About the book
Crohn’s disease is a chronic inflammatory disease that can affect the gastrointestinal tract from the mouth to the anus. The exact etiology is unknown. The incidence is about 10.7 cases per 100,000 people in the United States. The disease is not only inflammatory in nature in the gastrointestinal tract but also can cause stricture, fistula, malignancy and extra-intestinal manifestations. The natural course of the disease is relapse and remission. As it affects the mostly young population, their life can be debilitating if the disease activity is not under control. There are various laboratory, imaging and endoscopic studies available to diagnose Crohn’s disease and follow up after treatment. The goal of treatment is not only clinical and endoscopic remission but also mucosal healing. There are various treatments available at the present time for Crohn’s disease. But treatment options are not optimal considering the efficacy rate and side effect profile. As a result, many clinical trials are ongoing for better control of Crohn’s disease. Many biologic agents are in the pipeline to be released into the market. When medical therapy fails, surgical intervention is done. Fortunately, the surgery rate in Crohn’s disease is decreasing.
This book will focus on the epidemiology, pathophysiology, different clinical aspects, appropriate investigations and current management strategy of Crohn’s disease.