Open access peer-reviewed Edited Volume

Principles of Osteoarthritis

Its Definition, Character, Derivation and Modality-Related Recognition

Edited by Bruce M. Rothschild

Northeast Ohio Medical University, United States of America

This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.

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Principles of OsteoarthritisIts Definition, Character, Derivation and Modality-Related RecognitionEdited by Bruce M. Rothschild

Published: February 22nd 2012

DOI: 10.5772/1487

ISBN: 978-953-51-0063-8

eBook (PDF) ISBN: 978-953-51-6822-5

Copyright year: 2012

Books open for chapter submissions

57496 Total Chapter Downloads

9 Crossref Citations

40 Web of Science Citations

48 Dimensions Citations


Open access peer-reviewed

1. Epidemiology and Biomechanics of Osteoarthritis

By Bruce M. Rothschild and Robert J. Woods


Open access peer-reviewed

2. Symptoms, Signs and Quality of Life (QoL) in Osteoarthritis (OA)

By Keith K.W. Chan and Ricky W.K. Wu


Open access peer-reviewed

3. An Atlas-Based Approach to Study Morphological Differences in Human Femoral Cartilage Between Subjects from Incidence and Progression Cohorts: MRI Data from Osteoarthritis Initiative

By Hussain Tameem and Usha Sinha


Open access peer-reviewed

4. The Application of Imaging in Osteoarthritis

By Caroline B. Hing, Mark A. Harris, Vivian Ejindu and Nidhi Sofat


Open access peer-reviewed

5. Biomarkers and Ultrasound in the Knee Osteoarthrosis Diagnosis

By Sandra Živanović, Ljiljana Petrović Rackov and Zoran Mijušković


Open access peer-reviewed

6. Biomechanics of Physiological and Pathological Bone Structures

By Anna Nikodem and Krzystof Ścigała


Open access peer-reviewed

7. Subchondral Bone in Osteoarthritis

By David M. Findlay


Open access peer-reviewed

8. The Relationship Between Gait Mechanics and Radiographic Disease Severity in Knee Osteoarthritis

By Ershela L. Sims, Francis J. Keefe, Daniel Schmitt, Virginia B. Kraus, Mathew W. Williams, Tamara Somers, Paul Riordan and Farshid Guilak


Open access peer-reviewed

9. Osteoarthritis in Sports and Exercise: Risk Factors and Preventive Strategies

By Eduard Alentorn-Geli and Lluís Puig Verdié


Open access peer-reviewed

10. Post-Traumatic Osteoarthritis: Biologic Approaches to Treatment

By Sukhwinderjit Lidder and Susan Chubinskaya


Open access peer-reviewed

11. The Genetics of Osteoarthritis

By Antonio Miranda-Duarte


Open access peer-reviewed

12. Genetic Association and Linkage Studies in Osteoarthritis

By Annu Näkki, Minna Männikkö and Janna Saarela


Open access peer-reviewed

13. Genetic Mouse Models for Osteoarthritis Research

By Jie Shen, Meina Wang, Hongting Jin, Erik Sampson and Di Chen


Open access peer-reviewed

14. Cartilage Extracellular Matrix Integrity and OA

By Chathuraka T. Jayasuriya and Qian Chen


Open access peer-reviewed

15. Biochemical Mediators Involved in Cartilage Degradation and the Induction of Pain in Osteoarthritis

By Michael B. Ellman, Dongyao Yan, Di Chen and Hee-Jeong Im


Open access peer-reviewed

16. Proteases and Cartilage Degradation in Osteoarthritis

By Judith Farley, Valeria C. Dejica and John S. Mort


Open access peer-reviewed

17. Simple Method Using Gelatin-Coated Film for Comprehensively Assaying Gelatinase Activity in Synovial Fluid

By Akihisa Kamataki, Wataru Yoshida, Mutsuko Ishida, Kenya Murakami, Kensuke Ochi and Takashi Sawai


Open access peer-reviewed

18. Toll-Like Receptors: At the Intersection of Osteoarthritis Pathology and Pain

By Qi Wu and James L. Henry


Open access peer-reviewed

19. Anion Channels in Osteoarthritic Chondrocytes

By Elizabeth Perez-Hernandez, Nury Perez-Hernandez, Fidel de la C. Hernandez-Hernandez and Juan B. Kouri-Flores


Open access peer-reviewed

20. The Cholinergic System Can Be of Unexpected Importance in Osteoarthritis

By Sture Forsgren


Open access peer-reviewed

21. Transcriptional Regulation of Articular Chondrocyte Function and Its Implication in Osteoarthritis

By Jinxi Wang, William C. Kramer and John P. Schroeppel


Open access peer-reviewed

22. TGF-β Action in the Cartilage in Health and Disease

By Kenneth W. Finnson, Yoon Chi and Anie Philip


Open access peer-reviewed

23. How Important are Innate Immunity Cells in Osteoarthritis Pathology

By Petya Dimitrova and Nina Ivanovska


Open access peer-reviewed

24. The Role of Synovial Macrophages and Macrophage-Produced Mediators in Driving Inflammatory and Destructive Responses in Osteoarthritis

By Jan Bondeson, Shane Wainwright, Clare Hughes and Bruce Caterson


Open access peer-reviewed

25. Cellular Physiology of Articular Cartilage in Health and Disease

By Peter I. Milner, Robert J. Wilkins and John S. Gibson


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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