Open access peer-reviewed Edited volume

Gynecologic Cancers

Basic Sciences, Clinical and Therapeutic Perspectives

Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers.

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Open access peer-reviewed

1. Role of BRCA1 in Breast Cancer Metastasis

By S. Satheesh Kumar, K.H. Sreelatha, Revathy Nadhan and Priya Srinivas

828

Open access peer-reviewed

2. Interplay of Epigenetics with Gynecological Cancer

By Coralia Bleotu, Demetra Socolov, Mariana Anton, Anca Botezatu, Adriana Plesa, Iulia Virginia Iancu, Lorelei Irina Brasoveanu, Gabriela Anton and Carmen Cristina Diaconu

799

Open access peer-reviewed

3. Antiangiogenic Therapy in Epithelial Ovarian Cancer

By M.A. Alonso Bermejo, Leticia Iglesias Rey, M.E. Pérez López, A. Fernández Montes and J. García Mata

537

Open access peer-reviewed

4. Peritonectomy Procedures and HIPEC for Peritoneal Metastasis from Ovarian Cancer

By Angelo Di Giorgio, Daniele Biacchi, Antonio Ciardi, Alessio Impagnatiello, Maurizio Cardi, Simone Sibio, Bianca Sollazzo, Joseph Maher Fouad Atta, Giuseppe Naso, Fabio Accarpio and Paolo Sammartino

984

Open access peer-reviewed

5. Individualized Novel Therapies for Patients with Tumor Suppressor Genes BRCA1 and BRCA2 Mutated Epithelial Ovarian Cancer

By Sandra García-Nieto, Carmen Guillén-Ponce, Carmen Alonso, María- Carmen Rodríguez-Soriano, María-Luz Pombo, Earl Julie and Samir A. Farghaly

635

Open access peer-reviewed

6. Ovarian Cancer Research in the Post Genomic Era — Challenges and Opportunities

By Alicia A. Goyeneche and Carlos M. Telleria

894

Open access peer-reviewed

7. Analysing Molecular Mechanism Related to Therapy- Resistance in In-vitro Models of Ovarian Cancer

By Jens C. Hahne, Arnd Honig, Jörg B. Engel, Andrea Lampis and Nicola Valeri

953

Open access peer-reviewed

8. Recurrent Ovarian Cancer — Basic Knowledge, Current Management, and Future Directions

By Bernardo L. Rapoport

926

Open access peer-reviewed

9. Management of Ovarian Cancer — Is There a Role for Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

By Melissa Ching Ching Teo and Grace Hwei Ching Tan

599

Open access peer-reviewed

10. Anti-Angiogenic and Anti-Cancer Effects by Targeting the Protein Kinase G Type-Iα (PKG-Iα) Signaling Pathway and its Downstream Effects on Expression of Inhibitor of Apoptosis Proteins, C-IAP1, Livin and Survivin

By Janica C. Wong, Priyatham Gorjala, Benjamin Costantino and Ronald R. Fiscus

632

Open access peer-reviewed

11. Adenocarcinoma of the Endometrium — The Art of Its Diagnosis

By Manoel Afonso Guimarães Gonçalves and Fernando Anschau

662

Open access peer-reviewed

12. Robotic Surgery in the Management of Endometrial Cancer

By Mark Williams, John Villeneuve and Bernice Robinson-Bennett

884

Open access peer-reviewed

13. Cervical Cancer in Human Immunodeficiency Virus (HIV) Positive Patients

By Atara Ntekim

738

Open access peer-reviewed

14. Sentinel Lymph Node Detection in Early Stage Cervical Cancer

By Elisa Moreno-Palacios, Elsa Delgado, Javier De Santiago and Ignacio Zapardiel

822

Open access peer-reviewed

15. Cancer of the Vulva — A Review

By Fernando Anschau and Manoel Afonso Guimarães Gonçalves

970

Edited volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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