About the book
Interleukins as a group of cytokines have a pivotal role in the innate and adaptive immune system and the related interactions. Interleukins are categorized into different family members based on their molecular biology, structure and function. Hence, any information regarding these characteristics may help us to know their importance and association with signaling pathways. Moreover, pathogenic microorganisms as the outsiders are able to stimulate the genes of the related interleukins to be turned on or turned off. In contrast to infectious diseases, autoimmune diseases are the results of endogenous stimulators which are in association with some disorders (genetic, environmental or both of them). This process may stimulate the production or prevention of interleukins as protein and glycoprotein molecules that mediate different mechanisms and signaling pathways. As aforementioned, genetic and environmental factors are important predisposing factors in this regard. Among versatile factors, polymorphism is a considerable genetic-environmental factor that is recognized as the cornerstone of abnormalities in immune system activities and functions. However, some kinds of polymorphisms are weak factors to contribute.
Cancers have different reasons, agents, mechanisms and characteristics. According to the type of cancer, different interleukins are contributed with different functions and activities.
All in all, choosing a suitable and effective therapeutics strategies has a direct effect on the result of these disorders.