Open access peer-reviewed Edited volume

New Developments in the Pathogenesis of Rheumatoid Arthritis

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

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New Developments in the Pathogenesis of Rheumatoid ArthritisEdited by Lazaros Sakkas

Published: February 22nd 2017

DOI: 10.5772/63175

ISBN: 978-953-51-2970-7

Print ISBN: 978-953-51-2969-1

Copyright year: 2017

Books open for chapter submissions

4987 Total Chapter Downloads

1 Dimensions Citations

chaptersDownloads

Open access peer-reviewed

1. MicroRNAs in Rheumatoid Arthritis: From Pathogenesis to Clinical Utility

By Agnieszka Paradowska-Gorycka and Barbara Stypińska

573

Open access peer-reviewed

2. Role of MicroRNAs in Rheumatoid Arthritis

By Merih Birlik, Ayşe Koçak and Duygu Harmancı

623

Open access peer-reviewed

3. Cytokines in Rheumatoid Arthritis (RA)

By Selim Nalbant and Ahmet Merih Birlik

668

Open access peer-reviewed

4. BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

By Codrina Ancuta, Cristina Pomirleanu, Claudia Mihailov, Eugen Ancuta and Daniela Opris

555

Open access peer-reviewed

5. The Gut Microbiota and Inflammation in Rheumatoid Arthritis

By Reem Hamdy A. Mohammed and Hesham Ibrahim I. Elmakhzangy

698

Open access peer-reviewed

6. Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay

By Codrina Ancuta, Cristina Iordache, Eugen Ancuta and Claudia Mihailov

759

Open access peer-reviewed

7. Synoviolin is a Novel Pathogenic Factor of Arthropathy and Chronic Inflammation

By Naoko Yagishita, Satoko Aratani, Hidetoshi Fujita, Yoshihisa Yamano, Kusuki Nishioka and Toshihiro Nakajima

479

Open access peer-reviewed

8. YKL‐40: The Search for New Biomarkers in Rheumatoid Arthritis

By Maria H. Kazakova and Victoria S. Sarafian

632

Edited volume and chapters are indexed in

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  • CNKI

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