Open access peer-reviewed Edited Volume

High-Throughput Screening for Drug Discovery

Shailendra K. Saxena

King George's Medical University

Dr. Saxena's H-index 28 is a clear indicator of his high merit as a researcher working on the molecular mechanisms of host defense during human viral infections. He is a Fellow of Royal Societies of Biology and Chemistry, United Kingdom, Academy of Translational Medicine Professionals, Austria, and is named as the Global Leader in Science by The Scientist magazine (USA) and International Opinion Expert involved in the vaccination for JE by IPIC (UK).

Covering

High Throughput Screening Ultra-High Throughput Screening Fluorescence Polarization Fluorescence Anisotropy Fluorescence Resonance Energy Transfer Time-Resolved FRET Standard Deviation Coefficient of Variation Compound Management DNA-Encoded Chemical Library Laboratory Automation Synthetic Genetic Array

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About the book

With the advances in biotechnology, identification of new therapeutic targets, and better understanding of human diseases, pharmaceutical companies and academic institutions have accelerated their efforts in drug discovery. The pipeline to obtain therapeutics often involves target identification and validation, lead discovery and optimization, pre-clinical animal studies, and eventually clinical trials to test the safety and effectiveness of the new drugs. In most cases, screening using genome-scale RNA interference (RNAi) technology or diverse compound libraries comprises the first step of the drug discovery initiatives. Conducting either genome-wide RNAi or small molecule screens has become possible with the advances in high-throughput screening (HTS) technologies, which are indispensable to carry out massive screens in a timely manner.

This book will analyze methods developed to meet the needs for handling large datasets generated from HTS campaigns. The growing number of statistical methods for HTS may further accelerate the discovery of drug candidates with higher confidence.

Publishing process

Book initiated and editor appointed

Date completed: October 16th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 13th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: January 12th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 2nd 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 1st 2021

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About the editor

Shailendra K. Saxena

King George's Medical University

Dr. Shailendra K. Saxena is Vice Dean and Professor at King George's Medical University, Lucknow, India. His research interests are to understand the molecular mechanisms of host defense during human viral infections and to develop new predictive, preventive, and therapeutic strategies for them using JEV, HIV and emerging viruses as a model, via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with high citation. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award (UK), Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India, and Fellow of various internationally prestigious societies/academies including Royal Societies of Biology and Chemistry, London, United Kingdom, Academy of Translational Medicine Professionals, Austria, and is named as the Global Leader in Science by The Scientist magazine (USA) and International Opinion Leader/Expert involved in the vaccination for JE by IPIC (UK).

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Book chapters authored 10

Books edited 6

Introducing your Author Service Manager

Ms. Jasna Bozic

As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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