About the book
Celiac disease is a common autoimmune disorder affecting a 0.5-1.0% global population in both sexes regardless of age. It is caused by eating gluten-containing food such as wheat. Clinical symptoms include diarrhea, abdominal pain, malnutrition, and oral ulcers. Sometimes it is mistaken for irresistible bowel syndrome or lactose intolerance. Diagnosis has been problematic due to the lack of gold criteria. Eighty percent are believed undiagnosed. Therefore, the actual incidence could be much higher. Genetically, a majority of patients carry a DQ2 or DQ8 variant in their allele for human leukocyte antigen (HLA) subunits, which constitute the class II major histocompatibility complex (MHC) that is responsible for distinguishing foreign peptides from their own. The MHC containing DQ2 or DQ8 has higher affinity for gluten and triggers autoimmune process upon gluten binding. People with such genetic background could have intestinal mucosal damage for eating gluten-containing food. Serious consequences, including anemia, intestinal lymphoma, and intestinal adenocarcinoma, could be resulted due to the lack of proper care. Currently, there is no effective treatment except for diet adjustment.
This book intends to raise the awareness of this common disease, hopefully, to stimulate research activity in this area, and by that to find better therapeutic solutions.