Open access peer-reviewed Edited Volume

New Developments in the Pathogenesis of Rheumatoid Arthritis

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

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New Developments in the Pathogenesis of Rheumatoid ArthritisEdited by Lazaros Sakkas

Published: February 22nd 2017

DOI: 10.5772/63175

ISBN: 978-953-51-2970-7

Print ISBN: 978-953-51-2969-1

eBook (PDF) ISBN: 978-953-51-7342-7

Copyright year: 2017

Books open for chapter submissions

11856 Total Chapter Downloads

9 Crossref Citations

8 Web of Science Citations

24 Dimensions Citations


Open access peer-reviewed

1. MicroRNAs in Rheumatoid Arthritis: From Pathogenesis to Clinical Utility

By Agnieszka Paradowska-Gorycka and Barbara Stypińska


Open access peer-reviewed

2. Role of MicroRNAs in Rheumatoid Arthritis

By Merih Birlik, Ayşe Koçak and Duygu Harmancı


Open access peer-reviewed

3. Cytokines in Rheumatoid Arthritis (RA)

By Selim Nalbant and Ahmet Merih Birlik


Open access peer-reviewed

4. BAFF System in Rheumatoid Arthritis: from Pathobiology to Therapeutic Targets

By Codrina Ancuta, Cristina Pomirleanu, Claudia Mihailov, Eugen Ancuta and Daniela Opris


Open access peer-reviewed

5. The Gut Microbiota and Inflammation in Rheumatoid Arthritis

By Reem Hamdy A. Mohammed and Hesham Ibrahim I. Elmakhzangy


Open access peer-reviewed

6. Rheumatoid Arthritis and Periodontal Disease: A Complex Interplay

By Codrina Ancuta, Cristina Iordache, Eugen Ancuta and Claudia Mihailov


Open access peer-reviewed

7. Synoviolin is a Novel Pathogenic Factor of Arthropathy and Chronic Inflammation

By Naoko Yagishita, Satoko Aratani, Hidetoshi Fujita, Yoshihisa Yamano, Kusuki Nishioka and Toshihiro Nakajima


Open access peer-reviewed

8. YKL‐40: The Search for New Biomarkers in Rheumatoid Arthritis

By Maria H. Kazakova and Victoria S. Sarafian


Edited Volume and chapters are indexed in

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  • Base
  • CNKI

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