Lazaros Sakkas

University Of Thessaly Greece

Dr Sakkas is Professor of Medicine and Rheumatology at the Faculty of Medicine, School of Health Sciences, University of Thessaly, and Director of Rheumatology Clinic, University General Hospital of Larissa, Larissa, Greece. He is also Adjunct Professor, Old Dominion University, Norfolk, VA, USA, and President of the Institute of Rheumatic Diseases, Greece. Dr Sakkas received his MD degree and his DM degree from the Medical School of National and Kapodistrian University, Athens, Greece, and his PhD degree from London University, UK. Since 1998 he has been at the Univesity of Thessaly and Director of the Rheumatology Clinic, and first as Assistant Professor, and then Associate Professor and Professor. Dr Sakkas has served as Editor of the Hellenic Rheumatology, the official journal of the Hellenic Society of Rheumatology (2007-present) and guest Editor of Current Rheumatology Reviews (2010). He has also served on the Editorial Boards of Clinical Immunology (2005-8), International Journal of Biomedical Sciences (2006-present), World Journal of Rheumatology (2011-present), and World Journal of Orthopedics (2011-present). His research interests include inflammation in rheumatic diseases and particularly rheumatoid arthritis, systemic sclerosis, and osteoarthritis where he has worked for nearly 10 years at Guy’s Hospital, London, UK, and Temple University, Philadelphia, PA, USA. Dr Sakkas has published more than 140 articles, reviews, and chapters in international and Greek scientific journals and textbooks, with impact factor more than 237, and more than 1600 citations.

Lazaros Sakkas

2books edited

2chapters authored

Latest work with IntechOpen by Lazaros Sakkas

The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

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