Applies to all print copies | Offer ends Dec 20th

Open access peer-reviewed Edited Volume


Present and Future

Neuroblastoma, once called "enigmatic", due to "unpredictable" clinical behaviors, is composed of biologically diverse tumors. Molecular/genomic properties unique to the individual tumors closely link to the clinical outcomes of patients. Establishing risk stratification models after analyzing biologic characteristics of each case has made a great success in patient management. However, the trend of improving survival rates in neuroblastoma over the last 30 years has started to level off, and currently available treatment modalities have almost reached to their maximized intensity. Furthermore, aggressive treatment causes significant long-term morbidities to the survivors. We really need to make the next step to the level of personalized medicine with more precise understanding of neuroblastoma biology. This book includes useful data and insights from the world's experts in this field. I believe this book can make an excellent contribution to all the investigators working hard and fighting for the children stricken by this disease.

Read more >Order hardcopy
NeuroblastomaPresent and FutureEdited by Hiroyuki Shimada

Published: February 8th 2012

DOI: 10.5772/1251

ISBN: 978-953-307-016-2

eBook (PDF) ISBN: 978-953-51-6638-2

Copyright year: 2012

Books open for chapter submissions

38386 Total Chapter Downloads

8 Crossref Citations

23 Web of Science Citations

33 Dimensions Citations


Open access peer-reviewed

1. Genetic Factors Influencing the Risk and Clinical Outcome of Neuroblastoma

By Diana T. Lau and Lesley J. Ashton


Open access peer-reviewed

2. Recurrent Neuroblastoma

By Loretta M.S. Lau and Wendy B. London


Open access peer-reviewed

3. The Cell Biology of Neuroblastoma

By John B. Denny


Open access peer-reviewed

4. Neuroblastoma: A Malignancy Due to Cell Differentiation Block

By Andrew Tee, Pei Y. Liu, Glenn M. Marshall and Tao Liu


Open access peer-reviewed

5. Interplay Between Protein Kinase C Isoforms Alpha and Epsilon, Neurofibromin, and the Ras/MAPK Pathway in Neuroblastoma Differentiation

By George Leondaritis, Xenia Koliou, Shalini Johnson, Chengjun Li, Andreas Florakis, Konstantinos Dimas, Nikos Sakellaridis and Dimitra Mangoura


Open access peer-reviewed

6. Alternative TrkA Splicing and Neuroblastoma

By Antonietta R. Farina, Lucia Cappabianca, Pierdomenico Ruggeri, Natalia Di Ianni, Marzia Ragone, Stefania Merolle, Alberto Gulino and Andrew R. Mackay


Open access peer-reviewed

7. Sympathetic Neurotransmitters in Neuroblastoma – Between Physiology and Pathology

By Magdalena Czarnecka, Jason Tilan and Joanna Kitlinska


Open access peer-reviewed

8. Bioactive Sphingolipids in Neuroblastoma

By Mehrdad Rahmaniyan, Amr Qudeimat and Jacqueline M. Kraveka


Open access peer-reviewed

9. The NBPF Gene Family

By Vanessa Andries, Karl Vandepoele and Frans van Roy


Open access peer-reviewed

10. Retinoic-Acid-Induced Downregulation of the 67 KDa Laminin Receptor Correlates with Reduced Biological Aggressiveness of Human Neuroblastoma Cells

By Juan M. Escamilla, Christine Bäuerl, Carlos M. R. López, Satu P. Pekkala, Samuel Navarro and Domingo Barettino


Open access peer-reviewed

11. The Different Faces of Angiogenesis in Neuroblastoma

By Pietro Luigi Poliani and Domenico Ribatti


Open access peer-reviewed

12. Application of Molecular Mimicry to Target GD2 Ganglioside

By Irena Horwacik and Hanna Rokita


Open access peer-reviewed

13. MicroRNA Target Signatures in Advanced Stage Neuroblastoma

By Victoria R. Chu and Inhan Lee


Open access peer-reviewed

14. Molecular Chaperones as Prognostic Markers of Neuroblastoma

By Yung-Feng Liao, Wen-Ming Hsu, Hsinyu Lee, Ming-Kuan Hu, Hsueh-Fen Juan, Min-Chuan Huang, Hsiu-Hao Chang, Bo-Jeng Wang, Yu-Yin Shih and Yeou-Guang Tsay


Open access peer-reviewed

15. Small Molecule Drugs and Targeted Therapies for Neuroblastoma

By Chengyuan Xue, Andrei Gudkov, Michelle Haber and Murray D. Norris


Open access peer-reviewed

16. FOXO Transcription Factors as Potential Therapeutic Targets in Neuroblastoma

By Michael J. Ausserlechner, Judith Hagenbuchner, Stefan Fuchs, Kathrin Geiger and Petra Obexer


Open access peer-reviewed

17. Oncolytic Poliovirus Therapy in a Mouse Model of Neuroblastoma: Preclinical Data Analysis and Future Studies

By Hidemi Toyoda, Eckard Wimmer and Jeronimo Cello


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£139

Order now

Residents of European Union countries need to add a Book Value-Added Tax Rate based on their country of residence. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase