Themes and frequency.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"},{slug:"intechopen-identified-as-one-of-the-most-significant-contributor-to-oa-book-growth-in-doab-20210809",title:"IntechOpen Identified as One of the Most Significant Contributors to OA Book Growth in DOAB"}]},book:{item:{type:"book",id:"1446",leadTitle:null,fullTitle:"Senescence",title:"Senescence",subtitle:null,reviewType:"peer-reviewed",abstract:'The book "Senescence" is aimed to describe all the phenomena related to aging and senescence of all forms of life on Earth, i.e. plants, animals and the human beings. The book contains 36 carefully reviewed chapters written by different authors, aiming to describe the aging and senescent changes of living creatures, i.e. plants and animals.',isbn:null,printIsbn:"978-953-51-0144-4",pdfIsbn:"978-953-51-4340-6",doi:"10.5772/1905",price:169,priceEur:185,priceUsd:219,slug:"senescence",numberOfPages:864,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"7aa2772cf0b5653b6c599dba90f4c709",bookSignature:"Tetsuji Nagata",publishedDate:"February 29th 2012",coverURL:"https://cdn.intechopen.com/books/images_new/1446.jpg",numberOfDownloads:94441,numberOfWosCitations:131,numberOfCrossrefCitations:69,numberOfCrossrefCitationsByBook:2,numberOfDimensionsCitations:162,numberOfDimensionsCitationsByBook:2,hasAltmetrics:1,numberOfTotalCitations:362,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 6th 2011",dateEndSecondStepPublish:"May 4th 2011",dateEndThirdStepPublish:"September 8th 2011",dateEndFourthStepPublish:"October 8th 2011",dateEndFifthStepPublish:"February 7th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9,10",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"93967",title:"Dr.",name:"Tetsuji",middleName:null,surname:"Nagata",slug:"tetsuji-nagata",fullName:"Tetsuji Nagata",profilePictureURL:"https://mts.intechopen.com/storage/users/93967/images/system/93967.jpg",biography:"Tetsuji Nagata, M.D, Ph.D, Professor Emeritus (Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Matsumoto, and Department of Anatomy, Shinshu Institute of Alternative Medicine and Welfare, Nagano) was Born in Nagano, Japan, February 5, 1931. 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\r\n\tOrganic electronics can impact healthcare, sports, and national security through inventions such as real-time biosensing and drug-delivery, stretchable and flexible sport track gear, and the electronic- nose and tongue. Organic semiconductors, based on carbon and hydrogen, two of the most abundant and low cost materials, can transduce ionic and electronic carriers into quantifiable data paving the way for multi-functional applications that are not easy to create with other material systems and often go beyond the working principle of the conventional field-effect transistor. We will begin our review with a general overview of the current state of OFETs focusing on complex architectures, materials and fabrication processes. We will discuss the device physics and explain the doping mechanisms that can exist in organic semiconducting channel materials. Then we will focus on exciting applications that include the electronic- nose and tongue, myriad biosensing applications for preventive, point-of-care testing and real-time drug delivery, emerging physico-chemical low cost sensing applications, and the well known flexible, stretchable electronics.
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The teacher has coded the robot to introduce the Science, Technology, Engineering, and Mathematics (STEM) Challenge to the class. The robot states: “We are going to complete a STEM challenge. Yesterday, we explored different bridges using our Virtual Reality Field Trip. Also, we read April Jones Prince’s ‘Twenty-One Elephants and Still Standing’ about how elephants were used to test durability of the Brooklyn Bridge. Today you are going to start to think about how you will build a bridge that can hold as many plastic elephants (weights) as possible.” The teacher shows the student materials that are available to use for the STEM challenge. Further, the teacher tells the students that they need to make sure that they create durable drawbridge that can open and close. The students examine the little baby-pool that was set-up in the classroom to see how the bridge will need to safely connect two different areas. Sophie, a girl in the class, starts to measure the area so she can consider this as he starts to create a plan. Davin, a boy in the class, goes to get his sketchpad so he can start to sketch a possible design. The students start to share ideas with their group members. The students are starting to work through the Engineer by Design (EbD) process.
The previous scenario is similar to what is occurring in a second-grade classroom in Pennsylvania, United States. Dr. Jessica D. Redcay codes Robon, the first female robot, from RoboKind® to co-teach lessons. Previously, teachers have not used robots as teaching assistants in the classroom so a limited amount of research is available. RoboKind® uses the platform of providing Robots4STEM. Therefore, the research study specifically focused-on the connection between using Robon during a STEM challenges with second grade students. Robon is a robot so the teacher can use a loop-code to repeat concepts to students who might benefit from repetition. Science topics include a lot of content-specific terms and concepts. Students can develop strong background knowledge about new content that will be covered throughout the unit. In addition, Robon is coded to model think alouds to students throughout STEM challenges. All of these types of activities should help foster metacognitive thinking. However, since this model for teaching was not previously utilized additional research was need to explore this model.
Science Technology Engineering Math (STEM) Challenges involve students using problem-based learning (PBL) [1]. Engineers are problem solvers who design or improve the design of different things in the world [2]. Designing is a process not a product so the word is used a verb not a noun [2]. Engineers use Engineer by Design (EbD) loop that include: (1) define and research a problem (2) brainstorm and explore possible solutions (3) develop a prototype (4) test (5) reflect (6) redesign (7) test [3]. The steps are centered around three main stages of the loop: beginning, middle, and end. The three main stages are connected to define, design, and optimize [4]. The beginning stage involves engineers defining the problem. This stage occurs during step one of the design loop. The middle stage involves designing. Steps two through four are included in the middle stage. The end stage involves optimizing or changing the new idea to address a problem. Steps five through seven occur during the end stage [4].
STEM challenges are used in the classroom with students to help students have a chance to learn more about real-world problems [3]. A STEM challenge involves the teacher providing a real-world problem, and the teacher provides a question for the students to try to solve. The students work with a team, within specified parameters, to try to develop and test possible solutions [5]. A STEM challenge has theoretical underpinnings within a constructivist or inquiry approach [6]. Further STEM challenges utilize Bybee’s 6 E’s Instructional Model. The 6 E’s include engage, explore, explain, elaborate, evaluate, and engineer [6]. Research studies have supported the use of STEM challenges with young children [5]. Prior to the current research study, social robots were not used in conjunction with STEM challenges.
Previous research studies have not directly linked STEM education and metacognition. However, STEM challenges have skills that have been linked to metacognition, Metacognitive thinking starts to occurs when a child is between the ages of 5 and 6 [7]. At this stage students start to think about their own process of thinking [7]. The research study involved students who are 7 and 8 years old. Students in second grade have only had a year or two to start developing metacognitive skills. Young children are naturally curious. As students work through a STEM challenges, children are using the inquiry model. Previous research studies have demonstrated that students show higher levels of metacognitive thinking when they become curious about task because students become more interested in activity seeking information to explain the unknown [8]. Additional research studies have demonstrated that students learn social metacognitive skills when working with groups [9].
Students demonstrate higher levels of metacognitive thinking when think-alouds are used by social robots [10]. Students need to be provided with guidance to encourage introspection. Vygotsky believed that students need to be provided with scaffolds or supports to help students understand that they can construct their own knowledge [7]. Additionally, students develop metalinguistic awareness when they are provided with models and time to reflect on experiences [7].
RoboKind® is a company that created a social, codable robot. The robot named Milo from RoboKind® has various facial expressions to encourage emotional awareness. Milo has a visual communicator on his chest. The pictures help make learning easier for students. Further, the robot can speak in different languages [11]. Originally, the robots were used to help children with Autism. Various teachers who have used Robots4Autism explained that social robots helped increase the engagement level of the students. Further, students develop better communication skills [12]. Social scripts are used with Milo to help increase students’ ability to converse [13].
RoboKind® expanded Robots4Autism to Robots4STEM with Jett. Students learn visual programming as they work through different modules focused-on different key coding concepts. Students are able to code a personalized avatar, and students can sync the code with a robot [14]. Students are able to see concrete results of what they are coding. Jett has a sister robot who was released in 2019. Her name is Robon [14]. Robon, the first female Robots4STEM robot, was used as a part of this research study. The robot which was a part of the research study is used by a Girls Who Code Robots Club. In addition to the coding club, Robon is coded to act as a teaching assistant in the classroom. Robon was used in the research study to provide students with an introduction to different STEM topics. Since the idea of using social robots as a teacher assistant in the classroom is a new concept, research does not exist yet. Specially, previous research did not explore parallels between the use of STEM challenges and social robots to metacognitive skill development.
Some elementary schools have STEM specialists, and some elementary school teachers are responsible for teaching STEM lessons. Further, some schools have adopted STEM programs, and sometimes teachers are designing their own STEM lessons. STEM education at an elementary level can occur within a teacher’s existing classroom or some schools have a STEM lab. The current research study involved a school that did not have a separate STEM lab area. Also, the school did not have a STEM specialist. At the school of research study, classroom teachers were responsible for the STEM education of the students. The integration of STEM education at an elementary is rather natural because students are with the same teacher for most of the day [15].
Teachers often find it challenging to obtain materials to use during a STEM challenge [16]. Recycled or free materials are a great option for STEM challenges. For example, teachers can use things like paper towel rolls, newspapers, cardboard boxes, and egg cartons. Additionally, teachers can purchase items that are versatile, and teachers can provide students with building materials that can be used in combination with other materials. Two examples of versatile materials include Creation Crate® TechCard® and SAM Labs®. The research study involved the use of recycled materials and versatile building materials.
Creation Crate® TechCard® are building materials designed for schools. The company provides kits that teachers can use with students to demonstrate different science concepts. Additionally, teachers can provide the students with materials to use to build freely. The materials are easy for students to use because the card contains punched holes that fit dowel rods. Further, the card sets are scored so students can fold it easily. The card kits are made from 100% recycled materials as well [17]. Young children benefit from using hands-on materials to understand abstract concepts [7]. The crane and drawbridge kits were used during the current research study. The students were encouraged expand or extend the original kit design.
SAM Labs® are wireless Bluetooth blocks that move, light-up, and make noises. The blocks pair with the coding app called SAM Blockly®. Students learn to code. The company provides lesson plans that teachers can use with students to teach coding skills [18]. Young learners need opportunities to see connections between concrete and abstract ideas [7]. Further, teachers can use the materials in other ways too. For example, during the current research study the SAM Labs® blocks were used in combination with the Creation Crate® TechCard® crane kit so the crane would move, light-up, and make a noise.
The most successful innovators find a balance between things they are doing with time to think and reflect [19]. In an era filled with technology and distractions, students are provided with a limited amount of time to stop, think, and reflect. Brain research has consistently demonstrated that students need enriched opportunities with time to reflect to help increase synaptic connections [7]. Neuroplasticity is the idea that the brain can improve for the better or for the worse. When students are overloaded with information without time to reflect then students are not able to find patterns within their own thinking [7]. Young students are processing a lot of information. The process of assimilating and accommodating information requires time for students to think [7]. The need for think time seems intuitive because every living being requires time. For example, if a Jade Plant is transplanted then it needs several weeks before it can be watered. The Jade Plant needed time to adjust to a new situation. In the classroom students are the same as Jade Plants and other living beings, they need time to reflect to foster metacognitive thinking skills.
FlipGrid® is an online video discussion. A grid is a class or group of students. The teacher posts topics for the students to respond to with a video response. The students are able to view and respond to the video posts of their peers [20]. Students benefit from going into a privacy pod to think and record individual reflections. The research study involved the use of FlipGrid®. Students shared their reflections in privacy pods. The video responses were transcribed in FlipGrid®, and the transcriptions were exported.
Students need opportunities to hear their voice and the voices of their classmates. Learning occurs when students have the opportunities to express their ideas and opinions [21]. When students have opportunities to be heard in the classroom then students benefit from trying-out new thoughts and ideas [22]. Students develop metalinguistic awareness, or a better understanding of how they develop new words, when they have the chance to practice and try out new words [7].
A qualitative, explanatory research study was used to explore one central research question. Research question 1: What, if any, themes will emerge when exploring the responses of second grade students after complete two STEM challenges?
A second-grade class of 25 students completed two different STEM challenges that involved the use of a social robot. At the conclusion of the challenge the students reflected upon their experiences using FlipGrid®—a video discussion platform. The students were able to hold their physical projects that they constructed as they recorded their reflections. The responses of the students were transcribed, coded, and categorized to explore possible themes to describe students” thinking throughout STEM challenges.
The students were provided with a STEM challenge to create a drawbridge that would be strong enough to hold at least 21 plastic elephants. At the beginning of the challenge, the students were introduced to the vocabulary using Virtual Reality (VR) exploration of different real-world bridges. As the students progressed through Nearpod® VR the teacher and social robot, Robon from RoboKind®, provided a guided a think aloud and helped develop content-specific vocabulary. The students used Creation Crate® TechCard® Bridge Kits. Creation Crate® TechCard® are recycled materials that used by young students to create and design different things. Further, the teacher read aloud
Another STEM challenge involved building a working crane. The students were able to learn about cranes by exploring VR on Nearpod®. Robon from RoboKind®, was coded and used throughout the challenge to provide a think aloud to support the challenge. The students were provided with Creation Crate® TechCard® Crane Kit. The kit involves the use of air pistons to move the crane. The students added the Crane to SAM Labs® Kit. SAM Labs® include wireless Bluetooth blocks that connect to the app. The students were able to use the blocks to add lights, movement, and sound to the crane.
Fifty video responses recorded in FlipGrid® were transcribed to explore students experiences when completing two different STEM challenges. The transcriptions included 20 minutes of responses. Only two segments of data were removed the study because the student was unaware that they were continuing to record, and the recording did not connect to the topic.
Seventy-seven segments of data were coded. Five themes emerged. The following themes emerged: (1) metalinguistic awareness (2) curiosity and real-world connections (3) problem solving strategies (4) social metacognition strategies (5) concrete to abstract thinking. The themes and frequency are listed in Table 1.
Theme | Frequency of response |
---|---|
Metalinguistic | 12 (16%) |
Curiosity and real-world connections | 26 (34%) |
Problem solving | 20 (26%) |
Social metacognition | 11 (14%) |
Concrete to abstract thinking | 8 (10%) |
Themes and frequency.
The theme with the highest frequency of response was curiosity and real-world connections with 26 segments of data (34%). Responses were coded as curiosity and real-world connection when the response connected to real-world examples or the STEM challenge. Additionally, responses that demonstrated an interest in topic of the STEM challenge were coded within this category as well. An example of a response within this category included one student who stated: “Real cranes use lights and sounds when moving.” Another example of a response in this category included: “The Brooklyn Bridge took 14 years to build, and 21 elephants walked across it to see if was sturdy.” Some students identified the Golden Gate Bridge or other types of actual bridges that were observed during the Virtual Reality Tour.
The theme with the second highest frequency of response was problem solving with 20 segments of data (26%). Responses were included within this theme when students described how they worked through the problem or challenge. Further, the students described how they figured things out throughout the STEM challenge process. One example of a response that was included in this theme included a student who stated: “The air in the piston makes the crane move.” Another student explained: “We used the blue-tooth blocks that were connected to the iPad to make our crane move, light-up, and it made sound.” Other examples involved explaining how the drawstring bridge was created so it would be sturdy enough to hold a lot of plastic elephants but it still had the ability to move up and down.
The theme with the third highest frequency of response was metalinguistic with 12 responses (16%). Responses were included within this theme if the students responded focusing on the language. Sometimes students would describe new words, but the students could not remember the name of the word. For example, on student stated: “There was one thing under the toy crane. I forget what it was called, but it was the thing that we used with the iPad to control it.” Another student stated: “We used a syringe as an air piston.” The students were becoming aware of new words, and the students were learning how to apply the words to describe what they did.
The theme with the second least amount of frequency of response was social metacognition with 11 responses (14%). Responses were included within this theme if the students reflected on the process involved with working and communicating with others. For example, one student stated: “We worked together as a team. I saw that people in my group were all doing a good job.” Another student stated: “As a group we made a crane. We all had different things to do. I had was able to put the glue dots on the TechCard.” Responses that involved group work and collaboration were coded in the Social Metacognition category.
The theme with the least amount of frequency of response involved concrete to abstract thinking with eight responses (10%). Responses within this category involved students using the concrete prototype to describe abstract concepts. When the students were reflecting on the experience then the student had the chance to hold the concrete object to help with the explanation. One student stated: “Let me show you how this works.” Another student said, “Watch this!” Whenever a student referenced the concrete object when explaining abstract ideas then the response was categorized as concrete to abstract thinking.
The research study results added to the existing body of knowledge in the area of STEM education. Previous research studies did not make a direct connection between STEM education, social robots, and metacognition. Different connections between STEM related skills were linked to metacognitive thinking, but it was not directly linked in a research study. FlipGrid® videos provide researchers an opportunity to explore students reflecting-upon their experiences.
Metacognitive thinking allows learners to transfer and adapt to different situations because learners have a strong understanding of their own knowledge [23]. Metacognition is similar to one looking into a toy kaleidoscope. As one turns or looks into the mirrors and reflections then the perspective changes. The word kaleidoscope is Greek, and the word means “beautiful form to see [24].” When a person is able to self-reflect then the thinking of the person transforms into a beautiful new understanding. The research study involved exploring the responses of students when using STEM challenges and social robots. The themes that emerged were connected the EbD loop and metacognition. When everything comes together then it can be explained by a new model called Redcay’s STEM-oscope Model (RSM).
A triangle is located inside of a kaleidoscope. Therefore, RSM has a triangle with the three sides labeled to correspond with the three stages of a STEM challenge: (1) beginning-define, (2) middle-design, (3) end-optimize. The five themes that emerged from the research study fit within the three stages of STEM education. The curiosity and real-world connection theme is connected to the beginning-define stage. The social metacognition and concrete to abstract themes are connected to the middle-design stage. The problem-solving theme is connected to the end-optimize stage (see Figure 1).
A picture depicting Redcay’s STEM-oscope Model that combines STEM education, social robots, and metacognition.
Two themes that emerged fall within the beginning-define stage of the EbD loop: (1) curiosity and real-world connections and (2) metalinguistic awareness. Within the beginning stage students are identifying the problem. Further, the engage phase of 6 E’s of Science Inquiry is connected to the beginning stage as well [6]. The engage phase involves making connections between old and new knowledge. The two STEM challenges included in the research study included Virtual Reality Tour with Nearpod®, an introduction from Robon from RoboKind®, and read aloud. The purpose of the activities that occur during the beginning-define stage involve developing vocabulary and providing an authentic, real-word connection to the challenge.
Curiosity and real-world connections theme had the highest frequency of response. The engage stage of the 6 E’s instructional method occurs at the beginning of a STEM challenge [6]. In the STEM challenge, Virtual Reality with Nearpod®were used to help students see real-world examples. Further, students were provided with read alouds about the topic. Robon from RoboKind® was coded to give an introduction, and provide the students with background knowledge. Previous research studies have demonstrated that students learn the most when they are curious about the content area of focus [8]. When students are curious then they are able to learn more about something news. Further, when students show neuroplasticity-ability to make synaptic connections in the brain due to an enhanced learning opportunity—then students’ ability to learn increases [8]. Students learn best when concepts are linked to real-world examples [11].
Metalinguistic was the theme with the third highest frequency. Students were able to use and apply new terms through the design process. Previous research studies have demonstrated that students’ metalinguistic skills increased after students had an opportunity to observe and try-out new words within a group [7]. Robon from RoboKind® was coded to provide students with think alouds through the STEM challenges. Previous research studies have demonstrated that students benefited from think alouds provided by social robots [10]. Further, students had the opportunity to try out the new words using FlipGrid®. Students could listen to their own reflections, and the students could listen to the reflections of their peers. These different opportunities helped the students further develop their own knowledge about how they are using and applying new words.
Two themes were connected to the middle-design phase of the EbD loop: (1) problem solving and (2) concrete to abstract. During the design phase students brainstorm ideas, create a prototype, and test the prototype. The purpose of this phase is to try-out different hands-on activities. Students are working through the explore, explain, and engineer phases of 6 E’s of Science Inquiry [6]. As students manipulate concrete objects then it helps students understand and explain abstract concepts. Further, students are working-on learning how to explain and properly communicate their ideas to others. Students need opportunities to collaborate and socialize.
Social metacognition had the second to least frequency of response. Students were reflecting upon how they worked together in teams. Previous research studies have demonstrated that students benefit from working collaboratively, and this helps develop social metacognitive thinking [9]. Students reflected upon the negative and positive aspects of working within a group. Students were able to organize their thinking into patterns then the patterns or ideas can be applied or used in the future [25].
The category with the least amount of frequency was concrete to abstract thinking. Materials like Creation Crate® TechCard® allow students to construct, build, and re-build an unlimited number of proto-types that can help students better understand the connection between the concrete object and the abstract idea. Further, another versatile material is SAM Labs® students are able to connect different circuits in the app, but the abstract concept is applied to motion in an actual concrete object. Young students learn best when concrete objects are linked to abstract concepts [7]. Some students might have already internalized abstract ideas so they did not need to rely on concrete objects.
One theme connected to the end-redesign phase: problem solving. During the end-redesign phase the students are re-designing and re-testing. The redefine phase align with the elaborate and evaluate phase of the 6 E’s of Science Inquiry [6]. Students are able to expand with new experiences to discover more about the topic. Students self-evaluate and reflect on the STEM challenge to make decisions about how to improve and change their initial ideas.
Problem solving was the theme with the second highest frequency. STEM challenges start with real-world problems [3]. Further, throughout the STEM challenge, students solve problems and students demonstrate flexible and creative thinking. Previous research has demonstrated that students benefit when they think through problems [3]. Students are able to reflect upon the process, and students can organize their thinking around patterns that can be used in future situations [11].
The research study was limited because it only included one group of students in one grade level. Additional research is needed to examine and explore the effectiveness of using social robots as teacher assistants when completing STEM challenges in the classroom. Further, additional research is needed to test the new STEM-oscope Model with students in differing grades and places. The current research had students reflect on the STEM challenges at the end. Future researchers might consider having students share reflections after the individual EbD loop phases. After exploring additional data per phase then possible subthemes might emerge. Quantitative research is needed to further explore the effectiveness of new educational models and methods.
The research study added to existing body of STEM Education Research because it connected STEM education, social robots, and metacognitive thinking in a new model called Redcay’s STEM-oscope Model. The qualitative, explanatory research study involved the exploration of 100 student responses after completing two STEM challenges. The students responded to the STEM challenges using FlipGrid®. The data were transcribed, coded, and analyzed to answer the research question: What, if any, themes will emerge when exploring the responses of second grade students after complete two STEM challenges?
Five themes emerged: (1) metalinguistic awareness (2) curiosity and real-world connections (3) problem solving strategies (4) social metacognition strategies (5) concrete to abstract thinking. The five themes connected to the three main stages of the EbD loop: (1) Beginning-Define (2) Middle-Design (3) End-Optimize. Further, the 6 E’s of Science Inquiry were embedded and connected to the themes as well. The model is arranged in the shape of triangle because kaleidoscopes use a triangle shape with mirrors. When STEM education is connected to metacognition then an experience similar to looking through a kaleidoscope occurs. As one turns and reflects then perspectives and understandings increase. STEM-oscope Model involves students self-reflecting throughout the STEM process to gain better self-awareness.
Metalinguistic awareness was promoted as a social robot, Robon from RoboKind® provided Think Alouds. Students were able to listen to their own recording, and students were able to listen to the recording of their peers. Students benefited from using versatile materials like Creation Crate® TechCard® and SAM Labs® that further allowed students to make connections between concrete objects and abstract ideas. Additionally, students benefited from having the opportunity to make real-world connections using Virtual Reality from Nearpod®. Students benefited from interacting within groups, and students learned more as they solved problems. These themes were previously recognized separately as benefiting students to think metacognitively. However, a STEM challenge allows the students to have an enhanced experience because it fosters metacognition by developing various skillsets.
I acknowledge using the following resources for the STEM challenges: RoboKind®, Creation Crate® TechCard®, SAM Labs®, FlipGrid®, Nearpod®, and
I would like to thank my supportive family. Sophie and Davin-I hope that you always take risks, and go for your dreams. This is dedicated to all of my fellow researchers and teachers. Let us continue to make a positive impact in lives of our students! I would like to thank my KTI Family for your support! Thank you and best wishes to all of the students that I have had the opportunity to teach.
Over the past decades, the semiconductor foundry business has gone through a dynamic transformation. Recently, the foundries are leading the process development race at 10 nm [1, 2] and even to 7 nm [3, 4] and will continue to do so. However, the traditional physical scaling of advanced MOSFETs in conjunction with Dennard’s scaling rules has become extremely challenging as to increase the drive currents for faster switching speeds at lower supply voltages is largely at the expense of large leakage current in extremely scaled device [5]. As a result, even with the huge R&D investments, the semiconductor firms gradually lagged the advertised on-chip feature sizes demonstrated in the scaling roadmap, and finally the end of Moore’s law has been declared with the end of the 2016 International Technology Roadmap of Semiconductors (ITRS) [5, 6]. Also, the emergence of internet of things (IoT) and big data applications has driven a necessity of abundant computing and memory resources that requires always-on and high-performance ultralow-power devices to generate data instantly. Several device architectures and novel materials based on both analytical and experimental academic research were proposed in the metal-oxide-semiconductor field-effect transistor (MOSFET) technology. Among the viable technologies, the compound semiconductor especially the III-V materials have stood out to be a promising channel candidate for the future highly scaled CMOS application.
The light effective mass of III-V materials compared to the Si even in the highly strained case leads to a higher electron mobility and a higher injection velocity, which should translate into a great turn-on performance even at a lower operation voltage (VDD) level down to 0.5 V. Moreover, there is already a mature industry that uses III-V high electron mobility transistors (HEMTs) for high-frequency applications [7, 8], and it provides excellent techniques such as InGaAs and InAs quantum well (QW) FETs [9, 10]. However, most of these III-V compound semiconductors have smaller bandgaps, which have great impact on the band-to-band tunneling leakage currents. In addition, according to Yan’s model [11], the higher permittivity of these materials may worsen the short channel effects (SCE). In spite of the demerits that may limit the scalability, the benefits are much more attractive which makes the III-V channel technology a powerful beyond CMOS solution. However, the use of III-V compound semiconductors has been reluctant to the industry because of its high-cost manufacturing process and CMOS-incompatible process. Naturally, it brought out a strong motivation of research of III-V hetero-integration on a Si platform. The main obstacle of III-V on Si integration research is that as huge lattice constant mismatch exists between those two materials, growing epitaxial films directly on Si without defect is difficult [12]. Accordingly, different approaches have been developed, and among them, direct wafer bonding [13, 14] and aspect ratio trapping (ART) [15, 16] technologies have projected the most promising results.
Consequently, the remaining issue toward the practical realization of III-V materials is its defective interface quality which has been the major drawback compared to Si [17, 18, 19, 20, 21]. The poor native oxide quality compared with SiO2 is challenging even more with III-V materials. The III-V compound semiconductors are typically composed of binary, ternary, or even quaternary material by covalent bonding, and more complex elements mean a much richer population of possible oxides for the III-V materials [22]. These native oxides are not thermodynamically stable and very leaky that rise serious issues of creation of significant surface states on the oxide-semiconductor interface and huge trap-assisted gate leakage current [17, 19]. At the early stage of research, GaAs MOSFET suffered from high density of interface states (over 3 orders compared to Si) hindering inversion mode operation.
In order to overcome the defective interface problem, many research groups conducted extensive research effort with a search for a perfect gate dielectric that suits the III-V substrate [23, 24]. The study of atomic layer deposition (ALD) high-k dielectric led to a successful integration of high-k gate dielectrics on III-V substrate, and recent research is mainly focused on the development and interface characterization of ALD high-k and III–V compound semiconductor. To evaluate the objective III-V metal-oxide-semiconductor (MOS) characteristics, it is important to understand the trapping mechanism and know what kind of measurement is required. For Si, the primary defects are the well-known Pb centers, which are dangling bonds at the immediate interface with the dielectric [25]. However, for the III-V material, the anti-sites and interstitials are the critical defect centers [17], and the small DOS of the III-V materials is also a weak point [26]. These differences lead to different trapping mechanism, and unlike Si MOS, the III-V MOS gate stack often exhibits a particular C-V phenomenon typically known as the frequency dispersion effect [27]. The features of the frequency dispersion effect are threefold. First, large inversion-like hump occurs even at high measurement frequency, which could not be an actual inversion characteristic theoretically. Secondly, the C-V curve horizontally shifts to the negative direction as the measurement frequency decreases. Finally, the accumulation capacitance increases as the measurement frequency decreases.
The large interfacial trap densities (Dit) that reside within high-k dielectric and III-V substrate are mostly responsible for the explained features [28]. The high Dit especially the near mid-gap states act as generation recombination centers that attribute to the inversion hump phenomenon in the weak inversion regime. In addition, the large donor-like Dit near the conductance band (for n-type substrate) induces a substantial surface charge that needs to be compensated by larger gate biases resulting in a horizontal shift in the C-V curve. Detailed discussions are well explained through both theoretical and experimental research [27, 28]. The accumulation capacitance increase, however, is quite difficult to be explained only by the interface traps. There have been numerous publications on this particular accumulation dispersion behavior, and discussion led to an explanation of a carrier transport model from the crystalline semiconductor into the border traps, which are defects within the bulk of the dielectric [29]. The capture and emission process occur at border traps with the interaction of conduction band electrons resulting in discrepancy of accumulation capacitance, and the thermal barrier in capture process is responsible for the strong temperature dependency.
Among the reported high-quality insulator/InGaAs interface studies, the direct deposition of hafnium oxide (HfO2) on InGaAs substrate has generally led to poor electrical characteristics, and there are only few studies aimed at improving the intrinsic HfO2/InGaAs interface quality [30, 31]. These studies also target only in pretreatments, which is vulnerable during oxide deposition. Meanwhile, O3 and H2O are the most common oxidants employed in HfO2 ALD. However, one of the disadvantages of H2O-based ALD is high-concentration hydroxyl groups in the films, which degrades the dielectric interface during the post deposition annealing process [32]. In addition, sufficiently long purge time is needed because H2O tends to physisorb on the surface strongly, especially at low temperature. To solve this problem, O3 is used as one of the most promising alternative oxidants in ALD process, due to its strong oxidization and high volatility. However, O3 is known to oxidize the III-V surface during the initial deposition cycles which will neglect the prior surface treatments that easily cause the formation of inferior native oxides [33]. The excess interfacial oxidation of the InGaAs surface initiated by the use of ozone is widely reported in the previous studies. H2O oxidant also is not totally free from surface oxidation [34]. Therefore, the research on alternative oxidation sources is necessary for the HfO2/InGaAs MOS studies to make the effort made in the pretreatment studies work.
Looking into the oxidant candidates, isopropyl alcohol (IPA) is known to be irresponsive to the semiconductor surface during the initial ALD cycles [35], and as most pretreatment studies are aimed at removing the native oxides of the III-V surface, the IPA oxidant will be able to efficiently suppress the surface oxidation after the pretreatment process.
In order to study the effect of using IPA oxidant, O3 was used as the reference to compare. The basic cycle of the HfO2 deposition is consisted of a TEMAH precursor pulse and an oxidant (O3 or IPA) exposure with N2 purging process between the precursor injection and oxidant process. The temperature of the IPA precursor was maintained at 4°C. The vapor pressure of IPA at 4°C is around 10 mmHg, which is four times smaller than that at the room temperature [36]. It is important to control the excessive vapor pressure because it leads to a longer purge time, which disables an efficient ALD cycle.
The ALD characteristics of HfO2 using O3 and IPA oxidants are shown in Figure 1. Oxidant pulse times were 1 and 3 s for O3 and IPA, respectively, which were chosen to meet the saturation requirement of ALD. Both oxidants had similar saturated deposition rate of 0.1 nm/cycle. Noticeable difference was observed in the temperature windows of oxidant type. While stable deposition rate of O3 oxidant was maintained in a large temperature range, saturated deposition rate of IPA oxidant was only observed in a small temperature range around 320°C. In low temperatures, low deposition rate is due to insufficient reaction which is originated from low reactivity of IPA. Also, in high temperatures above 320°C, thermal decomposition of Hf precursor occurs, and it hinders the self-limiting characteristics of ALD. Therefore, the deposition temperatures of HfO2 ALD were chosen to be 230 and 320°C for O3 and IPA, respectively. Moreover, the film thickness per ALD cycles is presented. It is observed that the linear deposition rate per cycle is obtained for both oxidants and a thicker interface layer thickness appears to be existed for the O3 oxidant due to is strong reactivity (Figure 2).
Comparison of the O
Comparison of O3- and IPA-based HfO2/Si MOS capacitors: (a) C-V and (b) leakage-E plot.
Based on the ALD characteristics, the HfO2/Si MOS capacitors are fabricated on the Si substrate. All samples underwent standard Si cleaning steps that consisted of SPM- and HF-based cleaning and 400°C 10 min annealing after the dielectric deposition. The C-V and forward gate leakage characteristics are measured and discussed. First of all, the C-V hysteresis difference is notable. As anticipated, the C-V hysteresis significantly decreases by employing the IPA oxidant. Powerful oxidation ability of ozone may induce undesired interfacial oxide at the Si interface forming defective hafnium silicate leading to a large hysteresis, while IPA-based HfO2 appears to be negligible on this effect [37]. The dielectric constants of IPA-based and O3-based HfO2 extracted by the thickness series method are 19.4 and 17.6, respectively [38]. While the C-V results report promising potential of IPA oxidant in ALD HfO2, the leakage properties suggest a different aspect. Leaky forward gate leakage especially in the medium gate voltage range of the IPA-based HfO2 is presented compared to the O3-based HfO2. It is well known that at this gate bias range, the dominant leakage mechanism is by the Poole-Frenkel tunneling, which is a conduction method of electron tunneling from a metal electrode to traps in a nearby insulator layer, followed by detrapping of the electrons from the traps by virtue of a lowered potential well due to an applied electric field [39]. It usually implies the bulk quality of dielectric; in short, the larger the leakage in this E-field is, the more inferior the gate insulator is. It is speculated that by using the IPA oxidant, the bulk quality may be inferior than using the O3 oxidant in ALD HfO2. This might affect the further scaling down potential and the border trap density in ALD HfO2 application on InGaAs substrate [40].
By using the developed O3- and IPA-based HfO2 dielectrics, HfO2/InGaAs MOS capacitors were successfully demonstrated [41]. The multifrequency (1 kHz–1 MHz) C-V characteristics of HfO2/n-In0.53Ga0.47As MOS capacitors using the O3 and IPA oxidants are presented in Figure 3. The C-V curves of the O3-based HfO2 ALD showed a large inversion hump in the negative bias range, which is attributed to the large density of interface defect states near the mid-gap trap level. In contrast, those of the IPA-based HfO2 ALD showed a notable suppression of the inversion hump behavior. In addition, by employing the IPA oxidant, the effective oxide thickness (EOT) has decreased. We hypothesize that the reduced inversion hump and decrease of the EOT originate from the suppression of unintentional interfacial oxides by the use of the IPA oxidant. Detailed material characteristics analysis was conducted and proved the hypothesis to be convincing [41]. To our knowledge, it is the first successful demonstration of HfO2 deposition using IPA at InGaAs substrate.
Multifrequency C-V responses of (a) O3- and (b) IPA-based HfO2/In0.53Ga0.47As MOS capacitors; insets are the hysteresis at 1 MHz.
Despite the advantages of using the IPA oxidant, frequency dispersion at the accumulation region slightly increased from 3.3 to 4.7% per decade. In Figure 4, these values were used to estimate the border trap densities (Nbt) by using a distributed bulk-oxide trap model, and increased Nbt of 1.1 × 1020 cm−3 eV−1 was extracted compared to 6.7 × 1019 cm−3 eV−1. Also, larger C-V hysteresis and severely degraded leakage currents at positive bias are noticed. Based on these results, an inferior quality of the HfO2 film for using IPA oxidant was predicted which should be resolved for reliable use of the IPA oxidant.
Border trap estimation of HfO2/InGaAs MOS capacitors by using the distributed oxide bulk trap model (a) O3-HfO2 and (b) IPA-HfO2.
In order to improve the weak IPA-based HfO2 bulk quality, the study of origin in HfO2 defect is necessary. One of the main concerns in the replacement of SiO2 to HfO2 is that compared to SiO2, HfO2 generally suffers from high defect densities leading to several issues such as large carrier trapping, mobility degradation due to coulombic scattering in the channel surface, and threshold voltage shifts in gate stress conditions [42]. To be specific, the threshold voltage shift issue was not a new phenomenon that suddenly happened with use of HfO2. In immature SiO2 MOSFETs, it is widely known that the extrinsic contaminations in SiO2 with alkali ions induce this similar phenomenon [43]. However, with HfO2, it appeared to be caused by the high defect concentrations, which originated from a more fundamental problem, not an extrinsic defect. Consequently, many researches were devoted to HfO2 physical model simulation in order to identify the type of defects and their energy levels, and by these physical studies, researchers hoped to learn how the deposition and processing conditions can be optimized to minimize these defect origins [42, 44, 45].
Based on computational calculations, it is identified that oxygen vacancies in HfO2 are both the principal trap and main cause of the discussed issues, and its formation energy and energy levels were also calculated [44]. Hence, in order to reduce the defect densities, experiments regarding deposition and post processing conditions were aimed to remove or passivate these defects, with an oxygen-rich ambient. However, in many cases, it only worked to some extent and led to new issues of excessive oxidation leaving oxygen interstitials and oxygen diffusion to the interface [46].
Additionally, due to the low density of states of III-V semiconductors, III-V substrates are heavily influenced to border traps that could severely worsen the device performance resulting in poor reliability properties. Therefore, not only the interface but also the bulk characteristics of HfO2 should be considered in III-V MOS studies, and improvement in both qualities is definitely important.
One of the most effective methods to improve the inherent properties of HfO2 is the incorporation of nitrogen to passivate oxygen vacancies, and it has been extensively utilized in many recent studies [47, 48, 49, 50, 51]. Significant improvement in the electrical characteristics of various high-k gate dielectrics by nitrogen incorporation has been demonstrated, and it is found that interfacial layer growth is effectively suppressed [49] and there is lower boron penetration with nitrogen incorporation [51]. Also, lower leakage current density in HfOxNy is widely reported due to suppression of oxygen vacancy traps [50]. It has been reported that nitrogen incorporation in HfO2 can be achieved by several methods mostly by nitrogen ambient plasma-based nitridation [47, 50] or ammonia (NH3) ambient high-temperature annealing treatment [52, 53]. For Si-based MOS studies, the later approach is known to be very powerful for achieving good uniformity of nitrogen incorporation and excellent interface quality due to the absence of plasma damage. However, in order to successfully apply nitrogen incorporation technology on III-V substrate, the low thermal budget of III-V compound semiconductor always has to be considered, and high-temperature annealing treatment should be ruled out for nitrogen incorporation study in III-V MOS. In the other hand, although plasma-based nitridation technology offers low thermal budget capacity, most studies generally suffers from several issues such as nonuniform nitrogen distribution throughout dielectric, plasma-induced damage due to high-power plasma for dielectric penetration, and high energy potential nitrogen species substituting well-combined Hf-O bonds. Post deposition plasma treatments have recently been suggested for InGaAs MOS devices [54]; however, no effort was made to improve the nitridation technology regarding the discussed issues.
As a result, in order to improve the film quality of HfO2, a cyclic nitrogen low-power plasma step was added within the ALD cycles to passivate oxygen vacancies uniformly without causing damage or surface degradation. Through this technology with a combination of IPA oxidant, achievement of improvement in both interface and bulk quality of high-k/InGaAs MOS properties is expected. The detailed information of the ALD sequence is depicted in Figure 5. Every cycle consisted of sequential precursor pulse steps and a gas stabilization step followed by 5 s of 50 W N2 plasma step with purge steps between pulse steps. It is discovered that there is a trade-off relationship of plasma condition. The plasma power should be enough for effective passivation although it may degrade the substrate by radiation damage. Through the developed ALD sequence, with adequate plasma condition, the HfO2 layer is improved without having influence in the substrate.
ALD cycle sequence of the developed HfOxNy processes on InGaAs substrates.
By using the proposed nitridation technology, HfOxNy/InGaAs MOS capacitors are fabricated showing promising results as shown in Figure 6 [41]. A significant suppression of the frequency dispersion was observed upon nitrogen incorporation in every gate bias range. The inversion humps and flat band voltage shift were effectively reduced for all samples, which imply that the defective interface states near the mid-gap level can be treated with nitrogen incorporation. It is hypothesized that oxygen diffusion through the oxygen vacancies of HfO2, which results in the formation of As-Ga anti-sites, was greatly reduced, as oxygen vacancies were effectively passivated with nitrogen [17]. Therefore, nitrogen may block further oxygen diffusion, thereby preventing surface oxidation, which could occur not only during but also after dielectric deposition. Furthermore, the frequency dispersion in the accumulation region greatly reduced to 2.1 and 3.2% per decade for O3- and IPA-based ALD, respectively. These values are comparable to suppressed dispersion values in low-EOT gate stacks, which imply excellent reliability quality of dielectric stacks on III-V substrate [55]. As the proposed nitridation technology is aimed to treat inferior bulk qualities of HfO2, it showed greater impact on IPA-based HfO2. The inversion behavior was observed for the IPA-based ALD HfO2 which has not been reported from the former HfO2/InGaAs MOS studies, and it will be further discussed (Figure 7).
Multifrequency C-V responses of (a) O3- and (b) IPA-based HfON/In0.53Ga0.47As MOS capacitors; insets are the hysteresis at 1 MHz.
Border trap estimation of HfON/InGaAs MOS capacitors by using the distributed oxide bulk trap model (a) O3-HfON and (b) IPA-HfON.
Based on the n-type MOS results, the Dit was extracted using the conductance method as shown in Figure 8. The combination of IPA oxidant and PA-ALD HfOxNy with standard interface treatments resulted in a reduced Dit level of 4.5 × 1011 eV−1 cm−2 at Ec − Et = 0.3 eV. Based on the Dit distribution, it is evident that the inversion behavior observed in the C-V curves is due to the significant mid-gap Dit decrease, which is consistent with the previously reported studies. As the mid-gap Dit is known to correlate to the As-Ga anti-site defect and the ozone-based HfOxNy lacked inversion characteristics with high mid-gap Dit, these defects might be the reason why the inversion behavior is difficult to be achieved in most studies. Also, these defects might be formed in the initial ALD steps through the oxidant exposure. Also, in Figure 9, we have benchmarked our results, comparing them to the best results ever reported in the field of III-V MOS device studies [56, 57, 58, 59, 60, 61]. Extraordinary mid-gap Dit values are achieved with low CET values with the proposed technology. Especially, while other studies mostly suffer from insufficient dielectric constant of the IL, our work employs HfO2 as an IL, which has merit in terms of the EOT scaling.
The Dit distribution of the fabricated III-V MOS capacitors showing great reduction in the mid-gap Dit with the IPA-based HfOxNy.
Benchmarking the mid-gap Dit values of the proposed high-k ALD compared to the best results in the field of III-V MOS. The filled circles represent C-V curves with inversion behavior.
In addition, with conductance method in the measurement frequency range of 1 kHz–1 MHz, the n-type MOS capacitor results can only provide information of Dit distribution near the conduction band. In order to estimate the total Dit distribution throughout the bandgap in InGaAs, p-type InGaAs MOS was fabricated and analyzed. The p-type InGaAs MOS capacitors are fabricated in the same process flow of n-type MOS capacitors.
The multifrequency C-V measurements of IPA-based PA-ALD HfOxNy/n-In0.53Ga0.47As MOS capacitors compared to the HfO2 (O3) sample is presented in Figure 10. Compared to the reference, the optimized HfON process exhibits significant frequency dispersion suppression with steeper C-V slope. This result is comparable to the previously reported high-quality p-type InGaAs MOS results. It is assumed that the interface improvement mechanism is similar to the previous n-type MOS analysis.
C-V characteristics of IPA-based PA-ALD HfOxNy (left) and O3-based HfO2 (right) on p-type In0.53Ga0.47As substrates.
Based on the results, the Dit distribution within the InGaAs bandgap is extracted with the conductance method shown in Figure 11. The Dit level at the exact mid-gap energy level (Eg/2 = 0.375 eV) is around 8 × 1011 eV−1 cm−2. This value is still low for reported III-V MOS interface, and it is suggested that based on the Dit distribution, the accumulation mode n-channel III-V devices are favorable than the inversion mode p-substrate III-V devices because the overall Dit levels are much lower at the conduction band area.
The total Dit distribution within the In0.53Ga0.47As bandgap, which is extracted from the n- and p-type MOS capacitors.
Moreover, temperature-dependent conductance method was performed in order to analyze the mid-gap Dit level thoroughly. High-temperature (350, 400 and 450 K) multifrequency C-V analysis was conducted on HfON/InGaAs MOS capacitors. The C-V results of each measurement temperature are shown in Figure 12.
C-V characteristics of IPA-based PA-ALD HfOxNy on n-type InGaAs substrate measured at (a) 350 K, (b) 400 K, and (c) 450 K.
As the measurement temperature increases, the inversion response gets stronger at higher frequencies compared to the room temperature-measured results. Also, while the dispersion at the accumulation region seems to be similar, there was a significant impact on the inversion hump phenomenon which is the interface trap characteristic. The measurement noise at higher temperature and lower frequencies was also noted. When the measurement temperature reaches around 450 K, the strong inversion response occurs even at 1 MHz, and it interferes with the interface trap-related conductance peak making the deconvolution process impossible.
The Dit distribution was estimated from the temperature-dependent conductance technique as shown in Figure 13. As the measurement temperature increases, the deeper energy range could be measured. Similar Dit profile was observed showing a peak energy level around the exact mid-gap level (~0.375 eV). The peak Dit value is slightly higher than the previously estimated value which would be the effect of enhanced thermal broadening of trap response in higher temperatures. The differences between the Dit profile estimation can be summarized as follows: While using p-MOS capacitors, a larger energy level range is observable with no thermal broadening of the trap response due to the fixed measurement temperature. On the other hand, using a temperature-dependent method has a thermal broadening issue but only requires one sample for characterization.
The total Dit distribution within the In0.53Ga0.47As bandgap, which is extracted from the temperature-dependent conductance method.
It was noted that the inversion behavior of IPA-based HfOxNy ALD is attributed to the mid-gap Dit level decrease. However, in order to verify true inversion characteristics, more analyses must be investigated. In Figure 14, the conductance profile of sample O3-based HfO2 and IPA-based HfOxNy InGaAs MOS capacitors are depicted.
The conductance profiles for (a) O3-HfO2 and (b) IPA-HfON ALD.
Both C-V profiles have shown inversion-like behavior in the negative bias region. However, clear difference is observed between the conductance profiles. While huge and Gaussian conductance profiles in the negative bias regions are observed for O3-based HfO2, smaller Gaussian conductance peaks are observed in depletion region, and distinct from these peaks, saturated conductance profiles are observed for IPA-based HfOxNy. Therefore, it is concluded that the inversion-like behavior in O3-based HfO2 is attributed from the huge and broad conductance peaks that reflect high mid-gap Dit levels, while inversion behavior in IPA-based HfOxNy might be attributed from real true minority carrier inversion.
In Figure 15, to verify true inversion characteristics of IPA-based HfOxNy, the minority carrier response was investigated based on the extraction of the transition frequency, wm, which is known to be a characteristic of a strong inverted surface for III-V MOS capacitors [62]. It is known that at the transition frequency, the –wdC/dw and Gm/w share the same peak magnitude in the strong inversion gate bias. Notably, –wdC/dw and Gm/w share the same peak magnitude at the same transition frequency of 4 kHz which suggests that IPA-based HfOxNy exhibits true inversion behavior. The true inversion behavior of hafnium oxide-based dielectrics on InGaAs substrate has not been reported yet which implies significant potential.
–wdC/dw and Gm/w profiles for IPA-HfON/InGaAs MOS.
In order to achieve both low EOT and low Dit, a highly advanced gate stack, prepared by using an IPA oxidant in the PA-ALD of HfOxNy on In0.53Ga0.47As substrates, was proposed and showed the most outstanding results. A cyclic nitrogen low-power plasma step was added within the ALD cycles to passivate the oxygen vacancies uniformly without causing damage or surface degradation in comparison to the post deposition nitridation technology. Remarkable mid-gap Dit levels with strong inversion characteristics were achieved which has not been reported in the previous HfO2/InGaAs interface studies. The improved interface characteristics can be attributed to both low surface oxidation ability of IPA and suppression of oxygen diffusion by effective nitrogen passivation to oxygen vacancies in HfO2. The proposed ALD HfOxNy was fully characterized by investigating different dopant types and measurement temperatures. The results show comprehensive understanding on the interface defect density distribution. It is suggested that not only surface treatments but also the development of an advanced HfO2 ALD process has a great impact on the quality of the III-V MOS interface and the IPA-based HfON interfacial layer might have great potential in future technology node.
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Buchholz",profilePictureURL:"https://mts.intechopen.com/storage/users/89438/images/6463_n.jpg",institutionString:null,institution:{name:"Loma Linda University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Plant Physiology",value:13,count:1},{group:"subseries",caption:"Human Physiology",value:12,count:2},{group:"subseries",caption:"Cell Physiology",value:11,count:8}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:1},{group:"publicationYear",caption:"2020",value:2020,count:4},{group:"publicationYear",caption:"2019",value:2019,count:5},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:302,paginationItems:[{id:"198499",title:"Dr.",name:"Daniel",middleName:null,surname:"Glossman-Mitnik",slug:"daniel-glossman-mitnik",fullName:"Daniel Glossman-Mitnik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/198499/images/system/198499.jpeg",biography:"Dr. Daniel Glossman-Mitnik is currently a Titular Researcher at the Centro de Investigación en Materiales Avanzados (CIMAV), Chihuahua, Mexico, as well as a National Researcher of Level III at the Consejo Nacional de Ciencia y Tecnología, Mexico. His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. 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At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. 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Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment"},{id:"5",title:"Parasitic Infectious Diseases",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology"},{id:"6",title:"Viral Infectious Diseases",scope:"The Viral Infectious Diseases Book Series aims to provide a comprehensive overview of recent research trends and discoveries in various viral infectious diseases emerging around the globe. The emergence of any viral disease is hard to anticipate, which often contributes to death. A viral disease can be defined as an infectious disease that has recently appeared within a population or exists in nature with the rapid expansion of incident or geographic range. This series will focus on various crucial factors related to emerging viral infectious diseases, including epidemiology, pathogenesis, host immune response, clinical manifestations, diagnosis, treatment, and clinical recommendations for managing viral infectious diseases, highlighting the recent issues with future directions for effective therapeutic strategies.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",keywords:"Novel Viruses, Virus Transmission, Virus Evolution, Molecular Virology, Control and Prevention, Virus-host Interaction"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 15th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:286,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRqB9QAK/Profile_Picture_1626163237970",institutionString:null,institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/38603",hash:"",query:{},params:{id:"38603"},fullPath:"/profiles/38603",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()