Minimum satellites needed to maintain global radio coverage.
\\n\\n
Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\\n\\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\nThank you all for being part of the journey. 5,000 times thank you!
\\n\\nNow with 5,000 titles available Open Access, which one will you read next?
\\n\\nRead, share and download for free: https://www.intechopen.com/books
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
\n\n"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
\n\n\n\nDr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\n\nThank you all for being part of the journey. 5,000 times thank you!
\n\nNow with 5,000 titles available Open Access, which one will you read next?
\n\nRead, share and download for free: https://www.intechopen.com/books
\n\n\n\n
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10633",leadTitle:null,fullTitle:"Biotechnology to Combat COVID-19",title:"Biotechnology to Combat COVID-19",subtitle:null,reviewType:"peer-reviewed",abstract:"This book provides an inclusive and comprehensive discussion of the transmission, science, biology, genome sequencing, diagnostics, and therapeutics of COVID-19. It also discusses public and government health measures and the roles of media as well as the impact of society on the ongoing efforts to combat the global pandemic. It addresses almost every topic that has been studied so far in the research on SARS-CoV-2 to gain insights into the fundamentals of the disease and mitigation strategies. This volume is a useful resource for virologists, epidemiologists, biologists, medical professionals, public health and government professionals, and all global citizens who have endured and battled against the pandemic.",isbn:"978-1-83968-627-6",printIsbn:"978-1-83968-626-9",pdfIsbn:"978-1-83968-628-3",doi:"10.5772/intechopen.93713",price:159,priceEur:175,priceUsd:205,slug:"biotechnology-to-combat-covid-19",numberOfPages:644,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"d834c746c5b159a201a9cdadfc473486",bookSignature:"Megha Agrawal and Shyamasri Biswas",publishedDate:"February 23rd 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10633.jpg",numberOfDownloads:8107,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:13,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:17,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 14th 2020",dateEndSecondStepPublish:"December 28th 2020",dateEndThirdStepPublish:"February 23rd 2021",dateEndFourthStepPublish:"May 14th 2021",dateEndFifthStepPublish:"July 13th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"193723",title:"Dr.",name:"Megha",middleName:null,surname:"Agrawal",slug:"megha-agrawal",fullName:"Megha Agrawal",profilePictureURL:"https://mts.intechopen.com/storage/users/193723/images/system/193723.jpg",biography:"Dr. Megha Agrawal is co-founder, executive publisher, and chief editor of Biotechnology Kiosk, an international journal in biotechnology. She is recognized as one of the world’s leading neuroscientists and biotechnologists. Dr. Agrawal’s research has been well cited. She has published more than 100 articles and edited several books in prestigious scientific journals in the field of biotechnology, neuroscience, molecular biology, and biochemistry. She was a faculty member and principal investigator at the University of Illinois Chicago and an associate editor for Frontiers in Molecular Diagnostics and Therapeutics. Dr. Agrawal is an invited columnist and contributing editor in biotechnology for a leading high-tech trade journal, Vacuum Technology & Coating Magazine, for which she writes a monthly column on vacuum advances in biotechnology.",institutionString:"Biotechnology Kiosk",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Illinois at Chicago",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"329553",title:"Dr.",name:"Shyamasri",middleName:null,surname:"Biswas",slug:"shyamasri-biswas",fullName:"Shyamasri Biswas",profilePictureURL:"https://mts.intechopen.com/storage/users/329553/images/system/329553.png",biography:"Dr. Shyamasri Biswas is co-founder, executive publisher, and chief editor of Biotechnology Kiosk, an international journal in biotechnology. She is an internationally recognized structural and molecular biologist, protein chemist, and biotechnologist and is well known worldwide for her works in solving challenging protein crystal structures of therapeutic relevance. She has published more than 100 articles in reputed journals. She received her Ph.D. in Biotechnology under the prestigious DAAD sandwich fellowship program jointly from the University of Potsdam, Germany and Banaras Hindu University, India. She was a senior scientist at UMass Worcester, North Carolina State University, and University of Florida Gainesville. She is a senior editorial board member of Proteins and Peptide Letters and a contributing editor for Vacuum Technology & Coating Magazine.",institutionString:"Biotechnology Kiosk",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Florida",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"200",title:"Public Health",slug:"medicine-public-health"}],chapters:[{id:"75208",title:"Epidemiology, Pathogenesis, and Healing Strategies of COVID-19",doi:"10.5772/intechopen.96200",slug:"epidemiology-pathogenesis-and-healing-strategies-of-covid-19",totalDownloads:328,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the present chapter, some notable features (epidemiology, pathogenesis, and clinical characteristics) regarding recent outbreak COVID-19 have been reviewed. Most significant features related to COVID-19 such as (i) roots of infection and disease manifestation, (ii) shape and structure of viral S-protein, (iii) genome sequence study and replication in host cell, (iv) role of environmental factors, (v) diagnosis tools and (vi) role of biosensor have been critically investigated. The biological and behavioral risk factors for pregnant women before and after child birth have been dictated clearly. Pulmonary abnormalities due to COVID-19 of the patient having diabetes, cancer etc. history have been clarified with help of CT imaging. Finally, prevention and cure strategies adopted by many health professionals based on the existing drugs are mentioned with their side effects.",signatures:"Basanta Bhowmik",downloadPdfUrl:"/chapter/pdf-download/75208",previewPdfUrl:"/chapter/pdf-preview/75208",authors:[{id:"341227",title:"Dr.",name:"Basanta",surname:"Bhowmik",slug:"basanta-bhowmik",fullName:"Basanta Bhowmik"}],corrections:null},{id:"75182",title:"Control of an Epidemic of SARS-CoV-2 by Assessing Transmissibility of Its Infected Cases in Absence of a Suitable Vaccine",doi:"10.5772/intechopen.96201",slug:"control-of-an-epidemic-of-sars-cov-2-by-assessing-transmissibility-of-its-infected-cases-in-absence-",totalDownloads:321,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"SARS-CoV-2 or Covid 19 and it’s pandemicity has been wreaking havoc in many countries worldwide. It is important to counter and contain the spread of Covid-19 using some effective infection control policies as we await an effective protection such as vaccine. Ahmedabad Model of Covid-19 Control could be used as an established epidemic management protocol for COVID 19 infection. It relies on the Cycle Threshold (Ct) Value, which was used as a proxy marker for assessing initial viral load. It was evident that cases with higher viral load spread the disease at much higher rate as compared to that of low viral load apart from population mobility and/or population density. Therefore, Ct value based segregation of infected cases with higher viral load along with contact tracing of them of previous 5 days is an effective epidemic control policy. It needs to be remembered that a section of infected cases is asymptomatic and capable of spreading infection in the community unknowingly. Hence, infection control practices must be accompanied with standard precautionary measures such as physical distancing, hand hygiene and wearing face mask. Community awareness is an integral part of it. Newer biotechnology based researches may be encouraged based on felt needs.",signatures:"Bidisa Sarkar and Kamalesh Sarkar",downloadPdfUrl:"/chapter/pdf-download/75182",previewPdfUrl:"/chapter/pdf-preview/75182",authors:[{id:"35086",title:"Dr.",name:"Kamalesh",surname:"Sarkar",slug:"kamalesh-sarkar",fullName:"Kamalesh Sarkar"},{id:"344221",title:"Dr.",name:"Bidisa",surname:"Sarkar",slug:"bidisa-sarkar",fullName:"Bidisa Sarkar"}],corrections:null},{id:"75255",title:"Whole Genome Sequencing: A Powerful Tool for Understanding the Diversity of Genotypes and Phenotypes among COVID-19 Infected Patients to Help in Controlling Outbreaks",doi:"10.5772/intechopen.96260",slug:"whole-genome-sequencing-a-powerful-tool-for-understanding-the-diversity-of-genotypes-and-phenotypes-",totalDownloads:247,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"In Wuhan, China (December 2019), viral pneumonia cases of uncertain origin have been reported. The emergency has drawn global attention. To determine the pathogenic potential, joint efforts were conducted by Chinese Multidisciplinary Task Forces. An integral component of wide range of research applications is not only determining the causative agent but also the nucleic acid bases order in biological samples. Research techniques determining genetic material features and its order is called “sequencing”, classified into three generations. Moreover, the first sequencing attempt was conducted and a genetic link identified between samples isolated from China and other previously sequenced Coronaviruses. However, there was patient to patient diversity in terms of clinical and laboratory manifestations and diseases severity. After the genetic material of the causative agent was successfully sequenced, it was named the novel coronavirus causing COVID-19. Here, we review the genome sequences of novel coronavirus infected patients from different countries such as India, Bangladesh and Ecuador compared to China (first reported case), seeking not only to recognize similarities and differences between genome sequences of novel coronavirus, but also to compare them with other forms of coronaviruses family. Utilizing this data will assist in making right decisions minimizing negative consequences of the outbreak.",signatures:"Rayan A. Ahmed",downloadPdfUrl:"/chapter/pdf-download/75255",previewPdfUrl:"/chapter/pdf-preview/75255",authors:[{id:"344351",title:"Assistant Prof.",name:"Rayan A.",surname:"Ahmed",slug:"rayan-a.-ahmed",fullName:"Rayan A. Ahmed"}],corrections:null},{id:"76134",title:"Glycan and Its Role in Combating COVID-19",doi:"10.5772/intechopen.97240",slug:"glycan-and-its-role-in-combating-covid-19",totalDownloads:280,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Newly identified beta-coronavirus i.e. the 2019 novel coronavirus is associated with a contagious transmittable respiratory disease called COVID-19. This disease has been declared as a “pandemic” by the World Health Organization (WHO). The entry of coronavirus in the human respiratory epithelial cells depends upon the interaction between host cell receptor ACE2 and viral S-glycoprotein. However, this type of molecular recognition in between cell surface receptors and envelope glycoproteins are mediated by specific glycan epitopes and attribute to viral entry through membrane fusion. Glycans are essential biomolecules made by all living organisms, have roles in serving structure, energy storage, and system regulatory purposes. The glycan shield plays a crucial role in concealing the surface S protein from molecular recognition. The immunomodulatory properties of Glycan-binding proteins (GBPs) like Lectins, build them as an attractive candidates for vaccine adjuvant. Investigations involving the complement system activation by the lectin pathway in COVID-19 and diseases are in need of the hour. The innate immune response involving complement system could have varied biological effects against an array of microbial infections. The advances in glycoprotein style methods especially immunomodulatory action of some lectins are necessary to boost the effectiveness of treatment of COVID-19 and other pandemics.",signatures:"Swapan Kumar Chatterjee and Snigdha Saha",downloadPdfUrl:"/chapter/pdf-download/76134",previewPdfUrl:"/chapter/pdf-preview/76134",authors:[{id:"344007",title:"Dr.",name:"Swapan",surname:"Kumar Chatterjee",slug:"swapan-kumar-chatterjee",fullName:"Swapan Kumar Chatterjee"},{id:"450851",title:"Dr.",name:"Snigdha",surname:"Saha",slug:"snigdha-saha",fullName:"Snigdha Saha"}],corrections:null},{id:"77553",title:"Epigenetic Regulation Mechanisms in Viral Infections: A Special Focus on COVID-19",doi:"10.5772/intechopen.98866",slug:"epigenetic-regulation-mechanisms-in-viral-infections-a-special-focus-on-covid-19",totalDownloads:155,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The outbreak of Coronavirus Disease-2019 (Covid-19), caused by a novel and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2), is a persisting global health concern. Research so far has successfully identified the molecular mechanisms of viral entry, alterations within the host cell upon infection, and the stimulation of an immune response to fight it. One of the most important cellular regulatory machineries within the host cell to be affected by the SARS-CoV-2 infection is epigenetic regulation, which modulates transcriptional activity by DNA sequence-independent factors such as DNA-methylation, RNA interference and histone modifications. Several studies in the literature have previously reported epigenetic alterations within the host due to infections of the Coronaviridae family viruses including SARS-CoV and MERS-CoV that antagonized immune system activation. Recent studies have also identified epigenetic dysregulation of host metabolism by SARS-CoV-2 infection, linking epigenetic mechanisms with the pathophysiology and illness severity of Covid-19. Therefore, this book chapter aims to provide a comprehensive overview of the epigenetic regulation mechanisms in viral infections with a special focus on SARS-CoV-2 infection.",signatures:"Burcu Biterge Süt",downloadPdfUrl:"/chapter/pdf-download/77553",previewPdfUrl:"/chapter/pdf-preview/77553",authors:[{id:"348679",title:"Assistant Prof.",name:"Burcu",surname:"Biterge Süt",slug:"burcu-biterge-sut",fullName:"Burcu Biterge Süt"}],corrections:null},{id:"76119",title:"Mesenchymal Stem Cells and Extracellular Vesicles: An Emerging Alternative to Combat COVID-19",doi:"10.5772/intechopen.97212",slug:"mesenchymal-stem-cells-and-extracellular-vesicles-an-emerging-alternative-to-combat-covid-19",totalDownloads:236,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The global SARS-CoV-2 outbreak has been accompanied with severe socio-economic and health burdens that will ripple through history. It is now known that SARS-CoV-2 induces a cytokine storm that leads to acute respiratory distress syndrome and systemic organ damage. With no definitive nor safe therapy for COVID-19 as well as the rise of viral variants the need for an urgent treatment modality is paramount. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have long been praised for their anti-viral, anti-inflammatory and tissue regenerative capabilities. MSCs and their EVs are now being studied for their possible use as a treatment modality for COVID-19. In this review we explore their capabilities and outline the evidence of their use in ALI, ARDS and COVID-19.",signatures:"Hugo C. Rodriguez, Manu Gupta, Emilio Cavazos-Escobar, Enrique Montalvo, Saadiq F. El-Amin III and Ashim Gupta",downloadPdfUrl:"/chapter/pdf-download/76119",previewPdfUrl:"/chapter/pdf-preview/76119",authors:[{id:"344686",title:"Dr.",name:"Ashim",surname:"Gupta",slug:"ashim-gupta",fullName:"Ashim Gupta"},{id:"346444",title:"Dr.",name:"Hugo .",surname:"Rodriguez",slug:"hugo-.-rodriguez",fullName:"Hugo . Rodriguez"},{id:"351617",title:"Dr.",name:"Manu",surname:"Gupta",slug:"manu-gupta",fullName:"Manu Gupta"},{id:"351618",title:"Mr.",name:"Emilio",surname:"Cavazos-Escobar",slug:"emilio-cavazos-escobar",fullName:"Emilio Cavazos-Escobar"},{id:"351619",title:"Dr.",name:"Enrique",surname:"Montalvo",slug:"enrique-montalvo",fullName:"Enrique Montalvo"},{id:"351620",title:"Dr.",name:"Saadiq",surname:"F. El-Amin III",slug:"saadiq-f.-el-amin-iii",fullName:"Saadiq F. El-Amin III"}],corrections:null},{id:"77695",title:"Application of Ex-Vivo/3D Organoid Models in COVID-19 Research",doi:"10.5772/intechopen.99100",slug:"application-of-ex-vivo-3d-organoid-models-in-covid-19-research",totalDownloads:138,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"COVID-19 treatment methods based on 3D organoids and ex-vivo platforms are analyzed in this chapter. Initially, the platforms available for cell culture and its working characteristics are explained. Subsequently discusses the organoids with their definition and included their uses in various applications. Further, the chapter extends to describe the uses of different organoids with their use in different stages. Most of these methods utilized the 3D ex-vivo cell culture method to develop organoids and test them over infected tissues. Based on the study in this chapter, it is found that the demonstration of active replication of the human organoids culture system of lungs is found to be more helpful for COVID-19 treatment.",signatures:"Allen Thayakumar Basanthakumar",downloadPdfUrl:"/chapter/pdf-download/77695",previewPdfUrl:"/chapter/pdf-preview/77695",authors:[{id:"336483",title:"M.Sc.",name:"Allen Thayakumar",surname:"Basanthakumar",slug:"allen-thayakumar-basanthakumar",fullName:"Allen Thayakumar Basanthakumar"}],corrections:null},{id:"76647",title:"In Vitro Diagnostics for COVID-19: State-of-the-Art, Future Directions and Role in Pandemic Response",doi:"10.5772/intechopen.97775",slug:"-em-in-vitro-em-diagnostics-for-covid-19-state-of-the-art-future-directions-and-role-in-pandemic-res",totalDownloads:257,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"There have been tremendous advances in in vitro diagnostics (IVD) for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although the confirmatory clinical diagnosis is made by real-time reverse transcriptase polymerase chain reaction (RT-PCR), lateral flow immunoassay (LFIA) based viral antigen (Ag) detection is used for mass population screening at point-of-care (POC) settings. The rapid RT-PCR tests (such as from Cepheid and Bosch) have an assay duration of less than 40 min, while most rapid Ag tests (such as Abbott’s BinaxNOW™ COVID-19 Ag card) have an assay duration of about 15 min. Of interest is the POC molecular test (ID NOW™) from Abbott that takes less than13 min. Similarly, many immunoassays (IAs), i.e., automated chemiluminescent IA (CLIA), manual ELISA, and LFIA, have been developed to detect immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA) produced in subjects after SARS-CoV-2 infection. Many IVD tests have been approved by the United States Food and Drug Administration (FDA) under emergency use authorization (EUA), and almost all IVD tests are Conformité Européenne (CE) certified.",signatures:"Sandeep Kumar Vashist, Subramanian Murugan and Guiffo Djoko",downloadPdfUrl:"/chapter/pdf-download/76647",previewPdfUrl:"/chapter/pdf-preview/76647",authors:[{id:"347663",title:"Dr.",name:"Sandeep Kumar",surname:"Vashist",slug:"sandeep-kumar-vashist",fullName:"Sandeep Kumar Vashist"},{id:"413931",title:"Dr.",name:"Subramanian",surname:"Murugan",slug:"subramanian-murugan",fullName:"Subramanian Murugan"},{id:"413932",title:"Mr.",name:"Guiffo",surname:"Djoko",slug:"guiffo-djoko",fullName:"Guiffo Djoko"}],corrections:null},{id:"75245",title:"Molecular Biology of PCR Testing for COVID-19 Diagnostics",doi:"10.5772/intechopen.96199",slug:"molecular-biology-of-pcr-testing-for-covid-19-diagnostics",totalDownloads:387,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"COVID-19 cases were first reported in December 2019, and since then it has spread quickly to create a global pandemic. This respiratory disease is caused by the SARS-CoV-2 virus. A major contributing factor for the fast spread of this virus is that the infectivity by the asymptomatic carriers is similar to symptomatic patients. Thus, to identify the asymptomatic individuals and to provide the essential treatment and care to COVID-19 patients, we rely heavily on diagnostic assays. Efficient, reproducible and accessible diagnostic tests are crucial in combatting a pandemic. Currently, there are few key detection tests which have been successfully employed to field-use. However, there are constant efforts to enhance their efficacy and accessibility. This chapter aims at explaining the basic principles of the current molecular diagnostic tests, which determine the presence of the virus through the detection of its genetic material. This chapter will aid the readers in understanding the basic workings of these molecular diagnostic tests.",signatures:"Vinita Chittoor-Vinod",downloadPdfUrl:"/chapter/pdf-download/75245",previewPdfUrl:"/chapter/pdf-preview/75245",authors:[{id:"336488",title:"Dr.",name:"Vinita",surname:"Chittoor-Vinod",slug:"vinita-chittoor-vinod",fullName:"Vinita Chittoor-Vinod"}],corrections:null},{id:"76026",title:"The Utility of Mechanical Homogenization in COVID-19 Diagnostic Workflows",doi:"10.5772/intechopen.97110",slug:"the-utility-of-mechanical-homogenization-in-covid-19-diagnostic-workflows",totalDownloads:186,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"The use of mechanical homogenization in patient sample preparation for COVID-19 diagnostics has proven impactful in the face of the global pandemic caused by SARS-CoV-2. Through methods including bead beating and shaker mill homogenization novel approaches to viral detection have been developed and improvements have been made to existing diagnostic workflows for the improvement of throughput and automation capacity. The application of mechanical homogenization techniques has enhanced the sensitivity and methodology for many molecular based approaches to COVID-19 detection and from a variety of sample types ranging from saliva to nasopharyngeal swabs. Additionally, this technology has been used to help increase laboratory safety during sample processing through efficient viral lysis. Herein, the many benefits of mechanical homogenization for COVID-19 detection will be discussed in the context of the many diagnostic workflows currently utilizing the technique.",signatures:"Zachary P. Morehouse, Rodney J. Nash, Caleb Proctor and Gabriella Ryan",downloadPdfUrl:"/chapter/pdf-download/76026",previewPdfUrl:"/chapter/pdf-preview/76026",authors:[{id:"344987",title:"Dr.",name:"Zachary P.",surname:"Morehouse",slug:"zachary-p.-morehouse",fullName:"Zachary P. Morehouse"},{id:"344988",title:"Dr.",name:"Rodney J.",surname:"Nash",slug:"rodney-j.-nash",fullName:"Rodney J. Nash"},{id:"344990",title:"MSc.",name:"Caleb",surname:"Proctor",slug:"caleb-proctor",fullName:"Caleb Proctor"},{id:"344991",title:"MSc.",name:"Gabriella",surname:"Ryan",slug:"gabriella-ryan",fullName:"Gabriella Ryan"}],corrections:null},{id:"75737",title:"Development of RT-PCR Based Diagnosis of SARS-CoV-2",doi:"10.5772/intechopen.96823",slug:"development-of-rt-pcr-based-diagnosis-of-sars-cov-2",totalDownloads:340,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In the 2020, COVID-19 pandemic disease created an havoc situation world widely and mainly caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). It has been challenging task for researchers, scientists and medico-pharmaceutical organisations to find out rapid and reliable diagnosis methods. Among the all testing services, a Reverse Transcription Polymerase Chain Reaction (RT-PCR) is the more accurate, rapid and authenticated molecular technique used for most of the diagnosis of major diseases. It has been a global priority to fix the rapid diagnosis method to combat against the pandemic COVID-19. Thus, the present chapter mainly focussing on the progress of RT-PCR method development though various processes of data collection on isolation of whole genome sequence, its primer and method designing. In this scenario, India suddenly become the global leader for vaccine development and hence the challenges and RT-PCR kit development in India and rest of the world has been be discussed. World wide many Government and private agencies and industries have taken an initiative for diagnosis of SARS-CoV-2 hence this chapter also summarised the scope of RT-PCR to combat pandemic situation in future.",signatures:"Rutuja Sunil Patankar and Vasudeo Pandharinath Zambare",downloadPdfUrl:"/chapter/pdf-download/75737",previewPdfUrl:"/chapter/pdf-preview/75737",authors:[{id:"174690",title:"Dr.",name:"Vasudeo",surname:"Zambare",slug:"vasudeo-zambare",fullName:"Vasudeo Zambare"},{id:"343962",title:"Ph.D. Student",name:"Rutuja",surname:"Sunil Patankar",slug:"rutuja-sunil-patankar",fullName:"Rutuja Sunil Patankar"}],corrections:null},{id:"75875",title:"Current Status of COVID-19 Diagnostics",doi:"10.5772/intechopen.96955",slug:"current-status-of-covid-19-diagnostics",totalDownloads:142,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In December 2019, an unexpected outbreak was caused by novel corona virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lung disease caused by SARS-CoV-2 was given the name of the novel coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO) on February 11, 2020. Since its origin in the Hubei province of Wuhan city in China, now it has spread to 218 countries worldwide. Panic situation created by COVID-19 has compelled researchers and doctors to work collaboratively. To combat with the disease, every control measures are under consideration from drug discovery to vaccine development. In the management of disease, rapid diagnosis is equally important as development of vaccine and drug. At present, various diagnostic kits are available for COVID-19. With the disease progression, global demand for diagnostics is raising. So, this chapter will include the updates on efficient diagnostic assays and future of diagnostic.",signatures:"Surabhi Dixit and Monal Sharma",downloadPdfUrl:"/chapter/pdf-download/75875",previewPdfUrl:"/chapter/pdf-preview/75875",authors:[{id:"337906",title:"Dr.",name:"Surabhi",surname:"Dixit",slug:"surabhi-dixit",fullName:"Surabhi Dixit"},{id:"350600",title:"Dr.",name:"Monal",surname:"Sharma",slug:"monal-sharma",fullName:"Monal Sharma"}],corrections:null},{id:"76409",title:"COVID-19 and Cancer: Biological Interconnection and Treatment",doi:"10.5772/intechopen.97482",slug:"covid-19-and-cancer-biological-interconnection-and-treatment",totalDownloads:193,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The COVID-19 pandemic has affected more than 125 million lives worldwide and more than 2.5 million people have died so far. Cancer in itself increases the risk of infection especially, cancer patients undergoing cancer-associated treatments are more susceptible to SARS-CoV2 infection. However, many questions related to the biological interconnection between the two diseases remain to be answered. This chapter summarizes some of the biological components that connect cancer to COVID-19 and provide knowledge to not only understand but also, target the co-morbidities.",signatures:"Nidhi Jyotsana",downloadPdfUrl:"/chapter/pdf-download/76409",previewPdfUrl:"/chapter/pdf-preview/76409",authors:[{id:"345282",title:"Dr.",name:"Nidhi",surname:"Jyotsana",slug:"nidhi-jyotsana",fullName:"Nidhi Jyotsana"}],corrections:null},{id:"77350",title:"Crosstalk between SARS-CoV-2 and Testicular Hemostasis: Perspective View",doi:"10.5772/intechopen.98218",slug:"crosstalk-between-sars-cov-2-and-testicular-hemostasis-perspective-view",totalDownloads:156,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The infection of SARS-CoV-2 and its COVID disease caused several economic and social disturbances worldwide. This chapter aimed to determine the severity of SARS-CoV-2 infection on the testicular hemostasis. This overview showed the possible mechanisms of how the SARS-CoV-2 can infect the testes. SARS-CoV-2-induced pneumonia, cytokine storm, and immunosuppressive state may transfer from the respiratory tract to the blood circulation, binding to testicular angiotensin-converting enzyme 2 receptors (ACSE2) and initiate its intracellular replication and action (cytotoxicity), that disrupting the testicular hemostasis. In severe states, COVID-19 disease can increase body/testes temperature, which may destroy the germ cell in the long term. The final mechanism is that SARS-CoV-2 infection causes stress, panic, and anxiety states, causing brain disorders that may perturb the hypothalamic–pituitary-testes-axis (HPTA). This disturbance may then lead to testicular dysfunction. The severity of COVID-19 may be age-dependent and depending on the expression and distribution of testicular ACSE2 receptors. Also, this chapter not only showed the sexual transmission of SARS-CoV-2 but also followed its impact on sexual behavior, pregnancy, and progeny. Thus, maintaining the testicular hemostasis may play a vital role in a healthy life for the offspring. Further research and clinical studies are required to explore this issue.",signatures:"R.G. Ahmed",downloadPdfUrl:"/chapter/pdf-download/77350",previewPdfUrl:"/chapter/pdf-preview/77350",authors:[{id:"138555",title:"Prof.",name:"R.G.",surname:"Ahmed",slug:"r.g.-ahmed",fullName:"R.G. Ahmed"}],corrections:null},{id:"76542",title:"COVID-19: A Catalyst for Novel Psychiatric Paradigms - Part 1",doi:"10.5772/intechopen.96940",slug:"covid-19-a-catalyst-for-novel-psychiatric-paradigms-part-1",totalDownloads:224,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the late 2019 and spread rapidly throughout the world, becoming a pandemic in March 2020. It became obvious early that the prognosis of this illness is highly variable, ranging from few mild symptoms to severe complications and death, indicating that aside from the pathogen virulence, host factors contribute significantly to the overall outcome. Like SARS-CoV and Human Coronavirus NL63 (HCoV-NL63-NL63), SARS-CoV-2 enters host cells via several receptors among which angiotensin converting enzyme-2 (ACE-2) are the most studied. As this protein is widely expressed in the lungs, blood vessels, brain, kidney, testes and ovaries, the effects of this virus are widespread, affecting many body tissues and organs. Viral attachment to ACE-2 downregulates this protein, disrupting angiotensin II (ANG II) hydrolysis that in return contributes to the unchecked accumulation of this peptide. ANG II toxicity is the result of excessive activation of ANG II type 1 receptors (AT-1Rs) and N-methyl-D-aspartate NMDA receptors (NMDARs). Overstimulation of these proteins, along with the loss of angiotensin (1–7) (ANG 1–7), upregulates reactive oxygen species (ROS), inflicting end-organ damage (hit 1). However, a preexistent redox impairment may be necessary for the development of SARS-CoV-2 critical illness (hit 2). Here we propose a two-hit paradigm in which COVID-19 critical illness develops primarily in individuals with preexistent antioxidant dysfunction. Several observational studies are in line with the two hit model as they have associated poor COVID-19 prognosis with the hereditary antioxidant defects. Moreover, the SARS-CoV-2 interactome reveals that viral antigen NSP5 directly inhibits the synthesis of glutathione peroxidase (GPX), an antioxidant enzyme that along with glucose-6-phosphate dehydrogenase (G6PD) protect the body from oxidative damage. Indeed, individuals with G6PD deficiency have less favorable COVID-19 outcomes compared to the general population.",signatures:"Adonis Sfera, Carolina Osorio, Jose E. Campo Maldonado, Afzaal Jafri, Aaron D. Chokka, Carlos Manuel Zapata Martín del Campo and Zisis Kozlakidis",downloadPdfUrl:"/chapter/pdf-download/76542",previewPdfUrl:"/chapter/pdf-preview/76542",authors:[{id:"225128",title:"Dr.",name:"Adonis",surname:"Sfera",slug:"adonis-sfera",fullName:"Adonis Sfera"},{id:"341414",title:"Dr.",name:"Carolina",surname:"Osorio",slug:"carolina-osorio",fullName:"Carolina Osorio"},{id:"341416",title:"Dr.",name:"Jose E. Campo",surname:"Maldonado",slug:"jose-e.-campo-maldonado",fullName:"Jose E. Campo Maldonado"},{id:"341421",title:"Dr.",name:"Afzaal",surname:"Jafri",slug:"afzaal-jafri",fullName:"Afzaal Jafri"},{id:"341422",title:"Mr.",name:"Aaron D",surname:"Chokka",slug:"aaron-d-chokka",fullName:"Aaron D Chokka"},{id:"341423",title:"Dr.",name:"Carlos Manuel Zapata",surname:"Martín Del Campo",slug:"carlos-manuel-zapata-martin-del-campo",fullName:"Carlos Manuel Zapata Martín Del Campo"},{id:"341425",title:"Dr.",name:"Zisis",surname:"Kozlakidis",slug:"zisis-kozlakidis",fullName:"Zisis Kozlakidis"}],corrections:null},{id:"75684",title:"Frequency of Hyperglycemia in Patients with Covid-19 Infection and Pneumonia",doi:"10.5772/intechopen.96306",slug:"frequency-of-hyperglycemia-in-patients-with-covid-19-infection-and-pneumonia",totalDownloads:266,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Diabetes mellitus can increase the risk of death in COVID-19 by 12 times, according to the portal of the us Centers for disease control and prevention. Coronavirus-infected diabetics are six times more likely to need inpatient treatment, and diabetes is the second most severe complication in COVID-19 after cardiovascular diseases. The state of carbohydrate metabolism in patients with COVID-19 has not been sufficiently studied in clinical studies. Isolated studies indicate that viral infection may be accompanied by an increase in the concentration of glycated hemoglobin in patients with viral pneumonia. To assess the frequency of hyperglycemia and diagnosis of newly diagnosed diabetes mellitus in patients with COVID-19 and acute lung damage aged 41–80 years, who were hospitalized in a repurposed infectious diseases hospital in Moscow with a diagnosis of pneumonia. In the observational study analyzed laboratory and clinical diagnostic data of 278 patients who had, according to the anamnesis and the medical conclusions of impaired glucose tolerance and manifested forms of diabetes, including 163 men and 115 women, aged 41–80 years, admitted to the hospital for diagnosis and treatment in the period from 12.04.2020 on 10.11.2020 of diagnoses according to ICD-10: U07.1 Coronavirus infection. In the selected groups of patients, the initial and subsequent fasting blood glucose levels were analyzed after 8 hours without food intake on a stationary automatic analyzer and using portable glucose, meters using diagnostic test strips. The concentration of glucose and ketones in the urine was determined by a semi-quantitative method. We evaluated the dynamics of indicators when detecting pathological values of glucose concentration. Glucose levels above 6.4 mmol/l were taken as pathological. In patients aged 41–80 years who were hospitalized with covid-19 infection and pneumonia, fasting hyperglycemia was diagnosed in 31–47%, glucosuria in 1.9–6.1%, ketonuria – 20.4-46.2% of cases, in different age groups. In 16.6–31.3% of cases in patients with covid-19,after treatment and regression of changes in the lungs, normalization of glucose levels was observed, but in 14.8–16.7% of the changes persisted, and in 9–13% of them, after an additional study, newly diagnosed diabetes mellitus was diagnosed. Hyperglycemia was significantly more often detected in patients with arterial hypertension of 2–3 degrees of severity and with a tendency to reliability, in patients with obesity of 2–3 degrees. Lipid metabolism disorders (hypertriglyceridemia and hypercholesterolemia), which are characteristic of changes in carbohydrate metabolism in patients with impaired glucose tolerance and diabetes, were significantly more often diagnosed in patients with covid-19 than in the group of patients with acute and chronic lung pathology without proven infection with this virus, but only in the group of patients aged 41–60 years. Covid-19 infection complicated by pneumonia occurs in individuals aged 41–80 years with a high incidence of hyperglycemia and ketonuria. The incidence of newly diagnosed diabetes mellitus in such patients is 9–13%.",signatures:"Valeriy Ivanovich Vechorko, Evgeny Mikhailovich Evsikov, Oksana Alekseevna Baykova, Natalya Vadimovna Teplova and Dmitriy Aleksandrovich Doroshenko",downloadPdfUrl:"/chapter/pdf-download/75684",previewPdfUrl:"/chapter/pdf-preview/75684",authors:[{id:"345556",title:"Dr.",name:"Evgeny",surname:"Mikhailovich Evsikov",slug:"evgeny-mikhailovich-evsikov",fullName:"Evgeny Mikhailovich Evsikov"}],corrections:null},{id:"75277",title:"Refocusing Functional Anatomy and Immunology of the Respiratory Mucosa in the Advent of Covid-19",doi:"10.5772/intechopen.96251",slug:"refocusing-functional-anatomy-and-immunology-of-the-respiratory-mucosa-in-the-advent-of-covid-19",totalDownloads:300,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Atmospheric oxygen is an indispensable element required in order for mammalian cells to function normally. The mammalian respiratory system, through pulmonary ventilation and gas diffusion, provides the physical mechanisms by which oxygen gains access to all body cells and through which carbon dioxide is eliminated from the body. The network of tissues and organs of the respiratory system helps the mammalian body cells to absorb oxygen from the air to enable the tissues and organs to function optimally. The advent of the coronavirus disease 2019 (Covid-19) Pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has stimulated heightened and refocused interest in the study of various aspects of the respiratory system. The SARS-CoV-2 targets the respiratory system mucosal cells and in a cascade of biological processes curtails the ability of the respiratory system to absorb and deliver oxygen to the pulmonary blood and body cells often resulting in severe disease and/or death. The mucosa and submucosa of the respiratory tract are adapted to provide both innate and adaptive immune defense mechanisms against pathogens including the SARS-CoV-2. The entire respiratory tract is covered by a mucosa that transitions in its structural and functional characteristics from the upper respiratory tract to the lower respiratory tract. This chapter provides an overview of the functional anatomy and immunology of the respiratory tract covering the mucosa from the upper respiratory tract all the way up to the alveolar epithelium. In the advent of the covid-19 pandemic, a broader perspective and understanding of the anatomy and immunology of the respiratory tract will enable general readers and researchers to fully appreciate the discourse in covid-19 research as it affects the respiratory tract.",signatures:"Humphrey Simukoko",downloadPdfUrl:"/chapter/pdf-download/75277",previewPdfUrl:"/chapter/pdf-preview/75277",authors:[{id:"335282",title:"Dr.",name:"Humphrey",surname:"Simukoko",slug:"humphrey-simukoko",fullName:"Humphrey Simukoko"}],corrections:null},{id:"75704",title:"Cellular Therapy as Promising Choice of Treatment for COVID-19",doi:"10.5772/intechopen.96900",slug:"cellular-therapy-as-promising-choice-of-treatment-for-covid-19",totalDownloads:237,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"In the pandemic of COVID-19, while living normals have been changing, there have been a huge effort globally to find out effective and safe treatment agents and vaccines. As of now, the advances show the progress in vaccine development, however the treatment of the COVID-19 is yet not fully specified. The drugs, i.e. antibiotics, antivirals, antimalarians, even anti-HIV agents which have been known already were taken out of the shelves and brought into use in different combinations. On the other hand, the cellular treatment, more specifically the mesenchymal stem cell therapy has been encouraged, resulting in various evidence published all over the world. This chapter aims to compile the published information, in means of methods, disease manifestations, results and limitations, about the stem cell treatment of the COVID-19 and to provide a source of harmonized reference for scientific society.",signatures:"Duygu Koyuncu Irmak and Erdal Karaoz",downloadPdfUrl:"/chapter/pdf-download/75704",previewPdfUrl:"/chapter/pdf-preview/75704",authors:[{id:"343450",title:"Assistant Prof.",name:"Duygu",surname:"Koyuncu Irmak",slug:"duygu-koyuncu-irmak",fullName:"Duygu Koyuncu Irmak"},{id:"349122",title:"Prof.",name:"Erdal",surname:"Karaoz",slug:"erdal-karaoz",fullName:"Erdal Karaoz"}],corrections:null},{id:"75622",title:"Repurposed Therapeutic Strategies towards COVID-19 Potential Targets Based on Genomics and Protein Structure Remodeling",doi:"10.5772/intechopen.96728",slug:"repurposed-therapeutic-strategies-towards-covid-19-potential-targets-based-on-genomics-and-protein-s",totalDownloads:331,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Target recognition is important for the identification of drugs with a high target specificity and/or for the development of existing drugs that could be replicated for the treatment of SARS-CoV-2 infections. Since SARS-CoV-2 is a pathogen recently discovered, no specific medicines have been identified or are available at present. The scientific community had proposed list of current drugs with therapeutic potential for COVID-19 on the basis of genomic sequence information coupled with protein structure modeling, posing an effective and productive therapeutic approach for repurposing existing drugs. The possible therapeutics for the treatment of COVID-19 involves a wide range of alternatives, encompassing nucleic acid-based treatments directed at the expression of genes of viruses, cytokine therapy, genetic engineered and vectored antibodies, and different formulations of vaccines. The future prospective in the treatment approaches the exploration of antiviral therapy, such as screening of prevailing molecules or libraries, testing of existing broad-spectrum antiviral medications, modern drug discovery focused on genomic knowledge and biochemical properties of various coronaviruses to create new targeted drugs.",signatures:"Ashok K. Singh, Aakansha Singh and Ankit Kumar Dubey",downloadPdfUrl:"/chapter/pdf-download/75622",previewPdfUrl:"/chapter/pdf-preview/75622",authors:[{id:"344211",title:"Mr.",name:"Ankit",surname:"Kumar Dubey",slug:"ankit-kumar-dubey",fullName:"Ankit Kumar Dubey"},{id:"344212",title:"Dr.",name:"Ashok K",surname:"Singh",slug:"ashok-k-singh",fullName:"Ashok K Singh"},{id:"344641",title:"Ms.",name:"Aakansha",surname:"Singh",slug:"aakansha-singh",fullName:"Aakansha Singh"}],corrections:null},{id:"78218",title:"Role of Anti-Viral Drugs in Combating SARS-CoV-2",doi:"10.5772/intechopen.99599",slug:"role-of-anti-viral-drugs-in-combating-sars-cov-2",totalDownloads:159,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Viruses are the eventual assertion of parasitism, they not only take nutriments from the host cell, apart from that they direct its metabolic machinery to amalgamate novel virus particle and to diminish the ability of flu viruses to reproduce in an individual antiviral drugs are used. When used as directed, antiviral drugs may help to lessen the duration of flu symptoms and may reduce the severity of common flu symptoms. Antiviral drugs are the class of drugs which comes under the antimicrobials, and that also accommodates the larger group i.e. of antibiotics. They are broad-spectrum in nature and can be effective against a wide range of viruses. They can be used as a single drug as well as in combination of drugs. Antiviral drugs are dissimilar from the antibiotics, they do not demolish their target pathogen ideally they obstruct development of pathogen. To the greatest extent antiviral drugs currently accessible are delineate to deal with herpes viruses, covid-19, HIV, the hepatitis b and c viruses herpes simplex, small pox, picornavirus and influenza a and b viruses etc. Scientists are searching to drag out the range of antiviral to the other families of pathogens. They mainly act by inhibiting the attachment of viruses on cells, prevent genetic reproduction of virus, prevent viral protein production and vital for production of virus. The emanation of antiviral is generally the outcome about an appreciably expanded skills or proficiency of the generative, microscopic and atomic activity of organisms, allowing biomedical analyst to acknowledge the structure, mechanism of action and activity of viruses, significant progress within the procedure for come across the current drugs. Coronavirus 2019 (COVID 19) is highly infectious disease triggered by SARS-CoV-2 (severe acute respiratory syndrome) coronavirus 2 causing nearly 2.9 million deaths worldwide. With the emergence of SARS-CoV-2, the repurposing of antiviral drugs has come into picture.",signatures:"Sweta Kamboj, Rohit Kamboj, Shikha Kamboj, Rohit Dutt, Reeva Chabbra and Priyanka Kriplani",downloadPdfUrl:"/chapter/pdf-download/78218",previewPdfUrl:"/chapter/pdf-preview/78218",authors:[{id:"344595",title:"Assistant Prof.",name:"Sweta",surname:"Kamboj",slug:"sweta-kamboj",fullName:"Sweta Kamboj"},{id:"345588",title:"Mr.",name:"Rohit",surname:"Kamboj",slug:"rohit-kamboj",fullName:"Rohit Kamboj"},{id:"345589",title:"Ms.",name:"Shikha",surname:"Kamboj",slug:"shikha-kamboj",fullName:"Shikha Kamboj"},{id:"345590",title:"Prof.",name:"Rohit",surname:"Dutt",slug:"rohit-dutt",fullName:"Rohit Dutt"},{id:"424484",title:"Ms.",name:"Reeva",surname:"Chabbra",slug:"reeva-chabbra",fullName:"Reeva Chabbra"},{id:"427553",title:"Dr.",name:"Priyanka",surname:"Kriplani",slug:"priyanka-kriplani",fullName:"Priyanka Kriplani"}],corrections:null},{id:"76142",title:"Convalescent Plasma: An Evidence-Based Old Therapy to Treat Novel Coronavirus Patients",doi:"10.5772/intechopen.97073",slug:"convalescent-plasma-an-evidence-based-old-therapy-to-treat-novel-coronavirus-patients",totalDownloads:242,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Novel Coronavirus (nCoV-2019) is a highly infectious viral outbreak that has so far infected more than 110 million people worldwide. Fast viral transmission and high infection rates have severely affected the entire population, especially the old aged and comorbid individuals leaving significantly less time to find some effective treatment strategy. In these challenging times, convalescent plasma (CP) therapy came as a ray of hope to save humankind. It is a form of passive immunization that has been used to treat various infectious diseases since 1890, including the 1918 Spanish flu, 2002/03 SARS-CoV, 2009 H1N1, 2012 MERS-CoV, and 2014 Ebola outbreak. The transfusion includes administration of CP containing a high value of neutralizing antibodies against the virus in hospitalized patients. This chapter summarizes the potential outcome of CP therapy in the treatment of nCoV-2019 patients.",signatures:"Saurabh Kumar, Chandra Devi, Subhabrata Sarkar, Vivek Kumar Garg, Priyanka Choudhary, Madhu Chopra, Vinit Sharma and Ravi Prakash",downloadPdfUrl:"/chapter/pdf-download/76142",previewPdfUrl:"/chapter/pdf-preview/76142",authors:[{id:"345069",title:"Mr.",name:"Saurabh",surname:"Kumar",slug:"saurabh-kumar",fullName:"Saurabh Kumar"},{id:"349522",title:"Ms.",name:"Chandra",surname:"Devi",slug:"chandra-devi",fullName:"Chandra Devi"},{id:"349523",title:"Dr.",name:"Subhabrata",surname:"Sarkar",slug:"subhabrata-sarkar",fullName:"Subhabrata Sarkar"},{id:"349524",title:"Dr.",name:"Vivek Kumar",surname:"Garg",slug:"vivek-kumar-garg",fullName:"Vivek Kumar Garg"},{id:"349526",title:"Ms.",name:"Priyanka",surname:"Choudhary",slug:"priyanka-choudhary",fullName:"Priyanka Choudhary"},{id:"349527",title:"Dr.",name:"Madhu",surname:"Chopra",slug:"madhu-chopra",fullName:"Madhu Chopra"},{id:"349528",title:"Mr.",name:"Vinit",surname:"Sharma",slug:"vinit-sharma",fullName:"Vinit Sharma"},{id:"349529",title:"Dr.",name:"Ravi",surname:"Prakash",slug:"ravi-prakash",fullName:"Ravi Prakash"}],corrections:null},{id:"75270",title:"Potential Therapeutics Pathways in Solving the Challenges of the COVID-19 Pandemic",doi:"10.5772/intechopen.96283",slug:"potential-therapeutics-pathways-in-solving-the-challenges-of-the-covid-19-pandemic",totalDownloads:213,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Millions of lives throughout the globe are under threat due to the COVID-19 pandemic. COVID-19 causes severe respiratory tract infections. In most countries COVID-19 Infections and deaths continue to soar despite the various measures put in place by the World Health Organization. These measures include limited mobility through lock down and banning international travelers. Furthermore, social distancing, wearing masks, frequent hand washing with soap and sanitizing were undertaken to slow down the rate of the virus spread. Only few countries like South Korea have been able to contain the virus to date. Our only hope is in biotechnology which have been used to develop diagnostic kits and more recently approved vaccines: vaccines by Pfizer-BioNTech and Moderna; AstraZeneca and Oxford University vaccine; Sputnik V vaccine; Sinopharm and the Beijing Institute of Biological Products vaccine. However, the vaccines are yet to reach the majority of the world population. Hence, there is need for concerted effort among governments and non-governmental organizations in all nations to develop the necessary infrastructures to step up vaccine production, and procurement as well as vaccination programmes. There is need for continued effort in biotechnology, to develop COVID-19 therapeutic drugs.",signatures:"Tafirenyika Mafugu",downloadPdfUrl:"/chapter/pdf-download/75270",previewPdfUrl:"/chapter/pdf-preview/75270",authors:[{id:"343964",title:"Dr.",name:"Tafirenyika",surname:"Mafugu",slug:"tafirenyika-mafugu",fullName:"Tafirenyika Mafugu"}],corrections:null},{id:"75920",title:"Different Therapeutic Strategies to Tackle the Infection Associated with COVID-19",doi:"10.5772/intechopen.96899",slug:"different-therapeutic-strategies-to-tackle-the-infection-associated-with-covid-19",totalDownloads:198,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Covid-19 is a pandemic and the whole world is facing the loss in terms of morbidity and mortality of the human resources. Therefore, there is an urgent need for various therapeutic agents or drugs to treat the covid-19 patients. Although, vaccination process is under way, it is not possible to provide the vaccination to whole world in a short period. Therefore, it is an essential strategy to work on the various therapeutic aspects of covid-19 treatment. The present book chapter will discuss and review the various aspects of the treatment strategies of the covid-19. Further, we will provide an overview of the virus and host based potential therapeutic targets along with existing therapeutics which are effective against SARS-CoV-2 virus. Also, the novel vaccines are being developed against covid-19 deadly virus will be discussed.",signatures:"Meemansha Sharma, Thakur Uttam Singh, Madhu Cholenahalli Lingaraju and Subhashree Parida",downloadPdfUrl:"/chapter/pdf-download/75920",previewPdfUrl:"/chapter/pdf-preview/75920",authors:[{id:"158017",title:"Dr.",name:"Thakur Uttam",surname:"Singh",slug:"thakur-uttam-singh",fullName:"Thakur Uttam Singh"},{id:"158019",title:"Dr.",name:"Subhashree",surname:"Parida",slug:"subhashree-parida",fullName:"Subhashree Parida"},{id:"298751",title:"Dr.",name:"Meemansha",surname:"Sharma",slug:"meemansha-sharma",fullName:"Meemansha Sharma"},{id:"349904",title:"Dr.",name:"Madhu",surname:"Lingaraju",slug:"madhu-lingaraju",fullName:"Madhu Lingaraju"}],corrections:null},{id:"75451",title:"COVID-19 Researches: Where India Stands So Far?",doi:"10.5772/intechopen.96397",slug:"covid-19-researches-where-india-stands-so-far-",totalDownloads:210,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"By the end of the year 2019, in the month of November first pneumonia-like case of COVID-19 was detected in an individual aged 55 years in the Hubei Province of Central China. However the ‘patient zero’ or the first patient contracted with the disease is still unknown, but it is speculated that first contraction with virus occurred in Wuhan province of China. The rate by which the number of cases of the disease surged in China was remarkable and by the mid of January 2020 cases begin to appear in different parts of the world. WHO declared the COVID-19 outbreak a Public Health Emergency of International Concern by the end of January 2020. Researchers from different parts of the world continue to study the pathogenesis and spread pattern of this disease. This chapter emphasizes upon some of the prominent studies in the field of COVID-19 researches from India. It also focuses upon the ACE2 gene polymorphism which has decreased the susceptibility against the virus amongst human population, and explains how at the molecular level ACE2 receptor concentration may affect the entry of the virus into the host cell. It also highlights the impact of the viral RNA on mitochondrial machinery of the host cell and how it instigates a pro-inflammatory response by declining the efficiency of immune system in whole. We also aim to highlight two potential drug candidates of COVID-19 and how these are performing against the virus according to several studies.",signatures:"Nikhil Srivastava and Gyaneshwer Chaubey",downloadPdfUrl:"/chapter/pdf-download/75451",previewPdfUrl:"/chapter/pdf-preview/75451",authors:[{id:"344035",title:"Prof.",name:"Gyaneshwer Chaubey",surname:"Chaubey",slug:"gyaneshwer-chaubey-chaubey",fullName:"Gyaneshwer Chaubey Chaubey"},{id:"344038",title:"Mr.",name:"Nikhil",surname:"Srivastava",slug:"nikhil-srivastava",fullName:"Nikhil Srivastava"}],corrections:null},{id:"76012",title:"Sensor Surface Design with NanoMaterials: A New Platform in the Diagnosis of COVID-19",doi:"10.5772/intechopen.97056",slug:"sensor-surface-design-with-nanomaterials-a-new-platform-in-the-diagnosis-of-covid-19",totalDownloads:244,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Mass testing for COVID-19 is essential to defining patient management strategies, choosing the best clinical management, and dimensioning strategies for controlling viral dissemination and immunization strategies. Thus, it is of utmost importance to search for devices that allow a quick and reliable diagnosis of low cost that can be transposed from the bench to the bedside, such as biosensors. These devices can help choose the correct clinical management to minimize factors that lead to infected patients developing more severe diseases. The use of nanomaterials to modify biosensors’ surfaces to increase these devices’ sensitivity and their biofunctionality enables high-quality nanotechnological platforms. In addition to the diagnostic benefits, nanotechnological platforms that facilitate the monitoring of anti-SARS-CoV-2 antibodies may be the key to determining loss of protective immune response after an episode of COVID-19, which leads to a possible chance of reinfection, as well as how they can be used to assess and monitor the success of immunization strategies, which are beginning to be administered on a large scale and that the extent and duration of their protection will need to be determined. Therefore, in this chapter, we will cover nanomaterials’ use and their functionalities in the surface design of sensors, thus generating nanotechnological platforms in the various facets of the diagnosis of COVID-19.",signatures:"Eliete A. Alvin, Anna V.B. e Borges, Rhéltheer de P. Martins, Marcela R. Lemes, Rafaela M. Barbosa, Carlo J.F. de Oliveira, Diógenes Meneses, Bruno G. Lucca, Noelio O. Dantas, Virmondes R. Junior, Renata P.A. Balvedi, Fabiane C. de Abreu, Marcos V. da Silva and Anielle C.A. Silva",downloadPdfUrl:"/chapter/pdf-download/76012",previewPdfUrl:"/chapter/pdf-preview/76012",authors:[{id:"74921",title:"MSc.",name:"Marcos",surname:"Silva",slug:"marcos-silva",fullName:"Marcos Silva"},{id:"340051",title:"Prof.",name:"Anielle C.A.",surname:"Silva",slug:"anielle-c.a.-silva",fullName:"Anielle C.A. Silva"},{id:"346701",title:"Prof.",name:"Noelio",surname:"Dantas",slug:"noelio-dantas",fullName:"Noelio Dantas"},{id:"346965",title:"Prof.",name:"Diógenes",surname:"Meneses",slug:"diogenes-meneses",fullName:"Diógenes Meneses"},{id:"346981",title:"MSc.",name:"Eliete A.",surname:"Alvin",slug:"eliete-a.-alvin",fullName:"Eliete A. Alvin"},{id:"346985",title:"MSc.",name:"Marcela",surname:"Lemes",slug:"marcela-lemes",fullName:"Marcela Lemes"},{id:"346987",title:"Prof.",name:"Carlo",surname:"Oliveira",slug:"carlo-oliveira",fullName:"Carlo Oliveira"},{id:"346988",title:"Prof.",name:"Virmondes",surname:"Rodrigues",slug:"virmondes-rodrigues",fullName:"Virmondes Rodrigues"},{id:"346992",title:"Prof.",name:"Fabiane",surname:"Abreu",slug:"fabiane-abreu",fullName:"Fabiane Abreu"},{id:"350141",title:"Ms.",name:"Anna",surname:"Borges",slug:"anna-borges",fullName:"Anna Borges"},{id:"350142",title:"Ms.",name:"Rafaela M.",surname:"Barbosa",slug:"rafaela-m.-barbosa",fullName:"Rafaela M. Barbosa"},{id:"350143",title:"Ms.",name:"Rhéltheer De P.",surname:"Martins",slug:"rheltheer-de-p.-martins",fullName:"Rhéltheer De P. Martins"},{id:"350144",title:"Prof.",name:"Bruno G.",surname:"Lucca",slug:"bruno-g.-lucca",fullName:"Bruno G. Lucca"},{id:"350146",title:"Prof.",name:"Renata",surname:"Balvedi",slug:"renata-balvedi",fullName:"Renata Balvedi"}],corrections:null},{id:"75473",title:"Role of Graphene and Graphene Derived Materials to Fight with COVID-19",doi:"10.5772/intechopen.96284",slug:"role-of-graphene-and-graphene-derived-materials-to-fight-with-covid-19",totalDownloads:345,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The COVID-19 pandemic is a genuine biosafety occasion that is causing an extreme effect on the worldwide society and economy. Various challenges associated with the outbreak of this pandemic include diagnosis, prevention, and proper medication. Engineered nanomaterials such as graphene and graphene derived materials could be the potential solution in preventing COVID-19. This study endeavors how the improvement of novel materials can assist researchers with handling the difficulties in biosafety. In recent years, 2D graphene had caught much consideration due to its efficient electrical properties and encouraging presentations, comprising methods to combat or identify drug-resistant bacterial contaminations. The bacteria lose its integrity when exposed to the graphene surface because of its efficient viral inhibition tendency.",signatures:"Vamsi Krishna Kudapa, Ajay Mittal, Ishita Agrawal, Tejendra K. Gupta and Rajeev Gupta",downloadPdfUrl:"/chapter/pdf-download/75473",previewPdfUrl:"/chapter/pdf-preview/75473",authors:[{id:"253563",title:"Ph.D.",name:"Rajeev",surname:"Gupta",slug:"rajeev-gupta",fullName:"Rajeev Gupta"},{id:"345087",title:"Prof.",name:"Vamsi Krishna",surname:"Kudapa",slug:"vamsi-krishna-kudapa",fullName:"Vamsi Krishna Kudapa"},{id:"345088",title:"Prof.",name:"Ajay",surname:"Mittal",slug:"ajay-mittal",fullName:"Ajay Mittal"},{id:"345089",title:"Prof.",name:"Tejendra Kumar",surname:"Gupta",slug:"tejendra-kumar-gupta",fullName:"Tejendra Kumar Gupta"},{id:"345090",title:"MSc.",name:"Ishita",surname:"Agrawal",slug:"ishita-agrawal",fullName:"Ishita Agrawal"}],corrections:null},{id:"76669",title:"Propagation Analysis of the Coronavirus Pandemic on the Light of the Percolation Theory",doi:"10.5772/intechopen.97772",slug:"propagation-analysis-of-the-coronavirus-pandemic-on-the-light-of-the-percolation-theory",totalDownloads:185,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Efforts to combat the Covid-19 pandemic have not been limited to the processes of vaccine production, but they first began to analyze the dynamics of the epidemic’s spread so that they could adopt barrier measures to bypass the spread. To do this, the works of modeling, predicting and analyzing the spread of the virus continue to increase day after day. In this context, the aim of this chapter is to analyze the propagation of the Coronavirus pandemic by using the percolation theory. In fact, an analogy was established between the electrical conductivity of reverse micelles under temperature variation and the spread of the Coronavirus pandemic. So, the percolation theory was used to describe the cumulate infected people versus time by using a modified Sigmoid Boltzman equation (MSBE) and several quantities are introduced such as: the pandemic percolation time, the maximum infected people, the time constant and the characteristic contamination frequency deduced from Arrhenius equation. Scaling laws and critical exponents are introduced to describe the spread nature near the percolation time. The speed of propagation is also proposed and expressed. The novel approach based on the percolation theory was used to study the Coronavirus (Covid-19) spread in five countries: France, Italy, Germany, China and Tunisia, during 6 months of the pandemic spread (the first wave). So, an explicit expression connecting the number of people infected versus time is proposed to analyze the pandemic percolation. The reported MSBE fit results for the studied countries showed high accuracy.",signatures:"Moez Guettari and Ahmed El Aferni",downloadPdfUrl:"/chapter/pdf-download/76669",previewPdfUrl:"/chapter/pdf-preview/76669",authors:[{id:"228088",title:"Dr.",name:"Moez",surname:"Guettari",slug:"moez-guettari",fullName:"Moez Guettari"},{id:"349723",title:"Dr.",name:"Ahmed",surname:"El Aferni",slug:"ahmed-el-aferni",fullName:"Ahmed El Aferni"}],corrections:null},{id:"75714",title:"The Link between Electrical Properties of COVID-19 and Electromagnetic Radiation",doi:"10.5772/intechopen.96815",slug:"the-link-between-electrical-properties-of-covid-19-and-electromagnetic-radiation",totalDownloads:575,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The ability of a new vaccine design based on control the intracellular physiological consequences of both the electrical properties and the electromagnetic radiation interactions between a virus and a host cell, which is a method to strengthen immune system develop protection against COVID-19 and new strains. The capacity of COVID-19 to bind to angiotensin-converting enzyme 2 (ACE2) and immune evasion mechanisms are only one of the properties required to stimulate a preventative immune response. In this chapter, a multidimensional new strategy is used to exemplify the empowerment function intracellular and extracellular level information can play in the support of immunogen against COVID-19 pathogens. Besides during this chapter, the nature of electromagnetic radiation is described as a vibrating string based on a string-theory and unification of electromagnetic radiation and gravitational waves by supporting with multiple cites strong evidence. Overall, we demonstrate a new approach to understand the important role of the physiological consequences of the interplay between the immune system and COVID-19 and designing vaccine strategy immunogens that take advantage of that information against COVID-19 and new strains.",signatures:"Awaad K. Al Sarkhi",downloadPdfUrl:"/chapter/pdf-download/75714",previewPdfUrl:"/chapter/pdf-preview/75714",authors:[{id:"343494",title:"Dr.",name:"Awaad K.",surname:"Al Sarkhi",slug:"awaad-k.-al-sarkhi",fullName:"Awaad K. Al Sarkhi"}],corrections:null},{id:"75881",title:"The Economic, Climate Change and Public Health Edges of the Geopolitics of COVID-19: An Exploratory Bibliometric Analysis",doi:"10.5772/intechopen.96797",slug:"the-economic-climate-change-and-public-health-edges-of-the-geopolitics-of-covid-19-an-exploratory-bi",totalDownloads:312,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"We are in the middle of the storm and this does not allow us to see clearly what is coming. This often generates partial analyses of the issues of the situation. Therefore, this manuscript attempts to generate an integral perspective on the issues of the crisis. This chapter proposes a discussion of the Coronavirus crisis following analysis and comparison of the most important outstanding conversations of general public health, economics and environmental issues. The objective of this chapter is to travel on the far side of the discussion of the articles presently planned within the academic world and that were analyzed within the bibliometric review, that consist of these three issues. This analysis that integrates these dimensions allows to give an additional prospective answer to the queries exposed by the COVID crisis, conjointly taking into consideration geopolitics as a forgotten dimension within the public discussion. Our paper helps to indicate the positions of every one of those ideas and enrich the literature on the environmental sciences and public health by providing analysis of the consequences of international policies.",signatures:"Jean Pierre Doussoulin and Benoît Mougenot",downloadPdfUrl:"/chapter/pdf-download/75881",previewPdfUrl:"/chapter/pdf-preview/75881",authors:[{id:"327931",title:"Assistant Prof.",name:"Jean Pierre",surname:"Doussoulin",slug:"jean-pierre-doussoulin",fullName:"Jean Pierre Doussoulin"},{id:"349605",title:"Prof.",name:"Benoît",surname:"Mougenot",slug:"benoit-mougenot",fullName:"Benoît Mougenot"}],corrections:null},{id:"77566",title:"Consequence of Meteorological Parameters on the Transmission of Covid-19",doi:"10.5772/intechopen.98978",slug:"consequence-of-meteorological-parameters-on-the-transmission-of-covid-19",totalDownloads:138,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Coronavirus disease (COVID-19) was first detected in Wuhan, China in December 2019. The characteristics of the spread of COVID-19 infection from one person to another have led to an increasing number of infected cases and caused tremendous pressure around the world. The rapid spread of COVID-19 infection has made it a pandemic. In India, as of mid-May 2020, there were approximately 75,048 confirmed cases and 2,440 deaths due to COVID-19 alone. In order to break the COVID-19 chain, the Indian government decided to implement a lockdown, which was first implemented on March 23, 2020. The significant benefits of the lockdown have led to a reduction in air pollutants in cities around the world. The significant benefits of the lockdown have led to a reduction in air pollutants in cities around the world. The importance of particulate matter, temperature (°C) and relative humidity (%) to the spread of the COVID-19 virus and its correlation with the total number of cases (TC), active cases (AC), recovered cases (RC) and death cases (DC) Reference DEL will be discussed in detail in this chapter.",signatures:"Manish Sharma, Pargin Bangotra and Alok Sagar Gautam",downloadPdfUrl:"/chapter/pdf-download/77566",previewPdfUrl:"/chapter/pdf-preview/77566",authors:[{id:"348163",title:"Dr.",name:"Manish",surname:"Sharma",slug:"manish-sharma",fullName:"Manish Sharma"},{id:"353193",title:"Dr.",name:"Pargin",surname:"Bangotra",slug:"pargin-bangotra",fullName:"Pargin Bangotra"},{id:"420098",title:"Dr.",name:"Alok Sagar",surname:"Gautam",slug:"alok-sagar-gautam",fullName:"Alok Sagar Gautam"}],corrections:null},{id:"77186",title:"COVID-19 Lockdown and the Aerosphere in India: Lessons Learned on How to Reduce Air Pollution",doi:"10.5772/intechopen.98513",slug:"covid-19-lockdown-and-the-aerosphere-in-india-lessons-learned-on-how-to-reduce-air-pollution",totalDownloads:173,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The giant increase in COVID-19 infection across India forced the government to impose strict lockdown in order to curb the pandemic. Although the stringent restrictions crippled India’s economy and poor people’s livelihood, it significantly improved the air quality of most of the polluted cities of India and rejuvenated the atmosphere. Thus, the major objective of this study is to provide a comprehensive overview of lockdown on pollutants prevailing in the atmosphere. A prominent decline in primary pollutants such as Particulate matter (PM), Black carbon (BC), Oxides of nitrogen (NOx), Carbon monoxide (CO) is observed across the country. However, lockdown had a trifling impact on Sulphur dioxide (SO2) concentration over some parts of India due to the constant operation of coal-fired thermal plants as a part of essential service. Furthermore, the sudden decline in NOx concentration disturbed the complex atmospheric chemistry and lead to an enhancement of surface ozone (O3) (secondary pollutant) in many cities of India. Thus, lockdown emerged as a unique opportunity for the atmospheric researchers, policymakers as well as stakeholders to collect baseline data of pollutants and their major sources. This will help to set new targets of air quality standards and to develop various mitigation processes to combat air pollution.",signatures:"Subhasmita Panda, Priyadatta Satpathy, Trutpi Das and Boopathy Ramasamy",downloadPdfUrl:"/chapter/pdf-download/77186",previewPdfUrl:"/chapter/pdf-preview/77186",authors:[{id:"350166",title:"Dr.Ing.",name:"Boopathy",surname:"Ramasamy",slug:"boopathy-ramasamy",fullName:"Boopathy Ramasamy"},{id:"416290",title:"Ms.",name:"Subhasmita",surname:"Panda",slug:"subhasmita-panda",fullName:"Subhasmita Panda"},{id:"416291",title:"Ms.",name:"Priyadatta",surname:"Satpathy",slug:"priyadatta-satpathy",fullName:"Priyadatta Satpathy"},{id:"416292",title:"Dr.",name:"Trupti",surname:"Das",slug:"trupti-das",fullName:"Trupti Das"}],corrections:null},{id:"75897",title:"A Qualitative Study of Pre-Vaccine Decrease of Mortality from COVID-19",doi:"10.5772/intechopen.97017",slug:"a-qualitative-study-of-pre-vaccine-decrease-of-mortality-from-covid-19",totalDownloads:207,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"More than a year has passed since the appearance of disease called COVID-19 in the world. This disease became the reason for unprecedented measures taken so far, having received the classification of pandemic. The world has faced with pandemics before, but society has not yet taken such unprecedented restrictive measures. The restrictions of not only local but even of global nature, such as the suspension of international flights, various scientific and political events were adopted around the world. Media resources have played a key role in the formation and development of the attitude towards the disease in people. Despite all the depressing news, the facts showed a low mortality rate, which is often ignored by the media. As a result, medical staff around the world have faced psychological health issues among the different groups of the population, especially vulnerable ones such as people with chronic disease and with weak immunity. At present, it is early to talk about the results and outcomes of the pandemic. However, previous year has taught us many lessons and can become a key factor in understanding the role of the media in pandemic times, developing strategies for combating diseases and protecting public health.",signatures:"Vugar Mammadov and Lala Jafarova",downloadPdfUrl:"/chapter/pdf-download/75897",previewPdfUrl:"/chapter/pdf-preview/75897",authors:[{id:"344206",title:"Prof.",name:"Vugar",surname:"Mammadov",slug:"vugar-mammadov",fullName:"Vugar Mammadov"},{id:"349935",title:"M.A.",name:"Lala",surname:"Jafarova",slug:"lala-jafarova",fullName:"Lala Jafarova"}],corrections:null},{id:"77494",title:"Targeting Mononuclear Phagocytes to Treat COVID-19",doi:"10.5772/intechopen.98967",slug:"targeting-mononuclear-phagocytes-to-treat-covid-19",totalDownloads:192,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Coronavirus disease 2019 (COVID-19) and its etiological agent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have caused considerable illness and death worldwide. The innate immune system seems to play a principal in the disease, as a hallmark of severe COVID-19 is excessive inflammation. Monocytes and macrophages are important innate immune cells that become pro-inflammatory and promote adaptive immune responses during viral infection. In this chapter we present evidence linking these cells to severity of COVID-19. Namely, monocytes and macrophages infiltrate the infected tissue during the early stages of infection and show pro-inflammatory responses that appear to be linked to those predicting tissue pathology during disease. Additionally, studies in isolated cells demonstrate that monocytes and macrophages respond by producing pro-inflammatory cytokines when directly stimulated by SARS-CoV-2. While most anti-inflammatory pharmaceutical treatments for COVID-19 have focused on systemic infiltration, some of the most promising have known or suspected effects on monocyte and macrophage inflammatory responses. Therefore, targeting these cells to treat severe COVID-19 is a promising strategy for this important disease.",signatures:"Brandt D. Pence and Theodore J. Cory",downloadPdfUrl:"/chapter/pdf-download/77494",previewPdfUrl:"/chapter/pdf-preview/77494",authors:[null],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6417",title:"The Management of Clinical Trials",subtitle:null,isOpenForSubmission:!1,hash:"5e50e22f9fc899a4c438299287c506f9",slug:"the-management-of-clinical-trials",bookSignature:"Hesham Abdeldayem",coverURL:"https://cdn.intechopen.com/books/images_new/6417.jpg",editedByType:"Edited by",editors:[{id:"72383",title:"Prof.",name:"Hesham",surname:"Abdeldayem",slug:"hesham-abdeldayem",fullName:"Hesham Abdeldayem"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10328",title:"AIDS Updates",subtitle:"Recent Advances and New Perspectives",isOpenForSubmission:!1,hash:"a3eff37a164c0b098d04379946609f12",slug:"aids-updates-recent-advances-and-new-perspectives",bookSignature:"Samuel Ikwaras Okware",coverURL:"https://cdn.intechopen.com/books/images_new/10328.jpg",editedByType:"Edited by",editors:[{id:"178641",title:"Dr.",name:"Samuel Ikwaras",surname:"Okware",slug:"samuel-ikwaras-okware",fullName:"Samuel Ikwaras Okware"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8794",title:"Leading Community Based Changes in the Culture of Health in the US",subtitle:"Experiences in Developing the Team and Impacting the Community",isOpenForSubmission:!1,hash:"5044f7244f5d99791ec13482f276a075",slug:"leading-community-based-changes-in-the-culture-of-health-in-the-us-experiences-in-developing-the-team-and-impacting-the-community",bookSignature:"Claudia S. 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Internationally recognized for her scholarly work and expertise in community-engaged and patient-oriented research, Dr. Corbie-Smith has empirically studied methodological, ethical, and practical issues relating to studying racial disparities in health. Dr. Corbie-Smith has served as the Principal Investigator of several community-based participatory research projects focused on disease risk reduction among rural racial and ethnic minorities. These projects have included funding through the National Heart Lung and Blood Institute, the Robert Wood Johnson Foundation (RWJF), the National Center for Minority Health and Health Disparities, the National Institute of Nursing Research, Greenwall Foundation, and the National Human Genome Research Institute. Dr. Corbie-Smith is accomplished in drawing communities, faculty, and healthcare providers into working partnerships in clinical and translational research. This engagement ultimately transforms the way that academic investigators and community members interact while boosting public trust in research. She has also shown a deep commitment to working in North Carolina by bringing research to communities, involving community members as partners in research, and improving the health of minority populations and underserved areas. In 2013 she established the UNC Center for Health Equity Research (CHER) to bring together collaborative multidisciplinary teams of scholars, trainees, and community members to improve North Carolina communities’ health through a shared commitment to innovation, collaboration, and health equity. Dr. Corbie-Smith is also the Co-Principal Investigator for RWJF’s Advancing Change Leadership Clinical Scholars Program, which provides intensive learning, collaboration, networking, and leadership development to seasoned clinicians to create a community of practitioners promoting health equity across the country. She served as President of the Society of General Internal Medicine (SGIM) in 2018–2019. In 2018 she was elected to the National Academy of Medicine. In 2019 Dr. Corbie-Smith created and is the current host of A Different Kind of Leader, a podcast that captures insights from diverse leaders so that organizations are in a stronger position to grow, innovate, and meet the challenges of our day. Dr. Corbie-Smith earned her MD from the Albert Einstein College of Medicine, NY, and MSc in Clinical Research from Emory University, Georgia.",institutionString:"The University of North Carolina at Chapel Hill",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of North Carolina at Chapel Hill",institutionURL:null,country:{name:"United States of America"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"3",chapterContentType:"chapter",authoredCaption:"Authored by"}},{type:"book",id:"7856",title:"Nutrition and HIV/AIDS",subtitle:"Implication for Treatment, Prevention and Cure",isOpenForSubmission:!1,hash:"94229224705db9f1cd430a32aa777bef",slug:"nutrition-and-hiv-aids-implication-for-treatment-prevention-and-cure",bookSignature:"Nancy Dumais",coverURL:"https://cdn.intechopen.com/books/images_new/7856.jpg",editedByType:"Edited by",editors:[{id:"40783",title:"Dr.",name:"Nancy",surname:"Dumais",slug:"nancy-dumais",fullName:"Nancy Dumais"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Significant losses due to mycotoxins and their impact on human and animal health have been linked with national economic implications and all these factors have combined to make mycotoxins important worldwide (Bhat and Vashanti (1999). According to Plancinta
In order to understand the mechanisms that can be adopted for controlling mycotoxins, it is essential to have relevant information on the prevailing climatic conditions in the agricultural zones where the crops are being produced. Thus Bhat and Vasanthi (2003) noted that in developing countries of the world, tropical conditions like high temperatures and moisture, monsoons, unseasonal rains during harvest and flash floods can lead to fungal proliferation and production of mycotoxin. In temperate climates, the most important toxins are deoxynivanelol, (DON), zearalenone, diacetoxyscirpenol (DAS), T-2 toxin and fumonisins (Balazs and Schepers, 2007) and in Europe, the most frequent toxigenic fungi are
In cereals grown in temperate regions of America, Europe and Asia,
Consumption of commodities contaminated with mycotoxins according to Bathnagar and Garcia (2001) leads to chronic mycotoxicoses which results in acute poisoning resulting in death. Therefore, as the global occurrence and importance of mycotoxins cannot be overemphasized, methods for preventing and reducing them before entering the food chain must be given continuous attention as 40% of the productivity lost to diseases in developing countries has been associated with diseases exacerbated by aflatoxins (Miller,1996).
There are over 300 mycotoxins that have been isolated and characterized (Adegoke, 2004). From the standpoints of health and trade, important mycotoxins are aflatoxins, ochratoxins, deoxynivalenol, zearalenone, fumonisin, T-2 and T-2 like toxins
(trichothecenes) and alternariol. Thomson and Henke (2000) noted that crops in tropical and subtropical areas are more susceptible to mycotoxin contamination than those in temperate zones because the high humidity and temperatures in tropical areas provide optimal conditions for toxin formation. Furthermore, it has been reported that drought conditions can stress plants and render them susceptible to contamination by
In the food chain, there are some ‘time-bound’ factors that are important in the production of mycotoxins during pre-harvest and post-harvest handling of agricultural products like:
intrinsic factors: moisture content, water activity, substrate type, plant type and nutrient composition;
extrinsic factors: climate, temperature, oxygen level;
processing factors: drying, blending, addition of preservatives, handling of grains
implicit factors: insect interactions, fungal strain, microbiological ecosystem (Magan
Generally, mycotoxin contamination of agricultural products can be prevented using
pre-harvest methods:
using resistant varieties;
field management;
use of biological and chemical agents;
harvest management and
post-harvest methods:
improved drying methods;
good storage conditions;
use of natural and chemical agents
irradiation (Kabab
The inclusion of sorbent materials in feed or addition of enzymes or microorganisms capable of detoxifying mycotoxins have been reported to be reliable methods for mycotoxin prevention in feeds (Jard et al. 2011). However, while bentonite and aluminosilicate clays have been used as binding agents for reducing aflatoxin intoxication in pigs (Schell
Aflatoxins
Aflatoxins may be produced by three species of
With thorough drying and proper storage of groundnuts in Guinea, Turner
Employing food safety practices like hazard analysis critical control point (HACCP) system can be useful in preventing and reducing aflatoxin contamination in agricultural products. Hell et al. (2000a) thus noted that cleaning stores before loading new produce correlated with reduced aflatoxin levels. Preharvest HACCP programmes (FAO/IAEA,2001) are available for controlling aflatoxin in corn and coconuts in South east Asia, peanuts, peanut products in Africa, nuts in West Africa, patulin in apple juice and pistachio nuts in South America. While Aldred and Magan (2004) suggested some HACCP approaches for wheat-based commodities, Lopez-Garcia
Application of potential bio-control agents like atoxigenic strains of
Spices and herbs and their bioactive components have been found useful for the reduction of aflatoxins. Olojede
In other studies conducted in a developing country, processing was found to reduce aflatoxins in cereal pastes boiled for 30 and 60 minutes by 68% and 80.8% respectively (Adegoke, et al. 1994). During the processing of cassava bread- a cassava-based product, while the initial raw material had aflatoxin level of 1.91µg /kg, however, after processing, the final concentration of aflatoxin in the final product, cassava bread, was found to be 0.03µg/kg (Adegoke et al. 1993). Roasting of peanuts has been reported to have more effect on reducing chemically detectable aflatoxins than boiling (Njapau
Camou-Arriola and Price (1989) found that using 1210C and alkaline treatment of naturally contaminated corn prior to frying resulted in very low levels of chemically detectable aflatoxin. Wet, dry milling processes and heat during cooking processes have been found to be effective in reducing levels of aflatoxin in foods (Scott, 1984). Conway et al. (1978); Hale and Wilson (1979) also found significant decreases in aflatoxin content arising from heating and roasting of corn.The use of traditional processing for reducing aflatoxin has also been examined, for example, Hwang
Detoxification using ozone has been found by some workers to be useful in reducing aflatoxins in food commodities for example de Alencar et al. (2012) noted reductions of 30 % and 25 % for total aflatoxins and aflatoxin B1 when peanuts were exposed to 21 mg L -1 of ozone. McKenzie
Ochratoxins
Benford et al. (2001) noted that
Post-harvest measures for preventing OTA from entering the food chain have been documented. Magan and Aldred (2007) suggested the following post-harvest critical control points-that can be equally adopted in developing countries:
regular and accurate moisture content measurements;
efficient and prompt drying of wet cereal grains for safe moisture levels (maize, 14%; rice, 13-14 %; barley, 14-14.5 % and canola or rapeseed, 7-8 %);
infrastructure for quick response including provision for segregation and appropriate transport conditions;
appropriate storage conditions at all stages in terms of moisture and temperature control, general maintenance and effective hygiene of storage facilities for prevention of pests and water ingress.
Modifying the gases in atmospheres where cereals are stored can be used in the prevention of OTA production. Paster
Using a combination of cleaning, scouring and removal of the bran and offal fraction, Scudamore
In grossly contaminated samples of cocoa beans, the essential oils of some plants can be used to reduce OTA contamination, for example, Aroyeun and Adegoke (2007) used the essential oils of
Fumonisins
Fumonisins are produced by
In developing countries and other countries where fumonisins occur in maize, useful pre-and post-harvest preventive strategies have been suggested by Maga and Aldred (2007):
pre-harvest measures:
proper selection of maize hybrids, prevention of use of soft kernel hybrids;
no late sowing dates and avoiding high cropping density;
good and balanced fertilization;
avoiding late harvesting;
effective control of pests for example corn borer.
post-harvest measures:
minimizing periods between harvesting and drying
effective cleaning of maize prior to storage;
efficient drying to less than 14 % moisture content;
effective hygiene and management of silos;
absence of pests in store-pests can provide metabolic water and initiate heating.
Insect damage of maize is a good prediction of
clear specifications and traceability from field to store.
While these pre-and post-harvest techniques for fumonisin management are not difficult to practise in developing countries, use of solar energy has been found useful elsewhere. Ahmad and Ghaffan (2007) in Pakistan noted that soil solarization was useful in reducing the incidence of corn ear rots and consequently fumonisins and aflatoxins in fields and stored corns. Processing can also be used for reducing fumonisins in food commodities as Jackson et al (1997) noted that when corn-based batter (for making muffins) was baked at 1750C and 200 0 C for 20 minutes, reductions of 15 % to 30 % respectively were found with increasing losses as the temperature increased. Voss
Patulin
Food commodities commonly affected by pathogens that produce patulin are apple, grape, pear, apricots and peaches (Speijers, 2004). The most important aspect of handling patulin is by controlling the quality of fruit before it enters the food chain as patulin is not found in intact fruit because it is the damage done to the surface of the fruit which makes the fruit susceptible to infection by
In reducing mycotoxin accumulation, it must be realized that the concentrations of aflatoxins, deoxynivalenol or fumonisins are greater in symptomatic than in non-symptomatic maize ears or kernels, thus, prevention or reduction in pre-and post-harvest infection is a critical factor (Scott and Zumno 1995; Reid
For sustained management of mycotoxins along the food chain, the following procedures are recommended:
HACCP-compliance: good agronomic practices through transportation and up to consumption;
best practices for harvesting, drying and storage of agricultural products coupled with effective insect management;
adoption and sustainability of relevant food safety education;
careful and systematic enforcement of legislation on food safety.
screening in developing countries where fruits and berries are grown and exported for alternariol, alternariol methylether and tenuazonic acid-mycotoxins produced by
adoption and utilization of sensitive and reliable methods for detection of mycotoxins. For public health protection and international trade, sensitive and accurate analytical methods are needed for mycotoxins (Rahmani et al. 2009).
sustained examination of agricultural commodities under different prevailing climatic conditions.
Rapid development and unification of the terrestrial part pertained to IMT-2020 (5G) as well as the limitations claimed for global coverage by terrestrial 5G networks, when using millimeter-wave band (MMWB), calls design engineers for special attention to this potential market segment of mobile satellite telecommunications.
In Summer 2017, within the framework of Paris air show in Le Bourget, European Space Agency (ESA) launched its new project “Satellite for 5G,” compiling 16 satellite businesses into consortium aimed at study to introduce 5G satellite-based access components [1].
The consortium is made up of such organizations and institutions as: EURESCOM, Fraunhofer Fokus, Fraunhofer IIS, NewTEC, SES, TU Berlin, and Universität der Bundeswehr. They all have conducted the work concerning the design of SATis5 intended to facilitate implementation, deployment, and evaluation of the integrated 5G satellite network, unveiling the advantages of satellite and terrestrial framework integration for advancing new technologies.
Additionally, the Working Group FM44 of ECC CEPT completed the preparation of ECC Report “Satellite Solutions for 5G” [2] that will determine the role of satellite component within 5G conception of in relation to the Regions, where services cannot be carried out in circumvention of satellites. In its turn, CEPT came forward with initiative to estimate the pros of satellites for 5G in terms of efficiency, capacity, and stability. Since CEPT Administrations are considering the issues related to 5G implementation in the nearest future, so the studies of satellite access in 5G are expected to facilitate the process of decision-making regarding the potential role of satellite subscriber’s links in the 5G ecosystem.
The implementation of 5G satellite component for 5G service access on principles “at any time with any user in any place” helps to meet many challenges. However, there are numerous other hindrances requiring comprehensive and global studies.
Generally, the regions that are subject to coverage by terrestrial mobile networks of radio access are of fragmentary nature and correspond with the places of population concentration, regarding the economic expediency of base stations building. In some cases, the sparsely populated territories not covered by modern telecommunications. Thus, at the outset of 3G (IMT-2000) development, the universal coverage by mobile services was the key prerequisite for network construction, contributing to the formation of global 3G segment. However, in the course of 4G network evolution, the idea of global coverage by these networks was not even contemplated, in the hope of finding the convergent solutions in the field of satellite and terrestrial mobile telecommunications.
The concept of 5G satellite component considered nowadays rests upon the following preconditions [3]:
5G satellite component is to be integrated into other mobile and fixed networks, but not as autonomy one for the provision of 5G services. The integration of satellite and terrestrial 5G segments forms the key aspect of this vision;
Satellite communication systems are fundamental components for reliable delivering of mobile services, not only in Europe, but also in other regions of the world as by continuum over time and at a reasonable price;
5G satellite component will facilitate universality of 5G networks as well as the solution for various issues dealt with maintenance of multimedia traffic growth, global coverage, M2M, and critical telecommunications (emergency and natural disasters) in optimizing costs for end-users;
Satellite component may become a part of configuration for 5G hybrid network, consisted of combination of broadcasting and broadband infrastructures, run in a manner to ensure uninterrupted and online convergence of 5G services for all end-users.
The requirements for 5G satellite component will be defined by, first of all, the aggregate of services carried out by 5G, consolidated in the families of usage scenarios of 5G terrestrial segment [4, 5]: enhanced Mobile Broadband (eMBB), Massive Machine-Type Communications (mMTC or mIoT), and Ultra-Reliable Low Latency Communication (URLLC).
The potential of satellite networks to uphold the key scenarios for 5G applications is specified by already existing characteristics applicable to modern satellite networks as well as tendencies in satellite technology development in future:
5G satellite networks are such networks, where radio access network NG-RAN is designed by means of satellite network utilization. Technical specifications of 3GPP [3] identified several cases for 5G satellite network use, presented below.
However, these cases do not finish and limit possibility of 5G satellite segment applications and will be proceeded in 3GPP study in Release 17 on 5G evolution.
The main flaw of satellite segment consists in increased delay of information transfer owning to distance between user units and gNB base station. The requirements submitted to the quality of service for data transfer within 5G satellite segment also depend on the relevant number of satellites in operation. The minimum quantity of satellites in operation needed to maintain radio coverage for orbits of different heights [6] is shown in Table 1.
Types of satellite orbits | Height, km | Number of satellites |
---|---|---|
Low earth orbit (LEO) | 800 | ≈ 80 |
1400 | ≈ 50 | |
Medium earth orbit (MEO) | 8000 | ≈ 10 |
Geostationary earth orbit (GEO) | 35,786 | ≈ 3 |
Minimum satellites needed to maintain global radio coverage.
The signal delays forming for different satellite orbits and satellite limits on satellite segment delays are presented in Table 2. Additionally, the indicated delays are summarized with 5 ms delay, added by satellite. Therefore, maximum delay limits reach 30, 90, and 280 ms.
Types of satellite orbits | Delays in link “User terminal-satellite”, ms | Maximum one-way delay, ms | |
---|---|---|---|
Minimum | Maximum | ||
LEO | 3 | 15 | 30 |
MEO | 27 | 43 | 90 |
GEO | 120 | 140 | 280 |
UE to satellite propagation delay.
Other QoS-requirements (Default Priority Level, Packet Delay Budget, Packet Error Rate) for 5G satellite segment have set in 3GPP technical specifications.
On the one hand, spectrum and wide bandwidth for 5G terrestrial networks will require utilization of millimeter-wave (mm-wave) bands to provide data transfer speed reaching up to 20 Gigabits per second in 5G radio interface connect with the process of delivery of the extended broadband mobile access (eMBB) service. On other hand such requirements to use frequency channels with bandwidth from 50 up to 400 MHz for eMBB-services can provide only in mm-wave bands which already utilized within satellite networks. That is why mm-wave bands in nearest future will turn out to be the most requested in 5G and satellite communications.
World Radiocommunication Conference 2019 (WRC-19) allocated of additional mm-wave frequency bands 24.25–27.5 GHz, 37–43.5 GHz, and 66–71 GHz for 5G terrestrial networks on a global basis. In a series of countries and regions, frequency bands of 45.5–47 GHz and 47.2-48.2 GHz received complimented allocation to terrestrial segment of IMT. This decision WRC-19 will be allowed to use some part of mm-wave bands on spectrum sharing basis for 5G satellite and 5G terrestrial network segments.
Table 3 shown the basic frequency bands allocated to fixed and mobile satellite services, sited within the band from 10.7 to 275 GHz, designed for satellite networks and satisfied the needs for 5G channel bandwidths [7].
Up-link | Down-link | Intersatellite link | |||
---|---|---|---|---|---|
Frequency range (GHz) | Bandwidth (GHz) | Frequency range (GHz) | Bandwidth (GHz) | Frequency range (GHz) | Bandwidth (GHz) |
12.5–13.25 | 0.75 | 10.7–11.7 | 1.0 | 22.55-23.55 | 1.0 |
13.75–14.8 | 1.0 | 17.7–21.2 | 3.5 | 25.25-27.5 | 2.25 |
27.5–31.0 | 3.5 | 37.0–42.5 | 5.5 | 59.0-66.0 | 7.0 |
42.5–47.0 | 4.5 | 66.0-76.0 | 10.0 | 66.0-71.0 | 5.0 |
48.2–50.2 | 2.0 | 123.0-130.0 | 7.0 | 116.0-123.0 | 7.0 |
50.4–51.4 | 1.0 | 158.5-164.0 | 5.5 | 130.0-134.0 | 4.0 |
81.0–86.0 | 5.0 | 167.0-174.5 | 7.5 | 174.5-182.0 | 7.5 |
209.0–226.0 | 17.0 | 191.8-200.0 | 8.2 | 185.0-190.0 | 5.0 |
252.0–275.0 | 23.0 | 232.0-240.0 | 8.0 | ||
Total of bandwidth | Total of bandwidth | Total of bandwidth |
Frequency bands allocated to fixed and mobile satellite services.
The analysis of spectrum bands within 12.5–86 GHz has revealed the availability of frequency bands with total bandwidth equals 17.75 GHz in up-link (UL) bands and within 10.7–76 GHz – the availability of frequency bands with total bandwidth equals 20 GHz in down-link (DL) bands for satellite networks.
In order to ensure the provision of services in the field of mass deployment of IoT devices in 5G satellite segment, it was suggested that part of S-band should utilize as a potential option with 30 MHz bandwidth [8]:
uplink (IoT device–satellite) in band: 1980–2010 MHz;
downlink (satellite–IoT device) in band: 2170–2200 MHz.
The connection between satellite 5G base station gNB and feeder link of satellite network can be performed in one of the fixed satellite service bands.
Furthermore, the study of most popular frequency bands, namely Ka-band (28 GHz) and Q/V-bands (37–53 GHz), has exposed the following features which are to be considered while elaborating the solutions for 5G.
While considering the use of Ka-band for 5G satellite segment, one should bear in mind that:
Ka-band is a traditional satellite band, enhancing access for satellite networks;
a part of this band has allocated for 5G terrestrial networks on a global basis by WRC-19;
a few national administrations are reviewing this band in terms of 5G terrestrial networks use.
While considering the use of Q/V-bands (37-53 GHz) for 5G satellite network, one should bear in mind that:
V-band has not been used yet for satellite applications, in particular, for feeder lines of satellite network;
a part of V-band has been added into bands which has allocated for 5G terrestrial networks on a global basis by WRC-19;
3GPP accelerates common efforts on joint researches as well as study of requirements attached to satellite as well as terrestrial segment of 5G in V-band in Release 17.
Thus, 5G satellite segment can be constructed as the multiband one, as well as 5G terrestrial segment, which was divided into frequency bands lower 6 GHz (FR1) and higher 6 GHz (FR2) also.
The main standardization body – 3GPP responsible for technical specifications on 5G equipment and 5G infrastructure conducted first studies regarding 5G satellite segment use, while elaborating Release 14 within Technical report 3GPP TR 38913 [4].
5G satellite options, presented by 3GPP related to the deployment of 5G satellite segment, are designed for 5G services delivery in areas, where their provision by 5G terrestrial segment is impeded as well as for the services supported by satellite systems.
According to Report [4], 5G satellite segment is to complement 5G services, which delivering especially on road, rail and waterways as well as in rural regions, where access to 5G terrestrial segment is unavailable. 5G services supported via 5G satellite segment go beyond data and voice communications, providing connection with IoT devices and M2M, access to broadcasting services and a number of other services, that is tolerant of signal delays.
Partnership project 3GPP has come up with three options in respect of deployment, shown in Table 4 [4].
Technical parameters | Option 1 | Option 2 | Option 3 |
---|---|---|---|
Carrier frequency | Around 1.5 or 2 GHz for both DL and UL | Around 20 GHz for DL Around 30 GHz for UL | Around 40 or 50 GHz |
Duplexing | FDD | FDD | FDD |
Satellite architecture | Bent-pipe | Bent-pipe, on-board processing | Bent-pipe, on-board processing |
Typical satellite system positioning in the 5G architecture | Access network | Backhaul network | Backhaul network |
System bandwidth (DL + UL) | Up to 2 × 10 MHz | Up to 2 × 250 MHz | Up to 2 × 1000 MHz |
Satellite orbit | GEO, LEO | LEO, MEO, GEO | LEO, MEO, GEO |
UE distribution | 100% out-of-doors | 100% out-of-doors | 100% out-of-doors |
UE mobility | Fixed, portable, mobile | Fixed, portable, mobile | Fixed, portable, mobile |
Satellites and frequency band options for 5G deployment.
The satellite orbits, shown in Table 4 and in Figure 1 enable using:
Geostationary satellites (GEO), located at an altitude of 35,786 km, providing full coverage of the Earth by a constellation ranging from one up to three satellites between 70°N and 70°S;
Medium Earth orbit (MEO), located at an altitude of 8000–20,000 km over the surface of the Earth, providing full coverage of the Earth by satellites ranging from 10 up to 12 satellites.
Low Earth Orbits (LEO) at an altitude of 500–2000 km above the Earth secures the continuity of coverage by satellite network with satellites ranging from 50 up to 100 satellites.
Typical earth orbit of communication satellite.
The frequency bands, specified in Table 4, are applicable solely to a part of satellite bands (Figure 1), whereas modern satellite networks are deployed in broad spectrum of frequency bands, including L-band (1–2 GHz), S-band (2–4 GHz), C-band (3.4–6.725 GHz), Ku-band (10.7–14.8 GHz), Ka-band (17.3–21.2 GHz, 27.0–31.0 GHz), Q/V-bands (37.5–43.5 GHz, 47.2–50.2 GHz and 50.4–51.4 GHz), and higher.
The system architecture of 5G satellite segment is being constructed based on the use cases, mentioned in Section 1 of this chapter and two satellite technologies:
The architecture based on the technology of bent-pipe (with invisible satellite transponders without On-Board Processing) – this option envisages signal reception from user devices, its amplification, its transfer on other frequency and relaying in the direction of satellite gateway.
The architecture based on the technology of On-Board Processing (with satellite transponders, complimented with data processing on board) – this option implies signal reception from user devices, its regenerations, including modulation and demodulation, encryption and decryption of these signals. The architecture on-board processing also provides for the partial allocation of base station equipment on the board of a satellite.
In December 2017, 3GPP in scope of work on Release 16 was published Report on using satellite access in 5G [3]. The Report submitted new business cases of 5G satellite segment utilization, including Internet of Things alongside with the requirements for performance of cross-border connections and the key characteristics for satellite segment of 5G: types of orbits, coverage area, and signal delays during propagation, network architecture for 5G satellite segment.
In accordance of proposed solutions, 5G satellite segment is inculcated into the integrated radio access network (5G RAN), which will be used satellite infrastructure and 5G core network (5G Core). 5G core can be linked up with the other generation RANs, in particular, 4G RAN, apart from satellite segment for 5G.
System architecture of 5G satellite segment, which is to be set up in accordance with the technology of bent-pipe (with transparent satellite transponders) when signal use solely to amplification and signal conditioning on retention of a modulation type has shown in Figures 2 and 3.
Signals relay architecture for 5G NR radio interface.
Relaying architecture based on 5G user device with UE relay.
As one can see in Figures 2 and 3, bent-pipe architecture refers to the architecture where the satellite transponders are transparent: only amplify and change frequency but preserve 5G waveform.
One of the important features of 5G radio access network design is that gNB base stations have a distributed architecture (Figure 4) and consist of a central module gNB-CU and one or more distributed modules gNB-DU(s) [9].
Architecture 5G base station gNB.
The gNB-CU and gNB-DU modules are connected by a logical interface F1. The distributed module gNB-DU supports one or more cells and can only be attached to one central module gNB-CU. This architecture of the gNB base station allows to implement the concept of building an integrated 5G radio access network by placing the gNB-CU and gNB-DU modules at earth stations and realization of F1-interface as a space link based on bent-pipe technology.
System architecture of 5G satellite segment when gNB-CU and gNB-DU modules connected each other through F1-interface by satellite links for on bent-pipe technology has shown in Figure 5.
Architecture 5G base station gNB with F1-satellite interface.
Next options of bent-pipe architecture of 5G satellite segment has used for retranslation NG1 and NG2 interfaces, which connecting 5G base stations gNBs to 5G core. This architecture of 5G satellite segment is shown in Figure 6.
Signals relay architecture for NG1 and NG2 interfaces.
In case where 5G user device (UE) has opportunity to use satellite modem with non-3GPP radio interface for bent-pipe architecture of 5G satellite segment, the architecture option of such segment could design as shown in Figure 7. 5G satellite segment architecture shall support different configurations where the radio access network is either a satellite NG-RAN or a non-3GPP satellite access network, or both.
Signals relay architecture for non-3GPP interface.
Figure 8 shows the 5G satellite segment system architecture implemented on the basis of on-board signal processing technology (with partial deployment of base station processing equipment in satellite). As on-board signal processing payload uses distributed module gNB-DU of 5G base station and as satellite link utilizes 5G NR radio interface.
5G satellite segment architecture based on the on-board processing technology [
In accordance design principle of base stations gNBs, some distributed modules gNB-DUs can connect to only one central module gNB-CU. That makes easier 5G coverage of big areas. The solution for 5G satellite segment architecture on regenerative payload enabled NR-RAN with intersatellite links (ISL) for regional or global coverage shown in Figure 9 [10]. Intersatellite links provide logical F1-interface between distributed modules gNB-DUs, which use Satellite Radio Interface (SRI) over F1 as a transport link between remote radio unit with gNB-CU and satellites.
5G satellite segment architecture on regenerative satellite payloads enabled NR-RAN, with ISL for regional or global coverage.
Second solution for 5G satellite segment architecture (Figure 10) has used 5G base station gNB on satellite (as regenerative payload) enabled NR-RAN with ISLs that provide SRI application over Xn-C and Xn-U interfaces. In this case between remote radio units and satellite gNBs will be used, and 5G standard NG-interfaces connect these gNBs with 5G core network.
5GS with regenerative satellite enabled NR-RAN, with ISL and multiple 5G Core connectivity.
Mobile devices of 5G satellite segment architecture (Figures 2–10) will be presented on the market by user terminals as well as the other wearable devices, installed in cars, ships, planes, etc. Nowadays the potential of wearable satellite user terminals is limited to L- and S-frequency bands. However, the studies regarding the potential functioning of 5G satellite user terminals within Ku and mm-wave bands are still ongoing.
Analysis of proposals and technological projects launched by leading manufacturers and related to usage of satellite networks for expanding the capabilities of 5G networks shows that Boeing [11] and Samsung [7] companies have already tried to make presentations of their projects applicable for 5G satellite segment deployment.
The Boeing company requested the US Federal Communications Commission for permission to launch and operate fixed satellite service (FSS) network on non-geostationary orbit (NGSO). The network would operate in a low-Earth orbit (LEO) in the frequency band 37.5–42.5 GHz (space-Earth) and in the frequency bands 47.2–50.2 and 50.4–52.4 GHz of V-band (Earth-space); it would be used as a NGSO system providing solution of 5G satellite segment operation issues.
The Boeing proposed NGSO system as depicted in Figure 11 and considered as a 5G satellite segment that is designed to provide a wide range of modern telecommunication services alongside with 5G internet services for a broad types of V-band earth stations and user terminals. V-band user terminals use modern antenna arrays for transmitting and receiving broadband signals in channels of different pass bands. It is to note that a high throughput is supported by multichannel and multiple polarization terminals.
Satellite solution of the Boeing company.
The Boeing presented NGSO system would consist of 2956 LEO satellites for the fixed satellite service network providing high throughput low latency access for user terminals connected through gateway (“hubs”) access to 5G network and to a terrestrial optic-fiber network as backhaul connecting to 5G.
The system gateways are expected to be located outside the densely populated areas in the regions with relatively low consumer demand for 5G services. Each NGSO satellite would form beams, corresponding to cell diameter from 8 up to 11 km on the Earth surface within the overall satellite coverage area.
The NGSO system gateways would operate in the same V-band as user terminals. These gateways would support both frequency and polarization selection of signals with two types of antennas polarization LHCP (Left Hand Circular Polarized) and RHCP (Right Hand Circular Polarized). In addition, the access gateways may contain more than one antenna thereby providing simultaneous access to multiple NGSO satellites visible from a relevant access gateway.
At the first stage of deployment, the Boeing NGSO system would comprise a constellation of 1396 LEO satellites in an altitude of 1200 km. The initial satellite constellation would consist of 35 circular orbital planes with an inclination of 45° and additional 6 circular planes inclined at 55°.
The NGSO system payload (Figure 12) would use the improved space-time processing in the course of antenna beam-forming as well as on board digital processing so as to generate thousands of narrow-band beams to provide 5G network services through satellite segment on the Earth surface.
Scheme of on-board processing payload.
Each satellite up-link or down-link may consist of up to five channels of 1 GHz pass band resulting in a total pass band of 5 GHz depending on instant capacity required for a cell supported by a relevant satellite antenna beam. Any satellite UL-channel may be connected to any satellite DL-channel in compliance with used connection algorithm.
Boeing company estimation results show that usage of a satellite network for fixed satellite channels and its spectrum sharing with a 5G terrestrial network in the frequency band 37.5–40.0 GHz would be feasible under the following conditions:
the frequency band 37.5–40.0 GHz is used only for signal reception in FSS network downlink;
spectrum sharing between 5G satellite segment and 5G terrestrial segment is feasible due to high satellite elevation angles;
applying of space-time selection beam-forming methods for terminal antennas of satellite networks and 5G equipment in the aim to achieve higher data rate.
The power flux density (PFD) limits approved by ITU [11, 12] would provide protection for 5G network terrestrial segment from interference caused by FSS satellite network downlinks subject to meeting the requirement of minimal reducing of 5G terrestrial network signal level to 0.2–0.6 dBW.
Boeing simulation results also show that in the assumed spectrum sharing scenario the increasing of 5G base station power would result in enlarging a number of satellite receivers affected by interference from 5G users. Hence, it is required to adopt a (>50 dBW) level of mitigating the interference from 5G networks between FSS earth station receivers and transmitting mobile and base stations of 5G terrestrial segment.
The results of Boeing statistical simulation and quantitative estimation of interference levels show that:
satellite earth stations may be in a higher degree directly affected by 5G base stations interferences;
EIRP values for 5G terrestrial segment should be limited to 62–65 dBW, so as to facilitate interference-free shared operation of 5G satellite and terrestrial segments of FSS system to provide for achieving the required data transfer rates in 5G networks.
Therefore, the joint deployment of satellite and terrestrial segments of 5G network is subject to particular conditions related to joint use of spectrum in V-band.
As confirmation, possibility of successfully utilization integrated satellite segment into 3GPP 5G testbed networks was the last demonstration of Surrey University achievements in 5G satellite network development [13].
Three use cases were demonstrated over a live satellite network via Avanti’s GEO HYLAS 4 satellite and using iDirect’s 5G-enabled Intelligent Gateway (IGW) satellite ground infrastructure that to 5G testbed core network of the University of Surrey to 5G UE terminals. All the 5G testbed use cases used this integrated 5G satellite system for the live satellite connectivity.
The use-case for 5G moving platform was demonstrated over SES’s O3b MEO satellite system, using real terminals and 5G core network.
The need to provide the coverage of large areas of developed countries with 5G networks and the creation of 5G satellite segment of integrate 5G system become relevant issues of development and standardization of 5G networks at the second stage of building these networks in the period 2020–2025, playing the pivotal role in forging Digital economy.
3GPP efforts allowed to obtain many different use cases of 5G satellite segment applications, architecture solutions on bent-pipe, and on-board processing technologies, which would implement in development of future satellite systems.
The leading international organizations in the field of telecommunications as ITU, 3GPP, 5G PPP joined their efforts with consortiums and satellite manufacturers in conducting the researches related to the elaboration of 5G within the radio frequency ranges that have been allotted to satellite radio service to 5G on WRC-19, especially in S-, Ka- and V-bands.
One of the most important issues of 5G satellite segment future development may refer to shared spectrum usage in the frequency bands allocated to 5G satellite and terrestrial segments on the primary basis. Also urgent is the issue of intersystem electromagnetic compatibility of aboard equipment and earth stations with base stations and user devices of 5G terrestrial segment.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
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\\n\\n1. RETRACTIONS
\\n\\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\\n\\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\\n\\nPublishing of a Retraction Notice will adhere to the following guidelines:
\\n\\n1.2. REMOVALS AND CANCELLATIONS
\\n\\n2. STATEMENTS OF CONCERN
\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\\n\\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\\n\\n3. CORRECTIONS
\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
\\n\\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\\n\\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n3.2. CORRIGENDUM
\\n\\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\\n\\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
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The most important one is that orthodontic appliances especially the brackets and the ligation mode create new retention areas in addition to blocking plaque-removing shear forces arising from fluid flow and masticatory loads with a resultant undesired effect of accumulation of dental plaque. Increased amount of dental plaque containing cariogenic bacteria is the main etiologic factor in decalcification of enamel during orthodontic treatment. This demineralization of the tooth surfaces results in appearance of white spots or even caries. However, in the literature, there are conflicting results in the relationship between orthodontic treatment and development of dental caries. Many preventive methods such as topical fluoride application, using bonding materials releasing fluoride, using mouth rinse with sodium fluoride, applying chlorhexidine, and so on were defined. The general comment of the authors is that supplying an adequate oral hygiene has the main role in prevention of demineralization-caries during orthodontic treatment. In the light of the previous studies’ results, it can be concluded that professional application like a varnish can be provided for patients who have high caries incidence.",book:{id:"6668",slug:"dental-caries-diagnosis-prevention-and-management",title:"Dental Caries",fullTitle:"Dental Caries - Diagnosis, Prevention and Management"},signatures:"Gamze Metin-Gürsoy and Fatma Deniz Uzuner",authors:[{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner"},{id:"235169",title:"Dr.",name:"Gamze",middleName:null,surname:"Metin Gürsoy",slug:"gamze-metin-gursoy",fullName:"Gamze Metin Gürsoy"}]}],onlineFirstChaptersFilter:{topicId:"995",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:290,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:1,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). 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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. 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