Open access peer-reviewed Edited Volume

Regulatory T Cells

Xuehui He

Radboud University Nijmegen Medical Centre

A pioneering researcher in the field of immune tolerance induction and immune profile of various immune-related diseases.


Treg Heterogeneity Thymus Foxp3 CD25 Autoimmune Diseases Solid Organ Transplantation Stem Cell Transplantation Immune Tolerance Metabolism Immune Checkpoint Inhibitors Cancer Personalized Medical Care

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About the book

CD4+FOXP3+ regulatory T cells (Treg) have an indispensable role in maintaining immune homeostasis and immune tolerance. They control unwanted immune responses that are involved in the regulation of immune tolerance to self as well as to foreign antigens. Loss-of-function mutation in FOXP3 locus, a gene encoding Treg lineage transcription factor FOXP3, leads to multiorgan autoimmune associated disease including diabetes, thyroiditis, eczema, hyper-IgE syndrome, and cytokine storm. However, FOXP3+ Treg might become unstable especially under certain inflammatory conditions, and might transform into proinflammatory cytokine-producing cells. The issue of heterogeneity and instability of Treg has caused considerable debate in the field and has important implications for Treg-based immunotherapy. Modulation of Treg is proposed as a means of treating autoimmunity and preventing organ transplant rejection. For optimizing these Treg-based therapies, it is vital to get a better understanding of Treg expansion, migration, and suppressive function. Besides, it is essential to consider the metabolic profiles of Treg throughout these capacities. A full understanding of Treg metabolic profile throughout proliferation, migration, and suppressive function, as well as how Treg metabolism could be exploited for tolerance-inducing therapies for autoimmune diseases are a few popular research topics at the current moment.

Publishing process

Book initiated and editor appointed

Date completed: December 2nd 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 28th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 19th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 18th 2022

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About the editor

Xuehui He

Radboud University Nijmegen Medical Centre

Dr. Xuehui He received her PhD at Tuebingen University, Germany, in the field of molecular biology. Thereafter, she moved to Nijmegen, The Netherlands, for continuing the adventure in immunology field. Over the years, the regulation of the immune system especially in relation to autoimmune diseases has been her main topic of research including the basics of T cell activation, the induction of immune tolerance, and the modulatory effect of various immune suppressants. Identification of biomarkers for personalized therapy and using the biomarker profile as a co-diagnostic tool is her recent research focus. Her final aim is to capture disease severity in validated outcome measures and assess side effects of treatments in real clinical practice.

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Book chapters authored 1

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