Open access peer-reviewed Edited Volume

Lipid Peroxidation

Pınar Atukeren

Istanbul University Cerrahpaşa

Prof. Atukeren does extensive research in free radicals and antioxidants, diabetes, cerebral ischemia-reperfusion, brain tumors, and aging.


Mitochondrial Diseases Oxidative Stress Antioxidants PABA Cholin Flavonoids Coenzyme Q10 Inositol Kolin Pycnogenol Lipoic Acid Dehydrolipoic Acid

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About the book

The imbalance between production and accumulation of free radical molecules, referred as reactive oxygen reactive species (ROS), in cells and tissues along with certain physiological effects has been called oxidative stress. Lipid peroxidation is a free radical mediated chain of reactions which involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids. Once initiated or enhanced by a number of toxic products, results in an oxidative deterioration of polyunsaturated fatty acids. The most common targets are the components of biological membranes. When propagated in biological membranes, with eventual destruction of membrane lipids, it ends up with the production of a variety of breakdown products leading to cell death. Lipid peroxidation end products are considered as second messengers of free radicals that act both as signaling molecules and as cytotoxic products which cause covalent modification of macromolecules. These end products may play important roles in the pathophysiology of various diseases, both in the development and in the progression via causing exposure to the cells at supraphysiological levels, altering redox signaling and induction under secondary pathological conditions, such as low-grade inflammation. 

New discoveries about the involvement of lipid peroxidation in cellular physiology and pathology continue to emerge every day. Given the enormity of this field, this book is accepted to focus on biochemical concepts of lipid peroxidation, production, metabolism, and signaling mechanisms of the end products of such as; malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), 8-iso-prostaglandin F2-alpha (8-isoprostane), and acrolein. The end products of lipid peroxidation have not only physiological and protective functions as signaling molecules stimulating gene expression and cell survival, but also they have cytotoxic role inhibiting gene expression and promoting cell death. An increasing understanding how lipid peroxidation can be controlled is expected to have significant medical impact. The treatment options that control the production of free radical mediated generation of lipid peroxidation end products could be potential therapeutic approaches to controlling human diseases.

Publishing process

Book initiated and editor appointed

Date completed: September 21st 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 18th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 8th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 7th 2021

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About the editor

Pınar Atukeren

Istanbul University Cerrahpaşa

Dr. Pinar Atukeren was born in Istanbul on May 1975. She is a senior Professor in Biochemistry teaching in Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biochemistry. She got her Ph.D. degree in 2005 in the same department. She has been awarded the National Research Grant For Successful Students from the Scientific and Technical Research Council of Turkey. Her research interests are oxidative and nitrosative stress, free radicals and antioxidants, neurodegenerative diseases, brain tumors and aging. Dr. Atukeren has published more than 50 papers in SCI and SCI-Exp indexed journals and edited and wrote both international and national books and book chapters. She is a reviewer for many international peer review journals. She attended many conferences and workshops, and involved in many training courses and consultations. She is the Head of Animal Welfare and Ethics Committee and member of Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa. At the community level, Dr.Atukeren is an active member in a number of governmental and nongovernmental societies and committees.

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Book chapters authored 3

Books edited 1

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