Open access peer-reviewed Edited Volume

Chronic Lymphocytic Leukemia

Edited by Pablo Oppezzo

Institut Pasteur, France

B-cell chronic lymphocytic leukemia (CLL) is considered a single disease with extremely variable course, and survival rates ranging from months to decades. It is clear that clinical heterogeneity reflects biologic diversity with at least two major subtypes in terms of cellular proliferation, clinical aggressiveness and prognosis. As CLL progresses, abnormal hematopoiesis results in pancitopenia and decreased immunoglobulin production, followed by nonspecific symptoms such as fatigue or malaise. A cure is usually not possible, and delayed treatment (until symptoms develop) is aimed at lengthening life and decreasing symptoms. Researchers are playing a lead role in investigating CLL's cause and the role of genetics in the pathogenesis of this disorder. Research programs are dedicated towards understanding the basic mechanisms underlying CLL with the hope of improving treatment options.

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Chronic Lymphocytic LeukemiaEdited by Pablo Oppezzo

Published: February 10th 2012

DOI: 10.5772/1156

ISBN: 978-953-307-881-6

eBook (PDF) ISBN: 978-953-51-6746-4

Copyright year: 2012

Books open for chapter submissions

44647 Total Chapter Downloads

10 Crossref Citations

14 Web of Science Citations

22 Dimensions Citations


Open access peer-reviewed

1. Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis

By Sergio Bianchi, Guillermo Dighiero and Otto Pritsch


Open access peer-reviewed

2. Microenvironment Interactions in Chronic Lymphocytic Leukemia: A Delicate Equilibrium Linking the Quiescent and the Proliferative Pool

By F. Palacios, C. Abreu, P. Moreno, M. Giordano, R. Gamberale and P. Oppezzo


Open access peer-reviewed

3. Dysregulation of Apoptosis and Proliferation in CLL Cells

By Marcin Wójtowicz and Dariusz Wołowiec


Open access peer-reviewed

4. DNA Damage Response/Signaling and Genome (In)Stability as the New Reliable Biological Parameters Defining Clinical Feature of CLL

By Jozo Delic, Jean-Brice Marteau, Karim Maloum, Florence Nguyen-Khac, Frédéric Davi, Zahia Azgui, Véronique Leblond, Jacques-Louis Binet, Sylvie Chevillard and Hélène Merle-Béral


Open access peer-reviewed

5. Current Knowledge of Microarray Analysis for Gene Expression Profiling in Chronic Lymphocytic Leukemia

By Ida Franiak-Pietryga and Marek Mirowski


Open access peer-reviewed

6. Contribution of microRNAs to CLL Biology and Their Potential as New Biomarkers

By Maria Rosa Garcia-Silva, Maria Catalina Güida and Alfonso Cayota


Open access peer-reviewed

7. The Biological Relevance of ZAP-70 in CLL

By Valerie Pede, Ans Rombout, Bruno Verhasselt and Jan Philippé


Open access peer-reviewed

8. Pathophysiology of Protein Kinase C Isozymes in Chronic Lymphocytic Leukaemia

By John C. Allen and Joseph R. Slupsky


Open access peer-reviewed

9. The Role of Polymorphisms in Co-Signalling Molecules’ Genes in Susceptibility to B-Cell Chronic Lymphocytic Leukaemia

By Lidia Karabon and Irena Frydecka


Open access peer-reviewed

10. Mouse Models of Chronic Lymphocytic Leukemia

By Gema Pérez-Chacón and Juan M. Zapata


Open access peer-reviewed

11. Altering microRNA miR15a/16 Levels as Potential Therapy in CLL: Extrapolating from the De Novo NZB Mouse Model

By Siddha Kasar, Yao Yuan, Chingiz Underbayev, Dan Vollenweider, Matt Hanlon, Victor Chang, Hina Khan and Elizabeth Raveche


Open access peer-reviewed

12. Prognostic Factors in Chronic Lymphoid Leukemia and Identification of New Clinically Relevant Molecular Markers

By José-Ángel Hernández, Marcos González and Jesús-María Hernández


Open access peer-reviewed

13. Genetics of Chronic Lymphocytic Leukemia: Practical Aspects and Prognostic Significance

By N. Put, I. Wlodarska, P. Vandenberghe and L. Michaux


Open access peer-reviewed

14. Immune Response and Immunotherapy in Chronic Lymphocytic Leukemia

By Leticia Huergo-Zapico, Ana P. Gonzalez-Rodríguez, Juan Contesti, Azahara Fernández-Guizán, Andrea Acebes Huerta, Alejandro López-Soto and Segundo Gonzalez


Open access peer-reviewed

15. In Vitro Sensitivity Testing in the Assessment of Anti-CLL Drug Candidates

By Günter Krause, Mirjam Kuckertz, Susan Kerwien, Michaela Patz and Michael Hallek


Open access peer-reviewed

16. Interactions of the Platinum(II) Complexes with Nitrogen- and Sulfur-Bonding Bio-Molecules in Chronic Lymphocytic Leukemia

By Jovana Bogojeski, Biljana Petrović and Živadin D. Bugarčić


Open access peer-reviewed

17. Infectious Diseases and Clinical Complications During Treatment in CLL

By Farhad Abbasi


Open access peer-reviewed

18. Emerging Therapies in Chronic Lymphocytic Leukemia

By Reslan Lina and Dumontet Charles


Open access peer-reviewed

19. Heat Shock Proteins in Chronic Lymphocytic Leukaemia

By Nina C. Dempsey-Hibbert, Christine Hoyle and John H.H. Williams


Open access peer-reviewed

20. Present and Future Application of Nanoparticle Based Therapies in B-Chronic Lymphocytic Leukemia (B-CLL)

By Eduardo Mansilla, Gustavo H. Marin, Luis Núñez, Gustavo Larsen, Nelly Mezzaroba and Paolo Macor


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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