Open access peer-reviewed

3. Ocular Melanoma

By Harika Regani and Santosh G. Honavar

249

Open access peer-reviewed

4. Anorectal Melanoma

By Rahul Gupta, Nalini Bansal, Houssem Ammar and Jyoti Gupta

281

Open access peer-reviewed

5. Mucosal Melanoma of the Head and Neck: From Diagnosis to Treatment

By Ullyanov Bezerra Toscano de Mendonça, Júlia Guimarães Soffientini, Victoria Ficher Barbosa and Keren Cozer

327

Open access peer-reviewed

6. The Role of the Meiotic Component in Reproduction of B-RAF-Mutated Melanoma: A Review and “Brainstorming” Session

By Dace Pjanova, Ninel M. Vainshelbaum, Kristine Salmina and Jekaterina Erenpreisa

414

Open access peer-reviewed

7. Role of RUNX2 in Melanoma: A New Player in Tumor Progression and Resistance to Therapy

By Rachael Pulica, Karine Cohen Solal and Ahmed Lasfar

228

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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