Open access peer-reviewed Edited Volume

Colorectal Cancer

Alberto Vannelli

Ospedale Valduce


Colorectal Cancer Pelvic Exenteration Rectal Cancer Cancer Recurrence Colorectal Surgery Chemotherapy Target Therapy Radiotherapy Neoadjuvant and Adjuvant Therapies Robotic Surgery Prevention Survival Rate

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About the book

Recent data suggest that approximately 10% of primary rectal carcinomas present with tumor invasion into adjacent organs without distant metastases. The wider application of total mesorectal excision and multimodal treatment regimens, including neoadjuvant and adjuvant therapy, have reduced the rate of local recurrence to < 8% . However, many patients with local recurrence exhibit disabling complications, including severe pain caused by bony or nervous tissue involvement, urinary obstruction, fecal obstruction or incontinence, or persistent bleeding. In patients with primary locally advanced colorectal cancer (LACRC) or locally recurrent colorectal cancer (LRCRC), en bloc excision of the tumor and/or adjacent organs, via pelvic exenteration, is often necessary to obtain a negative surgical margin.

Total pelvic exenteration implies en bloc resection of the rectum, distal colon, bladder, lower ureter, internal reproductive organs, draining lymph nodes, and pelvic peritoneum. The procedure was first described by Brunschwig in 1948 as a palliative operation for advanced cervical cancer.

Disease-free survival following salvage resection is dependent upon achieving an R0 resection margin. A clear understanding of applied surgical anatomy, appropriate preoperative planning, and a multidisciplinary approach to aggressive soft tissue, bony, and vascular resection with appropriate reconstruction is necessary.

This book will discuss technical tips, tricks, and pitfalls that may assist in managing these cancers as well as the roles of additional boost radiation and intraoperative radiation therapy in the management of such cancers.

Publishing process

Book initiated and editor appointed

Date completed: May 27th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: August 16th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: November 4th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: January 3rd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Alberto Vannelli

Ospedale Valduce

Alberto Vannelli obtained his Doctor of Medicine degree from “La Statale” University of Milan after which he did an internship and four years of residency in Liver Transplantation Unit at Maggiore Hospital (Milan). He completed a residency in Colorectal Cancer Surgery at Fondazione IRCCS Istituto Nazionale dei Tumori of Milan. He was an Attending Surgeon at Fondazione IRCCS Istituto Nazionale dei Tumori of Milan (2001- 2011) and Senior Attending Surgeon at Valduce Hospital at Como (2011- to date). Since October 2018, he is Director of General Surgery at Valduce Hospital. His practice is devoted to pelvic surgery with a particular interest in rectal cancer. Dr. Vannelli has contributed to the literature with an innovative theory on pelvic lymphedema and new modified tension-free technique in wall defects after abdominoperineal resection.

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Book chapters authored 3

Books edited 1

Introducing your Author Service Manager

Mrs. Mia Vulovic

r. Hülya Şenol graduated from the Biology Department, Atatürk Education Faculty at Marmara University, Turkey in 1991. She has completed two master degrees, one in the field of Educational Sciences, Eastern Mediterranean University, Cyprus and one in Molecular Medicine, Near East University, Cyprus. Dr. Şenol holds a Ph.D. degree in Educational Administration, Management, Inspection, and Economy. She is a multidisciplinary researcher and has 28 years of teaching experience. From 1991 to 2011, she worked at many colleges in Turkey and in North Cyprus as an instructor, ISO 9001 committee member, and deputy principal. Dr. Şenol is a senior instructor in the Faculty of Arts and Sciences at Eastern Mediterranean University. She has earned many certificates about the education of trainers in Montessori education, educational sciences, and molecular medicine. Her current research interest areas are Educational Leadership, School Culture, Total Quality Management in Education, Service Quality in Education.

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