About the book
Immunosuppression is known as the suppression of the host’s innate ability to ward off disease and infection. This suppression may be the result of a disease that targets the immune system, or as a consequence of pharmaceutical agents used to fight certain conditions, like cancer. In some cases, immunosuppression may also be deliberately induced acting as therapeutic interventions, such as tissue and organ transplantation, to reduce the risk of organ rejection. Many autoimmune diseases develop as a consequence of an altered balance between (auto)reactive and suppressive immune cells. Restoring of functional suppressive immune cells represents a promising strategy to treat autoimmune disease as well as for transplantation patients. Controrally, immuno-boosting therapies are necessary for cancer treatments where accessive immunsuppression and the inefficient immune reaction are often observed especially in the tumor microenvironment.
This book intends to provide the reader with a comprehensive overview of the current state-of-the-art knowledge in the regulation of immunosuppression. Several types of immune suppressive cells and their potential clinical usages will be discussed in details.