Open access peer-reviewed Edited Volume

Recent Developments in Myelodysplastic Syndromes

Edited by Ota Fuchs

Institute of Hematology and Blood Transfusion

This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.

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Recent Developments in Myelodysplastic SyndromesEdited by Ota Fuchs

Published: February 20th 2019

DOI: 10.5772/intechopen.73936

ISBN: 978-1-78985-478-7

Print ISBN: 978-1-78985-477-0

Copyright year: 2019

Books open for chapter submissions

1154 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Introductory Chapter: Progress in Myelodysplastic Syndrome Area

By Ota Fuchs

140

Open access peer-reviewed

2. Diagnosis and Classification of Myelodysplastic Syndrome

By Gamal Abdul Hamid, Abdul Wahab Al-Nehmi and Safa Shukry

297

Open access peer-reviewed

3. Myelodysplastic Syndrome and Autoimmune Disorders: Causal Relationship or Coincidence?

By Kam A. Newman, Mojtaba Akhtari and Sheda Heidarian

175

Open access peer-reviewed

4. Immune Dysregulation in MDS: The Role of Cytokines and Immune Cells

By Selma D’Silva, Sunil B. Rajadhyaksha and Meenakshi Singh

171

Open access peer-reviewed

5. Myelodysplastic Syndromes: An Update on Pathophysiology and Management

By Wanxing Chai-Ho and Gary J. Schiller

230

Open access peer-reviewed

6. Noncoding RNAs in Myelodysplastic Syndromes

By Andrea Hruštincová, Katarina Szikszai, Zdeněk Krejčík, Nikoleta Loudová and Michaela Dostálová Merkerová

141

Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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