Michael Fasullo

State University of New York Polytechnic Institute United States of America

Michael Fasullo, Ph.D., is an associate professor at SUNY Polytechnic University, New York. He earned a BSc at the Massachusetts Institute of Technology and a Ph.D. at the Department of Biochemistry, Stanford University, California. He was an American Cancer Society fellow at Columbia University, New York, and held faculty positions at Loyola University Chicago and Albany Medical College, New York. He has authored more than forty peer-reviewed publications, book chapters, and review articles in the field of yeast genetics, DNA recombination and repair, oncolytic viruses, and toxicology. His present work focuses on profiling the yeast and mammalian genome for resistance to P450-activated mycotoxins and heterocyclic amines. His research has been funded by the National Institutes of Health, Department of Defense, March of Dimes, and Leukemia Research Foundation.

1books edited

2chapters authored

Latest work with IntechOpen by Michael Fasullo

Reactive oxygen species (ROS) and DNA double-strand breaks can result from mitochondrial defects and external sources, such as ionizing radiation. If not repaired properly, pathogenic mutations are generated. Human diseases resulting from inherited mitochondrial defects manifest in organs that physiologically require a high level of ATP synthesis. These diseases are clinically challenging, but new experimental clinical therapies include gene editing and mitochondrial transplants. Pathogenic ROS-associated cellular damage includes DNA double-strand breaks, and mouse models are now available to study multiple repair pathways. This book discusses the clinical manifestations of mitochondrial diseases in both the eye and the kidney, and presents new insights into double-strand break repair pathways and developmental phenotypes of g-ray-associated ontogenic mutations of Drosophila melanogaste.

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