Open access peer-reviewed Monograph

Aldosterone-Mineralocorticoid Receptor

Cell Biology to Translational Medicine

Edited by Brian Harvey

Royal College of Surgeons in Ireland, Ireland

Co-editor:

This book is an open access dissemination of the EU COST Action ADMIRE in Aldosterone/Mineralocorticoid Receptor (MR) physiology and pathophysiology. Aldosterone is the major hormone regulating blood pressure. Alterations in blood levels of aldosterone and genetic mutations in the MR receptor are major causes of hypertension and comorbidities. Many of the drugs in clinical use, and in development for treating hypertension, target aldosterone and MR actions in the kidney and cardiovascular system. The ADMIRE book assembles review chapters from 16 European ADMIRE laboratories providing the latest insights into mechanisms of aldosterone synthesis/secretion, aldosterone/MR physiology and signaling, and the pathophysiological roles of aldosterone/MR activation.

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Aldosterone-Mineralocorticoid ReceptorCell Biology to Translational MedicineEdited by Brian Harvey

Published: September 25th 2019

DOI: 10.5772/intechopen.69065

ISBN: 978-1-83962-199-4

Print ISBN: 978-1-83962-198-7

eBook (PDF) ISBN: 978-1-83962-200-7

Copyright year: 2019

Books open for chapter submissions

605 Total Chapter Downloads

chaptersDownloads

Open access peer-reviewed

1. Mineralocorticoid Receptor Antagonists in the Treatment of Coronary Artery Disease, Myocardial Infarction and Heart Failure

By Carolin Zwadlo and Johann Bauersachs

31

Open access peer-reviewed

2. Mineralocorticoid Receptor and Leptin: A Dangerous Liaison in the Obese Heart

By Gema Marin-Royo, María Luaces, Victoria Cachofeiro and Ernesto Martínez-Martínez

29

Open access peer-reviewed

3. Aldosterone/Mineralocorticoid Receptor Downstream Targets as Novel Therapeutic Targets to Prevent Cardiovascular Remodeling

By Jaime Ibarrola, Frederic Jaisser and Natalia López-Andrés

35

Open access peer-reviewed

4. Aldosterone/MR Signaling, Oxidative Stress, and Vascular Dysfunction

By Ana M. Briones and Rhian M. Touyz

53

Open access peer-reviewed

5. Renin-Angiotensin-Aldosterone System in Heart Failure: Focus on Nonclassical Angiotensin Pathways as Novel Upstream Targets Regulating Aldosterone

By Urszula Tyrankiewicz, Agnieszka Kij, Tasnim Mohaissen, Mariola Olkowicz, Ryszard T. Smolenski and Stefan Chlopicki

28

Open access peer-reviewed

6. Primary Aldosteronism: A Glimpse into the Most Common Endocrine Cause of Arterial Hypertension

By Gian Paolo Rossi and Teresa M. Seccia

35

Open access peer-reviewed

7. Potential Benefit of Mineralocorticoid Receptor Antagonists in Kidney Diseases

By Jonatan Barrera-Chimal, Lionel Lattenist and Frederic Jaisser

46

Open access peer-reviewed

8. Mineralocorticoid Receptor in Novel Target Tissues: A Closer Look at the Adipocyte

By Andrea Armani, Vincenzo Marzolla, Alessandra Feraco, Stefania Gorini, Caterina Mammi, Marco Infante and Massimiliano Caprio

38

Open access peer-reviewed

9. Investigating the Role of Mineralocorticoid Receptor Signaling in Cancer Biology in the Genomic Era

By Ozlen Konu and Seniye Targen

43

Open access peer-reviewed

10. MR/GR Signaling in the Brain during the Stress Response

By Edo R. de Kloet and Onno C. Meijer

43

Open access peer-reviewed

11. View on Aldosterone and the Brain Revisited

By Natasa Hlavacova and Damiela Jezova

30

Open access peer-reviewed

12. Transcriptional Regulation and Epigenetics in Cardiovascular Cells: Role of the Mineralocorticoid Receptor

By Lisa Deng, Lutz Hein and Achim Lother

32

Open access peer-reviewed

13. MicroRNAs in Aldosterone Production and Action

By Scott M. MacKenzie, Josie van Kralingen, Hannah Martin and Eleanor Davies

33

Open access peer-reviewed

14. Post-Translational Modification of MR Activity

By Diego Alvarez de la Rosa and Natalia Serrano-Morillas

32

Open access peer-reviewed

15. Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na+ Transport by Non-genomic Mechanisms

By Warren Thomas and Brian Harvey

23

Open access peer-reviewed

16. Advances in the Development of Non-steroidal Mineralocorticoid-receptor Antagonists

By Felipe L. Pérez-Gordillo, Maria Jesús Pérez de Vega, Guillermo Gerona-Navarro, Yoel Rodríguez, Diego Alvarez de la Rosa, Rosario González-Muñiz and Mercedes Martín-Martínez

47

Open access peer-reviewed

17. COLT: A New Weapon to Disseminate Knowledge

By Bernard C. Rossier, Michelle Rossier and Jean-Pierre Kraehenbühl

27

Monograph and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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