Main characteristics of the engine tested.
\r\n\t
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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"73894",title:"Bioethanol-Diesel Blends Used in Diesel Engines and Vehicles under Transient Operation",doi:"10.5772/intechopen.94359",slug:"bioethanol-diesel-blends-used-in-diesel-engines-and-vehicles-under-transient-operation",body:'The interest of using renewable fuels started at the beginning of the 21st century due mainly to: the reduction of fossil fuels consumption and the decrease of carbon footprint of the combustion products. Although biodiesel is the biofuel most widely used in compression engines, bioethanol became in a competitor since its composition presents an oxygen concentration three times higher than biodiesel. Additionally, the production cost is competitive with fossil fuel because it can be produced locally through fermentation of sugar derived from corn or cellulosic biomass [1].
Bioethanol can be used as fuel in diesel engines by means three ways:
Dual fuel system. Apart from the traditional diesel injection system, an additional system for the injection of bioethanol is added which can be located in the intake air manifold [2] or in the cylinder but independently of the injector of diesel fuel [3, 4]. This configuration implies an additional cost but allows to work with a higher ethanol-diesel ratio.
Fumigation. Bioethanol is atomized using a carburation in the intake air manifold and introduced together with air in the cylinder. The main advantage is that the evaporation of ethanol reduces the temperature in the cylinder (increasing the air density) could reach higher engine power [5, 6]. However, the concentration of alcohol is limited to avoid the “knocking” at high engine load and the “misfiring” at low engine load [7, 8].
Bioethanol-diesel blends. No engine modifications are required for blends up to 30% of alcohol concentration, making bioethanol-diesel blends (named as e-diesel) the most common way to use this alcohol as fuel in compression ignition engines. The main drawbacks associated to these blends are the limited miscibility of bioethanol in diesel and their poor lubricity properties.
Reductions in terms of pollutant emissions are associated to the use of e-diesel blends. Ethanol’s oxygen reduces the probability of rich-zone formation and promotes the oxidation of soot nuclei generated, reducing smoke, Particulate Matter (PM) and other pollutant emissions such as Total Hydrocarbons (THC) and Carbon Monoxide (CO). These benefits are even further than those obtained with biodiesel-diesel blends [9, 10].
The effect of e-diesel blends under steady state conditions with different ethanol concentrations has been widely studied, being the alcohol concentrations most used 5%, 7.7%, 10% and 15%. Most of the bibliography remark the reduction of smoke opacity and PM emissions with these blends [11, 12, 13]. However, real driving conditions are majority transient sequences and the effect of fuel under transient conditions could be different since the engine working characteristics are also quite different to the stationary ones. Literature related to the effect of e-diesel blends under transient operation was scarce. Giakoumis et al. [14] reviewed the effect of e-diesel (and butanol-blends) under transient operations i.e., acceleration, load increase, starting process and driving cycles, until 2013. In the introduction of this chapter, this literature is updated and enlarged with studies related to the influence of bioethanol on the durability or wear of different engine parts.
Regarding engine testing, Ahmed et al. [15] carried one of the first works out by where two e-diesel blends (with 10% and 15% of alcohol concentrations) were tested under Federal Test Procedure (FTP) transient cycle of a heavy-duty diesel engine. Reduction up to 41% of PM emissions were recorded, being the decrease proportional to the alcohol concentration, with no penalty in NOx emission (slightly decreases were obtained).
Armas et al. [16] started to evaluate the effect of bioethanol testing an E10 blend under different transient sequences. Subsequently, this research studied the effect of the same percentage of ethanol, and a butanol-diesel blend (But16) under two different engine working conditions: the starting process (under warm and hot temperatures) and reproducing the New European Driving Cycle (NEDC) [17, 18]. Tests were carried out in a test bench with a light-duty diesel engine. Reductions in smoke opacity, PM and CO emissions were reported with e-diesel blend except during the cold starting process, where the high enthalpy of vaporization and low cetane number of bioethanol favor delayed premixed combustion process, increasing PM, NOx and THC emissions under this engine working sequence although the oxygen presence in the fuel.
The aim of the study of van Niekerk et al. [19] was investigating the effect of ethanol-biodiesel-diesel blends tested over the World Harmonized Light Vehicle Test Procedure (WLTP) using an ignition compression engine. Seven binary and ternary blends were selected by means a Design of Experiments (DoE). Pollutant emissions were measured, and different statistical models were used to describe trends obtained. Authors concluded that the ternary blend B2E9, considered as the optimum, showed reductions in CO emissions of 34%, in NOx emissions of 10% and 21% in CO2 emissions compared to diesel.
Regarding vehicles testing, emissions tests were carried out by Randazzo et al. [20] with a light-duty vehicle positioned over a chassis dynamometer under NEDC conditions. In this work, bioethanol was added (at very low concentration, 2% and 5%) of two blends biodiesel-diesel with 20% of biodiesel concentration. Authors concluded that the use of bioethanol reduced NOx and CO2 emissions but, surprisingly, it was unfavorable for CO, THC and PM emissions. Although the higher oxygen concentration of bioethanol (compared to biodiesel fuel), its lower cetane was considered as a factor that favored the PM emissions.
Two busses used for urban transportation were tested by Mata et al. [21] using a bioethanol-diesel blend (7.7% of alcohol) in two cities at different altitudes. Notable reductions in particle concentrations were obtained with e-diesel blend while the trend of NOx emissions depended on the altitude. The engine of other bus (a Cummins B Series) was used to evaluate the effect of two e-diesel blends (10% and 15%) under the 8-mode AVL test cycle conditions [22]. PM emissions decreased 20% and 30% with e-diesel blends but no noticeable effect on the emission of NOx and even small increases in THC and CO were observed.
Regarding non-road engines or vehicles testing (machinery), few works were found about the use of bioethanol as fuel in construction machinery vehicle. Armas et al. [23] evaluated the effect of an e-diesel blend with a 7.7% of ethanol in a vibration roller under four operation engine conditions: engine start, idle, circulation and work. Significant reductions of smoke opacity were obtained during transient engine operation.
Three non-road heavy-duty diesel engines were used in the work of Merrit et al. [24] where three e-diesel blends (E7.7, E10 and E15) were used. The FTP smoke test was reproduced, results being classified into acceleration, lugging, and peak modes. Smoke and particulate matter emissions decreased (up to 20%) as ethanol concentration increased. CO emissions were also lower than those of diesel base fuel while NOx concentration was similar.
As it was commented previously, the main drawback of e-diesel blends is the limited miscibility of both fuels which requires knowing conditions where these blends are stable. Bioethanol’s miscibility in diesel mainly depends on three parameters: water content (hydrous ethanol), temperature and ethanol concentration [25]. The presence of water in ethanol, the low temperatures and the high ethanol concentration difficult the miscibility between both hydrocarbons [25, 26, 27].
To ensure the miscibility between bioethanol and diesel, especially at low temperatures, different additives are usually added: alcohols (butanol, pentanol, octanol, dodecanol) [28, 29], ethers, and different co-solvents [26, 30] or emulsifiers [31, 32] whose composition is, sometimes, not published. One of the most common additives for bioethanol-diesel blends is biodiesel fuel which, in addition to its renewable origin, contributes to improve the cetane number and lubricity of e-diesel blends [33, 34]. Different authors evaluated the stability of bioethanol-biodiesel-diesel (named as e-b-diesel) blends at different temperatures, indicating the different instability areas [9, 35].
Apart from the limited miscibility, easily resolved by the incorporation of additives, the poor lubricity properties of bioethanol could imply wear of the fuel injection system and other engine components. Two types of investigations have been carried out in relation to this topic:
Wear of metallic materials. Wear Scar Mean Diameter (WSMD) of different e-diesel and e-b-diesel blends was evaluated in the work of Lapuerta et al. [36]. The increase of WSMD was not linear with the increase of ethanol concentration. Durability tests of fuel injection system using several experimental techniques were carried out by Armas et al. [37]. A E7.7 blend showed similar effect on durability of the injection pump parts than that the diesel fuel but a reduction (around 20%) of nozzle hole effective sections was produced with the blend. In the rest of literature, wear of the injection system parts with bioethanol-diesel blends is observed [38, 39].
Material degradation/oxidation. Some metals (zinc, plumb, copper, aluminum) and some plastics (rubber and polyvinylchloride, PVC) are oxidized when contacting with bioethanol [40]. To solve this drawback, some authors suggest the use of stainless steel as a substitute for metals (aluminum, magnesium and brass) [41, 42] and, in other work, high-density polyethylene is used instead of rubber or other plastic materials in [40].
The aim of this chapter is to show the main results of several works about the effect of bioethanol-diesel blends on the durability of fuel injection system and on the performance and emissions in diesel engines or vehicles under transient working conditions.
With the objective to evaluate the effects of bioethanol blended with diesel fuel, under transient operation, previously to the direct use in vehicles, an experimental study with an engine mounted on a test bench is recommendable. In this case, Figure 1 shows a general sketch of the experimental installation used for testing the engine under discrete transient sequences. A turbocharged intercooled, direct injection Diesel engine, 4-cylinder, 4-stroke, typically equipped in European light duty vehicles, was employed as experimental unit. In Table 1, main characteristics of the engine tested are listed.
Sketch of the experimental installation for engine testing.
Parameter | Value |
---|---|
Compression ratio | 18:1 |
Swept volume (L) | 2.2 |
Stroke (m) | 0.94 |
Bore (m) | 0.865 |
Cylinders arrangement | 4, in line |
Maximum rated torque (at 2000 min−1) (Nm) | 237.4 |
Maximum rated power (at 4000 min−1) (kW) | 85.2 kW |
Fuel injection system | VP44 pump, electronically controlled |
Main injection pressures (bar) at full load (at 2000 min−1) at idle (750 min−1) | 1100 200 |
Main characteristics of the engine tested.
The engine was coupled to an asynchronous machine Schenck Dynas3 LI 250 (operating as a dynamometer). The dynamometer control system allowed measuring, controlling, and registering the engine speed, accelerator position and effective torque. Instantaneous fuel consumption was registered by means of a PLU 401/116H flow meter, while the air mass flow rate was measured by means of a hot-wire flow meter Siemens 5WK9628, previously calibrated in the 0–718 kg/h range with an accuracy of 2% around the measured value.
The Exhaust Gas Recirculation (EGR) ratio was calculated by comparison of the CO2 gas concentration at the inlet and at the exhaust manifolds using an infrared absorption gas analyzer Environnement MIR2
For assessing the effect of changes in engine load on the smoke opacity and NOx emissions, two discrete transient sequences were tested and compared. In each sequence both, the initial and final conditions of effective torque and engine speed, were the same independently of the fuel tested.
Figure 2 shows these two transient sequences, both with effective torque (Me) increase at relative low engine speed (n) and denoted as AM-AF and A-A’. The aim of this methodology was to evaluate the smoke opacity and NOx emissions behavior under two of the most common transient sequences with fuel consumption demand in any type of vehicles. Under AM-AF sequence, the engine was driven from motored to fired conditions. This test tries to simulate a vehicle acceleration from zero fuel delivery to a given load condition. Meanwhile A-A’ is the typical transient sequence with load increase at constant speed (for example, under a slope positive change in a road profile, remaining constant the vehicle velocity without gear changes). Under both cases, the engine control unit (ECU), tuned by manufacturer, controlled the EGR valve opening.
Engine transient sequences tested.
Initial and final operating modes of the sequences shown in Figure 2 and Table 2 were chosen due to their operation representativeness of that zone on the engine torque-engine speed map (under low load and engine speed) where the pollutant emissions restrictions are very important (typical of urban driving conditions).
Transient sequence | Engine speed (min−1) | Effective torque (Nm) | |
---|---|---|---|
Start | End | ||
Am-Af | 1661 | −40 | 55 |
A-A’ | 26 | 90 |
Steady state operating conditions before and after each transient sequence.
Under engine transient testing, a low Sulfur diesel fuel was used as reference (denoted as Ref). A 10% v/v blend of bioethanol with this diesel fuel, without stabilizing additive, was denoted as E10. This blend was selected because the ambient temperature was higher than 25°C. Under these thermal conditions and, during relative short time period, the blend is stable without additive since Bioethanol used has a purity of 99.94%. The bioethanol concentration of the tested blend was defined attending to the results of previous studies [26]. The main properties, either measured or calculated, of the tested fuels are presented in Table 3.
Property | Fuel | ||
---|---|---|---|
Ref | E10 | E | |
Density (kg/m3)a | 833.5 | 828 | 792 |
Kinematic viscosity (cSt)b | 2.79 | 2.13 | 1.13 |
Gross heating value (MJ/kg) | 45.89 | 43.48 | 28.05 |
Low heating value (MJ/kg)c | 42.84 | 40.44 | 25.18 |
Low heating value (MJ/L)c | 35.70 | 33.49 | 19.94 |
% C (in weight) | 85.23 | 82.08 | 52.17 |
% H (in weight) | 13.92 | 13.83 | 13.04 |
% O (in weight) | 0.74 | 3.98 | 34.78 |
% S (in weight) | 0.026 | 0.024 | 0 |
Molecular weight | 206.9d | 155.2e | 46.06e |
Stoichiometric fuel-air ratioe | 1/14.60 | 1/14.07 | 1/9.01 |
Distillation | |||
Initial Boiling Point (°C) | 182 | 78 | 78 |
T10 (°C) | 204 | 79 | |
T50 (°C) | 266 | 257 | |
T90 (°C) | 348 | 347 |
Fuel properties used under engine testing.
Measured at 15 °C.
Measured at 40°C.
Calculated from composition and gross heating value.
Calculated with software Aspen-Advisor.
Calculated from composition.
Before the extension of the work for assessing the benefits of bioethanol-diesel blends in vehicle captive fleets, two works must be done: a study about the miscibility and stability of the blends with different bioethanol concentrations [26] and the study of the effect of the fuel blend on the integrity of some parts of the engine injection system [37]. Both works are essential for verifying the lubricant capacity of the fuel blend under real driving conditions. This sub-section describes, as example, part of the work done with some pieces of a modern injection system.
The experimental unit used was a Bosch high-pressure injection pump. Normally this pump operates connected to a common rail and this one connected to a fuel injector, electronically controlled. This model of experimental unit equips great number of different models of Mercedes Benz light duty cars. This system also equips great part of diesel engines, with around 2 liters of cylinder displacement, commercialized in Europe. The main characteristics of the injection system studied in this work are shown in Table 4.
Injection system characteristic | Value (unit) and/or information |
---|---|
Pump manufacturer | Bosch |
Pump type | first generation with pistons |
Common rail model | 270 CDI MB/4 injectors |
Common rail length (m) | 0.55 |
Pump-common rail line length (m) | 0.40 |
Common rail-injector line length (m) | 0.15 |
Inner diameter of lines (m) | 0.002 |
Main characteristics of the injection system tested.
Figure 3 shows the scheme of the hydraulic circuit of the experimental installation used for simulating a long-term work of an injection system under demanding operating mode. The injection system worked on an injection test bench (model Asia Diesel). In dark black, the circuit (without modifications) for testing diesel fuel is presented. Those parts modified for testing bioethanol-diesel blends are presented in light gray (valve 2 and tank caps). Those parts were added to remain the water content in the range established by the European fuel quality standard EN-590 and for avoiding the ethanol evaporation to the atmosphere. In addition, the fuel tank was instrumented with a pressure and/or vacuum safety valve, to prevent the pressure variation inside the fuel tank. These modifications were also needed in the fuel tanks of the vehicles tested.
Scheme of the hydraulic circuit of the test bench for simulating long-term work with fuels tested.
Table 5 shows the test conditions for simulating reproduced by the test bench during the long-term work of a new injection system used with each fuel tested.
Parameter | Unit | Value |
---|---|---|
Rotation speed | min−1 | 2500 |
Injection pressure | bar | 1500 |
Injection time | ms | 1 |
Fuel temperature | °C | 40 |
Operation time | hours/day | 10–12 |
Total test time | hours | 600 |
Test conditions for simulating reproduced by the test bench.
Before and after the long-term operation with each fuel, the total fuel delivery was determined using diesel fuel and those conditions presented in Table 5. Selected test conditions (600 work hours at 2500 min−1 and 1500 bar of injection pressure) are equivalent to the driving of a light duty vehicle during more than 120,000 km.
For characterizing, the effect of fuels on the integrity of some parts of the injection system, different techniques can be used. Among these techniques are the following: measurement of the fuel delivery, characterization of the roughness surface of elements, observation of the surface microstructure, weigh of elements and measurement of the nozzle geometry inner shape obtained by casting silicone, determined from images of a Scanning Electronic Microscope (SEM). In this chapter, the effect of E8 fuel blend on the surface roughness of the drive shaft of the fuel high-pressure pump (Figure 4a, surfaces Ds1, Ds2 and Ds3), the geometry of the nozzle (Figure 4b, diameters along the nozzle hole in three positions d1, d2, d3) and the total fuel delivery is compared. Comparison was done, before and after 600 work hours, with diesel fuel.
a) Surfaces of the drive shaft of the high-pressure pump studied and (b) example of a SEM image from the silicone mold of a hole of the injector nozzle.
For determining the effect of the long-term work on the surface roughness a tester Hommel Werke, model T500, was used. This tester has capacity to determine different parameters of surface roughness, along 10 mm of the sampled surface, with 100 microns amplitude and with a precision of 0.01 μm. Diameters along the nozzle hole were determined from images obtained by means of a scanning electronic microscope Philips model XL30 of the hole inner shape obtained by casting silicone [43].
This part of the work and the work done with both busses and with construction machine, as will be explain later, was carried out with a different bioethanol-diesel fuel blend. In these two cases, a low Sulfur diesel fuel was used as reference (denoted as Ref). A 7.7% v/v bioethanol-fuel blend, with 0.62% v/v of a confidential stabilizing additive, was used and denoted as E8. Table 6 shows properties of fuels used in this part of the work. Bioethanol purity was 99.94%. Since the additive composition was not known, all E8 fuel characteristics, dependent on the fuel composition, were determined only from diesel and bioethanol fuels.
Property | Fuel | ||
---|---|---|---|
Ref | E8 | E | |
Density (kg/m3)a | 834.9 | 831 | 792 |
Kinematic viscosity (cSt)b | 2.72 | 2.41 | 1.13 |
Gross heating value (MJ/kg) | 45.54 | 43.82 | 28.05 |
Low heating value (MJ/kg)c | 42.58 | 40.86 | 25.22 |
Low heating value (MJ/L)c | 35.55 | 33.95 | 19.97 |
% C (in weight) | 86.13 | 83.63 | 52.14 |
% H (in weight) | 13.87 | 13.82 | 13.13 |
% O (in weight) | 0 | 2.55 | 34.73 |
% S (in weight) | 0.0034 | 0 | 0 |
Molecular weight | 211.7d | 167.5e | 46.06e |
Stoichiometric fuel-air ratioe | 1/14.67 | 1/14.25 | 1/9.00 |
Distillation | |||
Initial boiling point (°C) | 172 | 78 | 78 |
T10 (°C) | 211 | 178 | |
T50 (°C) | 270 | 256 | |
T90 (°C) | 340 | 337 |
Properties of fuels used in parts durability testing and in busses and construction machinery testing.
Measured at 15 °C.
Measured at 40°C.
Calculated from composition and gross heating value.
Calculated with software Aspen-Advisor.
Calculated from composition.
Two similar busses used for urban transportation were tested. One of the vehicles was a Euro II IVECO Europolis 915 city bus (denoted as IV), around 10 T in weight, equipped with a 6-cylinder, with around 6 L of displacement, direct injection, turbocharged, heavy-duty diesel engine. This bus was equipped with an automatic ZF transmission. The bus length is 9 m. The other vehicle was a Euro II Renault city bus (denoted as RE), around 13 T in weight, equipped with a 6-cylinder, with around 8 L of displacement, also turbocharged, direct injection, heavy-duty diesel engine. This bus was equipped with an automatic Voith transmission and its length is 10 m. Both busses were equipped with injection systems including injection pumps electronically controlled. Both busses operate with single injection and advanced Start of Injection (SoI) and without Exhaust Gas Recirculation (EGR). Both vehicles, with similar mileage, were not equipped with after-treatment devices (Diesel Oxidizer Catalyst (DOC) nor Diesel Particulate Filter (DPF)). This configuration of the exhaust systems allowed studying the effect of fuels on pollutant emissions without influence of after-treatment devices.
As Figure 5 shows, both busses and the construction machine were instrumented with a HORIBA OBS 1300 gas analyzer and with a TSI Engine Exhaust Particle Sizer (EEPS) spectrometer. The first of them includes sensors for measuring and registering the relative fuel-air ratio and ambient conditions (temperature, pressure and humidity). In both cases, vehicle velocity and its position were determined by means of a Global Positioning System (GPS) and an inertial sensor. Although the HORIBA OBS 1300 includes different measurement modules, only the MEXA 720 NOx with a zirconia sensor for nitrogen oxides measuring was used. For characterizing particulate matter, an EEPS spectrometer was used to measure particle size distributions under transient vehicle operation. Figure 5 also shows, the EEPS spectrometer coupled to a Rotating Disk (RD) diluter model MD19-2E, as primary dilutor, and an air supply-thermal conditioner model ASET15–1 with an evaporating tube, as secondary dilutor.
Sketch of the experimental installation for vehicle testing (busses and construction machine).
At Ciudad Real city, the tests were carried out in a route with 14.5 km length (around one hour in time). This route mostly runs throughout the city center, characterized by a low mean velocity. However, it includes some stretches of medium speed (around 50 km/h). The altitude profile is almost constant during the entire route (∼650 m above the sea mean level). The route has 67 stops for passengers, uniformly distributed along the trajectory and it includes 31 traffic lights.
At Sevilla city, the tests were carried out in route with 13 km length (also one hour in time). The route runs mostly throughout the city center with similar mean velocity as occurred at Ciudad Real city. The altitude profile is almost constant during the entire route (∼10 m over the sea level). The route has 35 stops for passengers, uniformly distributed along the trajectory and it includes 21 traffic lights.
The comparison of the results obtained from real driving operation of test vehicles is relatively complex. By this reason, results presented in this chapter were processed following the methodology presented in [44]. In this case, comparison between busses and fuels, based on the obtained mean values from categories, will be presented below. Cycle is the whole data from the beginning to the end of the route while category is that part of the cycle with similar variation of the most important operating parameters (relative fuel-air ratio, denoted as Fr and vehicle velocity, denoted as Vv).
A great number of different categories such as accelerations, decelerations, idle, etc. composes one cycle [44]. In this text only the analysis of part of the events included within the acceleration category is presented. Within the acceleration category, there are three possible situations: a) acceleration coming from idle, b) acceleration coming from deceleration without fuel consumption and c) acceleration coming from deceleration with fuel consumption. As example, Figure 6 shows vehicle velocity and fuel-air ratio profiles, registered during part of a cycle.
Vehicle velocity and relative fuel-air ratio profiles from part of the bus cycle.
Four categories, idle (I), acceleration (A), deceleration with fuel consumption (DwF) and deceleration without fuel consumption (D) [21] were selected as example for this work. In this chapter, as example, only the comparison under acceleration coming from idle sequence is presented.
As experimental unit was used a vibrating roller Lebrero model Rahile 155TT. This machine equips a direct injection Diesel engine, 6-cylinder, 4-stroke turbocharged, typically used during roads and railways construction. Table 7 shows the most important characteristics of its engine.
Parameter | Value |
---|---|
Model | Deutz FL6913 turbocharged |
Rated power highly intermittent at 2500 min−1 (kW) | 109 |
Rated torque at 1700 min−1 (Nm) | 510 |
Compression ratio | 15.5:1 |
Displacement (L) | 6.128 |
Cylinder arrangement | 6, in line |
Bore (m) | 0.102 |
Stroke (m) | 0.125 |
Fuel injection system | Bosch in line injection pump |
Main engine characteristics of the construction machine.
This machine was instrumented with a HORIBA OBS 1300 system as Figure 7 shows. Its connection to the exhaust pipe was similar to that used in public busses. However, the smoke opacity (indicative of the particulate matter emitted), which ranges from zero to 100% and proportional to the total light extinction across the exhaust gas stream, was determined by a smoke opacimeter Wager 6500. This signal was also registered by the OBS system.
View of the experimental installation located on the construction machine.
The comparative analysis of pollutant emissions registered under the operation of a construction machine is complex. As occurred with public busses and regarding the engine work, the work done by the machine can be classified into five categories [23]. These categories are engine start on (denoted as S), idle (denoted as I), circulation (denoted as C) and work (denoted as W).
This categorization allows the daily machine operation without disturbance on its own work. This machine, during the tests, worked under real operating conditions during the construction of a railway. The best option is to register engine parameters and pollutant emissions in different occasions during the selected operation sequences. In result and discussion section, results related to C and W sequences are presented as example.
Time evolution of the smoke opacity (characteristic parameter of particulate matter emission) and NOx concentration, under transient sequence AM-AF, is presented in Figure 8. This behavior can be explained because both relative fuel-air and EGR ratios were zero at the beginning of the transition avoiding, this way, soot depositions on the internal of the manifold walls and thus any further blowing effect. Great reduction of smoke opacity is observed when E10 blend is used compared to reference fuel. The increase of the oxygen content of the fuel blend and the reduction of the aromatic content explain this result. Additionally, as Figure 9 shows, the EGR ratio at the end of the transient sequence with the E10 blend, would hardly reach that of reference fuel. This also would leads to a greater availability of oxygen at the end of the transition, contributing to the smoke opacity reduction registered.
Time evolution of the smoke opacity (a) and NOx concentration (b) during the AM-AF transition.
Time evolution of EGR ratio during the AM-AF transition.
However, the slight increase of NOx concentration registered along the transition with E10 blend (see Figure 8b) can be explained by the initial oscillations of the EGR ratio (due to the sensibility of the EGR valve opening) presented in Figure 9. It is important to take into account two factors: i) manufacturer tuned the engine (included the EGR valve opening) with diesel fuel and ii) under a typical diesel combustion process, increases in EGR ratio generally produce decreases of NOx concentration but increases of smoke opacity, this last as characteristic parameter of particulate matter.
Figure 10 presents the smoke opacity and NOx concentration time evolution along the transition A-A’ registered with both fuels. As Figure 10 shows, the shape of the smoke opacity and NOx concentration curves during their time evolution are similar between both fuels.
Time evolution of the smoke opacity (a) and NOx concentration (b) during the A-A’ transition.
This shape is consistent with the shape of the relative fuel-air ratio (related to the stoichiometric fuel-air ratio) and EGR ratios as Figure 11 presents.
Time evolution of relative fuel-air ratio (a) and EGR ratio (b) during the A-A’ transition.
In this figure, as example, is presented the time evolution of both parameters registered with both fuels. It is important to remember that the engine is forced to reach the same torque value at the beginning and at the end of the transition.
The sudden increase of the relative fuel-air ratio is caused by the delayed response of the turbocharger. As consequence, this produces a time lag between the fresh inlet airflow and the increase of fuel delivery demanded to reach the torque target at the end of transition. Additionally, other contributor factor of the smoke opacity peaks is the release of soot deposited on the pipe walls during the steady operation previously to the transition, which could be blown out as consequence of the increased exhaust gas flow with higher thermal conditions.
As can be seen in Figure 10a, the smoke opacity is clearly lower with E10 blend. The lower viscosity and higher volatility of E10 fuel could favor the fuel spray atomization and its evaporation, just during the transition. Effectively, the reduced content of aromatic compounds and the higher oxygen content of the E10 blend follows being the most important contribution to the reduced smoke peak.
Regarding NOx concentration presented in Figures 8b and 10b, different properties of the bioethanol-blend cause opposite effects on this pollutant emission. First, the low adiabatic flame temperature and the high vaporization heat of the E10 blend reduce the combustion temperature and the NO formation [45]. Second, a low cetane number (leading to longer delay time), the high oxygen content, a fast combustion velocity and an advanced fuel injection (this being a response of the control unit for compensating the longer injection process due to the reduced heating value), are those factors which favor high combustion temperature and NO formation [45, 46, 47, 48]. According to these two groups of factors and depending on the engine operating mode and the type of engine both increases and decreases of NOx with bioethanol-diesel blends have been reported [45, 46, 47, 48].
These results indicate the great potential to obtain important reductions of smoke opacity without penalty of NOx emissions by tuning the engine with a bioethanol-diesel blend.
For the surface roughness analysis, two parameters were used: the arithmetic mean roughness value (Ra) and the mean peak to valley height (Rz), both defined by the DIN4777 and ISO4287 standards. The mean roughness (Ra) is defined as the arithmetic mean of the profile deviation of the filtered roughness profile from the mean line (ML) within the measuring length (L), according to Eqs. (1) and (2) and the representation shown in Figure 12.
Sketch of the surface roughness with peaks and valleys.
The mean peak to valley height (Rz) is defined as arithmetic mean from the peak to valley heights y1 to y5 of five successive sampling lengths in the filtered roughness profile, according to Eq. (3).
The absolute differences ΔRa and ΔRz were calculated by means of the Eqs. (4) and (5) in order to determine the effect on surface roughness of each fuel tested before and after of the long-term work. These differences were obtained between the final and initial mean values of the Ra and Rz parameters of each zone of the drive shaft shown in Figure 4a.
Ra and Rz parameters measured on the drive shaft surfaces Ds1, Ds2 and Ds3, with both fuels, are presented in Figure 4a. In addition, the 95% confidence interval using three measurements at each point is indicated. According to the results presented in Figure 13, the greatest Ra and Rz parameters values were calculated in that surface denoted as Ds3 and this occurred independently of the fuel tested.
Ra and Rz parameters calculated for surfaces Ds1, Ds2 and Ds3 of the drive shaft.
The surface roughness measured on this zone was more pronounced than those measured on Ds1 and Ds2 surfaces were. The zone Ds3 is located on the most loaded section surface of the drive shaft. The measured surface roughness fits in the grade N4 to N2 (N is the surface finish grade as per the standard ISO1302). This classification corresponds to machined surfaces derived from lapping and/or finishing turning operations. It is important to highlight that if the surface roughness of two contact surfaces drastically decreases (below 0.025 mm), it could lead to the blockage of the elements due to surface adherence (lapping effect). In the surface Ds3), the flange transmits a great force to the drive shaft, and this action leads to a high friction value. The values calculated of the parameters Ra and Rz for the surfaces Ds1, Ds2 and Ds3 were similar, prior to and after the durability test, independently of the type of fuel used. Figure 14 shows the maximum ΔRa and ΔRz values that were measured on each point along the drive shaft.
Maximum ΔRa (a) and ΔRz (b) values determined from each surface of the drive shaft.
Results presented in Figures 13 and 14 indicate similar effect of both fuels tested along the drive shaft. The lower lubricity of the E8 fuel blend produces a negligible effect on the surface under a long-term work equivalent to more than 120,000 km.
Table 8 presents diameters (d1, d2 and d3) measured from the silicone casting images taken from two randomly selected nozzle holes used with each fuel, before and after the tests. This table also shows the relative difference (ΔAd) of the effective sections (A) before (denoted as B) and after (denoted as A) the tests, calculated from mean diameters dB and dA, respectively.
Fuel | Hole | dA (μm) (600 h) | Mean dA (μm) | dB (μm) (o h) | Mean dB (μm) | Δ | ||||
---|---|---|---|---|---|---|---|---|---|---|
d1 | d2 | d3 | d1 | d2 | d3 | |||||
Ref | 1 | 192.8 | 192.8 | 193.0 | 192.9 | 192.8 | 192.8 | 193.1 | 192.9 | 0 |
2 | 193.0 | 192.8 | 193.2 | 193.0 | 192.8 | 192.7 | 193.0 | 192.8 | −0.2 | |
E8 | 1 | 200.7 | 200.6 | 199.8 | 200.4 | 175.4 | 182.0 | 184.0 | 180.5 | −18.9 |
2 | 201.9 | 200.9 | 202.9 | 201.6 | 172.5 | 178.2 | 179.3 | 176.7 | −23.2 |
Geometrical characterization of sections of nozzle holes.
Differences obtained, section by section, among diameters of a same nozzle used with each fuel is lower than 1.5%. This value is within the dispersion range of Bosch nozzles. Reductions of the effective sections of 18.9% and 23.2% respectively were obtained after using E8 fuel blend. These reductions can be explained by a probable sedimentation and/or oxidation along nozzle holes. This explanation could be justified because of the test bench was not completely hermetic. This situation provoked a slight reduction of ethanol concentration (around 0.2% v/v). Additionally, the water concentration increased in the blend from 243 ppm to 460 ppm, after 600 h. After the test, the experimental installation was checked. One point without a correct sealed was detected: the nozzle tip. This fact could produce the contact between the ambient air with the nozzle tip. The air oxygen could produce a slight oxidation along the holes, causing the reduction of their effective sections (Table 9).
Fuel | Fuel delivery (cm3 per stroke) | ||
---|---|---|---|
Before | After | Relative difference % | |
Ref | 6.0 | 6.2 | +3 |
E8 | 6.1 | 4.3 | −29.5 |
Total fuel delivery before and after the tests with both fuels.
The total fuel delivery determined before and after the tests with each fuel is shown in Table 10. This parameter varied within a narrow range of variation (around 3%), before and after the long-term work with diesel fuel. Contrary, the total fuel delivery decreased approximately 30% after the test with E8 fuel blend.
Sequence | Parameter | ||||||
---|---|---|---|---|---|---|---|
Fuel | Fr | Tamb (°C) | Texh (°C) | υ (km/h) | |||
C | Ref | 0.308 | 9 | 243 | 5444 | 1.221 | 7.6 |
E8 | 0.312 | 0 | 238 | 4025 | 0.950 | 6.6 | |
W | Ref | 0.528 | 2 | 387 | 5905 | 1.750 | 6.7 |
E8 | 0.471 | 3 | 348 | 4638 | 1.340 | 3.5 |
Mean values of engine and/or vehicle operating parameters obtained during the W and C sequences.
In this section, the time analysis of acceleration sequences (A) registered through the test cycles is presented. This analysis has been carried out by comparison of five seconds of those sequences with similar time profiles of the relative fuel-air ratio (Fr). Figure 15 presents the average time evolution of Fr, Vv, NOx concentration and its mass flow rate from both busses and fuels tested respectively.
Relative fuel-air ratio (Fr) and vehicle velocity (Vv) profiles (a) and NOx concentration and mass flow rate profiles (b).
As can be seen in Figure 15, the Fr profiles between vehicles and fuels were similar enough for comparing the effects of fuels. NOx concentrations from E8 fuel were lower compared to diesel fuel when the IV bus was tested, and it was higher when the RE bus was tested. In both cases, the difference between average NOx concentrations produced by fuels, in both vehicles, was practically constant along the sequence.
Low NOx concentration produced by the E8 fuel blend when the IV bus was tested at Ciudad Real city, can be explained as follows: the higher enthalpy of vaporization and its cooling effect, combined with the lower oxygen availability at altitude, lead to a decrease in NOx concentration. This occurred even when the engine compression ratio of IV bus is higher than that of the RE bus. An opposite effect was registered the RE bus tests. The lower altitude of Seville leaded to a higher air oxygen availability during the combustion process that, together with the oxygen content of E8 blend, produced an increase of NOx concentration. This occurred even the lower engine compression ratio of the RE bus and the higher enthalpy of vaporization of E8 fuel blend both compared to the IV bus and the diesel fuel respectively.
Compared along the time analyzed and with each bus, NOx mass flow rates are similar between fuels. NOx mass flow rates differences between busses can be explained by the different engine displacement of busses. The RE engine is two liters larger than the IV engine. More displacement leads to more quantity of gas displaced by the engine.
Figure 16 shows time evolution of particle concentration emitted by busses with both fuels under the acceleration sequence. As shown in this figure, particle concentration evolution followed the time profiles of Fr (see Figure 16a).
Particle concentration profiles.
Maximum particle concentration is reached around the 4th second as occurred with maximum Fr. Particle concentration increases proportionally respect to the Fr increase. As lower the oxygen concentration in the air as higher the particle concentration. Compared to diesel fuel, in both busses, particle concentration produced by E8 fuel blend is lower. Vehicles engines reproduce similar trend seen on the engine test bench. The lower quantity of aromatic compounds and the presence of molecular oxygen in E8 fuel blend lead to a cleaner combustion process and explain the obtained results.
Average values of some characteristic parameters of the work done by the roller engine are listed in Table 8. These are indicative of the engine and/or vehicle operation such as: relative fuel-air ratio (
Figure 17 shows the relative fuel-air ratios, the smoke opacity and NOx concentration mean values registered during sequence C with both fuels. Important reductions of NOx concentration (20%) and smoke opacity (25%) was observed with E8 fuel. Smoke opacity reductions registered are comparable to results presented in [49].
Average values of relative fuel-air ratio, smoke opacity and NOx concentration from test fuels during the sequence C.
Two factors contributed to provide reductions in NOx concentration higher than expected. First, the ambient temperature registered during the test with E8 fuel (9°C) lower than during the diesel tests. Second, machine velocity was 29% lower and thus the fuel consumption (as well as the exhaust gas flow) were lower (24%).
The average values of relative fuel-air ratios, smoke opacity and NOx concentration determined during the sequence W with both fuels are shown in Figure 18.
Average values of relative fuel-air ratio, smoke opacity and NOx concentration from test fuels during the sequence W.
In this sequence NOx concentration and smoke opacity were reduced with E8 fuel blend 8% and 27% respectively. These decreases are in concordance with those presented in Ref.s [16, 47, 49]. During the test of this sequence, the ambient temperature was similar with both fuels. However, the E8 fuel consumption was 33% lower than the consumption of diesel fuel. This can be explained because the vibrating roller packed down harder ground when diesel fuel was used in comparison than when using E8. This difference, together with the lower machine velocity (16%) could partly explain the observed differences in opacity and NOx concentrations.
According to the results exposed in this chapter, most important strengths of the use of bioethanol blended with diesel fuel are the following:
Molecular oxygen content of bioethanol is a key factor for reducing the emission of soot which is the main component of particulate matter emitted by diesel engines. Bioethanol molecular oxygen enables more complete combustion.
Bioethanol, as linear chain alcohol, does not have aromatic compounds in its composition. In this sense, the addition of bioethanol to diesel fuel reduces the probability of soot nuclei formation in locally rich zones.
By the contrary, the use of bioethanol-diesel blends has several weaknesses:
Limited miscibility reduces possibilities of using high percentages of bioethanol blended with diesel fuel. Low temperatures and high bioethanol concentration force the use of additives (such as biodiesel) to ensure the stability of bioethanol-diesel blends.
Low lubricity is a key factor which negatively contributes on the lubrication of the injection systems and different engine parts. As occurred with miscibility, it is necessary the use of additives for improving lubricity properties of these blends.
Bioethanol is highly hygroscopic. This forces to implement actions to avoid the water content increase of the blends. The water increase has double negative effect: decrease the miscibility of bioethanol-diesel blends and decrease their lubricity properties.
Other physicochemical properties of bioethanol can produce positive or negative effects on the engine operation when this alcohol is used blended with diesel fuel. However, the effects will depend on both the engine operating and ambient conditions. The high enthalpy of vaporization of bioethanol decreases the combustion process temperature, favoring lower NOx emissions under high engine load conditions but, under starting process or low engine load, this may provoke misfiring. Bioethanol has low cetane number that delay the start of combustion process which implies longer premixed phase of combustion. Also, bioethanol has low density and viscosity which can affect the fuel spray formation and its mixing with the inlet air. In this sense, the engine tuning should by adapted to fuel properties to maximize the benefits in terms of performance and emissions.
Hepatoblastoma is the third most commonly diagnosed intra-abdominal solid tumor [1]. It is also the most common primary hepatic malignancy in children [2]. More than 90% of hepatoblastoma occur in children under the age of 5 years [3, 4]. Although its absolute incidence is very low, its growth rate is gradually increasing, which increased from 1.89 per 1,000,000 in 2000 to 2.16 per 1,000,000 in 2015, with an annual percentage change of 2.2%. This increase mainly occurs in male children between 2 and 4 years of age, which was found to be an independent predictor for short overall survival [5]. With the development of multimodal treatment and cooperation between international organizations, the prognoses have been greatly improved in recent years [6].
Clinical manifestations are not typical at the early stage of hepatoblastoma. There would be epigastric or total abdominal distention, nausea, vomit, loss of appetite, abdominal pain, diarrhea, jaundice, even varicosity of abdominal wall, and dyspnea. Another clinical feature is often accompanied by fever, and the temperature can reach 39–40°C. About 3% of patients have sex hormone and sexual organ development abnormalities. And a few children have obvious osteoporosis and pathological fracture.
Physical examination could find diffuse or nodular enlargement of the liver, of which the volume varies, sometimes with splenomegaly and varicosity of the abdominal wall. Abdominal pain and abdominal muscle tension may be due to tumor rupture. In the late stage, the hepatoblastoma progresses rapidly and cachexia appeared soon.
Alpha fetoprotein (AFP) increases in more than 90% of patients, which is a specific indicator for hepatoblastoma and important for disease follow-up. Age should be considered when analyzing the clinical significance of AFP. The average AFP of the newborn is about 62.7ng/ml, and it reaches the peak in the first month after birth, the average AFP is about 1200 ng/ml. After three months, it decreases to 3.15ng/ml (the level of normal adult). In addition, the LDH, cholesterol, and alkaline phosphatase are also increased. The liver function is normal at early stage, middle, and late stage.
Imaging is necessary for diagnosis and preoperative evaluation, including tumor location, number, and the relationship with peripheral blood vessels and organs. The commonly used examination includes ultrasound, CT, MRI, angiography, etc.
Enhanced CT and MRI are important imaging studies, which are recommended. However, due to the difficulty of MRI examination for children, we usually choose enhance CT and reconstruct the images into three-dimensional images to understand the spatial structure of the tumor and the anatomical relationship with the blood vessels.
Additionally, the deep exploration of CT/MRI images is also important for the overall evaluation of hepatoblastoma. Identifying the CT/MRI image features of hepatoblastoma will help distinguish the more malignant tumor, which is potentially useful for guiding the clinical treatment. A study of 34 patients, aimed at studying contrast-enhanced CT characteristics of hepatoblastoma associated with metastatic disease and patient outcomes, found that irregular tumor margins, vascular invasion, capsule retraction, and PRETEXT staging are associated with poor patient prognosis. Among them, irregular tumor margins are the only imaging features that are significantly associated with more aggressive tumor subtypes [7]. For investigating the image characteristics, artificial intelligence has demonstrated remarkable progress in image recognition tasks. Radiomics is used to investigate the quantitative features that are invisible to the naked eye from conventional image with methods of artificial intelligence. The image features could be used to predict the pathology characteristics, therapeutic response, and survival. Previous studies have evaluated the value of radiomics in adult liver cancer. The results were achieved, particularly in the preoperative prediction of pathological features and postoperative recurrence [8, 9].
The four centers in the world that have performed prospective controlled studies of hepatoblastoma joined forces to form the CHIC. It includes the International Childhood Liver Tumor Strategy Group (SIOPEL), the Children’s Oncology Group (COG), the German Society for Pediatric Oncology and Hematology (GPOH), and the Japanese Study Group for Pediatric Liver Tumors (JPLT). Such international cooperation provides a large-scale database for clinical trials. The CHIC has developed a centralized online platform that combines data from eight completed clinical trials to form a database of 1605 hepatoblastoma cases treated between 1988 and 2008. The resulting data set has been used for investigating the relationship between the patient prognosis and the tumor characteristics and patient stratification for treatment selection and follow-up. And the collaboration has led to a uniform implementation of staging system (PRE-Treatment EXTent of tumor, PRETEXT), which is helpful for systemically evaluating the hepatoblastoma at diagnosis and useful for establishing consensus classification. Moreover, pathologists in the collaboration have established a new histopathological consensus classification for pediatric liver tumors. There have also been advances in chemotherapy treatments and liver transplantation for unresectable tumors. These advances will be further evaluated in the upcoming Pediatric Hepatic International Tumor Trial (PHITT) [10].
Imaging is an important basis for disease assessment and treatment selection. The PRETEXT system has been firstly proposed for staging and risk stratification for hepatoblastoma in 1992 [11]. The PRETEXT system is used to classify the tumor extent before treatment, which has a good prognostic value in patients with hepatoblastoma. The PRETEXT system has been widely used to evaluate the hepatoblastoma in recent years, which could stratify patients into groups with different prognosis.
The 2017 PRETEXT has updated the 2005 PRETEXT definitions [12]. The liver was divided into four sections. For PRETEXT I, II, and IV groups, there were no obvious differences between 2017 PRETEXT and 2005 PRETEXT. For PRETEXT I group, the tumor involves only one of the two lateral sections (right posterior and left lateral section). For PRETEXT II group, the tumor involves the left lobe, right lobe, left medial section only, and right anterior section only; two separate tumors involves the two lateral sections or the caudate lobe only. For PRETEXT III group, the tumor involves three sections of the liver, leaving only one normal section. For PRETEXT IV group, the tumor involves all four sections. The 2017 PRETEXT has mainly standardized the PRETEXT annotation factors, preparing the future clinical trials. It includes hepatic venous/inferior vena cava involvement (V), portal venous involvement (P), extrahepatic disease contiguous with the main liver tumor (E), multifocality (F), and tumor rupture (R) [12].
Many single centers have put effort to investigate the prognostic factor of hepatoblastoma [13, 14, 15, 16]. But the results were limited due to the small patients’ number and the use of multiple disparate staging systems. CHIC has created a new staging system to staging and risk stratification in children with hepatoblastoma, named the Children’s Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS). Based on a 5-year event-free survival and clinical applicability, the system was established with risk factors including PRETEXT groups, metastatic disease, age, AFP concentration, PRETEXT annotation factors (VPEFR), and surgically resectable at diagnosis [17]. PRETEXT group is the primary and most important for risk stratification. If the tumor is resectable at diagnosis for patients of PRETEXT I/II group, they are in very low or low risk. After PRETEXT group, metastatic disease is the first risk factor for stratification. All patients with metastatic disease were defined as high risk. Then, age ≥ 8 years in PRETEXT I, II, and III group and age ≥ 3 years in PRETEXT IV group were high-risk factor. For younger patients, AFP ≤100 ng/mL was defined as high-risk group. And VPEFR+ patients were in intermediate-risk group. In PRETEXT I/II group, older patients showed a relatively poor prognosis. But many of these tumors can be surgically resected; they defined the patients at 3–7 year age in the lower-risk group; patients who had low PRETEXT and positive VPEFR were placed in the intermediate-risk group; patients with PRETEXT I and low AFP (≤100 ng/mL) should not be stratified into high-risk group due to surgically resectable small tumors; patients with PRETEXT III group (younger than 8 years, no metastasis (M−) and AFP 100–1000 ng/mL) were defined as intermediate risk due to the poor 5-year event-free survival. CHIC-HS is by far the most complete system for risk stratification of pediatric hepatoblastoma and has important guiding significance for guiding individualized treatment [17]. Further study should also pay attention to the prognostic effect of treatment selection, such as anatomical or nonanatomical partial hepatectomy [18] and the dosage of chemotherapy [19, 20].
Multimodal therapy is recommended for the management of hepatoblastoma, including surgical resection, liver transplantation, chemotherapy, or radiofrequency ablation [21]. Multimodal therapy can improve tumor remission rate of children with advanced hepatoblastoma and prolong the survival. Surgical resection is the preferred treatment of resectable hepatoblastoma at the time of diagnosis. Neoadjuvant chemotherapy could improve the rate and safety of complete surgical resection for unresectable hepatoblastoma. Liver transplantation is one of the main treatments for unresectable hepatoblastoma [22, 23]. Prognosis has been greatly improved due to advances in chemotherapeutic agents and dosing regimens as well as innovations in surgical procedures, including the preoperative three-dimensional reconstruction, the usage of energy device, and liver transplantation. The management of high-risk patients and patients with recurrent or metastatic disease remains challenging [21].
Hepatectomy is the first choice for hepatoblastoma. It is suitable for PRETEXT I, II, and part of III patients. For most PRETEXT III and IV patients, chemotherapy is preferred first. Then, reevaluate the tumor and decide the treatment, hepatectomy or liver transplantation. However, there is still controversy about whether surgery should be performed first or chemotherapy first and the selection of extended hepatectomy or liver transplantation.
Over the past 40 years, the management of hepatoblastoma has changed significantly. For patients with unresectable tumors, neoadjuvant chemotherapy has become the standard treatment which can lead to a significant reduction in preoperative tumors and sometimes even complete ablation [24]. Neoadjuvant chemotherapy may facilitate partial hepatectomy by withdrawal of the tumor boundary from the confluence of portal vein bifurcation, hepatic veins, and inferior vena cava. And the tumor volume of hepatoblastoma could be significantly resolved with increasing neoadjuvant chemotherapy cycles [25]. For patients who underwent cisplatinum-based neoadjuvant and postoperative chemotherapy, microscopically positive resection margin did not affect the overall survival rate. And the “wait-and-see policy” is recommended [26].
For patients with hepatoblastoma that could be resected at diagnosis, postoperative chemotherapy with cisplatin, fluorouracil, and vincristine is useful to control the disease progression [27]. And for the subtype of pure fetal histology hepatoblastoma, complete surgical resection can achieve good survival without additional chemotherapy. Further study should be performed to identify the patients for whom chemotherapy is not necessary [28].
The management of patients in PRETEXT III or IV was difficult, including the selection between an aggressive liver resection and liver transplantation. There has been several study comparing the prognosis of partial hepatectomy and liver transplantation, the 5-year overall survival rate was 92% in patients who were performed partial hepatectomy, and about 83% in patients who underwent liver transplantation [29, 30, 31, 32].
Although primary liver transplantation is recommended for POSTTEXT III and IV hepatoblastoma, some of the patients may be possible to perform extended hepatectomy after careful preoperative evaluation. In a prospective study that involved 18 patients with PRETEXT III and IV, extended major hepatic resection is safe and feasible with a comparable prognosis. The prognosis was similar with liver transplantation, while patients could avoid long-term immunosuppressive treatment. But there should always be a potential donor for salvage liver transplantation [33, 34]. A study including 24 patients performed liver transplantation or extensive liver resection. Two patients in five who underwent liver transplantation experienced tumor recurrence and death within a mean period of 6 months, while 6 patients were recurrent in the extended hepatectomy group, with 63.2% event-free survival and 94.7% overall survival rate. The results support extensive surgical resection in patients of advanced tumor [35]. Although the surgical resection is complicated and sometimes remains positive or close negative margins, the patients could have good outcomes. Combined with neoadjuvant therapy, extensive surgical resection may spare the morbidity of orthotopic liver transplantation. And it will offer an alternative treatment for patients who are ineligible for liver transplantation [36].
In our center, we have performed extended hepatectomy for 27 cases of PRETEXT or POSTEXT III and IV, the 3-year disease-free survival was 75.0%, and the overall survival was 87.5%.
Neoadjuvant therapy has become the standard treatment for unresected hepatoblastoma. After neoadjuvant therapy, tumor volume may reduce, and surgical resection could be safely performed [37]. Although the patients may have good survival, neoadjuvant therapy may be related with postoperative complications. A study assessing the surgical outcomes focusing on resection margins, postoperative complications, 30-day mortality, and overall survival found that patients who underwent partial hepatectomy after chemotherapy experienced high rate of surgical complications (58%). But the complications were not detrimental to survival [29]. In another report, the incidence of complications after surgical resection following adjuvant chemotherapy is high and is associated with overall survival in high-risk hepatoblastoma. One of the possible reasons is that postoperative complication will delay the chemotherapy [38]. In our experience, precise preoperative evaluation of the anatomy of tumor and intrahepatic vascular with three-dimensional (3D) reconstruction and compare with the intraoperative situation will ensure the safety of surgery.
Three-dimensional reconstruction has been widely used in preoperative evaluation and assisting hepatectomy [39] or living donor liver transplantation [40]. 3D simulation software could reconstruct the whole liver, tumor, and intrahepatic vascular, clearly displaying the anatomical variation and the correlation of tumor with the surrounding vascular. It is helpful for making the precise surgical plan and enables individualized anatomic hepatectomy for each pediatric patient with hepatoblastoma. For surgical resection, precisely understanding the location of tumor and the relation of tumor with the surrounding vascular and accurately evaluating the remnant liver volume are important for safe hepatectomy of giant hepatoblastoma. In our center, we have used a novel virtual hepatectomy simulation software named Hisense CAS for preoperative evaluation. The Hisense CAS software could simulate a 3D liver image quickly and accurately with DICOM files of contrast-enhanced CT. With the Hisense CAS, we could confirm the anatomical relationship of tumor with the surrounding vascular from any direction, preoperatively mimic hepatectomy by extracting Glisson territory for anatomical liver resection or nonanatomical hepatectomy, automatically calculate the remnant liver volume, and navigate the liver resection during operation [41, 42]. As shown in Figure 1, with the help of 3D reconstruction, we performed extended hepatectomy for the patients. In total, we have performed extended hepatectomy for 27 patients in PRETEXT or POSTTEXT III and IV. All the hepatoblastoma were successfully removed with no complications. There were shorter operation time and less intraoperative bleeding in the reconstructing group. And the postoperative hospital stays tended to be shorter [41, 42].
Precise evaluation of hepatoblastoma with 3D reconstruction software.
Although extended hepatectomy for advanced hepatoblastoma has achieved favorable results, liver transplantation is still the only treatment for unresectable hepatoblastoma.
Liver transplantation can achieve a good prognosis for patients with hepatoblastoma, with a 5-year survival rate of 86% and a 10-year survival rate of about 80% [32, 43]. Compared with deceased donor transplantation, the prognosis of living liver transplantation was a little better (5-year survival rates were 83.3 and 77.6%). And compared with salvage liver transplantation, primary liver transplantation has a better prognosis (5-year survival rates were 82 and 30%) [31]. Compared with liver transplantation performed before 2010, patients who received liver transplantation after 2010 have a better prognosis (5-year survival rates were 82.6 and 75.1%) [43]. Preoperative liver metastasis, tumor lysis after chemotherapy, and perioperative anticoagulation can significantly improve the prognosis of patients with liver transplantation. And the outcome was not affected by tumor pathology [44]. For unresectable hepatoblastoma, vascular infiltration and poor resection are often present, and liver transplantation has become the first choice [45]. Adjuvant chemotherapy after transplantation can significantly improve the long-term prognosis of patients [22]. For unresectable hepatoblastoma, the pretransplantation trend of alpha-fetoprotein levels after live donor liver transplantation can be used as an indicator of predictive recurrence. Since the AFP response cannot be accurately predicted before each chemotherapy cycle, liver transplantation may be appropriate if the AFP level does not decrease after the last cycle and before AFP levels are found to rise again [46].
The lung is the most common metastatic organ of hepatoblastoma. In addition to lung, brain and bone metastases have also been reported [12, 47]. At the first diagnosis of hepatoblastoma, 17% of patients had pulmonary metastases [48]. Patients with lung metastasis will have a poor overall prognosis. Therefore, a CT scan of the lung should be performed before treatment to determine whether there is lung metastasis. Treatment after lung metastasis is also critical to extend the prognosis of patients. Comprehensive treatment of primary and metastatic lesions can improve the prognosis of patients.
The treatment of patients with synchronous lung metastasis and hepatoblastoma has been systemically reviewed [49]. To summarize, if the primary lesions and metastases are resectable, combine resection; if unresectable, eradicate or reduce the metastasis by neoadjuvant chemotherapy and then flowing combined resection. For single lung metastatic nodule, surgical resection is safe and feasible for the treatment [50]. Neoadjuvant chemotherapy combined with surgical resection of primary and metastatic lesions can achieve a better prognosis for patients with lung metastases. Most lung metastatic lesions are sensitive to chemotherapy. About half (26/60) of patients can achieve complete remission by chemotherapy. Then flowing surgical removal of primary lesion, the patient’s survival could be significantly improved (3-year survival rate 67.2%) [51]. For the patients whose lung metastasis cannot be completely eradicated by chemotherapy, the prognosis is relatively poor [52]. For patients who cannot achieve complete remission, increasing the intensity of chemotherapy or expanding the scope of surgical resection may prolong the patient’s prognosis. In addition, the patients will experience poor prognosis if it occurs as lung metastases while on treatment [52]. If the primary liver lesion is resectable, chemotherapy-resistant lung lesions should be surgically removed before, after, or at the same time as liver tumor surgery. In patients with unresectable primary liver tumor, liver transplantation combined with metastasectomy can be performed after chemotherapy, the 5-year survival rate of which can reach 86%. For patients with an unremovable hepatoblastoma and residual lung metastasis, overall tumor burden may be an important prognostic factor for these patients [53]. Local treatment (e.g., transcatheter arterial chemoembolization or radiofrequency ablation) may be considered to reduce tumor size [49, 54]. Sometimes it is difficult to diagnose whether there is viability of residual lung lesions after chemotherapy; it will affect the operation for the primary tumor. It is difficult to determine the pathology of tiny lesions in imaging and find the lesions during intraoperative exploration; indocyanine green fluoroscopy may be helpful. But further study is necessary to verify the usefulness [55].
Compared with pediatric hepatoblastoma, adult hepatoblastoma has a lower incidence and a higher degree of malignancy [56]. There is no significant gender difference in the incidence of adult hepatoblastoma, and the average age of onset is 42 years [57]. About 25% of adult hepatoblastomas are associated with hepatitis and cirrhosis, while it is rare in pediatric patients. Abdominal pain is the main clinical manifestation, and abdominal mass is the most common sign. As with children, surgical resection is the first choice for adult hepatoblastoma. Most hepatoblastomas are unresectable at diagnosis; chemotherapy can be used for patients who cannot be resected to gain opportunities for surgery [58]. Chemotherapy protocols are not standardized, and there was no statistically significance in survival rate between patients treated with drugs or TACE and patients not treated [57]. Due to low incidence, liver transplantation has yet to be fully evaluated. The prognosis of adult hepatoblastoma is extremely poor. The median survival time was 8 months and a 1-year survival rate of 39.2% after treatment [59]. And patients had a longer survival if operation was performed [59]. Compared with nonsurgical treatment, surgery has a better prognosis. Hepatic multilobed involvement, embryonic histology, multifocal nodules, and AFP <100 or AFP > 1000 are the poor prognostic factors [60].
In summary, surgical resection is the primary treatment for hepatoblastoma. Preoperative three-dimensional reconstruction can improve the resection rate of the tumor and the safety of the resection. For patients who cannot be directly resected, the tumor volume can be reduced by neoadjuvant therapy and then surgically treated. Liver transplantation is the best treatment for unresectable hepatoblastoma and has a good prognosis. For patients with distant metastasis, chemotherapy or metastasis resection combined with primary resection can effectively control disease progression.
This research was funded by the National Natural Science Foundation of China (81600490 and 81600691), the Research and Development Project of Shandong Province (2016GSF201221), China Postdoctoral Science Foundation (2016M602098 and 2018M640615), and Qingdao Postdoctoral Science Foundation (2016046).
The authors declare no conflict of interest.
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Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[{id:"4",title:"Fungal Infectious Diseases",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/355898",hash:"",query:{},params:{id:"355898"},fullPath:"/profiles/355898",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()