Open access peer-reviewed Edited Volume


Edited by Ahmed Lasfar

Rutgers University


Karine Cohen-Solal

Rutgers University

Although melanoma represents a limited number of cutaneous cancers each year, it remains a significant public health crisis because the metastatic disease is associated with poor survival. The incidence of the disease has increased 200% since 1973 and the median age at diagnosis is 40 years, making it one of the most significant cancers responsible for productive years of life lost. Fortunately, there has been unprecedented progress in the treatment of advanced melanoma, largely through advances in understanding how to manipulate immune responses and target selective genetic mutations in melanoma patients. Clinical benefits to patients with advanced melanoma have been nevertheless limited by the development of innate and acquired drug resistance, and numerous efforts are focusing on the elucidation of these mechanisms. Combination strategies are being actively investigated to overcome drug resistance, by awakening existing anti-tumor mechanisms disabled by a cancer-promoting microenvironment. This book explores the advances and challenges associated with melanoma today, particularly those related to its diagnosis and management. It also proposes new avenues for therapeutic opportunities based on sustained research efforts and ever-growing technological advances. This is a relevant source of knowledge, very useful for researchers, medical doctors, health providers and all individuals interested in learning more about this devastating disease.

Read more >Order hardcopy
MelanomaEdited by Ahmed Lasfar

Published: May 27th 2021

DOI: 10.5772/intechopen.91524

ISBN: 978-1-83880-879-2

Print ISBN: 978-1-83880-878-5

eBook (PDF) ISBN: 978-1-83880-880-8

Copyright year: 2021

Books open for chapter submissions

1956 Total Chapter Downloads

4 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Melanoma and Therapeutic Perspectives

By Karine Cohen Solal and Ahmed Lasfar


Open access peer-reviewed

2. Uveal Melanoma

By Kristina Horkovicova and Alena Furdova


Open access peer-reviewed

3. Ocular Melanoma

By Harika Regani and Santosh G. Honavar


Open access peer-reviewed

4. Anorectal Melanoma

By Rahul Gupta, Nalini Bansal, Houssem Ammar and Jyoti Gupta


Open access peer-reviewed

5. Mucosal Melanoma of the Head and Neck: From Diagnosis to Treatment

By Ullyanov Bezerra Toscano de Mendonça, Júlia Guimarães Soffientini, Victoria Ficher Barbosa and Keren Cozer


Open access peer-reviewed

6. The Role of the Meiotic Component in Reproduction of B-RAF-Mutated Melanoma: A Review and “Brainstorming” Session

By Dace Pjanova, Ninel M. Vainshelbaum, Kristine Salmina and Jekaterina Erenpreisa


Open access peer-reviewed

7. Role of RUNX2 in Melanoma: A New Player in Tumor Progression and Resistance to Therapy

By Rachael Pulica, Karine Cohen Solal and Ahmed Lasfar


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£119

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase