About the book
The imbalance between production and accumulation of free radical molecules, referred as reactive oxygen reactive species (ROS), in cells and tissues along with certain physiological effects has been called oxidative stress. Lipid peroxidation is a free radical mediated chain of reactions which involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids. Once initiated or enhanced by a number of toxic products, results in an oxidative deterioration of polyunsaturated fatty acids. The most common targets are the components of biological membranes. When propagated in biological membranes, with eventual destruction of membrane lipids, it ends up with the production of a variety of breakdown products leading to cell death. Lipid peroxidation end products are considered as second messengers of free radicals that act both as signaling molecules and as cytotoxic products which cause covalent modification of macromolecules. These end products may play important roles in the pathophysiology of various diseases, both in the development and in the progression via causing exposure to the cells at supraphysiological levels, altering redox signaling and induction under secondary pathological conditions, such as low-grade inflammation.
New discoveries about the involvement of lipid peroxidation in cellular physiology and pathology continue to emerge every day. Given the enormity of this field, this book is accepted to focus on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of the end products of such as; malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), 8-iso-prostaglandin F2-alpha (8-isoprostane), and acrolein. The end products of lipid peroxidation have not only physiological and protective functions as signaling molecules stimulating gene expression and cell survival, but also they have cytotoxic role inhibiting gene expression and promoting cell death. An increasing understanding how lipid peroxidation can be controlled is expected to have significant medical impact. The treatment options that control the production of free radical mediated generation of lipid peroxidation end products could be potential therapeutic approaches to controlling human diseases.