Open access peer-reviewed Edited Volume

Myelodysplastic Syndromes

Edited by Ota Fuchs

Institute of Hematology and Blood Transfusion

This book is a comprehensive overview of myelodysplastic syndromes (MDS). MDS are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral cytopenias, frequent karyotypic abnormalities, and risk of transformation to acute myeloid leukemia (AML). Median age of patients with MDS is about 70 years. Various immune abnormalities occur in MDS patients, and the relationship between autoimmune disorders and MDS is described. Accurate prognostication and risk stratification for individual patients with MDS are important for clinical treatment decisions. Patients with MDS are classified into two broad prognostic categories: lower risk and higher risk. The approval of lenalidomide, azacitidine, and decitabine in last 10 years helped to diminish the clinical impact of MDS and delayed its progression to AML.

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Myelodysplastic SyndromesEdited by Ota Fuchs

Published: September 7th 2016

DOI: 10.5772/61879

ISBN: 978-953-51-2587-7

Print ISBN: 978-953-51-2586-0

eBook (PDF) ISBN: 978-953-51-7296-3

Copyright year: 2016

Books open for chapter submissions

13172 Total Chapter Downloads

3 Crossref Citations

3 Web of Science Citations

9 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Myelodysplastic Syndromes

By Ota Fuchs


Open access peer-reviewed

2. Immune Dysregulation in Myelodysplastic Syndromes: Pathogenetic-Pathophysiologic Aspects and Clinical Consequences

By Argiris Symeonidis and Alexandra Kouraklis-Symeonidis


Open access peer-reviewed

3. Disorders Mimicking Myelodysplastic Syndrome and Difficulties in its Diagnosis

By Lale Olcay and Sevgi Yetgin


Open access peer-reviewed

4. Myelodysplastic Disorders, 5q-Syndrome

By Khalid Ahmed Al-Anazi


Open access peer-reviewed

5. Myelodysplastic Disorders, Monosomy 7

By Khalid Ahmed Al-Anazi


Open access peer-reviewed

6. Chronic Myelomonocytic Leukaemia

By Andreas Himmelmann


Open access peer-reviewed

7. Different Mechanisms of Drug Resistance in Myelodysplastic Syndromes and Acute Myeloid Leukemia

By Lucia Messingerova, Denisa Imrichova, Martina Coculova, Marian Zelina, Lucia Pavlikova, Helena Kavcova, Mario Seres, Viera Bohacova, Boris Lakatos, Zdena Sulova and Albert Breier


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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