Open access peer-reviewed Edited Volume

Epstein-Barr Virus

Emmanuel Drouet

Université Grenoble-Alpes

Covering

Epstein-Barr Virus Multiple Sclerosis Breast Cancer Breast Carcinoma Epstein-Barr Virus Reactivation Stress Animal Model Human Gammaherpesvirus Infectious Mononucleosis Nasopharyngeal Carcinoma Latent Proteins Central Nervous System

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About the book

Epstein-Barr virus (EBV) is one of the most common human viruses and the cause of pathologies such as infectious mononucleosis (IM) and certain cancers, such as immunodeficiency-related B cell lymphoma, Burkitt and Hodgkin lymphoma, nasopharyngeal carcinoma, and gastric carcinomas. In the past two decades, the association of EBV other cancers (breast cancer) or other chronic pathologies (multiple sclerosis or MS) has also been proposed. EBV, like other Human Herpesviruses (HHV1-8), has co-evolved through a persistent infection in the host, spread efficiently to others, generally without causing serious disease. Despite its discovery now more than fifty years ago, immune control of this virus is still not very well understood and no vaccine is available.

This knowledge gap is due in part to the lack of a preclinical small animal model which can faithfully recapitulate EBV infection and immune control and would allow testing of EBV specific vaccine candidates. With the advent of mice with reconstituted human immune system compartments (HIS mice) during the past decade, this is changing. The complex interplay between host and virus has made it difficult to elaborate useful vaccine strategies to protect against the EBV-associated diseases (including chronic diseases like MS) or to find efficient drugs specifically targeting EBV malignancies.

One challenge is that the EBV expresses very different proteins during its lytic and its latent phases. To address this, vaccine candidates have been designed to include proteins from both phases. As EBV is associated with nearly 200,000 new malignancies each year worldwide, an EBV vaccine to prevent these diseases is needed. Parallel to this needs one could propose priorities for future research: (i) Identification of surrogate markers that predict the development of EBV-related malignancies. (ii) Definition of a goal for an EBV vaccine and criteria for licensure (iii), investigation of the potential usefulness of targeting certain lytic proteins in the context of drug discovery.

Publishing process

Book initiated and editor appointed

Date completed: December 3rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: May 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: July 24th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

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Expected publication date: September 22nd 2020

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About the editor

Emmanuel Drouet

Université Grenoble-Alpes

Expertise : Human Virology & Microbiology - NAME : DROUET Given name : Emmanuel Degree : PhD, PharmD Current position : Full Professor CEX1 Teaching & Education Professor at School of Pharmacy, UGA http://www.univ-grenoble-alpes.fr/en/ Research :Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS, http://www.ibs.fr/ Postal address CIBB-IBS 38044 Grenoble, France 71 Rue des Martyrs, 38000 Grenoble, France Principal investigator in more than 20 research projects in virology since 2000 Member of the CNU ('Conseil National des Universités” nominated by Ministère de l’Enseignement Supérieur et Recherche, France or French ministry of higher education and research, 87th section)) (2012-) – Expert at the AERES (Evaluation Agency for Research and Higher Education, France) Collaborations: University Medical Center, Utrecht (NL), University of Heidelberg (D) Research interest : Main activities : Research as group leader in the French Institution CNRS and european EMBL. Principal investigator in more than 20 research projects since 1994 Subjects : (i) Pathobiology of the viruses belonging to the Flaviviridae family (Hepatitis C Virus) (ii) Innovative diagnosis markers for Herpesviruses and immune response (iii) Virus- associated Cancers Teaching in Medical Microbiology (Bacteriology, Virology, and Immunity) (School of Pharmacy students of bachelor & master level) 5 main publications (key-words: Hepatitis C Virus, Epstein-Barr Virus, Cancer biomarkers) Habib M, et al., Morand P, Drouet E (2017) Lytic EBV infection investigated by detection of Soluble Epstein-Barr virus ZEBRA in the serum of patients with PTLD Nature Sci Rep 7: 10479 | DOI:10.1038/s41598-017-09798-7 1 Le Berre L, Rousse J, Gourraud PA, Imbert-Marcille BM, Salama A, Evanno G, Semana G, Nicot A, Dugast E, Guérif P, Adjaoud C, Freour T, Brouard S, Agbalika F, Marignier R, Brassat D, Laplaud DA, Drouet E, Van Pesch V, Soulillou JPDecrease of blood anti-α1,3 Galactose Abs levels in multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients. Clin Immunol. 2017 Jul;180:128-135. Fallecker C, et al. Petit MA, Drouet E (2017) New insights into HCV replication in original cells from Aedes mosquitoes Virology Journal 14:161 DOI 10.1186/s12985-017-0828-z Souii A, Elargoubi A, Fallecker C, Mastouri M, Drouet EHepatitis C Genotype Prevalence in Monastir Region, Tunisia: Correlation between 5' Untranslated Region (5'UTR), Non-structural 5B (NS5B), and Core Sequences in HCV Subtyping. Curr Microbiol. 2016 Sep;73(3):324-334. doi: 10.1007/s00284-016-1064-2. Epub 2016 May 17. Marrão G, et al., Drouet E (2014). Epstein-Barr virus infection and clinical outcome in breast cancer patients correlate with immune cell TNF-α/IFN-γ response. BMC Cancer. Sep 11;14:665. doi: 10.1186/1471-2407-14-665 Pérard J, et al., Drouet E, Jamin M (2013). Structure of the full-length HCV IRES in solution. Nature Comm. 4: 1612. doi: 10.1038/ncomms2611 Rothe R, et al. Drouet E, Lenormand J-L. (2010). Characterization of the Cell-penetrating Properties of the Epstein-Barr Virus ZEBRA trans-Activator. J. Biol. Chem. 285:20224–20233. Book chapter (most recent) https://www.intechopen.com/online-first/the-role-of-the-epstein-barr-virus-lytic-cycle-in-tumor-progression-consequences-in-diagnosis-and-th

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