Papers reporting myogenic induction without transgenes from hPSCs [23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38].
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7920",leadTitle:null,fullTitle:"Infectious Process and Sepsis",title:"Infectious Process and Sepsis",subtitle:null,reviewType:"peer-reviewed",abstract:"Sepsis is a very complex clinical condition that can be considered the central point of the infectious process: the arrival point in the evolution of a localized septic outbreak that has caused a systemic inflammatory reaction. In the clinical setting two important questions regarding the transition from local inflammation, with beneficial effect, to systemic inflammatory disease, with deleterious results, remain unanswered. First, why does the transition from local to systemic disease only occur in some subjects? Second, how long does this transition take? This book attempts to answer these questions. Chapters cover such topics as surgical infections, microbiota therapy in sepsis, cytokines for host immune response, and the role of serum amyloid A in the acute phase of sepsis.",isbn:"978-1-83880-394-0",printIsbn:"978-1-83880-393-3",pdfIsbn:"978-1-83962-983-9",doi:"10.5772/intechopen.77750",price:119,priceEur:129,priceUsd:155,slug:"infectious-process-and-sepsis",numberOfPages:102,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"15ab9e0f38bdfb589c1dd56f8211a860",bookSignature:"Vincenzo Neri",publishedDate:"July 15th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7920.jpg",numberOfDownloads:3570,numberOfWosCitations:1,numberOfCrossrefCitations:1,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:4,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:6,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 16th 2019",dateEndSecondStepPublish:"September 17th 2019",dateEndThirdStepPublish:"November 16th 2019",dateEndFourthStepPublish:"February 4th 2020",dateEndFifthStepPublish:"April 4th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"170938",title:"Prof.",name:"Vincenzo",middleName:null,surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri",profilePictureURL:"https://mts.intechopen.com/storage/users/170938/images/system/170938.jpeg",biography:"Vincenzo Neri is a former Professor of General Surgery (retired), Department of Medical and Surgical Sciences, University of Foggia, Italy. He also held positions such as Director of Division of General Surgery, Director of Residency School of General Surgery, Director of Department of Surgical Sciences, and President of Course of Degree of Medicine and Surgery at the same university. He also served as an assistant professor (1974–1982) and associate professor (1982–2001) at the School of Medicine and Surgery, University of Bari, Italy, where he obtained a degree in Medicine and Surgery and completed postgraduate training in General Surgery and Emergency Surgery. He obtained a diploma of 'Maitrise Universitaire en Pedagogie des Sciences de la Santè” from the University Paris-Nord Bobigny in 1995. Dr. Neri’s research interests include hepatobiliary pancreatic surgery, acute pancreatitis, and treatment of pancreatic and liver tumors. He has published research papers, reviews, congress proceedings, and book chapters. In the period 1991–2016, he attended the Hepatobiliarypancreatic Surgery Service of Beaujon Hospital, Universitè de Paris, Clichy. As part of the 2010–2011 ERASMUS Program, Dr. Neri developed a seminar on 'Cystic Tumours of the Pancreas” at Ghent University, Belgium. He is a member of several scientific associations including Società Italiana di Chirurgia (SIC), International Hepato-Pancreato Biliary Association (IHPBA), European Association for the Study of the Liver (EASL), New European Surgical Academy (NESA), and Society of Laparoscopic and Robotic Surgeons (SLS).",institutionString:"University of Foggia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"9",totalChapterViews:"0",totalEditedBooks:"5",institution:{name:"University of Foggia",institutionURL:null,country:{name:"Italy"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"71967",title:"Introductory Chapter: Surgical Infections",doi:"10.5772/intechopen.92259",slug:"introductory-chapter-surgical-infections",totalDownloads:385,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Vincenzo Neri",downloadPdfUrl:"/chapter/pdf-download/71967",previewPdfUrl:"/chapter/pdf-preview/71967",authors:[{id:"170938",title:"Prof.",name:"Vincenzo",surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri"}],corrections:null},{id:"68828",title:"Immunoparalysis in Septic Shock Patients",doi:"10.5772/intechopen.88866",slug:"immunoparalysis-in-septic-shock-patients",totalDownloads:986,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In the recent years, it has become clear that septic shock is characterized by the simultaneous production of inflammatory and anti-inflammatory mediators; the primary role of the latter is to counterbalance the former, thus limiting the severity of their systemic effects. However, in a number of patients, the anti-inflammatory substances can cause a downregulation in both the innate and adaptive immune capabilities, leading a second phase characterized to secondary infections caused by opportunist germs and the reactivation of latent viruses, muscle wasting; altogether, these abnormalities set the stage for a chronic critical condition. This condition, whose identification is relatively recent, is called immunoparalysis. Unfortunately, the current approach to septic shock is focused much more on the inflammatory phase than in the ensuing immunoparalysis, whose diagnosis can be challenging. In this chapter, the role played by both classes of mediators, the monitoring of the immune system, and the possible current and not yet available therapeutic strategies of immunoparalysis are reviewed and discussed.",signatures:"Giorgio Berlot and Silvia Passero",downloadPdfUrl:"/chapter/pdf-download/68828",previewPdfUrl:"/chapter/pdf-preview/68828",authors:[{id:"304402",title:"Prof.",name:"Giorgio",surname:"Berlot",slug:"giorgio-berlot",fullName:"Giorgio Berlot"}],corrections:null},{id:"69140",title:"Microbiota-Oriented Diagnostics and Therapy in Sepsis: Utopia or Necessity?",doi:"10.5772/intechopen.89187",slug:"microbiota-oriented-diagnostics-and-therapy-in-sepsis-utopia-or-necessity-",totalDownloads:601,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"When diagnosing sepsis, it is common to look for pathogens, microbe’s DNA, lipopolysaccharide (LPS), or host biomarkers while missing out on microbiota. The next-generation sequencing of 16S rRNA gene allowed characterizing the gut microbiota taxonomy and clarifying the gut microbial population being more complex than was previously thought. We suppose that significant disruption of the microbiota is an indicator of the major role it plays in sepsis. Serious metabolic disorders of the gut microbiota may contribute to an unfavorable outcome in septic patients. With the changes not only in the composition but also in the metabolic activity of the gut microbiota taken into account, the characteristics of the mechanisms of interactions in the “septic” microbiome will allow the advances in the optimization of the diagnostics and therapy of sepsis to be made.",signatures:"Ekaterina Chernevskaya and Natalia Beloborodova",downloadPdfUrl:"/chapter/pdf-download/69140",previewPdfUrl:"/chapter/pdf-preview/69140",authors:[{id:"199461",title:"Prof.",name:"Natalia V.",surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova"},{id:"308228",title:"Dr.",name:"Ekaterina",surname:"Chernevskaya",slug:"ekaterina-chernevskaya",fullName:"Ekaterina Chernevskaya"}],corrections:null},{id:"70619",title:"Cytokine Gene Polymorphism and Sepsis",doi:"10.5772/intechopen.90572",slug:"cytokine-gene-polymorphism-and-sepsis",totalDownloads:646,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Trauma is a significant problem across the globe with mortality more than 50%. Despite the advancement of pre-hospital care to trauma patients, early resuscitation in the emergency department, surgical interventions and intensive care monitoring mortality rate has not improved yet. The higher rate of mortality in trauma patients is usually associated with development of complications such as sepsis, septic shock, and MOF which may occur due to hysterical immune inflammatory responses. Trauma patients who developed these complications in the ICU have comparatively higher chances of mortality. Cytokines are very important for host immune response against infections and play vital roles in the regulation of innate and adaptive immunity. The slanted expression of cytokines due to trauma may be involved in development of sepsis and related complications. The recently published work from various studies suggested that slanted expression of cytokines correlates with the variations in the promoter and structural regions of cytokine genes, which may be responsible for inter-individual differences in susceptibility to sepsis. Therefore, understanding the variations in cytokine genes and associated outcomes due to trauma would possibly contribute to the event of latest genetically changed diagnostic and therapeutic interventions that will improve the outcome in post-traumatic sepsis patients.",signatures:"Dablu Lal Gupta, Tejparkash Sinha, Sanjeev Bhoi and D.N. Rao",downloadPdfUrl:"/chapter/pdf-download/70619",previewPdfUrl:"/chapter/pdf-preview/70619",authors:[{id:"97678",title:"Prof.",name:"D.N.",surname:"Rao",slug:"d.n.-rao",fullName:"D.N. Rao"},{id:"267549",title:"Prof.",name:"Sanjeev",surname:"Bhoi",slug:"sanjeev-bhoi",fullName:"Sanjeev Bhoi"},{id:"311249",title:"Dr.",name:"Dablulal",surname:"Gupta",slug:"dablulal-gupta",fullName:"Dablulal Gupta"},{id:"315420",title:"Dr.",name:"Tej Prakash",surname:"Sinha",slug:"tej-prakash-sinha",fullName:"Tej Prakash Sinha"}],corrections:null},{id:"70750",title:"Hemostatic Aspect of Sepsis",doi:"10.5772/intechopen.90800",slug:"hemostatic-aspect-of-sepsis",totalDownloads:522,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The hemostatic system is composed of primary hemostasis and coagulation on the one hand, and natural regulatory anticoagulant protein mechanisms and fibrinolysis, on the other hand. Under physiological conditions, these processes are balanced. Under septic conditions, coagulopathy may followed by disseminated intravascular coagulation (DIC). Tissue factor (TF) pathway is regarded to be the core way for activation of the coagulation cascade in sepsis. TF is triggered by pro-inflammatory mediators, encompassing cytokines, C-reactive protein, and advanced glycation end products in peripheral blood cells and on microparticle molecules. Once a septic patient develops DIC, a significant increase in the susceptibility of developing organ dysfunction, morbidity, and mortality may occur. This work was basic elucidation of the idea that coagulation and its inhibitors are of major importance in coagulation-inflammation noise, similarly as in cure from sepsis.",signatures:"Bashir Abdrhman Bashir Mohammed",downloadPdfUrl:"/chapter/pdf-download/70750",previewPdfUrl:"/chapter/pdf-preview/70750",authors:[{id:"311402",title:"Associate Prof.",name:"Bashir A.",surname:"Bashir",slug:"bashir-a.-bashir",fullName:"Bashir A. Bashir"}],corrections:null},{id:"71957",title:"The Invariant Peptide Clusters of Serum Amyloid A Are Humoral Checkpoints for Vital Innate Functions as Probed by Monoclonal Antibodies, Including in Sepsis: Induction by Febrile Temperatures and Path of Discoveries",doi:"10.5772/intechopen.91983",slug:"the-invariant-peptide-clusters-of-serum-amyloid-a-are-humoral-checkpoints-for-vital-innate-functions",totalDownloads:431,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Serum amyloid A (SAA) is the most prominent acute-phase protein in vertebrates and its role in innate immunity has been reviewed. SAA functions are located on special regions of SAA, which are highly conserved in all vertebrates. 1. The discovery of the acute-phase nature of SAA before its existence was known by experimental murine AA amyloidosis induced by septic conditions. 2. Identification of the amyloid substance and its precursor. 3. SAA changes its conformation and antigenic presentation when it is separated from HDL during the acute phase. Febrile temperatures activate SAA through the separation from HDL. There is a temperature-specific gradual separation of SAA isotypes or groups of isotypes from HDL. 4. Generic monoclonal AA antibodies mc4 and mc29 assist in elucidating selected SAAs’ vital functions (as in defense, platelet functions, female propagation and others). 5. In a murine sepsis model, the monoclonals mc4 and mc29 can cause early death while the intact SAA can prevent this. Through this, a checkpoint (“stop and go”) for survival was discovered. Generic monoclonals can also identify the life-saving structures of SAA’s vital functions and those of other acute-phase proteins. This principle is essential for the production of novel drugs against sepsis and other innate-related diseases. 6. Some remarks follow.",signatures:"Reinhold P. Linke",downloadPdfUrl:"/chapter/pdf-download/71957",previewPdfUrl:"/chapter/pdf-preview/71957",authors:[{id:"33634",title:"Prof.",name:"Reinhold P.",surname:"Linke",slug:"reinhold-p.-linke",fullName:"Reinhold P. Linke"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"10729",title:"Infections and Sepsis Development",subtitle:null,isOpenForSubmission:!1,hash:"de8b1d035f242a8038f99d48b9069edf",slug:"infections-and-sepsis-development",bookSignature:"Vincenzo Neri, Lixing Huang and Jie Li",coverURL:"https://cdn.intechopen.com/books/images_new/10729.jpg",editedByType:"Edited by",editors:[{id:"170938",title:"Prof.",name:"Vincenzo",surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6352",title:"Gastrointestinal Surgery",subtitle:"New Technical Proposals",isOpenForSubmission:!1,hash:"f75fc66eb312d3a8a6be8256c5ffb279",slug:"gastrointestinal-surgery-new-technical-proposals",bookSignature:"Vincenzo Neri",coverURL:"https://cdn.intechopen.com/books/images_new/6352.jpg",editedByType:"Edited by",editors:[{id:"170938",title:"Prof.",name:"Vincenzo",surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10314",title:"Esophagitis and Gastritis",subtitle:"Recent Updates",isOpenForSubmission:!1,hash:"018c77c0b435770edd232fbdf706d573",slug:"esophagitis-and-gastritis-recent-updates",bookSignature:"Vincenzo Neri and Monjur Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/10314.jpg",editedByType:"Edited by",editors:[{id:"170938",title:"Prof.",name:"Vincenzo",surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri"}],equalEditorOne:{id:"206355",title:"Associate Prof.",name:"Monjur",middleName:null,surname:"Ahmed",slug:"monjur-ahmed",fullName:"Monjur Ahmed",profilePictureURL:"https://mts.intechopen.com/storage/users/206355/images/system/206355.jpeg",biography:"Monjur Ahmed, MD, FRCP, is an Associate Professor of Medicine at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. He has been a practicing gastroenterologist for twenty-two years. He has a special interest in inflammatory bowel disease, eosinophilic esophagitis, gastrointestinal motility, and dysphagia. Dr. Ahmed also serves as an editor in chief for the World Journal of Gastrointestinal Oncology.",institutionString:"Thomas Jefferson University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Thomas Jefferson University",institutionURL:null,country:{name:"United States of America"}}},equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8443",title:"Gastrointestinal Stomas",subtitle:null,isOpenForSubmission:!1,hash:"2e8dfeaf7ef41c96a76cb124dccbac94",slug:"gastrointestinal-stomas",bookSignature:"Vincenzo Neri",coverURL:"https://cdn.intechopen.com/books/images_new/8443.jpg",editedByType:"Edited by",editors:[{id:"170938",title:"Prof.",name:"Vincenzo",surname:"Neri",slug:"vincenzo-neri",fullName:"Vincenzo Neri"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"825",title:"Current Topics in Tropical Medicine",subtitle:null,isOpenForSubmission:!1,hash:"ef65e8eb7a2ada65f2bc939aa73009e3",slug:"current-topics-in-tropical-medicine",bookSignature:"Alfonso J. 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The current demand is also intensified by increased water utilization for hand washing due to the COVID-19 pandemic. Today, around 20,000 desalination plants operating around the world produce 100 million cubic meters of water per day to supply 300 million people. These desalination plants are a major source of environmental and marine pollution due to their inefficient operation. Scientists and researchers are encouraged to develop out-of-box solutions to achieve future sustainability. This book addresses key challenges related to the desalination industry.",isbn:"978-1-83968-877-5",printIsbn:"978-1-83968-876-8",pdfIsbn:"978-1-83968-878-2",doi:null,price:119,priceEur:129,priceUsd:155,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"ca25e9eca70d54deb503d2663f75218c",bookSignature:"Dr. Muhammad Wakil Shahzad, Dr. Mike Dixon, Dr. Giancarlo Barassi, Prof. Ben Bin Xu and Dr. Yinzhu Jiang",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10682.jpg",keywords:"Conventional Desalination, Processes Limitations, Desalination CAPEX and OPEX, Innovative Processes, Hybrid Systems, Solar Desalination, Wind-RO, Standard Primary Energy, Performance Ratio, Sustainable Desalination, Environment Friendly, Low Cost",numberOfDownloads:324,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 8th 2021",dateEndSecondStepPublish:"April 5th 2021",dateEndThirdStepPublish:"June 4th 2021",dateEndFourthStepPublish:"August 23rd 2021",dateEndFifthStepPublish:"October 22nd 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"a year",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Dr. Shahzad is a pioneering researcher in hybrid desalination processes, he received many international awards including the global innovation award in water 2020, served as IDA-YLP regional coordinator, and is a holder of 9 registered patents. He is also a member of two spin-off companies.",coeditorOneBiosketch:"Dr. Dixon has a Ph.D. in Chemical Engineering from the University of Adelaide and business training from Stanford University. He has more than 60 publications in international journals and has been an Editor of the International Desalination Association Journal.",coeditorTwoBiosketch:"Dr. Barassi returned to Chile, after finishing his Ph.D. in Chemistry in New Zealand, and started his own company H2OPR. He is currently working at FEDCO USA as a leader in hydraulic solutions for the desalination industry.",coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"174208",title:"Dr.",name:"Muhammad Wakil",middleName:null,surname:"Shahzad",slug:"muhammad-wakil-shahzad",fullName:"Muhammad Wakil Shahzad",profilePictureURL:"https://mts.intechopen.com/storage/users/174208/images/system/174208.jpg",biography:"Dr. Muhammad Wakil Shahzad is a senior lecturer in the Mechanical and Construction Engineering Department, Northumbria University (NU), Newcastle Upon Tyne, United Kingdom.\nHe is an expert in hybrid desalination processes and renewable energy applications for water treatment. He has won many international awards for his innovative desalination cycle, including the National Energy Globe Award Saudi Arabia 2021, Sustainability Medal 2020, Global Innovation Award 2020, National Energy Globe Award Saudi Arabia 2020 and 2019, Excellence and Leadership Award 2019, and IDA Environmental & Sustainability Award 2019. His research has been highlighted at Yahoo Business, Nature Middle East, Arab News, and many other national and international platforms.\nDr. Shahzad has a Ph.D. in Mechanical Engineering from the National University of Singapore and research training from KAUST Saudi Arabia. He has extensive experience in intellectual property development and the commercialization of innovative technologies. He holds eleven international patents. To date, he has published two books, seventeen book chapters, more than seventy peer-reviewed journal papers, and more than 110 conference papers. He also received three best paper awards in international conferences. He is an editor of International Communications in Heat and Mass Transfer, an editorial board member of SN Applied Sciences, and a guest editor for topical collections. He is a Chartered Engineer and a mentor for International Desalination Association’s Young Leader Program (IDA-YLP). He is also a member of many professional organizations, including the Institute of Mechanical Engineers, International Desalination Association (IDA), International Water Association (IWA), and American Society of Mechanical Engineers (ASME).",institutionString:"Northumbria University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"11",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Northumbria University",institutionURL:null,country:{name:"United Kingdom"}}}],coeditorOne:{id:"351853",title:"Dr.",name:"Mike",middleName:null,surname:"Dixon",slug:"mike-dixon",fullName:"Mike Dixon",profilePictureURL:"https://mts.intechopen.com/storage/users/351853/images/system/351853.png",biography:"Dr. Mike Dixon is a desalination and water treatment technology professional with 15 years’ experience working with membrane and thermal technologies in Australia, North America, the Middle East, the Caribbean, and Asia. He has worked across the entire value chain with technology manufacturers, water utilities, oil and gas companies, pharmaceutical companies, and research hubs.\nAs the current Chief Technology Officer of WaterNEXT (a water business accelerator based in Calgary, Canada), Dr. Dixon’s responsibilities include technology assessment and intake assessment. He is also a senior technical advisor, and on the founding team, of MIT start-up Sandymount Technologies.\nPrior to WaterSMART, Dr. Dixon was Applications Development Manager for NanoH2O, a global provider of reverse osmosis membranes that leveraged UCLA developed nanotechnology developed at the University of California, Los Angeles, to lower the cost of desalination with more than 300 installations in 40+ countries in the three years from market launch. LG Chem acquired NanoH2O in 2014. He was also R&D Engineer for the 300,000 m3/day Adelaide Desalination Plant.\nDr. Dixon has a Ph.D. in Chemical Engineering from the University of Adelaide, Australia, and business training from Stanford University, California. He is experienced with the development of intellectual property and the commercialization of new technologies. He has more than sixty publications in international journals and is an author of several books and book chapters. He has been an editor of the International Desalination Association Journal and a reviewer for the Journal of Membrane Science, Desalination and Water Research. He was National President of the Young Water Professionals for the Australian Water Association and in 2012 won the prestigious International Desalination Association Fellowship Award.",institutionString:"Synauta Inc.",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:{id:"351875",title:"Dr.",name:"Giancarlo",middleName:null,surname:"Barassi",slug:"giancarlo-barassi",fullName:"Giancarlo Barassi",profilePictureURL:"https://mts.intechopen.com/storage/users/351875/images/system/351875.png",biography:"After obtaining his Ph.D. in Chemistry in New Zealand, Dr. Giancarlo Barassi returned to his home country of Chile and started his own company, H2OPRO. His business sells projects and equipment for Culligan, Voltea, and FEDCO in Chile and Peru. He has hands-on experience in designing, commissioning, and troubleshooting reverse osmosis plants for industrial, agriculture, and haemodialysis applications. Dr. Barassi joined the pump and ERD manufacturer, FEDCO, in September 2017 where he collaborated in sales and business development in the Western Hemisphere until 2021. He was appointed the co-chair of the Young Leader Program at the International Desalination Association for the 2019–2022 term where he promotes benefits to young professionals in the industry. In 2022, he joined Aquatech International LLC, as the Desalination and Reuse Market Manager, where he oversees all desalination and reuse projects.\nHe is currently based in Tampa, FL, USA.",institutionString:"FEDCO USA",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorThree:{id:"417448",title:"Prof.",name:"Ben Bin",middleName:null,surname:"Xu",slug:"ben-bin-xu",fullName:"Ben Bin Xu",profilePictureURL:"https://mts.intechopen.com/storage/users/417448/images/system/417448.png",biography:"Dr. Ben Bin Xu is a Full Professor of Materials and Mechanics, Department of Mechanical and Construction Engineering (MCE), Northumbria University (NU), Newcastle Upon Tyne, United Kingdom. and leads the research group of the Smart Materials and Surfaces Lab. He obtained his Ph.D. in Mechanical Engineering at Heriot-Watt University, Scotland, in 2011 and subsequently worked as a postdoc researcher at the University of Massachusetts Amherst (2011–2013). His research interests include advanced materials, smart surfaces, energy materials/systems, thin films, flexible electronics, and microengineering. He has published more than 120 journal articles and 3 book chapters. He has four patents to his credit. He has given more than sixty invited talks and won multiple awards, such as the Outstanding Paper Award at the 2018 IEEE International Flexible Electronics Technology Conference, the 2016 Young Investigator Award from the International Polymer Networks Group, and the 3rd prize in the 2016 EPSRC photo competition, among others. \r\n\r\nDr. Xu is a fellow of the Royal Society of Chemistry (RSC), Institute of Materials, Minerals, and Mining (IoM3), and Royal Society for the Encouragement of Arts, Manufactures and Commerce (RSA). He is also a Chartered Scientist and Chartered Engineer. He has been an elected member in the Advisory Council and Nomination Committee of IoM3 since 2019, an elected member in the RSC Materials Chemistry Division Council since 2020, an elected member in the RSC Newcastle upon Tyne and North East Coast Committee since 2020, and the executive committee for the Chinese Society of Chemical Science and Technology (CSCST-UK) since 2016.",institutionString:"Northumbria University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Northumbria University",institutionURL:null,country:{name:"United Kingdom"}}},coeditorFour:{id:"458611",title:"Dr.",name:"Yinzhu",middleName:null,surname:"Jiang",slug:"yinzhu-jiang",fullName:"Yinzhu Jiang",profilePictureURL:"https://mts.intechopen.com/storage/users/458611/images/system/458611.jpg",biography:"Dr. Yinzhu Jiang is a professor at the School of Materials Science\nand Engineering, Zhejiang University, China. He received his Ph.D.\nin Materials Science and Engineering from the University of Science and Technology, China, in 2007. He worked as a post-doctoral\nresearcher at Heriot-Watt University, Scotland, from 2007 to 2008,\nand an Alexander von Humboldt Fellow at Bielefeld University,\nGermany, from 2008 to 2010. His research interests focus mainly on\nenergy-related materials and electrochemistry, including rechargeable batteries, metal\nanodes, and solid electrolytes. He has published more than 100 articles in journals such\nas Advanced Materials, Advanced Energy Materials, Energy & Environmental Science, Nano Energy, and others.",institutionString:"Zhejiang University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorFive:null,topics:[{id:"872",title:"Water Resources",slug:"water-resources"}],chapters:[{id:"77735",title:"Desalination Brine Management: Effect on Outfall Design",slug:"desalination-brine-management-effect-on-outfall-design",totalDownloads:73,totalCrossrefCites:0,authors:[null]},{id:"78990",title:"Remineralization and Stabilization of Desalinated Water",slug:"remineralization-and-stabilization-of-desalinated-water",totalDownloads:167,totalCrossrefCites:0,authors:[null]},{id:"78819",title:"Elimination of Acid Red 88 by Waste Product from the Phosphate Industry: Batch Design and 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"61400",title:"Making Skeletal Muscle from Human Pluripotent Stem Cells",doi:"10.5772/intechopen.77263",slug:"making-skeletal-muscle-from-human-pluripotent-stem-cells",body:'\n
When injured, skeletal muscle regenerates by activation and proliferation of its own stem cells: muscle satellite cells. Therefore, muscle satellite cells were expected to be a cell source for cell therapy for devastating muscular dystrophies. However, clinical trials in the 1990s were unsuccessful [1], possibly because myoblasts that had been expanded in vitro lost the high ability to fuse with the host’s injured myofibers, indicating that improvement of muscle function requires a large quantity of myogenic progenitors with regenerative potential. Human embryonic stem cells (hESCs) and human-induced pluripotent stem cells (hiPSCs) [2] have almost unlimited proliferative potential and the ability to differentiate into the skeletal muscle lineage (reviewed in [3, 4]). Therefore, they are a promising source of new cells for cell therapy of muscle diseases such as muscular dystrophy (DMD). They are also useful for biological and physiological studies of human skeletal muscle.
\nDisease-specific hiPS cells are generated from patients’ somatic cells (usually blood cells or skin fibroblasts) with almost the same efficiency and quality as cells from healthy donors [5]. Therefore, disease-specific-induced pluripotent stem (iPS) cells are being widely used to study the molecular mechanisms of these diseases and to screen potential drugs. As a method to directly derive skeletal muscle cells from hPSCs, MyoD-mediated reprogramming was established and is widely used. MyoD induces muscle cells in a relatively short period with high efficiency. In this chapter, we review the literature on derivation of skeletal muscle from human PSCs and discuss the next steps toward clinical applications. In the last part, we review the recent reports on successful disease modeling in vitro using patient iPS cells and discuss future directions.
\nMuscle satellite cells were first identified by electron microscopy as a mononuclear cell between myofibers and the basal lamina and named by Mauro in 1961 [6]. Later, muscle satellite cells were shown to be skeletal muscle-specific stem cells in postnatal muscle [7]. Muscle satellite cells are activated upon muscle injury, proliferate as myoblasts, and fuse with each other or with regenerating myofibers to repair damaged muscle [8]. In 1989, Partridge et al. reported successful recovery of dystrophin expression in dystrophin-deficient mdx mice after direct injection of wild-type myoblasts [9]. Based on this finding, myoblast transfer therapy was performed on DMD patients in several hospitals. Unfortunately, the clinical trials failed to recover the muscle function of these patients. The majority of injected cells seemed to be lost within 48 h [1]. The results were unexpected at that time because endogenous muscle satellite cells themselves have high regenerative activity in situ and repair damaged muscle quickly. Later, researchers started to search for multipotent stem cells, which can be delivered systemically, engraft in muscle, and differentiate into myofibers. One of these cells is the mesoangioblalst, which showed an amazing ability to recover dystrophin expression in the muscles of dystrophic dogs after intra-arterial injection [10]. Mesenshymal stem/progenitor cells (MSC/MPC) are also expected to be a tool for regenerative medicine. They themselves do not differentiate into myofibers, but support muscle regeneration by paracrine effects [11]. The history of direct reprogramming in the muscle field is long, starting with the discovery of MyoD by Weintraub and his colleagues [12, 13]. MyoD powerfully converts non-muscle cells to skeletal muscle cells, but it is difficult to induce Pax7+ myogenic progenitors using MyoD alone. Recently Ito et al. reported that a combination of transcription factors (
History of research on muscle stem cells and cell therapy for muscular dystrophies [
Muscle satellite cells were identified and named by Mauro in 1961 [6]. Direct reprogramming was reported for the first time in the skeletal muscle field in 1987 [15], but MyoD alone cannot induce myogenic progenitors. After a surprising report of BM-derived myogenic cells by Ferrari in 1998 [16], researchers looked for multipotent stem cells that can be delivered via the circulation. MSCs are modulators of muscle regeneration and widely used in regenerative medicine. Human iPS cells are a relative newcomer in the muscle stem cell field.
\nDarabi et al. [21] reported derivation of engraftable muscle progenitors from hiPSCs by using a lentiviral vector encoding DOX-inducible PAX7. PAX7 expression was induced transiently in differentiating cells in a monolayer culture after a 7-day embryoid body (EB) culture [21]. Pax7-expressing GFP-positive cells purified by fluorescence-activated cell sorting (FACS) were then transplanted into the skeletal muscle of immune-deficient dystrophin-deficient mice,
The majority of stepwise muscle induction protocols recently reported for human ESCs/iPSCs utilize a GSK3b inhibitor in common, myogenic growth factors (HGF, IGF-1, bFGF, EGF, etc.), and a serum-free medium (Table 1; [3]). For example, Chal et al. treated hiPS cells with CHIR-99021, which activates Wnt signaling, and LDN-193189, which prevents hiPSCs from differentiation into lateral mesoderm and induces differentiation into paraxial mesoderm. Treatment with these molecules of hESC cultures induced myogenin(+) myogenic cells with 25–30% efficiencies [34, 36, 39].
\nEB culture and sphere culture are often used to induce muscle progenitor cells (Table 1). Hosoyama et al. reported that hESCs/hiPSCs cultured as floating cell aggregates (termed EZ spheres) in a medium developed for neural stem cells supplemented with bFGF and EGF efficiently differentiated into myogenic cells. After a 6-week floating culture, 40–50% of cells expressed PAX7, MyoD or myogenin [32]. Because dissociation of sphere cells into single cells during the induction process drastically reduces myogenic activity, direct cell-cell interaction might be essential for commitment of hPSCs to the skeletal muscle lineage.
\nThe extra-cellular matrix (ECM) is an interactive environment having, apart from its simple role as a mechanical support or physical barrier, a role in signaling and providing a niche for the stem cell [40].
\nCollagens, laminins, fibronectin, or Matrigel have been used for in vitro studies in order to mimic the ECM of muscle cells in 2D or 3D culture systems because ECM is indispensable for skeletal muscle development [41]. Interestingly, native ECM obtained by decellularization of skeletal muscle stimulated muscle differentiation and a more rapid cell organization compared to single matrix glycoprotein culture [42], indicating again that ECM has functions in myogenesis. The use of a 3D fibrin-based hydrogel culture after production of myogenic cells with transient overexpression of Pax7 was recently reported to generate functional biomimetic skeletal muscle tissues from hiPSC-derived paraxial mesoderm cells for the first time [43].
\nThe stiffness of the microenvironment has also been reported to regulate differentiation of myogenic cells [44, 45]. More precisely, in an in vitro context, 12 kPa stiffness was shown to give optimal results for muscle stem cells, compared to the harsh 106 kPa stiffness of a regular polystyrene plastic culture dish [45]. The impact of stiffness can be partially explained by the activation of pathways such as N-RAP, FAK, or PKC [44].
\nSome studies showed improvement of myoblast migration and differentiation through MMP-1 treatment [46], migration with MMP-13 [47], and fusion through MMP-7 overexpression [48], suggesting the importance of remodeling of the ECM for migration and differentiation of myogenic cells even in vitro.
\nThe interaction between myogenic cells and non-myogenic cells in muscle tissue may influence myogenesis either by interacting directly or by secretion of paracrine factors (Figure 2). Motor neurons were used to form neuro-muscular junctions [49] and further adapted to a 3D culture system [50]. The presence of motor neurons had positive effects on myotube maturation [50]. Co-culture with mesenchymal stem cells (MSCs) significantly enhanced the proliferation of muscle cells [51]. Co-culture of fibroblasts with myoblasts improved the alignment of the formed myotubes, but reduced differentiation [52]. Another paper, however, reported that the myoblasts formed longer, thicker myotubes with a mature phenotype in the presence of fibroblast-conditioning media, compared with control media [53].
\nSummary of environmental inputs that promote differentiation of muscle cells.
Exosomes are major tools of cross talk between cells throughout the body and miRNAs are one of the elements they transport. Some miRNAs, such as miR-206, have been identified as promoters of skeletal muscle development and differentiation [54]. Therefore, miRNA-mediated induction of skeletal muscle from human iPSCs is a topic of great interest.
\nBy mimicking the muscle microenvironment, it might be possible to increase the overall quantity, quality, and functionality of skeletal muscle cells produced from hiPSC.
\nMost published protocols for muscle induction from human iPS cells generate a heterogenous cell population, including myogenic cells, undifferentiated cells, and non-myogenic cells. Non-myogenic cells are in many cases of neuronal lineage. Undifferentiated cells proliferate actively and form tumors in the host muscle. Therefore, purification of myogenic progenitors is an important step for clinical use. Purification of myogenic cells would also facilitate the study of molecular pathogenesis and drug screening. To enrich myogenic cells by FACS, several iPS cell lines where the expression cassette of fluorescent proteins are inserted in the locus of myogenic regulators such as PAX7 [62] or Myf5 [63]. Combinations of myogenic cell-specific surface markers to enrich myogenic cells are also reported, for example, CD56 and CD82 [64], or CXCR4 (CD184) and C-MET [31]. We identified CD271 (NGFR) as a myogenic marker (submitted). M-cadherin antibody is also useful when the cells are dissociated into single cells by non-enzymatic treatment. Recently, Hicks et al. [38] identified ERBB3 (HER3) as a cell surface marker that enriches transplantable hiPSC-derived myogenic cells. To exclude neurogenic cells, CD57(HNK-1) is useful [31].
\nDuring the past decades, researchers have generated numerous mouse models, such as knock-out mice to analyze the pathogenesis of muscle diseases. However, mouse models often fail to reproduce the phenotypes of patients. For example, dystrophic
These days, iPSCs from many kinds of muscular diseases have been established. For example, Abujarour et al. generated iPSC lines from patients with DMD or Becker muscular dystrophies (BMD) [19]. Shoji et al. established DMD-iPSCs and reported abnormal calcium ion influx in DMD myotubes. Importantly, dystrophin expression was restored to DMD myotubes by an exon-skipping technique, and the calcium ion overflow was suppressed [70]. Choi et al. [71] reported that DMD-iPS cells showed aberrant expression of inflammation or immune-response genes and collagen genes, increased BMP/TGFβ signaling, and reduced fusion competence. Tanaka et al. [20] established iPSC lines from patients with Miyoshi myopathy. Patient-iPSC-derived myotubes showed defective membrane repair, and the authors rescued the phenotype by expression of full-length DYSFERLIN. Snider et al. [72] showed the expression of full length DUX4 in embryoid bodies from iPSCs with facioscapulohumeral dystrophy (FSHD). Caron et al. reported that FSHD1 myotubes were thinner, and the genes involved in cell cycle control, oxidative stress response, and cell adhesion were differentially regulated [37]. Du et al. and Ueki et al. [73, 74] reported that the CTG-CAG triplet repeats were expanded by passaging iPSCs derived from myotonic dystrophy type1 (DM1) patients. Yoshida et al. [75] generated iPSCs from a patient with infantile-onset Pompe disease that showed lysosomal glycogen accumulation, which was dose-dependently rescued by rhGAA.
\nThese successful in vitro disease modelings using patient-iPSCs are encouraging and would be useful for screening new drugs. Because hiPSCs have unlimited proliferative potential, one can perform experiments repeatedly and screen potential drugs extensively even if it is a rare disease. It should be, however, also recognized that skeletal muscle cells derived from hPSCs are much more immature in gene expression, morphology, and function than real myofibers in the body. Therefore, to what extent patient-derived iPSCs can reproduce a disease phenotype in vitro is important. In addition, there are variations in differentiation propensity among hiPS cell lines [76], and it is important to confirm the reproducibility of the results. Patient-iPS cells whose mutated genes were corrected by genome-editing technique [77] would serve as good controls and help to validate the findings.
\nSkeletal muscle can be induced from hPSCs by direct reprogramming or a stepwise differentiation method. Disease modeling using patient-derived iPSCs is now widely used to elucidate disease mechanisms and to screen for drugs. For successful disease modeling, it is important to induce mature myofibers. For cell-based therapy, the protocols for induction of myogenic progenitors from hiPS cells and their purification have been almost completely established. However, to eliminate the risk of tumor formation by engrafted cells, more study is needed.
\nThis study is supported by (1) Research Funds for “Development of cell transplantation methods for refractory muscle diseases” (Projects for Technological Development) and “Research on refractory musculoskeletal diseases using disease-specific induced pluripotent stem (iPS) cells” from the Research Center Network for Realization of Regenerative Medicine, Japan Science and Technology Agency (JST), and Japan Agency for Medical Research and Development (AMED), (2) Grants-in-aid for Scientific Research (C) (16 K08725, 24590497) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan and (3) Intramural Research Grants (24-9, 25-5, 27-7, and 28-6) for Neurological and Psychiatric Disorders of NCNP.
\nThe authors declare that they have no conflicts of interest.
We thank Ms. Motoko Shimizu for supporting our research.
The wearables are identified as 1 of the 10 technologies which will change our lives [1]. They offer attractive solutions in diverse areas including healthcare, education, finance, sport, and entertainment. For example, in the area of the healthcare, wearable devices can collect data (on blood pressure, temperature, heart rate, steps, calories burned, and even glucose levels) in real-time and send this information to nearby node (on-body communication between two wearable devices) or remote station (off-body communication between a wearable device and mobile phone, tablet, or personal computer) using body area networks (BANs). In order to realize remote monitoring and real-time feedback to the user, the wearable device needs to be equipped with a sensor, processor, memory, power unit, transceiver, and an antenna.
The wearable antenna plays a significant role in the overall performance of each wireless wearable device because it determines the reliability of the wireless link and directly influences the energy efficiency and battery life of the device [2, 3]. However, because the wearable antenna operates in a specific environment (on or near to the human body), the effects due to lossy body tissues (as impedance mismatching, radiation-pattern distortion, radiation efficiency reduction) make the design of a wearable antenna a difficult task. Therefore, care is needed in designing antennas for wearable devices [4, 5].
The design of wearable antennas for body-centric communications is discussed in [2, 3, 4, 5, 6, 7, 8], and the most important requirements are summarized Table 1.
Requirements | |
---|---|
Electrical |
|
Mechanical |
|
Safety | |
Manufacturing |
|
General design requirements for wearable antennas.
Generally, in wearable antenna design, electrical, mechanical, and safety requirements should be taken into account. Moreover, to obtain the best antenna performance, the antenna-human interaction needs to be taken into account during the first stage of the wearable antenna design process. As the body is composed of different tissues with different material properties, the choice of a proper body model (called phantom) is critical in ensuring a good trade-off between simulation accuracy and complexity [4]. For the initial design, the simplest and fastest option is to use a homogenous flat phantom of the human body. A detailed review of various types of human body models is presented in [3, 11, 12].
The selection of materials for the conductive and non-conductive elements of the antenna is also an important factor to consider, especially when the antenna is required to possess characteristics such as low-profile, lightweight, compactness, flexibility, and robust. Hence, flexible, thinner, and low-cost materials should be chosen to make the antenna conformable to the person wearing the wearable device and to meet mechanical and manufacturing requirements. Materials like polymers [3, 13], non-conductive fabrics [4], paper [14], and flex film [5, 6] have been used as the substrates in the existing wearable antennas [3, 15]. The choice of material for the antenna’s substrate is a critical factor in the performance of the antenna and is examined in depth in Section 3. After the selection of a suitable material for the antenna substrate, its electromagnetic properties (complex permittivity and permeability and loss tangent) must be characterized via measurements [4]. Several (resonant and non-resonant) methods described in [16] can be used for characterization of the electromagnetic properties of flexible materials. For conductive antenna elements, thinner copper or brass foils, electrically conductive fabrics, threads, or ink can be chosen.
Finally, the impact of wearable antennas on the human body also needs to be considered. To study possible effects on body tissues, we must examine the rate at which energy (W) is deposited in a given volume (V) of tissue with specific density (ρ), as shown in Eq. (1):
SAR can be also calculated from the electric field (E) within the tissue, as shown in Eq. (2):
where σ is the electrical conductivity of the tissue [S/m].
To control the possibility of high local peaks, the maximum permitted SAR is specified as applying to any 1 g or 10 g of tissue [17].
Therefore, the antenna topology with high body-antenna isolation is required to guarantee satisfactory performance and to reduce the SAR when the antenna is placed on the human body. Several antenna designs with a high degree of isolation between the antenna and human tissues have been reported. These designs use a full ground plane [15, 18], an artificial magnetic conducting surface [19], a reflector [13], an electromagnetic bandgap structure [20], or substrate integrated waveguide techniques [2, 21].
Based on the above requirements, a flexible wearable antenna with a low profile, high radiation efficiency, and low SAR can be developed using the algorithm for numerical design and optimization proposed in [3].
After that, a prototype of the optimized design of the wearable antenna can be fabricated using the methods for fabrication of flexible and wearable antennas presented in [5, 8, 13].
Finally, the antenna designs need to be confirmed by both numerical simulations and experimental measurements, first in free space and after that, when antennas are placed on a human body model.
During the wearable antenna design and development process, measurements of classical parameters that describe the antenna’s performance such as reflection coefficient magnitude (|S11|), bandwidth, gain, radiation efficiency, and radiation patterns need to be performed using passive approaches. In passive antenna measurements, the prototype is connected to the measuring equipment (a network analyzer, signal generator, receiver, or spectrum analyzer) using an external coaxial cable. Moreover, full verification of the antenna design requires more extensive testing, such as flexibility tests (described in [4, 5]) and tests which represent the behavior of the antenna in real working conditions (also called active antenna measurements). In these measurements, a wearable device simulator (or a radio communication test module) is used to set up a connection to the antenna under test, which is embedded into a complete operating wearable device (or connected to a radio communication module) to reproduce real-world behavior. In order to conduct accurate and repeatable measurements, a test (anechoic or reverberation) chamber with a controlled environment is required. The schematic setup for passive (cable-fed) and active testing of antennas in an anechoic and reverberation chamber can be found in [22].
Moreover, different measurement scenarios should be investigated to guarantee optimal antenna performance in a variety of operating conditions: free-space (the antenna is in an isolated test fixture made from foam, placed away from the human body) and on-body scenarios (the antenna is very close to the human body phantom or in direct contact with the phantom).
For wearable applications, the effect of antennas on the human body also must be quantified [8]. The SAR distribution can be measured by the thermographic method (described in [23]) or by a commercial DASY-4 system (presented in [24]).
The major challenge of designing wearable antennas is to make an antenna that is invisible and unobtrusively integrated inside a garment as well as comfortable and non-hindering for the wearer [7, 25]. The integration of antennas into clothes involves using textile materials as dielectric substrates [7].
The substrate material offers not only ergonomic properties and ease of integration into the users’ garments, but it impacts on the antenna performance. Moreover, the thickness of the substrate also influences the overall antenna dimensions [26]. A brief survey on electromagnetic (EM) properties of textile materials used in wearable antennas can be found in [4, 26, 27]. However, little information can be found on the effect of EM properties of the substrate materials on the performance of wearable antennas with body-antenna isolation. The following subsections describe the characterization of the EM properties of textile materials (polar fleece, polyester, polyamide-elastane, cotton, and denim) and their effects on performance (resonant frequency, bandwidth, radiation efficiency, and maximum gain) of wearable antennas with body-antenna isolation.
The EM properties (real (
EM properties | ||||||
---|---|---|---|---|---|---|
Thickness mm | Material layers | Density g/cm3 | ||||
Polar fleece | 1.5 | One | 1.21831 | 0.00221 | 0.00183 | 0.20 |
Polyester | 0.35 | One | 1.49797 | 0.00578 | 0.00389 | 1.38 |
1.5 | Four | 1.62022 | 0.00824 | 0.00509 | ||
Polyamide-elastane | 0.5 | One | 1.52389 | 0.03103 | 0.02040 | 1.14 |
1.5 | Three | 1.54927 | 0.02268 | 0.01463 | ||
Cotton | 0.52 | One | 1.63850 | 0.10199 | 0.06218 | 1.52 |
1.5 | Three | 1.63215 | 0.08049 | 0.04930 | ||
Denim | 0.5 | One | 1.86986 | 0.11786 | 0.06310 | 1.54 |
1.5 | Three | 1.87813 | 0.11166 | 0.05942 |
Parameters of the textile materials and results from measurements of their EM properties.
From the results presented in Table 2, it can be observed that the EM properties of the textile materials show a variation with increasing number of layers in the sample. Moreover, the
A comparison of different textile materials at the same thickness (1.5 mm) shows that denim has the highest values of
Based on the EM properties provided by the above subsection, five textile wearable antennas with high body-antenna isolation were designed using the xFDTD (xFDTD, Remcom Inc., State College, PA, USA), a finite-difference time-domain (FDTD) method-based simulation software. The configuration of the wearable textile antenna with a substrate from denim fabric is illustrated in Figure 1a. It consists of a hexagonal shaped monopole on the top of the substrate and a planar rectangular reflector on the bottom. The antenna is fed by a coplanar waveguide (CPW) feed line. This antenna structure is chosen due to its advantages of lightweight, low-profile, low-cost, and easy fabrication, which satisfies the requirements for wearable antennas presented in Table 1.
The (a) 3D numerical model of the textile antenna with a substrate from denim fabric and photographs of the fabricated prototypes, (b) antenna with a denim substrate, (c) antenna with a cotton substrate, (d) antenna with a polyester substrate, (e) antenna with a polyamide-elastane substrate, and (f) antenna with a polar fleece substrate.
Then, five antennas were manufactured by a cost-effective and time-saving fabrication technique, as described in [28]. The radiating elements of the antennas were built using a highly conductive woven fabric P1168 (supplied by Adafruit, Italy) with a thickness of 0.08 mm and sheet resistance of 0.05 Ω/sq. Figure 1b–f shows the fabricated prototypes of the antennas.
Two scenarios were investigated in this subsection to study the effect of the EM properties of the textile substrate on the antenna performance.
Configuration of the wearable antenna.
At the first stage, a wearable antenna with a substrate from polar fleece was designed (Figure 2) to operate in the 2.4–2.48 GHz industrial scientific and medical (ISM) band. The geometrical dimensions of the monopole, CPW, and reflector were tuned by numerical simulations, following the optimization procedure in [3], to achieve the optimal impedance match, high radiation efficiency, and high front-to-back (FB) ratio at the targeted ISM band. The dimensions of the antenna are listed in Table 3.
Antenna with an air-filled substrate | Antenna with a polyester substrate | Antenna with a polyamide-elastane substrate | Antenna with a cotton substrate | Antenna with a denim substrate | Antenna with a polar fleece substrate | |
---|---|---|---|---|---|---|
A | 141.0 | 141.0 | 141.0 | 141.0 | 141.0 | 141.0 |
B | 103.5 | 103.5 | 103.5 | 103.5 | 103.5 | 103.5 |
C | 134.0 | 110.0 | 112.0 | 109.0 | 103.0 | 123.0 |
D | 21.0 | 21.0 | 21.0 | 21.0 | 21.0 | 21.0 |
E | 59.0 | 47.0 | 48.0 | 46.5 | 43.5 | 53.5 |
F | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
G | — | 16.5 | 15.5 | 17.0 | 20.0 | 10.0 |
H | — | 16.5 | 15.5 | 17.0 | 20.0 | 10.0 |
I | 90.0 | 78.0 | 79.0 | 77.5 | 74.5 | 84.5 |
J | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 | 2.0 |
K | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
O1 | 17.0 | 17.0 | 17.0 | 17.0 | 17.0 | 17.0 |
O2 | 17.0 | 17.0 | 17.0 | 17.0 | 17.0 | 17.0 |
R1 | 138.0 | 127.0 | 127.0 | 127.0 | 127.0 | 127.0 |
R2 | 93.0 | 87.5 | 87.5 | 87.5 | 87.5 | 87.5 |
The geometrical dimensions of the optimized antennas.
For comparison purposes, five different numerical models of the wearable antenna with different substrates (from cotton, denim, polyester, polyamide-elastane, air) and geometrical dimensions as that of the antenna with a substrate from polar fleece were built. The resonant frequency of the antennas calculated by the simulations is compared in Figure 3a.
Variation of (a) resonant frequencies and (b) bandwidths with the
As expected, the antenna with a substrate filled by air (
Next, the effects of the EM properties of the textile substrate on the bandwidth were evaluated and illustrated in Figure 3b–d. The bandwidth of all antennas was defined for |S11| = −10 dB. Figure 3b shows the bandwidth as a function of the
As shown in Figure 3d, the antennas with a substrate from denim and cotton have the largest bandwidth (150.5 MHz) because these two fabrics have the highest values of
From the results mentioned here, it also can be concluded that fabrics made from synthetic fibers (polar fleece, polyamide-elastane, polyester) exhibit a narrow bandwidth compared to the fabrics made from natural fibers (cotton and denim).
Moreover, it is well known that the bandwidth and radiation efficiency not only are determined by the substrate’s EM properties and thickness but also depend on the size of the antenna radiating elements and matching. Consequently, it is necessary to know the effect of the EM properties of the textile materials on antenna performance when antenna elements are optimized. For this reason, in the second scenario, the structure of the antennas with a polyester, polyamide-elastane, denim, cotton, and air-filled substrate was optimized for the maximum impedance bandwidth, radiation efficiency, and high FB ratio at the 2.4–2.48 GHz frequency band. The optimized dimensions are listed in Table 3.
To illustrate the effects of textile materials on the antenna performance, the optimized antenna designs considered in Table 3 were evaluated in the free space and when placed on a flat phantom. First, a flat homogeneous semisolid phantom of the human body with dimensions 265 × 50 × 350 mm to emulate 2/3 muscle tissue was fabricated accordingly to the recipe and technique described in [29]. After the phantom mixture had solidified, EM properties were measured at 2.564 GHz:
Flat phantom and the antenna with a denim substrate: (a) a photograph and (b) numerical models.
The results from numerical simulations in both free space and on-body are presented in Figures 5–9. Figure 5 displays the bandwidth as a function of the loss tangent of the textile substrate. As seen in these plots, the bandwidth remains unchanged in both free space (Figure 5a) and on-body (Figure 5b) for the antennas with a polyester, cotton, and denim substrate. A slight bandwidth broadening is observed when the optimized antennas with an air-filled, polar fleece and polyamide-elastane substrate are placed on the flat phantom. The reason for this effect is that the real part of the relative permittivity of these materials (at a thickness of 1.5 mm, see Table 2) is between 1 and 1.55. Consequently, we can conclude that the performance of the wearable antennas with substrates made from fabrics with real part of the relative permittivity small than 1.6 will be influent from the proximity of the human body.
Variation of the bandwidth with the loss tangent of the textile substrates used in optimized wearable antennas with geometrical dimensions listed in
Simulated radiation efficiency curves versus frequency of the wearable antennas: in the free space (FS) and on the flat phantom (FP).
Simulated maximum gain curves versus frequency of the wearable antennas: in the free space (FS) and on the flat phantom (FP).
Simulated three-dimensional radiation patterns at 2.4, 2.44, 2.46, and 2.48 GHz for the antenna with a polar fleece substrate (a) in the free space and (b) on the flat phantom.
Simulated three-dimensional radiation patterns at 2.4, 2.44, 2.46, and 2.48 GHz for the antenna with a denim substrate (a) in the free space and (b) on the flat phantom.
A comparison between the simulated radiation efficiency of the antennas is displayed in Figure 6. The radiation efficiency is defined as the ratio of the power radiated from the antenna to the net input power, which is the radiated power plus material losses [30]. The comparison shows that the antennas with polar fleece, polyester, and polyamide-elastane substrates achieve a much better radiation efficiency than the antennas with substrates from cotton and denim. These differences are attributed to the fact that fabrics made from synthetic fibers have lower
From the results presented in Figure 6, a slight reduction of radiation efficiency when the antennas are placed on the flat phantom (FP) also can be observed. For example, across the operating band, the radiation efficiency of the antenna with a substrate from polar fleece is estimated to be −0.47 dB (90%) in the free space and − 1.1 dB (78%) when it is placed on the phantom.
The maximum gain of the optimized antennas was also evaluated and illustrated in Figure 7. As seen, in the target frequency band, the gain varies between 11 and 7 dBi (for the antenna with a polar fleece substrate) and between 1 and −1 dBi (for the antenna with a denim substrate). The variation in maximum gain values is related to the maximum directivity (see Figure 8) and is primarily due to the coupling between radiating elements and the reflector. The gain difference between the antennas with substrates from fabrics made with synthetic fibers and fabrics made with natural fibers can be associated with the differences in their radiation efficiency (see Figure 6). Moreover, the maximum gains of the antennas mounted directly on the flat phantom are not strongly affected by the phantom (human body).
Figures 8 and 9 compare the three-dimensional (3D) radiation patterns of the optimized wearable antennas with polar fleece and denim substrates, at 2.4, 2.44, 2.46, and 2.48 GHz. These frequencies approximately correspond to the lower, middle, and upper end of the 2.45 GHz ISM band. As shown in Figures 8 and 9, the radiation is unidirectional for the antennas at all frequencies. Three-dimensional patterns show that a small amount of the energy is radiated in the backward direction (i.e., behind the antenna) into the human body. Moreover, it can be observed that in the free space, the Eφ is the dominant field component at 2.4, 2.44, and 2.46 GHz for the antennas. At 2.48 GHz, the Eθ is the dominant field component for these antennas. Hence, we observe that the directivity is decreased with increasing frequency because more energy is radiated in θ direction.
As can be seen in the figures, the radiation patterns of the antennas are not significantly modified by the presence of the flat phantom.
Figure 10 shows FB radio as a function of frequency both in free space and on a phantom. As seen, in the target frequency band, the FB ratios vary between 12 and 33 dB in the free space and between 18 and 36 dB on the phantom, depending on the antenna’s substrate. A FB ratio of about 30 dB is achieved for the antennas with denim and cotton substrates in the free space, in the frequency band of 2.4–2.46 GHz, indicating a small amount of radiation behind the antenna.
Simulated front-to-back radio as a function of frequency in both (a) free space and (b) on phantom.
As seen in Figure 10, both antennas with polyester and polyamide-elastane substrates have FB ratio better than 17 dB in the free space and better than 23 dB on the phantom. Moreover, the antennas with cotton, polyester, polyamide-elastane, and denim preserve their FB ratios when placed directly on the flat phantom. In the case of the antennas with polar fleece and air-filled substrate, we see a FB ratio between 12 and 20 dB in the free space and between 25 and 35 dB when antennas are placed directly on the flat phantom; this will result in an increase in SAR values (see Figure 11). Comparing the FB ratios of the antennas, it can be concluded that the cotton and denim textile substrates improve FB ratio of the antenna.
SAR as a function of frequency (a) the maximum local SAR, (b) average SAR in exposed flat phantom, (c) maximum 1 g average SAR and (d) maximum 10 g average SAR.
Because the wearable textile antennas are designed to operate near to the human body, in this subsection, we investigate the effects of these antennas on the human body by evaluating the SAR. For these computations, each antenna was placed directly on the numerical flat homogeneous human body model as presented in Figure 4b.
Figure 11a–d shows the maximum local SAR, average SAR in exposed flat phantom, and maximum 1 g and 10 g average SAR as a function of frequency. The results presented in Figure 11a–d were normalized to net input power of 100 mW. As can be seen in the figures, the SAR values from the antennas with air-filled and polar fleece substrates are higher than the SAR from the other antennas. Moreover, the maximum 10 g average SAR is 0.18 (antenna with a polar fleece substrate) and between 0.04 and 0.1 W/kg for the rest of the antennas. Therefore, maximum 10 g average SAR for all antennas is 90% lower than the specification required by the ICNIRP [10] and also smaller than most of the previously proposed wearable textile antennas.
The differences in SAR distributions between the antennas are illustrated in Figure 12a–f. For all antennas, the peak SAR in the phantom occurs in the region near the antenna edges. Moreover, the SAR distribution of the antenna with a polar fleece substrate is similar to that of the antenna with an air-filled substrate. Also, the SAR distribution of the antennas with a substrate from cotton and denim is quite similar.
SAR distributions at 2.4, 2.44, 2.46, and 2.48 GHz for the antenna with (a) an air-filled substrate, (b) a polar fleece substrate, (c) a polyamide-elastane substrate, (d) a polyester substrate, (e) a cotton substrate, (f) a denim substrate, and (g) scale.
SAR values presented in Figure 12 were averaged over a volume of 0.125 mm3 containing a mass of 0.14575 mg.
Measurements were carried out to validate the simulations. Figure 13 shows the simulated and measured reflection coefficient magnitudes of the wearable antennas in the free space and on the phantom. A small difference between simulated and measured results was observed. This difference can be attributed to fabrication and assembly inaccuracies (due to the manual assembly). Moreover, the coaxial cable and U. FL connector were not integrated into the FDTD simulations, which also lead to a difference between the simulations and measurements.
|S11| curves versus frequency (a) simulated in the free space, (b) measured in the free space, (c) simulated on the phantom, and (d) measured on the phantom.
We can conclude that the antennas demonstrate stable performance on both in the free space and when placed directly on the flat phantom.
In this chapter, the main parameters and characteristics of wearable antennas and their design requirements have been presented. The electromagnetic properties of the textile substrates also have been examined. From the results mentioned here, it is concluded that fabrics made from synthetic fibers (polar fleece, polyamide-elastane, polyester) have a lower relative permittivity and
Five low-profile all-textile antennas with high body-antenna isolation have been presented. The in-depth performance evaluations on both in the free space and on the flat phantom of these antennas indicate that they cover 2.45 GHz ISM band and the maximum 10 g average SAR for all antennas is 90% lower than the specification.
The author would like to acknowledge the Bulgarian National Science Fund, Ministry of Education and Science, Bulgaria, for the support through a grant № KP-06-H27/11 from 11 December 2018 “Antenna technology for wearable devices in the future communication networks.”
IntechOpen publishes different types of publications
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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. 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He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNVJQA4/Profile_Picture_2022-03-07T13:23:04.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Associate Prof.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"93",type:"subseries",title:"Inclusivity and Social Equity",keywords:"Social contract, SDG, Human rights, Inclusiveness, Equity, Democracy, Personal learning, Collaboration, Glocalization",scope:"