About the book
Antimicrobial peptides (AMPs) are found in single-cell and multiple-cells organisms such as bacteria, fungi, algae, insects, scorpions, frogs, and mammals. AMPs are peptides with a varying number (12-50 of amino acids residues) and they belong to the first line defense molecules of multicellular organisms. They have a broad-spectrum antimicrobial activity including bacteria, fungi, and viruses. More than 3000 AMPs have been discovered since the first discovery and isolation. AMPs are mostly synthesized as a precursor containing signal sequences that determine their localization in the cell. Next, the precursor molecules go through cleavage and formation of biologically active peptide. Target and mechanism of action of AMPs can be differing and depend on microorganism against which action is directed; by inhibiting proteins, by disrupting membrane integrity, by inhibiting DNA and RNA synthesis, or by interacting with intracellular targets.
This book will thus aim to include information on AMPs and their targets and mechanisms of action.