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Ali Gamal Al-Kaf

Sana'a University Yemen

Prof. Dr. Ali Gamal Al-kaf obtained a Ph.D. in Pharmaceutical Sciences in 2006. He is the previous Chief Council for Accreditation and Quality Assurance and former dean of the Faculty of Pharmacy, Sana'a University, Yemen. He is currently the dean of the Faculty of Medical Sci-ences and a professor in the Medicinal Chemistry Department at the National University. He is a member of the Yemeni Higher Medical Council and many other associations and internation-al groups. He is also chairman of the Universal Journal of Pharmaceutical Research. Dr. Al-kaf is an editor and associate editor of several international journals. His research interests include the synthesis and biological activity of 4-oxopyrimidine and quinazolinone -4 derivatives, structural biology and bioinformatics in drug design, Yemeni medicinal plants, development and validation of spectrophotometric and high-performance liquid chromatography (HPLC) methods for different drugs, and antibiotic and antimicrobial resistance in Yemen. He is the author of more than ninety articles and fifteen books. He also has four patents to his credit.

3books edited

6chapters authored

Latest work with IntechOpen by Ali Gamal Al-Kaf

This book investigates and identifies novel therapeutic compounds for the treatment of a range of illnesses. Heterocyclic compounds are a significant class of substances with biological activity. Among them, quinazoline has attracted a lot of interest because of its important biological properties. Numerous compounds with quinazoline moiety have been shown to exhibit a wide range of therapeutic properties, including antioxidant, antifungal, antiviral, antidiabetic, anticancer, anti-inflammatory, and antibacterial activities. This book presents a comprehensive overview of quinazoline and its derivatives. The chapters address recent advances in the synthesis of several different heterocyclic compounds, the use of computational studies for finding new active quinazoline derivatives, the biological activities of quinazoline, and much more.

Recent Advances on Quinazoline

Recent Advances on Quinazoline

Edited by Ali Gamal Al-Kaf

Books edited

Quinazolinone and Quinazoline Derivatives

Quinazolinone and Quinazoline Derivatives

Edited by Ali Gamal Al-Kaf

Corticosteroids

Corticosteroids

Edited by Ali Gamal Al-Kaf

Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal Anti-Inflammatory Drugs

Edited by Ali Gamal Al-Kaf

Chapters authored

Introductory Chapter - The Newest Research in Nonsteroidal Anti-inflammatory Drugs

By Ali Gamal Al‐kaf

Part of the book: Nonsteroidal Anti-Inflammatory Drugs

Introductory Chapter: The Newest Research in Corticosteroids

By Ali Gamal Al-kaf

Part of the book: Corticosteroids

Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives

By Ali Gamal Al-kaf

Part of the book: Quinazolinone and Quinazoline Derivatives

Adrenal Cortex Hormones

By Ali Gamal Ahmed Al-kaf

Over 50 different steroids, including precursors to other steroid hormones, are secreted by the adrenal glands, which are located directly above the kidneys. Aldosterone and hydrocortisone, however, are the two most significant hormonal steroids created by the adrenal cortex. Since aldosterone is too expensive to produce commercially, other semi-synthetic analogues are now used to treat Addison’s disease in its place. Fludrocortisone, for example, greatly increases both salt retention and anti-inflammatory activity when combined with hydrocortisone. The kidneys’ ability to reabsorb sodium is increased by aldosterone. Increased blood volume will follow an increase in plasma sodium concentration. Additionally, aldosterone boosts potassium ion excretion. Addison’s disease is brought on by inconsistency. Glycogen storage synthesis is induced by the synthesis of glycogen synthase, and gluconeogenesis (the production of glucose from glucose) is induced in the liver.

Part of the book: Adrenal Glands

Introductory Chapter: Recent Advances on Quinazoline

By Ali Gamal Al-Kaf

Part of the book: Recent Advances on Quinazoline

Biological Activities of Recent Advances in Quinazoline

By Ali Gamal Al-Kaf and Rana Abdullah Al-Robaidi

Quinazolines are important stable heterocyclic compounds of great biological activates. Naturally, they are found in many plants that are the source of these quinazolines in addition they are synthesized chemically. Recently quinazolines represent a nucleus of the vast majority of novel compounds that have promising biological activity. They show different activities by acting on different body targets such activities are anticancer, antihypertensive, antimicrobial, antifungal, antibacterial, analgesic, anti-inflammatory, antituberculosis, and antimalarial activity. This chapter highlights the recent advance in the biological activates of quinazolines and quinazolines derivatives on different biological targets.

Part of the book: Recent Advances on Quinazoline

View all chapters

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