Open access peer-reviewed Edited Volume


Xuehui He

Radboud University Nijmegen Medical Centre


Immune Suppression Foxp3 Tolerogenic Dendritic CellS Immune Regulation Immune Tolerance Mesenchymal Stem Cells Regulatory B Cells Cancer Immunotherapy T cell infusions Cellular Therapy Allogeneic cell therapy Stem Cell Transplantation

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About the book

Immunosuppression is known as the suppression of the host’s innate ability to ward off disease and infection. This suppression may be the result of a disease that targets the immune system, or as a consequence of pharmaceutical agents used to fight certain conditions, like cancer. In some cases, immunosuppression may also be deliberately induced acting as therapeutic interventions, such as tissue and organ transplantation, to reduce the risk of organ rejection. Many autoimmune diseases develop as a consequence of an altered balance between (auto)reactive and suppressive immune cells. Restoring of functional suppressive immune cells represents a promising strategy to treat autoimmune disease as well as for transplantation patients. Controrally, immuno-boosting therapies are necessary for cancer treatments where accessive immunsuppression and the inefficient immune reaction are often observed especially in the tumor microenvironment.

This book intends to provide the reader with a comprehensive overview of the current state-of-the-art knowledge in the regulation of immunosuppression. Several types of immune suppressive cells and their potential clinical usages will be discussed in details.

Publishing process

Book initiated and editor appointed

Date completed: November 13th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: May 26th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: August 14th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 13th 2020

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About the editor

Xuehui He

Radboud University Nijmegen Medical Centre

The maintenance of the immune balance between active and suppressive immune cells is crucial for being healthy. In general, FOXP3+ Treg plays a key role in immune tolerance. Under certain microenvironment, Treg could lose their suppressive capacity and start to producing pro-inflammatory cytokines including IL-17. Better understanding the mechanisms of Treg stability would benefit their clinical usage not only in the organ transplantation and autoimmune diseases treatment but also for cancer treatment (in which suppressive function of Treg should be minimized as much as possible). Dr. He mainly focuses on the identification of biomarkers for personalized therapy and the using of biomarkers as co-diagnosticsn in the novel treatment approaches. Her research interests include 1) to unravel the (immune)pathogenesis of the inflammatory disease, 2) to monitor the efficacy and side effects of current immunotherapy strategies applied to cancer patients, 3) to assess the immune profiles involved in regulating local immunity and inflammation. Her final research aim is to capture disease severity in validated outcome measures and assess the side effects of treatments in real clinical practice.

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