Rohit Singh

By Rohit Singh and Swastika Ganguly

Imidazole analogs have proved to be a very good source of medicinal agents. The various activities associated with these moieties include antibacterial, antifungal, anthelmintic, Anti HIV activity, anticancer, antihypertensive, analgesic, anti-inflammatory, anticonvulsant, sedative and other pharmacological activities.

Part of the book: Heterocycles

By Rohit Singh and Avneet Kaur

This Review article gives an overview of substituted azole based synthetic medicine and their significance application in treating various ailments. The chemical reactions of azoles with other heterocyclic compounds/chemical reagents produce a lot of new substituted molecules, which have plentiful biological actions and potential pharmaceutical applications. Azoles is considered a major class of heterocyclics and worldwide researchers have put great efforts in studying this nucleus in order to design and synthesize various new derived of imidazole and hybrid molecules with the identification of their significant role in many classes of drugs such as antiviral including anti-HIV. Azoles has inspiring molecular geometric structure that offers a suitable skeleton to build newer chemical entities which has encouraged medicinal chemists to design and synthesis of novel and effective molecule as potential therapeutic agents. However, there is an urgent need to study the mechanism of action at molecular level of several pharmacological actions resulting from azoles scaffold through modern methods to furnish safer and effective new molecules for the treatment of various diseases.

Part of the book: Strategies for the Synthesis of Heterocycles and Their Applications