Open access peer-reviewed Edited Volume


Mechanisms and Prospects for Therapy

Amyloidoses are a heterogeneous group of diverse etiology diseases. They are characterized by an endogenous production of abnormal proteins called amyloid proteins, which are not hydrosoluble, form depots in various organs and tissue of animals and humans and cause dysfunctions. Despite many decades of research, the origin of the pathogenesis and the molecular determinants involved in amyloid diseases has remained elusive. At present, there is not an effective treatment to prevent protein misfolding in these amyloid diseases. The aim of this book is to present an overview of different aspects of amyloidoses from basic mechanisms and diagnosis to latest advancements in treatment.

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AmyloidosisMechanisms and Prospects for TherapyEdited by Svetlana Sarantseva

Published: September 22nd 2011

DOI: 10.5772/757

ISBN: 978-953-307-253-1

eBook (PDF) ISBN: 978-953-51-6497-5

Copyright year: 2011

Books open for chapter submissions

33256 Total Chapter Downloads

2 Crossref Citations

8 Web of Science Citations

22 Dimensions Citations


Open access peer-reviewed

1. Current and New Perspectives on the Molecular and Cellular Mechanisms of Amyloid Formation and Toxicity in Light Chain Amyloidosis

By Ara Celi DiCostanzo and Marina Ramirez-Alvarado


Open access peer-reviewed

2. Amyloid A Amyloidosis Secondary to Rheumatoid Arthritis

By Tadashi Nakamura


Open access peer-reviewed

3. Diagnosis and Treatment of AA Amyloidosis with Rheumatoid Arthritis: State of the Art

By Takeshi Kuroda, Yoko Wada and Masaaki Nakano


Open access peer-reviewed

4. Apolipoprotein A-I Associated Amyloidoses: The Intriguing Case of a Natively Unfolded Protein Fragment

By Daria Maria Monti, Renata Piccoli and Angela Arciello


Open access peer-reviewed

5. Interaction and Aggregation of Amyloid β Peptide with Multivalent Sulfonated Sugar

By Yoshiko Miura and Tomohiro Fukuda


Open access peer-reviewed

6. Laboratory Methods for the Diagnosis of Hereditary Amyloidoses

By S. Michelle Shiller, Ahmet Dogan and W. Edward Highsmith, Jr.


Open access peer-reviewed

7. Electron Microscopy in the Diagnosis of Amyloidosis

By Tosoni A., Barbiano di Belgiojoso G. and Nebuloni M.


Open access peer-reviewed

8. Amyloidosis in Domestic Animals: Pathology, Pathogenesis, Gross and Microscopic Lesions and Clinical Findings

By Moges Woldemeskel


Open access peer-reviewed

9. Mouse Models to Study Systemic Amyloidoses: Is Prion-Like Transmission a Common Pathogenic Mechanism?

By Keiichi Higuchi, Xiaoying Fu, Pengyao Zhang, Jinko Sawashita, Beiru Zhang, Jinze Qian, Wang Yaoyong and Masayuki Mori


Open access peer-reviewed

10. Transthyretin Amyloidosis in Aged Vervet Monkeys, as a Candidate for the Spontaneous Animal Model of Senile Systemic Amyloidosis

By Shinichiro Nakamura, Mitsuharu Ueda, Naohide Ageyama, Yukio Ando and Ryuzo Torii


Open access peer-reviewed

11. Amyloidosis Associated to Leishmania Infection in Murine Model

By Ana Lucia Abreu-Silva, Gabriel Xavier-Silva, Marlise Neves Milhomem, Mylena Andrea Oliveira Torres and Kátia da Silva Calabrese


Open access peer-reviewed

12. Modeling Amyloid Diseases in Fruit Fly Drosophila Melanogaster

By Svetlana Sarantseva and Alexander Schwarzman


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

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