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Pınar Erkekoglu

Hacettepe University Faculty of Pharmacy Department of toxicology

Pınar Erkekoğlu graduated from the Faculty of Pharmacy, Hacettepe University, Turkey, where she received her MSci and Ph.D. in Toxicology. She completed her Ph.D. studies at the University of Joseph Fourier, France, and the French Alternative Energies and Atomic Energy Commission/Institute for Nanosciences and Cryogenics/Nucleic Acid Lesions (CEA/INAC/LAN). She worked as a post-doc and visiting associate in the Biological Engineering Department, Massachusetts Institute of Technology (MIT), USA. She is currently a full professor and head of the Department of Toxicology, Hacettepe University, and a faculty staff/board member at the Hacettepe University Vaccine Institute and Hacettepe University Center for Stem Cell Research and Development (PEDI-TEM). Her main interests are endocrine-disrupting chemicals, neurotoxic chemicals, and the toxic effects of vaccines. Dr. Erkekoğlu has published more than 180 papers and 16 book chapters. She has edited seven international books and served as the translation editor for three others. She has been a European Registered Toxicologist (ERT) since 2014.

7books edited

6chapters authored

Latest work with IntechOpen by Pınar Erkekoglu

Bisphenols are a group of abundant environmental chemicals. Many bisphenol derivatives, including bisphenol A (BPA), are used to manufacture plastics, epoxy resins, and other products. Thus, human exposure to bisphenols is inevitable. BPA may cause reproductive, developmental, and systemic toxic effects and there are questions about its potential impact, particularly on children’s health and the environment. Due to these concerns, new alternatives are now being used; however, these alternatives also have a bisphenol chemical structure and may lead to toxicity in humans. This book focuses on the toxicity mechanisms, pathological conditions, detection methods, and regulations of bisphenol derivatives. It presents the latest findings on the toxic effects of BPA, diseases that may be related to bisphenol exposure, and the regulations of the US Food and Drug Administration, European Food Safety Authority, and European Union.

Bisphenols Edited by Pınar Erkekoglu

Bisphenols

Edited by Pınar Erkekoglu

Books edited

Vitamin E in Health and Disease Interactions, Diseases and Health Aspects Edited by Pınar Erkekoglu

Vitamin E in Health and Disease

Edited by Pınar Erkekoglu

Medical Toxicology Edited by Pınar Erkekoglu

Medical Toxicology

Edited by Pınar Erkekoglu

Oncogenes and Carcinogenesis Edited by Pınar Erkekoglu

Oncogenes and Carcinogenesis

Edited by Pınar Erkekoglu

Glutathione in Health and Disease Edited by Pınar Erkekoglu

Glutathione in Health and Disease

Edited by Pınar Erkekoglu

Bisphenol A Exposure and Health Risks Edited by Pınar Erkekoglu

Bisphenol A

Edited by Pınar Erkekoglu

Nutritional Deficiency Edited by Pınar Erkekoglu

Nutritional Deficiency

Edited by Pınar Erkekoglu

Chapters authored

Protection Studies by Antioxidants Using Single Cell Gel Electrophoresis (Comet Assay)

By Pınar Erkekoglu

Part of the book: Gel Electrophoresis

Environmental Effects of Endocrine-Disrupting Chemicals: A Special Focus on Phthalates and Bisphenol A

By Pinar Erkekoglu and Belma Kocer-Gumusel

Several environmental chemicals are classified as endocrine-disrupting chemicals (EDCs). Many of them have an impact on reproductive functions and sex hormones because of their estrogenic and/or antiandrogenic properties. Phthalates and bisphenol A (BPA) are two well-known EDCs. They are abundant in the environment. Phthalates are usually classified as antiandrogens, whereas BPA is considered as estrogen-like EDC and xenoestrogen. Other than their endocrine-disrupting effects, these two chemicals are also known to have genotoxic and epigenetic effects. Besides, they are hepatotoxic and have substantial effects on other organs/systems (thyroid, kidney, neuroendocrine system, immune system, etc.). In this chapter, we will mainly focus on the toxic effects of different phthalate esters and BPA by discussing their availability in the environment, mechanism and mode of actions, their biotransformation and reproductive effects, and their effects on other systems (hepatic, renal, etc.). Besides, we discuss epidemiological studies that are conducted to reveal their effects on the reproductive and endocrine systems. This chapter provides the readers a compact piece of knowledge on these abundant substances and helps them to understand the action of these substances at the molecular and cellular levels.

Part of the book: Environmental Health Risk

Introductory Chapter: A General Overview of Glutathione, Glutathione Transport, and Glutathione Applications

By Pinar Erkekoglu

Part of the book: Glutathione in Health and Disease

Introductory Chapter: Interactions between Environmental Chemicals and KRAS Oncogene in Different Cancers - Special Focus on Colorectal, Pancreatic, and Lung Cancers

By Pinar Erkekoglu

Part of the book: Oncogenes and Carcinogenesis

Introductory Chapter: Medical Toxicology

By Pınar Erkekoğlu and Suna Sabuncuoğlu

Part of the book: Medical Toxicology

Toxic Effects of Bisphenols: A Special Focus on Bisphenol A and Its Regulations

By Pınar Erkekoğlu, Anil Yirün and Aylin Balci Özyurt

Bisphenol A (BPA), which is an abundant chemical in the environment, is suggested to cause different toxic effects, including endocrine disruption, reprotoxicity, developmental toxicity, and neurotoxicity. Due to these effects, regulatory authorities have restricted the use of BPA in different consumer products, particularly in products used by children. These restrictions have led to researchers and plastic industry to find new and safer alternatives. Today, bisphenol F (BPF) and bisphenol S (BPS) are highly used although their toxic effects are less known. In the past years, several studies showed that these derivatives might also act as endocrine disruptors and cause toxic effects. BPA is a substance that is carefully monitored by regulatory agencies, and toxicological data are evaluated regularly. The alternatives, such as BPF and BPS, should also be monitored, and the regulations concerning their use in consumer products must be implemented soon. The increase in the number of studies on BPA and different bisphenols is very important in terms of obtaining new toxicological data and guiding regulatory institutions. This chapter will mainly focus on BPA, its toxicity, BPA alternatives, and regulations implemented by different American and European authorities.

Part of the book: Bisphenols

View all chapters

Related collaborators

Orhan Ince

Istanbul Technical University , Turkey

Zeynep Cetecioglu

Istanbul Technical University , Turkey

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Boğaziçi University , Turkey

Gizella Győrffyné Dr. Jahnke

University of Pannonia , Hungary

Loretto Contreras-Porcia

Andrés Bello University , Chile

Jesús Manuel Cantoral Fernández

University of Cádiz , Spain

Francisco Javier Fernández-Acero

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Maria Esther Rodríguez

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Laureana Rebordinos

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