Open access peer-reviewed Edited Volume

Celiac Disease

Jianyuan Chai

Baotou Medical College

Dr. Chai received his Ph.D. from the City University of New York and completed his postdoctoral training at Harvard University. Then he served in the United States Department of Veterans Affairs as a Principal Investigator (2002-2016), in affiliation with the School of Medicine, the University of California in Irvine. Dr. Chai holds memberships with AGA, AHA, ASBMB, and other professional organizations.


DNA Test Antibody Detection HLA-DQ2 HLA-DQ8 Gluten Intestinal Mucosal Integrity Gluten-free Diet Enzyme Supplement Gluten Detoxification Gluten Degrading Enzyme Incidence Geographic Distribution

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About the book

Celiac disease is a common autoimmune disorder affecting a 0.5-1.0% global population in both sexes regardless of age. It is caused by eating gluten-containing food such as wheat. Clinical symptoms include diarrhea, abdominal pain, malnutrition, and oral ulcers. Sometimes it is mistaken for irresistible bowel syndrome or lactose intolerance. Diagnosis has been problematic due to the lack of gold criteria. Eighty percent are believed undiagnosed. Therefore, the actual incidence could be much higher. Genetically, a majority of patients carry a DQ2 or DQ8 variant in their allele for human leukocyte antigen (HLA) subunits, which constitute the class II major histocompatibility complex (MHC) that is responsible for distinguishing foreign peptides from their own. The MHC containing DQ2 or DQ8 has higher affinity for gluten and triggers autoimmune process upon gluten binding. People with such genetic background could have intestinal mucosal damage for eating gluten-containing food. Serious consequences, including anemia, intestinal lymphoma, and intestinal adenocarcinoma, could be resulted due to the lack of proper care. Currently, there is no effective treatment except for diet adjustment.

This book intends to raise the awareness of this common disease, hopefully, to stimulate research activity in this area, and by that to find better therapeutic solutions.

Publishing process

Book initiated and editor appointed

Date completed: September 23rd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 20th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 10th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 9th 2021

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About the editor

Jianyuan Chai

Baotou Medical College

Dr. Chai received his Ph.D. from the City University of New York in 1998 and completed his postdoctoral training at Harvard University in 2001. Then he served in the United States Department of Veterans Affairs as a Principal Investigator (2002-2016), in affiliation with the School of Medicine, the University of California in Irvine. Currently, he is a professor at Baotou Medical College, Inner Mongolia University of Science and Technology. He has published dozens of research articles on various subjects including zoology, cardiovascular biology, gastroenterology, and cancer biology. In addition, he holds memberships with AGA, AHA, ASBMB and other professional organizations. Dr. Chai has also served on the editorial board of multiple journals and has been a solicited reviewer for national and international funding agencies.

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Book chapters authored 4

Books edited 5

Introducing your Author Service Manager

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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