Filip Cristiana

Grigore T. Popa University of Medicine and Pharmacy Romania

Dr. Filip has accumulated experience in the field of pharmacokinetic, drug-delivery systems and HPLC by accomplishing the PhD 2001 thesis entitled: 'Analytical Methods for the Bioavailability Estimation of some Drugs Bound on Polymeric Support” at 'Al. I. Cuza” University, Iasi, Romania. She also acquired knowledge in reactive species involvement in pathological processes, homocysteine role in pathology, and in mechanisms of endothelial dysfunction in cardiovascular diseases as team member of related projects.

1books edited

4chapters authored

Latest work with IntechOpen by Filip Cristiana

Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.

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Reactive Oxygen Species (ROS) in Living Cells

Edited by Filip Cristiana

Chapters authored

Homocysteine in Red Blood Cells Metabolism - Pharmacological Approaches

By Filip Cristiana, Zamosteanu Nina and Albu Elena

Part of the book: Blood Cell

Introductory Chapter: The Biology of Reactive Species

By Filip Cristiana

Part of the book: Reactive Oxygen Species (ROS) in Living Cells

Is Homocysteine a Marker or a Risk Factor: A Question Still Waits for an Answer

By Cristiana Filip, Elena Albu, Hurjui Ion, Catalina Filip, Cuciureanu Magda, Radu Florin Popa, Demetra Gabriela Socolov, Ovidiu Alexa and Alexandru Filip

Homocysteine, a non-proteinogenic sulfur-containing amino acid, was discovered in 1932, and 30 years passed until, in 1969, for the first time, its involvement in pathology was reported. It was only in the last two decades that homocysteine has become a subject of scientific interest and has begun to be intensively studied. A large number of scientists consider homocysteine as an independent risk factor particularly for cardiovascular disease, while others indicate homocysteine as a marker of this disease. Both sides bring scientific arguments for their opinions, yet the dilemma of homocysteine characterization still persists. Although the reported studies do not lead to a unique answer, it is generally accepted that homocysteine is associated with vascular dysfunction. Numerous scientific data show that the link between homocysteine and inflammation is achieved via the reactive oxygen species (ROS) pathway. The latest data indicate hydrogen peroxide as a possible messenger in cellular signaling in physiological or pathological processes and present the consequences of disturbing the oxidation-reducing balance. In this chapter, we present the latest scientific evidences gathered from the literature for both hypotheses regarding homocysteine involvement in pathology, and we propose a possible mechanism of action for homocysteine, based on our preliminary (yet unpublished) work.

Part of the book: Non-Proteinogenic Amino Acids

Filip Cristiana

Latest work with IntechOpen by Filip Cristiana

Reactive Oxygen Species (ROS) in Living Cells

Chapters authored

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