Open access peer-reviewed Edited Volume

Hypoxia and Human Diseases

Edited by Jing Zheng

University of Wisconsin–Madison, United States of America


Chi Zhou

University of Wisconsin–Madison, United States of America

This book contains a total of 21 chapters, each of which was written by experts in the corresponding field. The objective of this book is to provide a comprehensive and updated overview of cellular and molecular mechanisms underlying hypoxia's impacts on human health, as well as current advances and future directions in the detection, recognition, and management of hypoxia-related disorders. This collection of articles provides a clear update in the area of hypoxia research for biomedical researchers, medical students, nurse practitioners, and practicing clinicians in the fields of high altitude biology, cardiovascular biology and medicine, tumor oncology, obstetrics, pediatrics, and orthodontics and for others who may be interested in hypoxia.

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Hypoxia and Human DiseasesEdited by Jing Zheng

Published: February 1st 2017

DOI: 10.5772/62960

ISBN: 978-953-51-2896-0

Print ISBN: 978-953-51-2895-3

eBook (PDF) ISBN: 978-953-51-7334-2

Copyright year: 2017

Books open for chapter submissions

28306 Total Chapter Downloads

10 Crossref Citations

19 Web of Science Citations

30 Dimensions Citations


Open access peer-reviewed

1. The Multifaceted Role of Hypoxia‐Inducible Factor 1 (HIF1) in Lipid Metabolism

By Guomin Shen and Xiaobo Li


Open access peer-reviewed

2. Hypoxic Upregulation of ARNT (HIF-1β): A Cell-Specific Attribute with Clinical Implications

By Markus Mandl and Reinhard Depping


Open access peer-reviewed

3. The Hypoxia-Reoxygenation Injury Model

By Domokos Gerő


Open access peer-reviewed

4. Vascular Smooth Muscle as an Oxygen Sensor: Role of Elevation of the [Na+]i/[K+]i

By Sergei N. Orlov, Yulia G. Birulina, Liudmila V. Smaglii and Svetlana V. Gusakova


Open access peer-reviewed

5. Hypoxia in Mesenchymal Stem Cell

By Wahyu Widowati, Dwi Davidson Rihibiha, Khie Khiong, M. Aris Widodo, Sutiman B. Sumitro and Indra Bachtiar


Open access peer-reviewed

6. Cardiovascular Adaptation to High-Altitude Hypoxia

By Jun Ke, Lei Wang and Daliao Xiao


Open access peer-reviewed

7. Arterial Oxygen Saturation During Ascent to 5010 m: Heart Rate and AMS Scores

By Christopher B. Wolff, Annabel H. Nickol and David J. Collier


Open access peer-reviewed

8. Hypoxia-Induced Molecular and Cellular Changes in the Congenitally Diseased Heart: Mechanisms and Strategies of Intervention

By Dominga Iacobazzi, Massimo Caputo and Mohamed T Ghorbel


Open access peer-reviewed

9. Adaptations to Chronic Hypoxia Combined with Erythropoietin Deficiency in Cerebral and Cardiac Tissues

By Raja El Hasnaoui-Saadani


Open access peer-reviewed

10. Hypothermia in Stroke Therapy: Systemic versus Local Application

By Mitchell Huber, Hong Lian Duan, Ankush Chandra, Fengwu Li, Longfei Wu, Longfei Guan, Xiaokun Geng and Yuchuan Ding


Open access peer-reviewed

11. Hypoxia and Pulmonary Hypertension

By Nicoletta Charolidi and Veronica A. Carroll


Open access peer-reviewed

12. Stage-Specific Effects of Hypoxia on Interstitial Lung Disease

By Sandeep Artham and Payaningal R. Somanath


Open access peer-reviewed

13. Hypoxia Modulates the Adenosinergic Neural Network

By Susana P. Gaytán and Rosario Pasaro


Open access peer-reviewed

14. The HIF System Response to ESA Therapy in CKD‐Anemia

By Sandra Ribeiro, Luís Belo, Flávio Reis and Alice Santos‐Silva


Open access peer-reviewed

15. Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

By Xiao Xiao Wang, Yu Chen and Wai Keung Leung


Open access peer-reviewed

16. Interplay between Hypoxia, Inflammation and Adipocyte Remodeling in the Metabolic Syndrome

By Ana Marina Andrei, Anca Berbecaru-Iovan, Felix Rareş Ioan Din- Anghel, Camelia Elena Stănciulescu, Sorin Berbecaru-Iovan, Ileana Monica Baniţă and Cătălina Gabriela Pisoschi


Open access peer-reviewed

17. Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction

By Paola Casanello, Emilio A. Herrera and Bernardo J. Krause


Open access peer-reviewed

18. The Critical Role of Hypoxia in Tumor-Mediated Immunosuppression

By Nassera Aouali, Manon Bosseler, Delphine Sauvage, Kris Van Moer, Guy Berchem and Bassam Janji


Open access peer-reviewed

19. Cross‐Talk Between Hypoxia and the Tumour via Exosomes

By Shayna Sharma, Mona Alharbi, Andrew Lai, Miharu Kobayashi, Richard Kline, Katrina Wade, Gregory E. Rice and Carlos Salomon


Open access peer-reviewed

20. A Novel Hypoxia Imaging Endoscopy System

By Kazuhiro Kaneko, Hiroshi Yamaguchi and Tomonori Yano


Open access peer-reviewed

21. Hypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases

By Deepak Bhatia, Mohammad Sanaei Ardekani, Qiwen Shi and Shahrzad Movafagh


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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